Clinical trials: Disorder of Circulatory System
Tricuspid Regurgitation, Tricuspid Valve Disease
Clinical Safety and Efficacy of the VDyne Transcatheter Tricuspid Valve Replacement System for the Treatment of Tricuspid Regurgitation ( VISTA-US)
The purpose of this clinical study is to evaluate the safety and clinical efficacy of the VDyne System in the treatment of symptomatic severe tricuspid regurgitation (TR).
- Conditions
- Tricuspid Regurgitation, Tricuspid Valve Disease, Tricuspid Valvular Disorders
- Trial name
- VISTA-US (NCT05848284)
- Testing
- VDyne Transcatheter Tricuspid Valve Replacement System
- Where
- 11 sites in United States, Canada
- Volunteers
- 30 people
- Sponsor
- VDyne, Inc.
Heart Failure
Randomized Clinical Trial to Evaluate the Regenerative Capacity of CardioCell in Patients With Chronic Ischaemic Heart Failure (CIHF)
The main objective of the CIRCULATE project is to compare the clinical outcomes of CardioCell administration in treatment of ischemic damages of cardiovascular system with control group, who will receive the placebo.
- Trial name
- NCT03418233
- Testing
- CardioCell
- Where
- 5 sites in Poland
- Volunteers
- 115 people
- Sponsor
- John Paul II Hospital, Krakow
Acute Ischemic Stroke
Safety and Efficacy Evaluation of the iNstroke 4F Thromboaspiration Catheter in Patients With Acute Ischaemic Stroke Due to Primary Distal Medium Vessel Occlusions (DMVO)
Prospective, Single-arm, Multi-centre Study to Evaluate the Efficacy and Safety of the iNstroke 4F Thromboaspiration Catheter in Patients with Acute Ischaemic Stroke due to Primary Distal Medium Vessel Occlusions.
- Trial name
- 4-NiVO (NCT07357285)
- Testing
- Thromboaspiration catheter
- Where
- 11 sites in Germany, Hungary and 1 more
- Volunteers
- 57 people
- Sponsor
- iVascular S.L.U.
Relapsed/Refractory Multiple Myeloma
A Dose-escalation Study to Evaluate the Safety and Clinical Activity of PBCAR269A, With or Without Nirogacestat, in Study Participants With Relapsed/Refractory Multiple Myeloma
This is a Phase 1/2a, nonrandomized, open-label, parallel assignment, single-dose, dose-escalation, and dose-expansion study to evaluate the safety and clinical activity of PBCAR269A, with or without nirogacestat, in adults with…
- Trial name
- NCT04171843
- Testing
- PBCAR269A, Fludarabine, Cyclophosphamide
- Where
- 5 sites in United States
- Volunteers
- 48 people
- Sponsor
- Precision BioSciences, Inc.
Stroke, Spinal Cord Injuries (SCI)
ZEPU-AI1 Gait Robot Training Study (ZEPUAI1RCT)
Walking problems caused by stroke, spinal cord injury, or orthopedic surgery are common and can seriously limit a person's independence.
- Conditions
- Stroke, Spinal Cord Injuries (SCI), Gait Disorders, Neurologic
- Trial name
- NCT07735676
- Testing
- ZEPU-AI1 Gait Training and Evaluation System, Standard-of-Care Rehabilitation (Individualized Rehabilitation and Exercise)
- Where
- Bangladesh
- Volunteers
- 51 people
- Sponsor
- Bangladesh Medical University
Multiple Myeloma
Evaluation of VELCADE Given as Retreatment to Multiple Myeloma Patients for Efficacy, Safety and Tolerability
Multiple myeloma represents the second most common hematological malignancy.VELCADE is a small molecule to treat human malignancies.
- Trial name
- NCT00257114
- Testing
- bortezomib
- Where
- United States
- Sponsor
- Millennium Pharmaceuticals, Inc.
Stroke, Ischemic
A Clinical Study of iEPC Intervent Subjects With Cerebral Hemorrhagic Stroke
This is a single centre、single arm、open-label，to investigate the safety and efficacy of EPC transplantation in the brain
- Trial name
- NCT03726814
- Testing
- EPC treatment group
- Volunteers
- 12 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Spinal Cord Vascular Diseases
Surgical Intervention of Spinal Arteriovenous Malformations and Fistulas
Spinal arteriovenous fistulas (AVFs) and arteriovenous malformations (AVMs) are complex neurosurgical lesions that are very challenging to manage.
- Trial name
- SUIT-SAVM (NCT03024749)
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Hongqi Zhang, MD
Lymphoma
Denileukin Diftitox in Treating Patients With Non-Hodgkin's Lymphoma
RATIONALE: Immunotoxins such as denileukin diftitox can locate cancer cells and kill them without harming normal cells. This may be an effective treatment for non-Hodgkin's lymphoma.
- Trial name
- NCT00003615
- Testing
- denileukin diftitox
- Where
- 10 sites in United States
- Volunteers
- 77 people
- Sponsor
- Eastern Cooperative Oncology Group
Subarachnoid Hemorrhage, Aneurysmal, Cognitive Dysfunction
Gamma Entrainment Stimulation for Cognitive Dysfunction After aSAH
The goal of this clinical trial is to Explore and verify whether 40Hz audio and binaural beat 40Hz audio can improve the postoperative cognitive dysfunction seen in patients with aneurysmal subarachnoid hemorrhage.
- Trial name
- GES-aSAH (NCT06346015)
- Testing
- Gamma Entrainment Stimulation
- Volunteers
- 60 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Effects of Gait Training With Assistance of a Robot-Driven Gait Orthosis in Hemiparetic Patients After Stroke
The purpose of this study is to investigate the effects of robot-assisted gait training on active walking in the patients with stroke.
- Trial name
- NCT00530543
- Testing
- Robot-assisted gait training
- Where
- South Korea
- Sponsor
- Samsung Medical Center
Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome
Postural Sway and Counterpressure Maneuvers for Pediatric Syncope
The investigators are interested in whether discrete counterpressure maneuvers, or muscle movements in the lower body, will boost blood pressure and cardiovascular control in children who faint.
- Conditions
- Syncope, Vasovagal, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- NCT05633693
- Testing
- Counterpressure Maneuvers, Baseline Stand
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Simon Fraser University
Chronic Lymphocytic Leukemia (CLL), Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia
Observational Study of Cardiac Arrhythmias During Treatment With BTK Inhibitors or Venetoclax
Background: Bruton s tyrosine kinase inhibitors (BTKi) are used to treat a form of leukemia. But taking BTKi can also increase a person s risk of developing an abnormal heart rhythm. This can cause sudden death.
- Conditions
- Chronic Lymphocytic Leukemia (CLL), Waldenstr(SqrRoot)(Delta)m s Macroglobulinemia, Mantle Cell Lymphoma, Sudden Cardiac Death
- Trial name
- NCT05724121
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke, Hemiplegia
Effects of Mirror Therapy and Bilateral Arm Training on Hemiparetic Upper Extremity in Patients With Chronic Stroke
The aim of this study included (1) to compare the effectiveness of mirror therapy (MT) and bimanual arm training (BAT) in improving motor and functional performance of hemiplegic upper extremity for adults with chronic stroke…
- Trial name
- NCT04242316
- Testing
- Mirror Therapy, Bilateral arm training
- Volunteers
- 101 people
- Sponsor
- The Hong Kong Polytechnic University
Cardiac Arrhythmias, Accessory Pathway
Cryotherapy Versus Radiofrequency Ablation for Treatment of Para-hisian Accessory Pathways
A randomized pilot study to evaluate safety and efficacy endpoints for treatment of para-hisian accessory pathways according to two different strategies of lesion formation.
- Conditions
- Cardiac Arrhythmias, Accessory Pathway, Wolf Parkinson White Syndrome
- Trial name
- NCT04361006
- Testing
- Radiofrequency (RF), Cryotherapy (CRYO)
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Diabetes Mellitus, Type 2
SomaSignal Tests on Medical Management and Change in Risk in Patients With Diabetes
Despite the development of novel treatments, cardiovascular disease (CVD) remains the leading cause of death and disability. It has been observed in clinical practice, that the use of novel glycemia-lowering therapies with…
- Trial name
- NCT05256706
- Testing
- SomaSignal Informed Medical Management SSCVD, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 143 people
- Sponsor
- Emory University
Stroke, Neurologic Diseases, General
Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy
The main objective of this study is to evaluate the safety, tolerability and pharmacokinetics of Cerebril™ in Cerebral Amyloid Angiopathy (CAA) patients who have had lobar cerebral hemorrhage.
- Trial name
- NCT00056238
- Testing
- NC-758 (Anti amyloidotic [Aß] agent)
- Where
- 5 sites in United States
- Volunteers
- 30 people
- Sponsor
- Bellus Health Inc. - a GSK company
Type 2 Diabetes Mellitus, Hypertension
LLM-Assisted Diabetes and Hypertension Management by Village Doctors
This is a prospective, assessor-blinded, randomized controlled study designed to evaluate whether large language model (LLM)-assisted decision support can improve village doctors' abilities in the comprehensive management of…
- Trial name
- NCT07678658
- Testing
- LLM
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Subarachnoid Hemorrhage
Study of Changes in CSF Ionic Composition After Aneurysmal Meningeal Hemorrhage
Hyponatremia is a frequent complication of subarachnoid hemorrhage (SAH) with a prevalence of 30 to 50% in patients with this condition.
- Trial name
- ION_SAH (NCT05942755)
- Testing
- Concurrent evaluation of blood and CSF ionograms to determine if there is a correlation between CSF change and the development of hyoponatremia between day 0 and day 14.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Revascularization, Carotid Artery Stenosis
Study on the Trans-Carotid Artery Occlusion Shunt System
The objective of the study is to evaluate the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System for Carotid Artery Revascularization during Endovascular Treatment
- Conditions
- Revascularization, Carotid Artery Stenosis, Carotid Artery Diseases
- Trial name
- NCT06924593
- Testing
- Trans-Carotid Artery Occlusion Shunt System
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Shenzhen Wecan Medical Technology Co.,Ltd
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