Clinical trials: Disorder, Pediatric
Hypospadias
The Effect of Caudal Block on the Postoperative Complications in Pediatric Patients After Hypospadias Repair
Hypospadias refers to a disease represented by a congenital defect in the urethra meatus (urinary opening) in male children. Due to the postoperative pain, symptoms such as discomfort, agitation, and restlessness are generally…
- Trial name
- NCT02164682
- Testing
- IV PCA group, IV PCA+ caudal block group
- Where
- South Korea
- Volunteers
- 404 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Childhood Obesity, Pediatric Obesity
Management of Childhood Obesity
The significant increase in the prevalence of obesity can also be attributed to various social changes, in which the environment (political, economic, social, cultural), and not only the individual and his choices, takes a…
- Trial name
- NCT05966259
- Testing
- Intervention Group- Intensive Multilevel Intervention, Control Group
- Where
- Brazil
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Adaliene Versiani M. Ferreira
Gastrointestinal Microbiome, Metabolome
Response of the Gut Microbiome and Circulating Metabolome to Diet in Children: Ancillary Study to KIDFIT (NCT03405246)
This is an ancillary study to KIDFIT (NCT03405246). KIDFIT tests whether preschool-age children, born to overweight or obese mothers, respond to a healthy DASH diet intervention with better cardiovascular health.
- Conditions
- Gastrointestinal Microbiome, Metabolome, Pediatric Obesity, Dietary Approaches to Stop Hypertension
- Trial name
- NCT03612479
- Testing
- KIDFIT Healthy, KIDFIT Safe
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Northwestern University
Liver Failure, Acute
Efficacy of L-ornithine L-aspartate and Therapeutic Plasma Exchange Versus Plasma Exchange Alone in Lowering Ammonia and Improving Outcomes in Pediatric Acute Liver Failure.
Pediatric acute liver failure (PALF) is associated with very high mortality and morbidity with native liver survival varying between 21 to 75%.Hyperammonemia manifesting as hepatic encephalopathy and causing cerebral edema…
- Trial name
- NCT05778461
- Testing
- L-ornithine L-Aspartate
- Where
- India
- Volunteers
- 32 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Childhood Obesity
Integrated Child Obesity Treatment Study: Bull City Healthy and Fit
The primary aim of this study is to reduce body mass index (BMI) among children ages 5-11 who are obese by integrating behavioral treatment strategies in both clinic (Healthy Lifestyles) and community (Bull City Fit) settings.
- Trial name
- BCHF (NCT02573142)
- Testing
- Bull City Healthy and Fit, Healthy Lifestyles Clinic
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Duke University
Single Ventricle
Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients
This pilot study is aimed at assessing the short-term effects of Tadalafil on the hemodynamic response to exercise and exercise capacity in patients with Fontan circulation.
- Trial name
- NCT01291069
- Testing
- Tadalafil Citrate, Sugar pill
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Utah
Bipolar 1 Disorder, Schizophrenia Disorder
An Expanded Access Program (EAP) for OLZ/SAM in Pediatric Participants With Schizophrenia or Bipolar I Disorder (ALKS 3831-315)
To provide continued access to OLZ/SAM for pediatric participants with schizophrenia or bipolar I disorder who have completed participation in the ALKS 3831-A313 long-term safety extension study.
- Trial name
- NCT07744113
- Testing
- OLZ/SAM
- Where
- United States
- Sponsor
- Alkermes, Inc.
Headache Disorders, Primary
Pediatric Headche Assessment Using HIT 6
The study is a prospective cohort study. The study population will include 100 children aged 6-18 years suffering from headaches who visited the Pediatric Neurology Clinic at Bnai Zion Medical Center and completed both the…
- Trial name
- NCT06598813
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Bnai Zion Medical Center
Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Lymphoma
A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins Lymphoma
This is a phase I study of temsirolimus (Torisel) combined with dexamethasone, cyclophosphamide and etoposide in patients with relapsed acute lymphoblastic leukemia (ALL), lymphoblastic lymphoma (LL) or peripheral T-cell lymphoma…
- Conditions
- Lymphoblastic Leukemia, Acute, Childhood, Lymphoblastic Lymphoma, Peripheral T-cell Lymphoma
- Trial name
- NCT01614197
- Testing
- Temsirolimus, Etoposide, Cyclophosphamide
- Where
- 32 sites in United States, Australia and 1 more
- Volunteers
- 16 people
- Sponsor
- Therapeutic Advances in Childhood Leukemia Consortium
HIV Infections
Routine Use of Antiretroviral Therapy to Prevent Mother-to-Child HIV Transmission in the Kafue District of Zambia
The investigators will enroll a cohort of HIV-infected pregnant women accessing PMTCT services, to better understand the incremental benefits (e.g. reduction in HIV transmission, improvements in HIV-free survival) and risks (e.g.
- Trial name
- NCT00753324
- Testing
- Routine three-drug antiretroviral prophylaxis
- Where
- Zambia
- Volunteers
- 284 people
- Sponsor
- University of North Carolina, Chapel Hill
Pharyngitis, Tonsillitis
PASS Study To Evaluate The Potential Of Zithromax To Cause Ocular Problems In Pediatric Patients
This Post-Authorization Safety Study (PASS) is intended to fulfill a regulatory post-marketing requirement to provide data regarding visual abilities in children taking azithromycin (immediate-release formulation) for acute…
- Trial name
- NCT01919996
- Testing
- Azithromycin
- Where
- 6 sites in United States
- Volunteers
- 8 people
- Sponsor
- Pfizer
Stroke
Thrombolysis in Pediatric Stroke (TIPS)
Thrombolysis in Pediatric Stroke (TIPS) is a five-year multi-center international safety and dose-finding study of intravenous (IV) tPA in children with acute ischemic stroke (AIS) to determine the maximal safe dose of…
- Trial name
- TIPS (NCT01591096)
- Testing
- Tissue plasminogen activator (Activase®)
- Where
- 15 sites in United States, Canada
- Volunteers
- 1 people
- Sponsor
- Seattle Children's Hospital
Injection Pain, Local Anesthesia
Efficacy of Virtual Reality in Reducing Injection Pain and Anxiety During Local Anesthesia in Children
The aim of this study is to determine the efficacy of a virtual reality (VR) device in reducing injection pain and anxiety associated with local anesthesia in pediatric dental patients.
- Trial name
- NCT03772483
- Testing
- Local anesthesia with conventional syringe, Local anesthesia with conventional syringe + VR device
- Where
- Bulgaria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Cleft Palate
Dexmedetomidine vs Placebo for Pediatric Cleft Palate Repair
The primary objective of this study is to evaluate the efficacy of administering intravenous dexmedetomidine as a single preemptive dose to placebo in reducing the total 24 hour dose of opioids as measured on a weight adjusted…
- Trial name
- NCT02915042
- Testing
- Dexmedetomidine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Obesity, Adolescent, PreDiabetes
Unsweetened Sparkling Water and Changes in Sweetness Perception in Adolescents
The study design is a prospective observational study in adolescents who are at risk for developing Type 2 Diabetes (T2D), to evaluate the effectiveness of sparkling water to reduce dietary intake of added sugars and thereby…
- Trial name
- NCT05966870
- Testing
- Unsweetened flavored sparkling water
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia, in Relapse
Phase II Study of Anti-CD19 CAR-T Cells Treating Leukemia Children
The investigators will conduct a phase II clinical trial of autologous murine anti-CD19 chimeric antigen receptor T cells treating refractory or relapsed B acute lymphoblastic leukemia children in Beijing Boren Hospital.
- Conditions
- Acute Lymphoblastic Leukemia, Pediatric, Acute Lymphoblastic Leukemia, in Relapse, Refractory Acute Lymphoblastic Leukemia
- Trial name
- NCT04325841
- Testing
- Murine autologous anti-CD19 chimeric antigen receptor T cells
- Where
- China
- Volunteers
- 2 people
- Sponsor
- Beijing Boren Hospital
Migraine
Study of Pediatric Migraine: The Pediatric Migraine Registry
This is a multi-center registry that will prospectively collect regulatory compliant data from children and adolescents with migraine.
- Trial name
- NCT03742024
- Where
- 19 sites in United States
- Volunteers
- 201 people
- Sponsor
- Duke University
Pediatric Crohn's Disease
Clinical Study of TA-650 in Pediatric Patients With Crohn's Disease
The purpose of this study is to evaluate the efficacy of TA-650 using Pediatric Crohn's Disease Activity Index (PCDAI) in pediatric patients with moderate to severe Crohn's disease after TA-650 administration at a dose of 5 mg/kg…
- Trial name
- NCT01580670
- Testing
- TA-650
- Where
- 7 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Tanabe Pharma Corporation
Leukemia, Aplastic Anemia
Methadone as an Alternative Treatment for Children Underdoing HSCT
Mucositis is a normal side effect of stem cell transplant which happens as a result of chemotherapy being given prior to a new donor cell infusion (bone marrow transplant).
- Conditions
- Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes, SCID
- Trial name
- MATCH (NCT06940570)
- Testing
- PCA plus methadone (Experimental), PCA Alone (SOC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Dermatitis, Atopic
WAL 801 CL Dry Syrup in Pediatric Atopic Dermatitis Patients
The safety and efficacy of WAL 801 CL (epinastine hydrochloride) Dry Syrup in the treatment of atopic dermatitis in children was evaluated and plasma drug concentrations were measured.
- Trial name
- NCT02182570
- Testing
- WAL 801 CL dry syrup
- Volunteers
- 62 people
- Sponsor
- Boehringer Ingelheim
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.