Clinical trials: Disorder, Mood
Major Depression, Treatment
fMRI Study of Treatment Changes in Major Depression
The overall purposes of this research are to determine if Cognitive Behavioral Therapy (CBT) has the same healing effect on the brain for people with depression as traditional antidepressants do, and in comparison to healthy…
- Trial name
- NCT01027559
- Testing
- Sertraline, Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
MDD
The MOOD Study - External Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for the Treatment of Major Depressive Disorder (MDD)
The MOOD study will evaluate the safety and efficacy of a noninvasive, self-administered external Combined Occipital and Trigeminal Neurostimulation (eCOT-NS) treatment for Major Depressive Disorder (Relivion®DP).
- Trial name
- MDD (NCT04279522)
- Testing
- Relivion®DP- Active
- Where
- 13 sites in United States, Israel
- Volunteers
- 124 people
- Sponsor
- Neurolief Ltd.
Bipolar Disorder Depression
Scopolamine in Bipolar Depression
This is a single-site, randomised, double-blind, placebo-controlled, parallel, phase IIb clinical trial. The primary objective of the SCOPE-BD study is to investigate the efficacy and safety of IV Scopolamine, compared to…
- Trial name
- SCOPE-BD (NCT04211961)
- Testing
- Scopolamine
- Where
- Ireland
- Volunteers
- 55 people
- Sponsor
- Dr. Brian Hallahan
Schizophrenia, Schizoaffective Disorder
Improving Diabetes Risk Factors in Persons With Schizophrenia or Bipolar Disorder by Switching to Ziprasidone
Having a diagnosis of schizophrenia or bipolar disorder and being treated with certain of the newer antipsychotics are risk factors for development of diabetes.
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT00538642
- Testing
- ziprasidone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Depression, Postpartum, Anxiety Disorders
Inhaled Oxytocin and HPA Axis Reactivity
Mothers who were enrolled in the Mood, Mother and Infant study will be eligible to participate in the 6-year follow-up maternal visit.
- Conditions
- Depression, Postpartum, Anxiety Disorders, Stress, Psychological
- Trial name
- NCT03593473
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- University of North Carolina, Chapel Hill
Major Depressive Disorder
5-HTP and Creatine for Depression
This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression.
- Trial name
- NCT04395183
- Testing
- 5-Hydroxytryptophan 100 MG, Creatine monohydrate
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- University of Utah
Depression, Mood Disorders
Functional MRI Before and After Treatment for Depression
The purpose of this study is to help us understand how depression changes brain activity and how this relates to mood, anxiety, and cognitive functions like memory.
- Conditions
- Depression, Mood Disorders, Depressive Disorder
- Trial name
- NCT00896441
- Testing
- Citalopram
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Stanford University
Depression, Suicidal Ideation
Paroxetine/Bupropion in Depression With Suicide Attempt or Thoughts: fMRI Study
This study uses functional magnetic resonance imaging (fMRI) to investigate the effects of two different antidepressant medications (Paxil CR versus Wellbutrin XL) on reward processing in depressed patients who have attempted…
- Trial name
- NCT01748955
- Testing
- Paroxetine CR for Major Depressive Episode, Bupropion XL for Major Depressive Episode
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- New York State Psychiatric Institute
Other Chronic Postoperative Pain
High Pain Intervention in Cesarean Sections
In previous studies the investigators have seen that the severity of pain one day after cesarean delivery can predict the presence of pain and depression 2 months later.
- Trial name
- NCT01298778
- Testing
- Duramorph 150, Acetaminophen, Duramorph 300
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Wake Forest University Health Sciences
Major Depressive Disorder
Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females
The investigators propose to determine if 8 weeks of dietary augmentation with oral 5g creatine monohydrate daily and 100 mg of 5-hydroxytryptophan (5-HTP) twice daily reduces hypoxia-related depressive symptoms measured by the…
- Trial name
- NCT02922725
- Testing
- 5-hydroxytryptophan and Creatine
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brent Michael Kious, MD, PhD
Depressive Disorder, Major
A Multicenter, Relapse Prevention Study With Levomilnacipran Extended Release (ER) in Participants With Major Depressive Disorder
This study evaluates the efficacy, safety and tolerability of levomilnacipran extended-release (ER) compared with placebo in the prevention of depression relapse in major depressive disorder (MDD).
- Trial name
- NCT02288325
- Testing
- Levomilnacipran ER
- Where
- 47 sites in United States
- Volunteers
- 644 people
- Sponsor
- Forest Laboratories
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Bipolar Disorder, Bipolar Affective Psychosis
Effectiveness of Quetiapine XR on the Control of Symptoms of Manic Phase of Bipolar Disorder.
The primary purpose of the study is to assess the efficacy of Quetiapine extended release 600mg per day either as monotherapy or combined therapy in the treatment of patients with mania associated to Bipolar disorder.
- Conditions
- Bipolar Disorder, Bipolar Affective Psychosis, Mania, Manic Disorder
- Trial name
- EMMY (NCT00521365)
- Testing
- Quetiapine 600mg
- Where
- 7 sites in Mexico
- Volunteers
- 88 people
- Sponsor
- AstraZeneca
Major Depressive Disorder
Developing New Clinical Management Strategies
The goal of this study is to develop new methods of administering antidepressant medications that will result in improved drug/placebo separation in randomized controlled trials (RCTs) for Major Depressive Disorder (MDD) and…
- Trial name
- NCT02082392
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- New York State Psychiatric Institute
Mental Disorder, Substance Use Disorders
Supported Employment in Patient Aligned Care Teams
In response to the Rehabilitation Research and Development (RR\&D) Deployment Health Research, this study addresses the delivery of an evidenced-based vocational rehabilitation, specifically Individual Placement and Support…
- Conditions
- Mental Disorder, Substance Use Disorders, Posttraumatic Stress Disorder, Major Depressive Disorder
- Trial name
- NCT02400736
- Testing
- Individual Placement and Support (IPS), Treatment as Usual Vocational Rehabilitation/Transitional Work (TUA-VR)
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- VA Office of Research and Development
Major Depressive Disorder, Anxiety Disorder
Ketamine Infusion for Adolescent Depression and Anxiety
The purpose of this study is to determine the tolerability and short-term efficacy of a single ketamine infusion for the treatment of adolescents with 1) medication-refractory major depressive disorder (MDD) and/or 2)…
- Trial name
- NCT02579928
- Testing
- Ketamine, Midazolam
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Yale University
Major Depressive Disorder
A Study Of DVS SR In Treatment Of Children And Adolescent Outpatients With MDD
This is a double-blind study evaluating Desvenlafaxine Succinate Sustained-Release (DVS SR) versus placebo in the Treatment of Children and Adolescent Outpatients with Major Depressive Disorder (MDD).
- Trial name
- NCT01371734
- Testing
- Desvenlafaxine Succinate Sustained-Release
- Where
- 42 sites in United States, Chile and 1 more
- Volunteers
- 363 people
- Sponsor
- Pfizer
Depressive Disorder, Cancer
Carcinogenicity Study of Bupropion
There is a lack of toxicology data on one bupropion metabolite, and limited literature examining bupropion use and cancer risk. This study evaluates the association between bupropion exposure and the development of cancer of the…
- Trial name
- NCT01077596
- Testing
- Regular bupropion use, Regular SSRI (Selective serotonin reuptake inhibitors) use, Regular TCA (Tricyclic antidepressants) use
- Volunteers
- 50,430 people
- Sponsor
- GlaxoSmithKline
Bipolar Depression
Exploring the Effects of Coenzyme Q10 on Bioenergetics Metabolism in Geriatric Bipolar Depression
The investigators propose to study and compare measures of brain energy metabolism in geriatric bipolar individuals and healthy older adults.
- Trial name
- NCT01390389
- Testing
- Coenzyme Q10
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder
Multicenter Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, fixed-dose study in patients with a primary diagnosis of MDD according to criteria of the Diagnostic and Statistical Manual of Mental Disorders…
- Trial name
- NCT05061706
- Testing
- Lumateperone
- Where
- 50 sites in United States, Argentina and 5 more
- Volunteers
- 480 people
- Sponsor
- Intra-Cellular Therapies, Inc.
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