Clinical trials: Disorder of Circulatory System
Stroke, Cognitive and Attention Disorders and Disturbances
The RenAtt Method for Diagnosing and Treating Attention Problems After Stroke and Brain Injury, Further Validation of RehAtt® DiSTRO Assessment of Cognitive and Visual Function
Stroke is one of the most common long-term disabilities in the world. Despite better access to more effective acute treatment, WHO reports a prediction of almost a doubling of disability-adjusted life-years (DALYs) in 2050.
- Conditions
- Stroke, Cognitive and Attention Disorders and Disturbances, Digital Health, Screening Strategy
- Trial name
- NCT07762274
- Testing
- Oxford Cognitive Screen
- Where
- 3 sites in Italy, Sweden and 1 more
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Umeå University
Diabetes Mellitus, Diabetic Foot Ulcer
Evaluation of 3D Imaging Ulcer Camera
The aim of the study is to evaluate the intra- and inter-rater variability of wound measurements using the 3D camera and to compare with standard measurement methods (2D image method and gel injection).
- Conditions
- Diabetes Mellitus, Diabetic Foot Ulcer, Wound, Chronic Disease
- Trial name
- 3D-DFU (NCT03063138)
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Odense University Hospital
Heart Failure, Cardiovascular Diseases
Anti-thrombotic Monotherapy in HeartMate 3 Left Ventricular Assist System (LVAS)
The purpose of this prospective controlled study is to obtain a multi-center safety and feasibility data on patients managed with anti-thrombotic monotherapy with HeartMate 3 LVAS.
- Trial name
- NCT03781258
- Testing
- Warfarin
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Coronary Artery Stenosis
Coronary Laser Atherectomy System for Treatment of Coronary Artery Stenosis (SHINE)
This prospective, multi-center clinical trial evaluates the safety and efficacy of the Coronary Laser Atherectomy System for the pretreatment of coronary artery stenosis.
- Trial name
- SHINE (NCT07697638)
- Testing
- Coronary Laser Atherectomy System, CVX300 Laser System
- Volunteers
- 218 people
- Sponsor
- Shanghai MicroPort Rhythm MedTech Co., Ltd.
Pulmonary Embolism, Venous Thromboembolism
Evaluation of the Short and Long Term Performance and Clinical Outcomes of the Crux Vena Cava Filter System
The Crux Vena Cava Filter (VCF) Registry is a clinical study, sponsored by Volcano Corporation, to evaluate the short and long term performance and clinical outcomes of the Crux Vena Cava Filter System.
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Deep Vein Thrombosis
- Trial name
- NCT02420626
- Where
- 3 sites in United States
- Sponsor
- Volcano Corporation
Cerebral Stroke, Malondialdehyde
Effect of Astaxanthin Supplementation on Plasma Malondialdehyde Levels and NIHSS of Stroke Patients
This is an interventional randomized, controlled trial in analyzing the effects of astaxanthin supplementation on plasma malondialdehyde levels and NIHSS of acute ischemic stroke patients.
- Conditions
- Cerebral Stroke, Malondialdehyde, Oxidative Stress
- Trial name
- NCT03945526
- Testing
- Astaxanthine
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Universitas Indonesia
Plasma Cell Myeloma
Stopping Maintenance Therapy in People With Multiple Myeloma in MRD-Negative Remission
This study will test whether stopping maintenance therapy in people with multiple myeloma in MRD-negative remission has the same effect on disease control as continuing this therapy.
- Trial name
- NCT04221178
- Testing
- Cessation of continuous matinenace therapy
- Where
- 7 sites in United States
- Volunteers
- 50 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Stroke
Comparing Mirror Therapy and CIMT for Hand and Arm Function in Post-Stroke Patients
The goal of this clinical trial is to find out whether Mirror Therapy (MT) combined with Constraint-Induced Movement Therapy (CIMT) improves hand and arm function after a stroke.
- Trial name
- NCT07139015
- Testing
- CONSTRAINT-INDUCED MOVEMENT THERAPY, MIRROR THERAPY
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Riphah International University
Coronary Artery Disease, Diabetes Mellitus
Comparative Response to Vascular Injury in Patients With Diabetes Mellitus: An OCT Study of BVS Versus Xience DES
Stents are used at centers around the world to unblock the arteries of the heart. These stents are usually made of metal and remain permanently within the blood vessel wall.
- Trial name
- NCT03236415
- Testing
- Xience Drug Eluting Stent, ABSORB Bioresorbable Vascular Scaffold
- Sponsor
- Ottawa Heart Institute Research Corporation
Breast Cancer, Leukemia
Phase I/II Study of Escalating-Dose Melphalan w/Autologous SCS & Amifostine Cytoprotect
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Neuroblastoma
- Trial name
- NCT00003425
- Testing
- filgrastim, amifostine trihydrate, cyclophosphamide
- Where
- 4 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Kentucky
Cerebral Stroke
FitMi Plus Home Therapy for Stroke Patients
The investigators will investigate the efficacy of a newly developed functional exercise device (FitMi Plus) for people in the chronic stage after a stroke compared to the FitMi Basic (i.e. without functional exercises).
- Trial name
- NCT03935425
- Testing
- FitMi Plus, FitMi Basic
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Flint Rehabilitation Devices, LLC
Stroke
A Self-efficacy Enhancing Stroke Self-management Program for Community-dwelling Stroke Survivors
The aim of this study is to examine the effectiveness of a nurse-led self-efficacy enhancing stroke self-management program on recovery of community-dwelling stroke survivors.
- Trial name
- SESSMP (NCT02112955)
- Testing
- Stroke self-management program, Usual care
- Where
- 3 sites in Hong Kong
- Volunteers
- 128 people
- Sponsor
- Queensland University of Technology
Type 2 Diabetes, Coronary Artery Disease
Effects of Linagliptin on Endothelial Function
This study is planned to evaluate if linagliptin can improve endothelial function in patients with type 2 diabetes mellitus. In addition, the effect of linagliptin on arginine bioavailability ratios and postchallenge glycaemic…
- Trial name
- NCT02350478
- Testing
- Linagliptin
- Where
- Austria
- Volunteers
- 49 people
- Sponsor
- Medical University of Graz
Ischemic Stroke, Coronary Heart Disease
Safety Study of Dengzhanxixin (a Chinese Medicine Injection) Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in October 2011.
- Trial name
- NCT01612585
- Volunteers
- 30,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Stroke
AI-assisted Continuous Stratification in Neurorehabilitation of Stroke Using Personalized Digital Twins
The goal of this clinical trial is to learn if a rehabilitation application on a smartphone, an app, can be used by adults who have had a stroke.
- Trial name
- STRATIF-AI (NCT07488143)
- Testing
- Smartphone rehabilitation application "app"
- Volunteers
- 30 people
- Sponsor
- University of Leeds
Subarachnoid Hemorrhage, Sleep Apnea
Effect of Sleep Apnea on Blood Pressure Control and Outcome Early After Subarachnoid Hemorrhage
In this observational study patients with subarachnoid hemorrhage (SAH) will be screened for sleep apnea (SA) to investigate if SA is associated with impaired blood pressure control and worse clinical outcome early after SAH.
- Trial name
- NCT02724215
- Testing
- Sleep Apnea Screening (Out of Center Polysomnography Device)
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Multiple Myeloma
Velcade, Thalidomide, Dexamethasone and Panobinostat Treatment and Panobinostat Maintenance in Multiple Myeloma
Velcade (bortezomib), thalidomide and dexamethasone (VTD) has been demonstrated to be a highly effective combination in both patients with previously untreated and those with relapsed multiple myeloma.
- Trial name
- MUKsix (NCT02145715)
- Testing
- Velcade, Thalidomide, Dexamethasone
- Where
- 5 sites in United Kingdom
- Volunteers
- 54 people
- Sponsor
- Prof Jamie Cavenagh
Elderly, Atrial Fibrillation (AF)
Low Dose Edoxaban in Elderly Patients With AF and a History of Stroke
This prospectively enrolled, pragmatic randomized trial aims to investigate whether very low dose edoxaban regimen (15 mg daily) achieves similar edoxaban concentrations as low dose edoxaban regimen (30 mg daily), while…
- Conditions
- Elderly, Atrial Fibrillation (AF), Ischemic Stroke
- Trial name
- LEAVE-Stroke (NCT06900725)
- Testing
- edoxaban, Edoxaban 30 mg
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Kidney Transplant, Familial Hypercholesterolaemia
Cardiovascular Risk in Children With Chronic Conditions Study
Children living with chronic health conditions face a higher risk of developing cardiovascular diseases than their peers, largely due to the accelerated aging of the heart and blood vessels.
- Conditions
- Kidney Transplant, Familial Hypercholesterolaemia, Type 1 Diabetes Mellitus (T1DM), Type 2 Diabetes Mellitus (T2DM)
- Trial name
- CR3C (NCT07086989)
- Where
- 3 sites in Hungary
- Volunteers
- 300 people
- Sponsor
- Semmelweis University
Multiple Myeloma
Pegylated Liposomal Doxorubicin, Low Freq Dexamethasone & Revlimid (Dd-R) in Newly Diagnosed Multiple Myeloma (MM)
The purpose of the research study is to determine the response rates when Revlimid® is combined with Doxil® and Dexamethasone (Dd-R) in newly diagnosed Multiple Myeloma.
- Trial name
- NCT00617591
- Testing
- Lenalidomide, Pegylated Liposomal Doxorubicin (PLD), Dexamethasone
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
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