Clinical trials: Disorder of Circulatory System
Stroke, Rehabilitation
The Kinesio-taping for the Prevention of Painful Shoulder and for the Functional Recovery of Upper Limb After Stroke
This RCT aims to investigate the effectiveness of the early use of Kinesio-taping (KT) together with standard physiotherapy treatment, in the prevention of the shoulder pain of the hemiplegic upper limb following a cerebral…
- Trial name
- NCT05156164
- Testing
- Kinesio Tape Group, Control Group
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- I.R.C.C.S. Fondazione Santa Lucia
Ischemic Stroke
hsCRP in Japan Statin Treatment Against Recurrent Stroke (J-STARS hsCRP)
Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A(HMG-CoA) reductase can play a role in preventing recurrent vascular events from ischemic heart disease patients, whose mechanism consists in not only the reduction of serum…
- Trial name
- NCT00361699
- Testing
- Statin
- Where
- 2 sites in Japan
- Volunteers
- 1,095 people
- Sponsor
- Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan
Diabetic Neuropathies, Peripheral Nervous System Diseases
Effect of Physical Therapy in Improving the Health of Patients With Diabetic Peripheral Neuropathy
People with diabetes can have nerve damage in their extremities (peripheral neuropathy), and this can lead them to being less able to maintain their balance when they are standing, walking or performing complex movement tasks in…
- Trial name
- DPN-QoL (NCT02115932)
- Testing
- Strength & Balance Training
- Where
- Singapore
- Volunteers
- 143 people
- Sponsor
- National University Health System, Singapore
Cardiac Amyloidosis
Cardiac Amyloidosis Registry of University Hospital Leipzig
This is a clinical registry of patients with cardiac amyloidosis being treated at University Hospital Leipzig. The aim of the registry is to collect detailed information about clinical events, symptoms, imaging, biomarkers…
- Trial name
- NCT06129656
- Testing
- Routine diagnostics, Routine treatment
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University of Leipzig
Waldenström Macroglobulinemia
The Comparison of RCD Versus BCD in Newly Diagnosed Waldenström Macroglobulinemia
The purpose of this study is to compare the efficacy of cyclophosphamide plus dexamethasone combined with rituximab or bortezomib regimens in newly diagnosed Waldenström macroglobulinemia patients.
- Trial name
- BDH-WM01 (NCT02844322)
- Testing
- Bortezomib, Rituximab
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Stroke
Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke
The risk of recurrence is greatest immediately after stroke or Transient Ischaemic Attack (TIA). Existing prevention strategies (antithrombotic, lipid/blood pressure lowering, endarterectomy) reduce, not abolish, further events.
- Trial name
- TARDIS (NCT01661322)
- Testing
- Aspirin, Dipyradimole, Clopidogrel
- Where
- United Kingdom
- Volunteers
- 3,096 people
- Sponsor
- University of Nottingham
Stroke
Development of a Tailored Life-Sustaining Treatment Decision Support Intervention for Stroke Surrogate Decision Makers
The trial is testing an investigator-developed decision support tool for surrogate decision makers for stroke patients that are unable to make medical decisions for themselves.
- Trial name
- NCT03427645
- Testing
- Decision tool
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dysphagia, Oropharyngeal, Stroke, Ischemic
Combined Conventional Speech Therapy and Functional Electrical Stimulation in Dysphagia Following Stroke
This study will evaluate the effectiveness of conventional speech therapy associated with functional electrical stimulation in patients with dysphagia after ischemic stroke.
- Trial name
- NCT03649295
- Testing
- Functional Electrical Stimulation, Conventional Speech Therapy
- Where
- Brazil
- Volunteers
- 33 people
- Sponsor
- Hospital Geral de Fortaleza
Stroke
Safe Implementation of Thrombolysis in Stroke - Monitoring Study
Study to evaluate the safety and efficacy of intravenous alteplase within 3 hours of symptom onset in acute ischemic stroke patients
- Trial name
- NCT02229812
- Testing
- alteplase
- Volunteers
- 6,475 people
- Sponsor
- Boehringer Ingelheim
Hypertension
An Examination of the Blood Pressure Lowering Ability and Safety of Olmesartan Medoxomil in Patients With Type II Diabetes
This study will examine the ability of olmesartan medoxomil to lower the blood pressure of patients with Type II diabetes and high blood pressure.
- Trial name
- NCT00403481
- Testing
- olmesartan medoxomil, Olmesartan medoxomil plus Hydrochlorothiazide
- Where
- 27 sites in United States
- Volunteers
- 192 people
- Sponsor
- Daiichi Sankyo
Stroke, Acute, Stroke, Ischemic
Trustworthy Artificial Intelligence for Improvement of Stroke Outcomes
Stroke is a leading cause of death and disability worldwide. The clinical validation of explainable and interpretable Artificial Intelligence (AI) solutions to assist a timely, personalised management of the acute phase of…
- Conditions
- Stroke, Acute, Stroke, Ischemic, Stroke
- Trial name
- TRUSTroke (NCT06710028)
- Testing
- NORA
- Where
- 3 sites in Belgium, Italy and 1 more
- Volunteers
- 1,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hodgkin Disease, Non-Hodgkin Lymphoma
Moxifloxacin in the Prevention of Bacteremia After High-dose Chemotherapy and Transplantation of Peripheral Stem Cells
This study investigates whether the prophylactic use of moxifloxacin during high-dose chemotherapy followed by autologous stem cell transplantation reduces the incidence of clinically significant bacteremia.
- Conditions
- Hodgkin Disease, Non-Hodgkin Lymphoma, Multiple Myeloma, Bacteremia
- Trial name
- MoxiProph (NCT00398411)
- Testing
- moxifloxacin
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- University of Cologne
Stroke
Comparison of Otago Exercises Versus Resistance Training on Functional Performance in Stroke Patients
Otago techniques are well known for addressing balance and strength deficiencies in healthy older population with fall risk. Despite this, there is limited literature about the Otago approaches' effectiveness in stroke patients.
- Trial name
- NCT06034236
- Testing
- Resistance training, Otago Exercises
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Shifa Tameer-e-Millat University
Stroke, Spasticity
Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke
Stiff knee gait is defined as the lack of knee flexion in the swing phase of gait. Stiff knee gait is a frequent condition among stroke patients leading to reduce gait speed and increase energy cost.
- Trial name
- NCT02114736
- Testing
- Tenotomy of the proximal rectus femoris tendon, Botulinum Toxin injection in the rectus femoris muscle
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital of Mont-Godinne
Left Bundle-Branch Block
Prediction of Outcome by Echocardiography in Left Bundle Branch Block
Patients with left bundle branch block have an increased risk for the development of heart-failure and death. However, risk factors for unfavorable outcomes are still poorly defined.
- Trial name
- EchoLBBB (NCT04293471)
- Where
- Norway
- Volunteers
- 2,000 people
- Sponsor
- University Hospital of North Norway
Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Testing Nivolumab and BMS-986016 (Relatlimab) as Potentially Targeting Treatment in Cancers That Are LAG-3+ and Have Mismatch Repair Deficiency (MATCH - Subprotocol Z1M)
This phase II MATCH treatment trial tests how well nivolumab and BMS-986016 (relatlimab) works in treating patients with cancer that has certain genetic changes called LAG-3 mutations with mismatch repair deficiency.
- Conditions
- Advanced Lymphoma, Advanced Malignant Solid Neoplasm, Refractory Lymphoma, Refractory Malignant Solid Neoplasm
- Trial name
- NCT06400264
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Sponsor
- National Cancer Institute (NCI)
Stroke, Hemiplegia
Rehabilitation of Early Stroke Patients Using an AFO: an RCT
Stroke is a major cause of disabilities worldwide. Stroke survivors commonly exhibit walking defects which lead to an altered, slow speed and asymmetric gait pattern.
- Trial name
- NCT01006772
- Testing
- Solid Ankle Foot Orthosis
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University of Strathclyde
Multiple Myeloma
A Study of Modakafusp Alfa Together With Daratumumab Adults With Relapsed or Refractory Multiple Myeloma
The main aim of this study is to determine safety and tolerability of modakafusp alfa given together with daratumumab to find out the best treatment dose.
- Trial name
- iinnovate-3 (NCT05590377)
- Testing
- Modakafusp Alfa, Daratumumab
- Where
- 27 sites in United States, Australia and 5 more
- Volunteers
- 15 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D LLC
Advanced Solid Tumors, Multiple Myeloma
Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma
For cancer cells to grow, they need to have nutrients supplied to them through blood vessels. The study drug, ACE-041, is designed to work by blocking the growth of those blood vessels and preventing cancer cells from growing.
- Trial name
- NCT00996957
- Testing
- ACE-041
- Where
- 4 sites in United States
- Volunteers
- 37 people
- Sponsor
- Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ USA
Coronary Artery Disease, Myocardial Infarction
WENBIT - Western Norway B Vitamin Intervention Trial
PURPOSE OF STUDY Observational studies have demonstrated that elevated levels of plasma total homocysteine is a risk factor for cardiovascular disease.
- Conditions
- Coronary Artery Disease, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- WENBIT (NCT00354081)
- Testing
- folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine), folic acid, vitamin B12 (cyanocobalamin), vitamin B6 (pyridoxine)
- Where
- 2 sites in Norway
- Volunteers
- 3,096 people
- Sponsor
- Haukeland University Hospital
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