Clinical trials: Disorder of Circulatory System
Aldosteronism
Postoperative Cardiovascular Index Change of Primary Aldosteronism
Primary aldosteronism (PA), characterized by an inappropriate production of aldosterone, is far more common than is usually perceived.
- Trial name
- TAIPAI (NCT00746070)
- Testing
- with the clinical treatment ( ex adrenalectomy or spironolactone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Coronary Artery Disease, Arrhythmias, Cardiac
Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics
The etiology and specific pathogenesis of many cardiovascular diseases such as coronary atherosclerosis, cardiomyopathy, atrial fibrillation, and stroke are still unclear.
- Conditions
- Coronary Artery Disease, Arrhythmias, Cardiac, Heart Valve Diseases, Aortic Dissection
- Trial name
- PROSPECT (NCT06001073)
- Testing
- Observational; No Interventions were given.
- Where
- China
- Volunteers
- 25,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Multiple Myeloma, Myeloma
FT576 in Subjects With Multiple Myeloma
This is a Phase I dose-finding study of FT576 as monotherapy and in combination with the monoclonal antibody daratumumab in multiple myeloma (MM). The study will consist of a dose-escalation stage and an expansion stage.
- Trial name
- NCT05182073
- Testing
- FT576 (Allogenic CAR NK cells with BCMA expression), Cyclophosphamide, Fludarabine
- Where
- 14 sites in United States
- Volunteers
- 31 people
- Sponsor
- Fate Therapeutics
Obstructive Sleep Apnea
Effects of Continuous Positive Airway Pressure (CPAP) in Heart Remodeling by Magnetic Resonance Imaging (MRI)
Obstructive sleep apnea (OSA) is independently associated with important heart remodeling that further contributes to overt heart failure.
- Trial name
- OSA-MRI (NCT00727454)
- Testing
- CPAP, No treatment
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Lung Neoplasms, Esophageal Neoplasms
The Impact of Different Anticoagulant Therapy on Hemorrhage and Coagulation After Thoracic Surgery
The purpose of this study is to determine whether the use of different dose of LMWH compared with fondaparinux for thromboprophylaxis is efficacious and safety after thoracic surgery.
- Conditions
- Lung Neoplasms, Esophageal Neoplasms, Venous Thromboembolism
- Trial name
- NCT01267305
- Testing
- Fondaparinux, Nadroparin Calcium
- Where
- China
- Volunteers
- 362 people
- Sponsor
- Shanghai Zhongshan Hospital
Obstructive Sleep Apnea, Alzheimer Disease
ENhancing Outcomes in Cognitive Impairment Through Use of Home Sleep ApNea Testing
Obstructive sleep apnea (OSA), which causes abnormal pauses in breathing during sleep, is common in patients with vascular cognitive impairment (VCI) and Alzheimer's disease (AD), and exacerbates the cognitive deficits seen in…
- Conditions
- Obstructive Sleep Apnea, Alzheimer Disease, Vascular Dementia, Mild Cognitive Impairment
- Trial name
- ENCHANT (NCT04335994)
- Testing
- In-laboratory polysomnography, Home Sleep Apnea Test
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Sunnybrook Health Sciences Centre
Ischemic Stroke
iTBS for Acute Ischemic Stroke After Thrombectomy
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic…
- Trial name
- NCT06941961
- Testing
- intermittent theta burst stimulation
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Yi Yang
Multiple Myeloma, Plasma Cell Leukemia
Bortezomib Followed by High-Dose Melphalan and Bortezomib as Conditioning Regimen for Tandem Stem Cell Transplants
The primary objectives of this study are to: To determine the maximum tolerated dose (MTD) of bortezomib in combination with high-dose melphalan as a conditioning regimen.
- Trial name
- NCT00307086
- Testing
- Bortezomib, Melphalan, PBSCT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Atrioventricular Block
RandomIsed sTudy of Physiologic cArdiac stimuLation in patIents With Atrio-ventricular Conduction Disease
Study objective is to assess whether stimulation of the conduction system reduces cardiac decompensation events in patient follow-up, and how applicable this is in clinical practice and also to determine the impact of the studied…
- Trial name
- ITALIA (NCT07279870)
- Testing
- Conduction System Pacing (CSP), Right Ventricular (RV) Pacing
- Where
- 14 sites in Italy
- Volunteers
- 1,260 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Multiple Myeloma
Telemonitoring Among Patients With Multiple Myeloma
A two-arm open-label parallel-group randomized controlled trial will be conducted to compare the telemonitoring (MM e-coach) with standard MM care.
- Trial name
- ITUMM (NCT05964270)
- Testing
- e-coach multipel myeloma (MM)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Isala
Stroke
Participative Rehabilitation in Stroke Patients
Primary objective of this study is to determine whether a case management of stroke patients after discharge to home or to nursing home results in improving physical and cognitive capacity one year after discharge.
- Trial name
- PaReSiS (NCT00687869)
- Testing
- Case management
- Where
- Germany
- Volunteers
- 322 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Multiple Myeloma, AL Amyloidosis
A Phase II Study to Evaluate the Efficacy and Safety of Teclistamab in Combination With Daratumumab (Tec-Dara) in Newly Diagnosed Multiple Myeloma With Concurrent Light Chain Amyloidosis (MM+AL).
The goal of this clinical trial is to learn if teclistamab in combination with daratumumab (Tec-Dara) works to treat newly diagnosed multiple myeloma with concurrent light chain amyloidosis (MM+AL).
- Trial name
- NCT07638683
- Testing
- Teclistamab
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Zhongshan Hospital
Stroke
Efficacy and Safety of Young Health Plasma on Acute Stroke
Stroke is one of the main severe disease of public health importance. Recent studies showed that old age is one of the most important factors in influencing the outcome of patients with acute stroke, and the young plasma can…
- Trial name
- NCT02913183
- Testing
- young Fresh Frozen Plasma, old Fresh Frozen Plasma
- Volunteers
- 78 people
- Sponsor
- Xinqiao Hospital of Chongqing
Stroke, Splints
Spiral Strapping for Improving Upper Limb Functions
Upper limb recovery after stroke is unacceptably poor with almost half of stroke survivors likely to regain some functional use.
- Conditions
- Stroke, Splints, Physical Disability
- Trial name
- NCT05725941
- Testing
- TogRite stretch Strapping, Traditional upper limb functional exercise training
- Where
- Saudi Arabia
- Volunteers
- 40 people
- Sponsor
- Umm Al-Qura University
ANCA-associated Vasculitis
MICRO-RNAs OF NEUTROPHILS IN RENAL ANTINEUTROPHIL CYTOPLASMIS ANTIBODY (ANCA) -ASSOCIATED VASCULITIS
Activation of neutrophils by ANCA ("Anti-Neutrophil Cytoplasm Antibodies") and subsequent microvascular endothelial cell damage is the main feature of ANCA-associated vasculitis (AAV), a severe autoimmune disease that often…
- Trial name
- MINERVA (NCT02954705)
- Testing
- Non interventional study
- Where
- France
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Stroke, Sleep Wake Disorders
The SLEEPR Study: SLEep Effects on Post-stroke Rehabilitation
Sleep is critical for health and quality of life; however, little is known about the prevalence or impact of non obstructive sleep apnea (non-OSA) sleep disorders in people with stroke.
- Conditions
- Stroke, Sleep Wake Disorders, Rehabilitation, Recovery of Function
- Trial name
- SLEEPR (NCT05012605)
- Testing
- Observation
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- State University of New York - Upstate Medical University
Systemic Lupus Erythematosus, Cardiovascular Disease
The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD
Background: People with systemic lupus erythematosus (SLE) are at risk of developing complications in their blood vessels. This can increase the risk of heart attacks or stroke.
- Conditions
- Systemic Lupus Erythematosus, Cardiovascular Disease, Premature Atherosclerosis
- Trial name
- NCT05440422
- Testing
- anifrolumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Multiple Sclerosis
Blood Flow Restriction And Veterans With MS
There currently is a lack of evidence to support exercise interventions in people with advanced disability due to MS (i.e., need assistance to walk or use a wheelchair).
- Trial name
- BRAVe-MS (NCT05433103)
- Testing
- Low-Load Exercise with Blood Flow Restriction, Low-Load Exercise Control Group
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- VA Office of Research and Development
Multiple Myeloma
Microdose Study of Melphalan, Bortezomib and Dexamethasone
The purpose of the study is to identify specific genes that are up- or downregulated in multiple myeloma patients who receive a microdose of either Melphalan (Alkeran®), Bortezomib (Velcade®) or Dexamethasone (Dexaven®).
- Trial name
- Phase-0-MM (NCT02109861)
- Testing
- Melphalan, Bortezomib, Dexamethasone
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Henrik Gregersen
Multiple Myeloma and Plasma Cell Neoplasm
Thalidomide, Doxorubicin, and Dexamethasone in Treating Patients With Untreated Stage II or Stage III Multiple Myeloma
RATIONALE: Thalidomide may stop the growth of multiple myeloma by stopping blood flow to the cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Trial name
- NCT00008242
- Testing
- dexamethasone, doxorubicin hydrochloride, thalidomide
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
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