Clinical trials: Disorder, Mood
Treatment Resistant Depression
Ketamine Frequency Treatment for Major Depressive Disorder
Depression is a wide spread illness. Depression contributes most significantly to national health care costs. While the number and types of treatments used for depression have expanded over the years, even with an increased range…
- Trial name
- NCT00646087
- Testing
- Ketamine, Ketamine/Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Essentia Health
Major Depression
Healthy Mood Internet Intervention Research Project
The purpose of the study is: 1. to study whether individuals WHO ARE NOT CURRENTLY SERIOUSLY DEPRESSED will participate in an online study to prevent clinical depression and 2.
- Trial name
- NCT01358487
- Testing
- Online self-help course plus live follow-up if needed, Online + incentives Follow-up Group
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder
Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)
The Department of Psychiatry at the University of Pittsburgh is conducting a research study to learn about the changes that occur in the brain when individuals suffer from and then are treated for depression.
- Trial name
- NEMO (NCT03128021)
- Testing
- Escitalopram Pill, Levomilnacipran Pill
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Howard Aizenstein
Ulcerative Colitis, Crohn's Disease
Treatment of Iron Deficiency Anaemia in Inflammatory Bowel Disease With Ferrous Sulphate
Iron deficiency anaemia is common in inflammatory bowel disease (IBD), affecting at least 20% patients at any one time. Hepcidin, a recently described anti-microbial peptide synthesized by the liver, is a key regulator of iron…
- Trial name
- NCT01991314
- Testing
- Ferrous sulphate
- Where
- United Kingdom
- Volunteers
- 90 people
- Sponsor
- Queen Mary University of London
Parkinson Disease, Depression
Probiotic Treatment for Depression and Associated Mood Disorders in Parkinson's Disease
This study evaluates the use of an oral multi-strain probiotic in the treatment of depression in individuals with Parkinson's Disease.
- Conditions
- Parkinson Disease, Depression, PARKINSON DISEASE (Disorder)
- Trial name
- ProD (NCT05568498)
- Testing
- Probiotic
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Major Depressive Disorder
Multi-domain Psychoeducation Self-management Program for Adults With MDD in Singapore
This is a single-centre, two-arm, unblinded pilot randomised controlled trial study on 60 participants (30 in each arm) from the community mental health service (CMHS) centre within a social service agency in Singapore based on…
- Trial name
- NCT05682183
- Testing
- Multi-domain Psychoeducation Self-management Programme, Treatment as usual
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- National University of Singapore
Dyspepsia
Effect of Genetic Association With Functional Dyspepsia and Mood Disorders
Background: Functional dyspepsia (FD) is one of the commonest digestive disorders. The pathophysiology of functional dyspepsia is uncertain. Risk factors include genetics, gender, age, helicobacter pylori infection, etc.
- Trial name
- FDFDR (NCT02282995)
- Where
- Hong Kong
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Postpartum Depression, Internet-based Intervention
Feasibility Study: Self-guided iCBT for Mothers With Postpartum Depression.
The purpose of this study is to conduct a feasibility study to test the study procedure and a newly developed self-guided internet-based cognitive behavioral therapy program for mothers with postpartum depression.
- Trial name
- NCT06569875
- Testing
- iCARE
- Volunteers
- 20 people
- Sponsor
- University of Southern Denmark
Postpartum Depression
A Long-Term Study of Patient-Reported Changes in Postpartum Depression Symptoms in People Starting Zuranolone
In this study, researchers will learn how postpartum depression symptoms may change after people first start taking zuranolone. This is a drug available for doctors to prescribe for people with postpartum depression, also known…
- Trial name
- NCT07398469
- Testing
- Zuranolone
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Biogen
Depressive Disorder, Depressive Disorder, Major
Synaptic Imaging and Network Activity in Treatment Resistant Depression
The main aim of this research is to explore the effects that ketamine has on the functional connectivity of the brain in participants with treatment resistant depression (TRD).
- Conditions
- Depressive Disorder, Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Bipolar Disorder
- Trial name
- SIGNATURE (NCT05870501)
- Testing
- Ketamine, Midazolam
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- King's College London
Labor Pain, Pregnancy Outcomes
The Association Between Epidural Labor Analgesia and Pregnancy Outcomes
Labor analgesia can alleviate intrapartum pain, in the importance of the delivery is very obvious.But some researches think labor analgesia may affect the progress of labor, increase the cesarean section rate.This research adopts…
- Conditions
- Labor Pain, Pregnancy Outcomes, Psychological Disorder
- Trial name
- NCT03381495
- Testing
- Ropivacaine Hydrochloride, Sufentanil
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Deng Dongrui
Advanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma
Resiliency Among Older Adults Receiving Lung Cancer Treatment
This trial studies how well physical therapy and progressive muscle relaxation works in improving physical performance and mood in older patients with stage IIIA-B or IV lung cancer who are undergoing treatment.
- Conditions
- Advanced Lung Carcinoma, Extensive Stage Lung Small Cell Carcinoma, Stage IIIA Lung Cancer AJCC v8, Stage IIIB Lung Cancer AJCC v8
- Trial name
- ROAR-LCT (NCT04229381)
- Testing
- Physical Therapy, Quality-of-Life Assessment, Questionnaire Administration
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Major Depressive Disorder
Feasibility Pilot of Accelerated Stimulation With TMS for Treatment of Major Depressive Disorder (FAST-MDD)
This is a mixed-methods study that includes three steps. The first is a focus group to collect opinions and feedback about implementation of aTMS among clinicians, technicians, nurses, and other clinical staff at the St.
- Trial name
- NCT06961851
- Testing
- aTMS utilizing the MagVenture TMS device
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Minnesota
Bipolar Disorder, Schizophrenia
Comparison of Physical Fitness, Physical Activity Level in Patients With Bipolar Disorder and Schizophrenia
According to the World Health Organization; Bipolar disorder ranks in the top 20 causes of disability among all medical conditions and 6th among mental disorders worldwide.
- Trial name
- NCT05936983
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Yeditepe University
Major Depressive Disorder
A Long-Term Study of Aripiprazole in Patients With Major Depressive Disorder
This trial is a 52-week safety study to evaluate the safety of adjunctive aripiprazole in outpatients with major depressive disorder who have experienced an incomplete response to an ongoing antidepressant trial.
- Trial name
- NCT00095745
- Testing
- Antidepressant + Aripiprazole
- Where
- 58 sites in United States
- Volunteers
- 1,002 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Bipolar Depression
The Safety and Effectiveness of Probiotic Supplementation on Bipolar Depression
This is an 8-week randomized, double-blind placebo-controlled proof of concept study assessing the combination of a mood stabilizer + Align in the treatment of participants with a bipolar depressive episode.
- Trial name
- ALIGN (NCT02155972)
- Testing
- Bifidobacterium infantis
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- Women's College Hospital
MDD
Take-home Functional Electrical Stimulation for MDD
The purpose of this study is to learn whether Functional Electrical Stimulation (FES) of the facial muscles is effective in treating major depressive disorder (MDD) and to develop a model for take-home delivery.
- Trial name
- NCT06261177
- Testing
- Functional Electrical Stimulation (FES)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Major Depression
Randomized Trial of Psychotherapy for Persistently Depressed Primary Care Patients
This is a pilot study. The purpose of this study is to determine whether adding 4 months of behavioral therapy to primary care physician medication treatment(relative to medication treatment alone) improves outcomes for…
- Trial name
- NCT00541957
- Testing
- behavior therapy, Medication prescribed by PCP
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Butler Hospital
Depressive Disorder, Major, Depression
Altering Default Mode Network Activity With Transcranial Focused Ultrasound to Reduce Depressive Symptoms
Depression is a leading cause of disability worldwide, affecting roughly 21 million adults. Repetitive Negative Thought (RNT) has been identified as a potential maintaining factor in depression, such that those who exhibit higher…
- Trial name
- DMNtFUS (NCT06320028)
- Testing
- Non-Invasive Transcranial Focused Ultrasound
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Depression
Deep Brain Stimulation for Treatment-Refractory Major Depression
This study will investigate the use of deep brain stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-refractory major depression.
- Trial name
- NCT00122031
- Testing
- Deep Brain Stimulation with Medtronic Activa Neurostimulator
- Where
- Germany
- Volunteers
- 13 people
- Sponsor
- University Hospital, Bonn
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