Clinical trials: Disorder, Mood
LSD, Major Depressive Disorder
Mood Effects of Serotonin Agonists: Depression
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression.
- Conditions
- LSD, Major Depressive Disorder, Depression
- Trial name
- MESA-D (NCT07017478)
- Testing
- LSD
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Major Depressive Disorder
Precision Medicine for the Prediction of Treatment (PROMPT) Response (PROMPT)
Major depressive disorder (MDD) is the most common psychiatric disease worldwide with a huge socio-economic impact. Pharmacotherapy represents the first-line treatment choice; however, only about one third of patients respond to…
- Trial name
- PROMPT (NCT05537558)
- Testing
- Antidepressant
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- University Hospital Muenster
Depression, Anxiety
Sea Swimming for Treatment of Depression and Anxiety
There is a developing evidence to suggest that open cold water swimming could have an impact on depression and anxiety: anecdotal reports of benefits to mental wellbeing as a result of regular open water bathing research…
- Trial name
- NCT04528485
- Testing
- Sea swimming
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Devon Partnership NHS Trust
Bipolar Disorder, Anxiety Disorders
Pilot Study of Cognitive Behavioral Therapy for Anxiety and Bipolar I Disorder
The specific goal of this research study is to investigate the feasibility, acceptability, and preliminary efficacy of a transdiagnostic, cognitive-behavioral therapy developed specifically to target common core processes across…
- Trial name
- NCT01892306
- Testing
- UP CBT, Treatment as usual
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Massachusetts General Hospital
Sleep, Sleep Apnea
Research Framework Exploring Sleep Health
This is a digital health study in which participants are recruited to collect sleep and activity data from digital activity trackers.
- Conditions
- Sleep, Sleep Apnea, Obesity, Mood
- Trial name
- REFRESH (NCT05197738)
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Bipolar Disorder
Study of Licarbazepine in the Treatment of Manic Episodes of Bipolar Disorder
The purpose of this study is to evaluate the effectiveness and tolerability of an investigational drug for the treatment of manic episodes of bipolar disorder.
- Trial name
- NCT00107926
- Testing
- Licarbazepine
- Where
- 44 sites in United States, Austria and 11 more
- Volunteers
- 343 people
- Sponsor
- Novartis Pharmaceuticals
Tobacco Dependence
Effects of Yoga and Cardiovascular Exercise on Smoking Motivation
The overall purpose of this pilot study is to examine effects of Hatha yoga and cardiovascular exercise on craving, mood, cue reactivity, and smoking behavior.
- Trial name
- NCT01423578
- Testing
- Hatha Yoga (HY), Cardiovascular Exercise (CE), Smoking Cessation Counseling
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Major Depressive Disorder
Korean Post Marketing Surveillance to Observe Effectiveness and Safety of PRISTIQ
On 6 Feb 2014, Pristiq was approved for the treatment of Major Depressive Disorder(MDD) in Korea. In accordance with the Standards for Re-examination of New Drug, it is required to conduct a PMS for 600 patients by 5 Feb 2020.
- Trial name
- PMS (NCT02548949)
- Where
- 22 sites in South Korea
- Volunteers
- 700 people
- Sponsor
- Pfizer
Endothelial Dysfunction, Mood Disorders
Relative Energy Deficiency in Rowers
This study aims to learn about relative energy deficiency in male and female rowers at the end of the direct sport preparation phase of the annual training cycle.
- Conditions
- Endothelial Dysfunction, Mood Disorders, Malnutrition, Calorie
- Trial name
- NCT06452758
- Testing
- 2000 meter ergometer test
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Poznan University of Physical Education
Major Depressive Disorder, Primary Hypersomnia
Neurophysiologic Correlates of Hypersomnia
The goal of this project is to examine the neurophysiology of hypersomnia during sleep and wakefulness, to identify biomarkers for excessive sleepiness in neuropsychiatric disorders, and pilot acoustical slow wave induction…
- Conditions
- Major Depressive Disorder, Primary Hypersomnia, Bipolar Disorder, Narcolepsy
- Trial name
- NCT01719315
- Testing
- Acoustical slow wave induction
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Schizophrenia, Schizoaffective Disorder
Improving Antipsychotic Adherence Among Patients With Serious Mental Illness
This is a randomized controlled trial examining the effectiveness of a pharmacy-based intervention designed to improve adherence with antipsychotic medications among patients with serious mental illness.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00057135
- Testing
- Unit of use medication packaging, Mailed reminders to patient when medication refills are due, Note to Mental Health Provider when refill is overdue
- Where
- 5 sites in United States
- Volunteers
- 150 people
- Sponsor
- US Department of Veterans Affairs
Bipolar Disorder, Suicidal Ideation
An fMRI Study on Temporal Discounting in Bipolar Disorder
The investigators propose to explore the link between bipolar disorder, anxiety, and suicide by investigating intertemporal discounting in depressed, suicidal patients with bipolar I and II disorder who have various levels of…
- Conditions
- Bipolar Disorder, Suicidal Ideation, Depression
- Trial name
- NCT02323763
- Testing
- fMRI Scanning
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Massachusetts General Hospital
Major Depressive Disorder (MDD), Bipolar Disorder Depression
Cognitive Effects Associated With Hippocampal Neurogenesis Induced by ECT in the Treatment of Depression
Electroconvulsive therapy (ECT) is the treatment of choice for drug-resistant depression (30% of patients), or when there is a short-term risk to the patient's life.
- Trial name
- CONHECT (NCT06661616)
- Where
- France
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier St Anne
Mania
Pharmacotherapy of Treatment-Resistant Mania
Verapamil has been found in some but not all studies to have antimanic activity. Therefore, we investigated the use of verapamil, alone or as an adjunctive treatment, in manic patients who did not respond to an initial adequate…
- Trial name
- TRM (NCT00518947)
- Testing
- Lithium, verapamil, verapamil plus lithium
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Pittsburgh
Anxiety Disorders, Trauma
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety.
- Conditions
- Anxiety Disorders, Trauma, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT05427708
- Testing
- Capnometry-Guided Respiratory Intervention, Psycho-Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Texas at Austin
Mood Disorder
Comparing Compliance, Tolerability, Efficacy and Adverse Events in Bipolar Tients From Valproic Acid to Depakote ER
The purpose of this study is to compare compliance, tolerability, effectiveness, and side-effects in Bipolar I and II patients switching from Valproic Acid to Depakote ER.
- Trial name
- NCT00211250
- Testing
- Valproic Acid and Depakote ER
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Joliet Center for Clinical Research
Treatment Resistant Depression
Deep Brain Stimulation in Treatment Resistant Depression
Recurrent major depressive disorder affects about 3-5% of the population. It is anticipated that by 2020, depression will be the most common cause of disability worldwide in the 18-55 age group.
- Trial name
- NCT01435148
- Testing
- Deep Brain Stimulation, implanted
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- North Bristol NHS Trust
Premenstrual Disorder
The Effect of Progressive Muscle Relaxation Exercises on Premenstrual Syndrome, Anxiety, and Tendency to Violence in Young Women
This study results will provide evidence on the effectiveness of Progressive Muscle Relaxation Exercises (PMRE) as a complementary method in improving Premenstrual Syndrome (PMS), an important women's health issue.
- Trial name
- NCT06909955
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Treatment Resistant Depression
Proof-of-Concept Trial of CERC-501 Augmentation of Antidepressant Therapy in Treatment-Resistant Depression
This study is looking at the efficacy, rapidity, safety, and tolerability of two doses of oral CERC-501 for treating patients with treatment resistant depression who are taking an antidepressant that is not working for them.
- Trial name
- RAPID KOR (NCT01913535)
- Testing
- CERC-501
- Where
- 4 sites in United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
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