Clinical trials: Disorder of Circulatory System
Persistent Atrial Fibrillation
Evaluation of the Phased Radio Frequency Ablation System
VICTORY AF is an IDE, prospective global, multi-center, single arm, controlled, unblinded, investigational clinical study. The purpose of this clinical study is to evaluate the risk of procedure and/or device related strokes in…
- Trial name
- VICTORY-AF (NCT01693120)
- Testing
- Medtronic Phased RF Ablation System
- Where
- 40 sites in United States, Canada and 3 more
- Volunteers
- 199 people
- Sponsor
- Medtronic Cardiac Ablation Solutions
Subdural Hematoma, Traumatic
To Study the Effect of Early Cooling in Acute Subdural Hematoma Patients
This randomized, prospective trial will study the effect of very early cooling in patients undergoing surgical evacuation of acute subdural hematomas (35°C prior to opening the dura followed by maintenance at 33°C for a minimum…
- Trial name
- HOPES (NCT02064959)
- Testing
- Temperature management Zoll Intravascular Temperature Management device
- Where
- 14 sites in United States, Japan
- Volunteers
- 32 people
- Sponsor
- The University of Texas Health Science Center, Houston
Diabetic Foot, Diabetes Type 2 With Diabetic Ulcer of Toe, Skin Breakdown
CGM and DFU Healing Post-discharge
The purpose of this study is to look at the benefits of using a Continuous Glucose Monitoring (CGM) system compared with standard-of-care testing for patients with type 2 diabetes and diabetic foot ulcers (DFU) and how this will…
- Trial name
- NCT06054659
- Testing
- Real Time Continuous Glucose Monitoring (rt-CGM), Fingerstick blood glucose (FBG) monitoring, Diabetes Education
- Where
- 2 sites in United States
- Volunteers
- 116 people
- Sponsor
- Emory University
Multiple Myeloma, Stem Cell Transplant
Randomized Study of Digital Life Coaching in Myeloma Patients Undergoing Transplantation
Autologous stem cell transplantation (SCT) is the standard of care for fit multiple myeloma (MM) patients; however, the first 100 days after SCT are marked by extensive life disruptions.
- Trial name
- NCT04589286
- Testing
- Pack Health's Digital Life Coaching (DLC), Electronic Handouts
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Francisco
Hereditary Angioedema (HAE)
A Survey of Icatibant in Pediatric Participants With Hereditary Angioedema
This study is a survey in Japan of Icatibant subcutaneous injection 30 mg syringe used to treat children or teenagers with acute attacks of hereditary angioedema (HAE).
- Trial name
- NCT05509569
- Testing
- Icatibant
- Where
- Japan
- Volunteers
- 32 people
- Sponsor
- Takeda
Stroke
Active Smart Wearable Orthosis for Enhanched Rehabilitation THErapy
The purpose of this study is to investigate the usability of a new upper limb robot assisted therapy device in stroke patients.
- Trial name
- ARTHE (NCT03153254)
- Testing
- Test upper limb robot assisted therapy device, Training with new upper limb robot assisted therapy device
- Where
- 4 sites in Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Thomas More Kempen
Dyslexia, Acquired, Brain Injuries
Therapy for Reading Problems in Adults After Brain Injury
Adults who sustain brain damage due to stroke, head injury, or traumatic surgery may develop difficulty reading. This study examines the effectiveness of behavior-based programs to improve reading ability in these individuals.
- Conditions
- Dyslexia, Acquired, Brain Injuries, Cerebrovascular Accident
- Trial name
- NCT00064805
- Testing
- Cognitive Therapy to Improve Reading
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Breast Cancer, Obesity
Implementation of a CDSS in Oncology Patients During COVID-19
The present randomised controlled trial aimed to investigate the effectiveness of a clinical decision support system (CDSS) in assisting clinicians to apply nutritional care to breast cancer (BC) patients during the COVID-19…
- Conditions
- Breast Cancer, Obesity, Cardiovascular Disease Other
- Trial name
- CDSS (NCT04876560)
- Testing
- Application of CDSS to provide nutritional care in breast cancer patients from home, General lifestyle advice to breast cancer patients by phone
- Where
- 2 sites in Greece
- Volunteers
- 44 people
- Sponsor
- Iaso Maternity Hospital, Athens, Greece
Multiple Myeloma and Plasma Cell Neoplasm
Isotretinoin Plus Dexamethasone in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with dexamethasone may be an effective treatment for multiple myeloma.
- Trial name
- NCT00021359
- Testing
- dexamethasone, isotretinoin
- Where
- 18 sites in United States
- Volunteers
- 17 people
- Sponsor
- Fox Chase Cancer Center
Type II Diabetes, Atherosclerosis
Effect of Tirzepatide on Progression of Coronary Atherosclerosis Using MDCT
A multi-center, randomized, double-blind, placebo-controlled, parallel-group phase IV Study evaluating the effects of tirzepatide on atherosclerotic plaque progression assessed by coronary computed tomography angiography (CCTA)…
- Trial name
- T-PLAQUE (NCT05708859)
- Testing
- Tirzepatide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Matthew J. Budoff
Cardiogenic Shock, Short Term Mechanical Circulatory Support
Outcomes in CArdiogenic SHock Patients Treated by MEchanical Circulatory suppoRt devicE : Impact of Shock Team
In this before-after monocenter study, the authors teste the hypothesis that the implementation of a dedicated shock team could improve the outcome of patients with refractory cardiogenic shock assisted by mechanical circulatory…
- Conditions
- Cardiogenic Shock, Short Term Mechanical Circulatory Support, Shock Team
- Trial name
- CASHMERE (NCT05309980)
- Testing
- standard of care
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Bordeaux
Diabetic Foot Ulcers
A Prospective, Randomized Clinical Trial of PRP Concepts Fibrin Bio-Matrix in Non-Healing Diabetic Foot Ulcers
A prospective, randomized, controlled, clinical study to establish clinical based evidence of PRP Concepts Fibrin Bio-Matrix and compare its performance with the usual and customary practice for the treatment of Wagner 1 or 2…
- Trial name
- NCT02312596
- Testing
- PRP Concepts Fibrin Bio-Matrix, Usual and Customary Practice
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- PRP Concepts, LLC
Stroke, Ischemic Stroke
Feasibility of a First-Line Physical Activity Intervention After Stroke
The goal of this study is to explore a new intervention that supports physical activity within the first 6 weeks after stroke. All participants will complete assessments at weeks 0 and 7.
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke
- Trial name
- PA-ChatS (NCT06679803)
- Testing
- Physical Activity Chats after Stroke (PA-ChatS)
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Minnesota
Parkinson Disease
Exercise to Improve Sleep in Parkinson's Disease
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with…
- Trial name
- NCT05644327
- Testing
- Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
PreDiabetes, Insulin Resistance
Disease Prevention in Clinical Practice Base on Patient Specific Physiology
It is well known that the Type 2 diabetes and vascular disease are preceded by over ten years by metabolic dysfunction and anatomic changes that can be quantified.
- Conditions
- PreDiabetes, Insulin Resistance, Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
- Trial name
- STOPDISEASE (NCT03308773)
- Testing
- Lifestyle modification in routine care of patients
- Volunteers
- 5,000 people
- Sponsor
- Pacific Coast Family Medical Group
Diabetes Mellitus
The Effect of Yogurt Enriched With Flaxseed on Cardiovascular Risk Factors in Type 2 Diabetic Patients
The investigators aimed to add flaxseed with high content of n-3 polyunsaturated fatty acids to low fat yogurt to obtain beneficial without adverse effects of it.
- Trial name
- NCT02436369
- Testing
- low fat yogurt enriched with flaxseed, low fat yogurt
- Volunteers
- 70 people
- Sponsor
- Urmia University of Medical Sciences
Stroke
Atrial Cardiomyopathy in Patients With Stroke of Undetected Mechanism
The goal of this study is to evaluate left atrial structural and functional abnormalities in stroke of undetected mechanism and atherosclerotic stroke with cardiac MRI.
- Trial name
- NCT03830983
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Stroke
A Caregiver-mediated Intervention Improves the Functional Ability of Home-living Chronic Stroke Patients
To examine the feasibility of improving stroke patients' physical functional recovery and social participation through improving caregiver's care capability.
- Trial name
- NCT01693341
- Testing
- Care-giver mediated training
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Asia University
Ischemic Stroke
Efficacy and Safety Evaluation of 3K3A-APC in Ischemic Stroke
The purpose of this study is to evaluate the efficacy and safety of intravenous doses of 3K3A-APC, a recombinant variant of human activated protein C (APC), in the treatment of acute ischemic stroke following treatment with…
- Trial name
- RHAPSODY-2 (NCT05484154)
- Testing
- 3K3A-APC
- Sponsor
- ZZ Biotech, LLC
Stroke
Measurement of Cerebral Oxygen Extraction Fraction Using MRI Technique
All images in this study were acquired on a 1.5 T Sonata whole body scanner (Siemens Medical Inc., Erlangen, Germany) using 2D multi-echo gradient echo/spin echo sequence and 2D single-shot gradient echo-planar imaging sequence…
- Trial name
- NCT00166920
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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