Clinical trials: Disorder Characterized by Fever
Acute Febrile Illness, Bacterial Infections
AI-Guided Proteomic Biomarker Panel for Differentiating Bacterial and Viral Infections in Acute Febrile Illness
This study is a proteomics-based diagnostic biomarker study conducted on the same patient cohort as the transcriptomic biomarker study (NCT065529754).
- Conditions
- Acute Febrile Illness, Bacterial Infections, Viral Infections, Sepsis
- Trial name
- NCT07205575
- Testing
- Proteomic Biomarker Panel
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Qilu Hospital of Shandong University
Malaria, Febrile Illness
Malaria Diagnostic Testing and Conditional Subsidies to Target ACTs in the Retail Sector: TESTsmART Aim 2 - Kenya
Highly subsidized first-line antimalarials (artemisinin combination therapy or ACT) are available over the counter in the private retail sector in most malaria-endemic countries.
- Trial name
- NCT04428307
- Testing
- Conditional artemisinin combination therapy subsidy, Testing incentive
- Where
- Kenya
- Volunteers
- 5,696 people
- Sponsor
- Duke University
Malaria, Fever
Cluster Randomised Trial of Malaria RDTs Used by CHWs in Afghanistan
Malaria is a common, but decreasing, cause of fever in endemic areas. The use of rapid diagnostic tests could improve treatment of malaria at the local community level. Deployment of these tests is, however, a considerable cost.
- Conditions
- Malaria, Fever, Acute Febrile Illness, Pneumonia
- Trial name
- NCT01403350
- Testing
- Malaria Rapid Diagnostic test
- Where
- 3 sites in Afghanistan
- Volunteers
- 2,421 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Febrile Illness
Village Malaria Worker Expansion
This project will conduct pragmatic operational research in rural communities served by approximately 12 health centres and 120 village malaria workers in Battambang/Pailin, western Cambodia.
- Trial name
- CAM-VMW (NCT05045547)
- Where
- Cambodia
- Volunteers
- 7,191 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Acute Febrile Illness
Acute Undifferentiated Fever in Ethiopia
A cross-sectional study on acute undifferentiated fever and the utility of biomarkers in differentiating bacterial from viral infection among acute febrile patients in Gondar, northwest Ethiopia.
- Trial name
- NCT04268732
- Where
- 2 sites in Belgium, Ethiopia
- Volunteers
- 200 people
- Sponsor
- Institute of Tropical Medicine, Belgium
Acute Febrile Illness
The Etiology of Acute Febrile Illness Requiring Hospitalization
This study is an observational cohort study of hospitalized patients with fever. This study will collect demographic data, history of illness, signs and symptoms, results of laboratory tests, clinical course, treatment and…
- Trial name
- AFIRE (NCT02763462)
- Where
- 8 sites in Indonesia
- Volunteers
- 1,492 people
- Sponsor
- Ina-Respond
Febrile Illness
Febrile Illness in Guinea
To date, the underlying causes of community-acquired fever, particularly non-malarial fever, are insufficiently documented in Guinea.
- Trial name
- MuSIFe (NCT06122259)
- Where
- Guinea
- Volunteers
- 2,500 people
- Sponsor
- Centre National de Formation et de Recherche en Sante Rurale
Febrile Illness
Incidences, Causes, and Outcomes of Febrile Illness in Rural South and Southeast Asia
The study will collect information to understand the causes and outcomes of febrile illness in rural areas in countries across South and Southeast Asia (including Cambodia, Laos, Myanmar and Bangladesh).
- Trial name
- SEACTN-WP-A (NCT04478578)
- Where
- 7 sites in Bangladesh, Burma and 3 more
- Volunteers
- 82,760 people
- Sponsor
- University of Oxford
Undifferentiated Febrile Illness
Nepal Undifferentiated Febrile Illness Trial
The purpose of the study is to determine whether azithromycin or cotrimoxazole is the best empirical treatment for undifferentiated febrile illness in Nepal
- Trial name
- NUFIT (NCT02773407)
- Testing
- Azithromycin, Co-trimoxazole
- Where
- 2 sites in Nepal
- Volunteers
- 330 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Acute Febrile Illness, Use of Antimicrobial Agents
Comparison of Rates of Antimicrobial Use in Febrile Patients With or Without the Use of C-reactive Protein Blood Test
In Health Posts of rural areas operated by the Government of Nepal, there are limitations of tests to differentiate between bacterial and viral infections.
- Conditions
- Acute Febrile Illness, Use of Antimicrobial Agents, C-reactive Protein Level
- Trial name
- CREATIB (NCT05292508)
- Testing
- C-reactive Protein Rapid Diagnostic Test
- Where
- Nepal
- Volunteers
- 924 people
- Sponsor
- Patan Academy of Health Sciences
Malaria, Non-malarial Febrile Illness
Non-malarial Febrile Illness in Children in Areas of Perennial Malaria Transmission
To evaluate the causes of non-malarial febrile illness in children living in an area of perennial malaria transmission and to determine if these children who test negative for malaria by rapid diagnostic test receive any benefit…
- Trial name
- NCT01043744
- Testing
- Artemether-Lumefantrine
- Where
- 2 sites in Tanzania
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Acute Febrile Illnesses
Etiologies of Fever Among Adults in Dar es Salaam
Following the decline of malaria in Sub-Saharan Africa, clinicians face febrile patients in whom an alternative diagnosis has to be made. This situation has led to an overuse of antibiotics by clinicians.
- Trial name
- NCT01947075
- Where
- Tanzania
- Volunteers
- 538 people
- Sponsor
- Swiss Tropical & Public Health Institute
Acute Diarrhea, Acute Respiratory Infection
Improving Nighttime Access to Care and Treatment (Part 2)
Children in resource-limited settings who develop illness at night are often isolated from pre-emergency care, resulting in progression to an emergency because families are forced to wait until morning to seek care.
- Conditions
- Acute Diarrhea, Acute Respiratory Infection, Acute Febrile Illness
- Trial name
- INACT2 (NCT03943654)
- Testing
- MotoMeds Healthline- illness assessment and treatment recommendation for non-emergent cases by telephone
- Where
- Haiti
- Volunteers
- 391 people
- Sponsor
- University of Florida
Enteric Fever, Acute Febrile Illness
Transcriptomic Responses for the Identification of Pathogens
Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions.
- Conditions
- Enteric Fever, Acute Febrile Illness, Typhoid, Paratyphoid Fever
- Trial name
- TRiP (NCT04878549)
- Testing
- 5-gene transcription signature
- Where
- India
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Sheffield
Fever, Infectious Disease
Etiology of Uncomplicated Fever in Children <5 in Rural Zanzibar
The purpose of this study is to study the most common etiologies of uncomplicated fever diseases among children under five years of age in rural Zanzibar.
- Trial name
- RDTNEG (NCT01094431)
- Where
- Tanzania
- Volunteers
- 690 people
- Sponsor
- Karolinska University Hospital
Critical Illness, Febrile Illness
Family Assisted Severe Febrile Illness Therapy for Critically-ill Kenyan Children
The purpose of this pilot study is to improve inpatient monitoring of severely-ill children admitted to the hospital in low resource settings at Kenyatta National Hospital in Nairobi, Kenya.
- Trial name
- FASTER (NCT03513861)
- Testing
- FASTER Assessment tool
- Where
- Kenya
- Volunteers
- 182 people
- Sponsor
- Seattle Children's Hospital
Fever
Hospital Admissions in Children Aged 3 Months to 5 Years Presenting With Fever to the Emergency Department
This study primarily aims to describe factors associated with hospitalisation of children aged 3 months to 5 years presenting with fever to an urban paediatric A\&E departments by describing and analysing characteristics both of…
- Trial name
- NCT01196793
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Febrile Illness
Clinical Usefulness of a Multi-analyte Immunoassay for Distinguishing Bacterial and Viral Infections in Children
Fever can be a clinical manifestation present in pediatric infections, posing a challenge for the doctor who must decide whether or not to prescribe an antibiotic therapy.
- Trial name
- PED_BIOMARKERS (NCT06852846)
- Testing
- Biological sample
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Malaria, Dengue
Validation of a CDSA Strategy to Reduce Antibiotic Prescription in Senegal
This trial aims to validate a novel clinical care strategy based on a electronic clinical decision support algorithm (CDSA) combined with point of care rapid diagnostic tests by evaluating its impact on antibiotic prescription…
- Conditions
- Malaria, Dengue, Influenza -Like Illness, Diarrhea
- Trial name
- NCT05050825
- Testing
- Patient clinical management based on the CDSA strategy
- Where
- 4 sites in Senegal
- Volunteers
- 470 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Dengue
Dengue Virus Infection Amongst Patients With Acute Febrile Illness
A prospective observational study that will be conducted in Tangerang Regency, Indonesia with primary objective to determine the clinical characteristics, specific immune responses, and viral serotypes in patients with confirmed…
- Trial name
- NCT06255509
- Where
- Indonesia
- Volunteers
- 400 people
- Sponsor
- Tangerang District Hospital