Clinical trials: Disorder of Circulatory System
Renal Impairment, Multiple Myeloma
PK of Melphalan During Treatment With Melflufen and Dexamethasone in Patients With RRMM and Impaired Renal Function
This was a multicenter study of the pharmacokinetics (PK) of melphalan during treatment with melflufen and dexamethasone in patients with relapsed refractory multiple myeloma (RRMM) and impaired renal function.
- Trial name
- BRIDGE (NCT03639610)
- Testing
- Melflufen, Dexamethasone
- Where
- 10 sites in Czechia, Greece and 1 more
- Volunteers
- 35 people
- Sponsor
- Oncopeptides AB
Stroke
Validation of 3D Simulations in Embolic Stroke
Stroke is a common condition which results in significant disability for patients. There are different causes of stroke, but around one quarter are as a result of clots or other material from the heart lodging in blood vessels in…
- Trial name
- NCT05055960
- Testing
- Stroke simulation and machine learning
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University of Leicester
Dysphagia
Adjunctive Neuromuscular Electrical Stimulation for the Rehabilitation of Swallowing
Neuromuscular Electrical stimulation (NMES) for swallowing has recently been proposed for the treatment of dysphagia post stroke and is clinically receiving favor as a treatment modality, in the absence of strong research…
- Trial name
- ANSRS (NCT01279824)
- Testing
- swallowing therapy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Florida
Colorectal Cancer, Venous Thromboembolism
Risk Factors of Venous Thromboembolism After Colorectal Cancer Surgery
Aim of our study is to find frequency and identify risk factors for venous thromboembolism development in patients who underwent surgery for colorectal cancer.
- Trial name
- NCT06302179
- Where
- Russia
- Volunteers
- 137 people
- Sponsor
- Pirogov Russian National Research Medical University
Hypoxic-Ischemic Encephalopathy
Neural Progenitor Cell and Paracrine Factors to Treat Hypoxic Ischemic Encephalopathy
The purpose of this study is to investigate the efficacy and safety of allogenic neural progenitor cell and paracrine factors of human mesenchymal stem cells for patients with moderate/severe Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT02854579
- Testing
- neural progenitor cell, Paracrine factors, progenitor cell and paracrine factors
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Navy General Hospital, Beijing
Stroke
Transcranial Direct Current Stimulation on the Risk of Falls and Lower Limb Function for Acute Stroke
Transcranial direct current stimulation (tDCS) has shown promising results in the modulation of cortical excitability and the promotion of neuronal plasticity after stroke.
- Trial name
- NCT02422173
- Testing
- Anodal transcranial direct current stimulation, Cathodal transcranial direct current stimulation, Bilateral transcranial direct current stimulation
- Volunteers
- 60 people
- Sponsor
- Federal University of Paraíba
Tachycardia, Ventricular, Arrhythmia, Ventricular
Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing
The MODULAR ATP Clinical Study is designed to demonstrate safety, performance, and effectiveness of the Modular Cardiac Rhythm Management (mCRM) Therapy System.
- Trial name
- MODULAR ATP (NCT04798768)
- Testing
- mCRM Therapy System
- Where
- 38 sites in United States, Austria and 7 more
- Volunteers
- 297 people
- Sponsor
- Boston Scientific Corporation
Resting Heart Rate, Blood Glucose Control
Assessing the Effects of Cool Roofs on Indoor Environments and Health
Ambient air temperatures in Asian, Latin American, African, and Pacific climate hotspots have broken record highs in 2024, driven by man-made climate change. Solutions are needed to reduce heat exposure in communities.
- Conditions
- Resting Heart Rate, Blood Glucose Control, Depression, Heat-related Symptoms
- Trial name
- REFLECT (NCT06579950)
- Testing
- Cool roof
- Where
- 5 sites in Burkina Faso, Fiji and 3 more
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- Aditi Bunker
Diabetic Foot Ulcer, Non-healing Wound
Debritom - Micro Water Jet Technology and Wound Healing
This study will investigate the clinical efficacy of micro water jet technology in the debridement and healing of chronic lower extremity ulcers.
- Conditions
- Diabetic Foot Ulcer, Non-healing Wound, Non-Healing Ulcer of Skin, Venous Leg Ulcer
- Trial name
- NCT04240574
- Testing
- Debritom
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Stephanie Wu
Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent
Epidemiology of Cardiovascular Disease in Diabetes
To locate and identify genes contributing to the genetic component of subclinical cardiovascular disease (CVD) in Type 2 diabetes and to evaluate the impact of lifestyle and environment on the expression of these genetic…
- Conditions
- Cardiovascular Diseases, Diabetes Mellitus, Non-insulin Dependent, Heart Diseases, Atherosclerosis
- Trial name
- NCT00037297
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Small Vessel Cerebrovascular Disease, Stroke
Intensive Blood Pressure Control in Ischaemic Stroke Patients With Severe Cerebral Small Vessel Disease
Objectives: Cerebral small vessel disease (SVD) is a common disease in patients with ischemic stroke and the most common cause of vascular dementia. Blood pressure (BP)-lowering is generally considered neuroprotective.
- Trial name
- NCT05690997
- Testing
- Intensive treatment, Standard treatment
- Where
- Hong Kong
- Volunteers
- 104 people
- Sponsor
- The University of Hong Kong
Infant, Newborn, Infant, Low Birth Weight
Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
This large randomized trial tested whether phenobarbital given to a pregnant woman about to deliver a premature infant would prevent brain injuries in their newborns.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- Phenobarbital (NCT00009620)
- Testing
- Phenobarbital, Saline
- Where
- 11 sites in United States
- Volunteers
- 610 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Cardiovascular Diseases, Hypercholesterolemia
Plant Sterols on Cardiovascular Markers, Microbiota and Sterol Metabolism (Cardiofoodsterol)
Potential cholesterol-lowering effect of a regular intake of a plant sterol (PS)-containing food supplement, in overweight/obese type 1 or 2, normoglycemic/pre-diabetic, with LDL-cholesterol values > 115 mg/dl and not…
- Conditions
- Cardiovascular Diseases, Hypercholesterolemia, Prediabetic State, Overweight and Obesity
- Trial name
- NCT06481020
- Testing
- Plant sterols 2g/day
- Where
- Spain
- Volunteers
- 42 people
- Sponsor
- University of Valencia
Stroke
Stroke Inpatient Rehabilitation Reinforcement of ACTivity
The purpose of this study is to determine the effects of daily feedback about physical activity (number of bouts of walking, duration of bouts, total walking distance, average and fastest walking speed) and walking average speed…
- Trial name
- SIRRACT (NCT01246882)
- Testing
- Augmented activity feedback, Speed-only feedback
- Where
- 18 sites in United States, Egypt and 10 more
- Volunteers
- 140 people
- Sponsor
- University of California, Los Angeles
Primary Aldosteronism, Finerenone
The Clinical Efficacy and Safety of Finerenone in the Treatment of Primary Aldosteronism
The purpose of our research is to clarify the therapeutic efficacy and safety of Finerenone in patients with Primary Aldosteronism and explore the effective clinical predictive indicators of Finerenone in the treatment of Primary…
- Conditions
- Primary Aldosteronism, Finerenone, Mineralocorticoid Receptor Antagonist
- Trial name
- NCT06381323
- Testing
- Finerenone
- Where
- China
- Volunteers
- 55 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Ischemic Stroke, Chronic Disease
Whole-life Investigation of Lishui Longevity
1. To establish a standardized, normalized and scientific joint screening and follow-up management system for chronic disease multimorbidity in Lishui City, and early identify common risk factors of major chronic diseases such as…
- Conditions
- Ischemic Stroke, Chronic Disease, Cardiovascular
- Trial name
- WILL (NCT07592962)
- Where
- China
- Volunteers
- 4,500 people
- Sponsor
- The Fifth Affiliated Hospital of Wenzhou Medical University & Lishui Central Hospital
Hodgkin Disease, Lymphoma, Non-Hodgkin
A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone Marrow Transplantation
Phase 2 study, conducted in patients with Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, or mantle cell lymphoma undergoing high-dose chemotherapy and autologous stem cell transplantation.
- Conditions
- Hodgkin Disease, Lymphoma, Non-Hodgkin, Multiple Myeloma, Mantle Cell Lymphoma
- Trial name
- NCT00275262
- Testing
- Leuprolide acetate depot (LAD) 11.25 mg 3 Month
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- Abbott
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Sweden Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES).
- Trial name
- NCT01667003
- Where
- 8 sites in Sweden
- Volunteers
- 406 people
- Sponsor
- Biotronik ApS
Diabetic Foot Ulcer Outcome, Quality of Patient Care
The Diabetic Foot Ulcer Registry
This is an observational, longitudinal real world registry of diabetic foot ulcers created from electronic health record data obtained in the course of clinical care.
- Trial name
- DFUR (NCT02813161)
- Testing
- cellular and tissue based therapy, negative pressure wound therapy, debridement
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- U.S. Wound Registry
Aneurysm, Intracranial
US IDE Study of the Contour NEurovasCular System™ for IntraCranial Aneurysm Repair
The purpose of this trial is to gather data on the safety and effectiveness of the Contour /Contour 021 System in the treatment of wide-necked bifurcated saccular, intracranial aneurysms for submission to FDA in support of a…
- Trial name
- NECC (NCT04852783)
- Testing
- Contour Neurovascular System
- Where
- 20 sites in United States
- Volunteers
- 250 people
- Sponsor
- Cerus Endovascular, Inc.
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