Clinical trials: Disorder of Consciousness
Anxiety, Biliary and Pancreatic Diseases
Effect of Patient Anxiety Level Prior to Undergoing ERCP and Procedure Tolerability and Outcomes.
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a specialized procedure combining upper GI endoscopy and x-rays to treat hepatopancreaticobiliary diseases. Patient experiences after ERCP has been relatively understudied.
- Conditions
- Anxiety, Biliary and Pancreatic Diseases, ERCP
- Trial name
- NCT07699731
- Testing
- Not applicable- observational study
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Mandip Rai
Brain Death
Alterations of Conjunctival Microcirculation in Brain Dead Patients
Study hypothesize that ocular microcirculation is reflecting cerebral perfusion. The purpose of this study is to evaluate ocular microcirculation in brain dead patients using side dark field (SDF) videomicroscope and compare it…
- Trial name
- NCT02483273
- Where
- Lithuania
- Volunteers
- 22 people
- Sponsor
- Lithuanian University of Health Sciences
Abdominal Aortic Aneurysm, Acute Kidney Injury
Dexmedetomidine vs Propofol Sedation in Endovascular Aortic Repair
Endovascular aortic repair (EVAR) is increasingly performed under local anesthesia with intravenous sedation, but the optimal sedative agent has not been established.
- Trial name
- NCT07857005
- Testing
- Dexmedetomidine, propofol
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 282 people
- Sponsor
- Bursa City Hospital
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Traumatic Brain Injury With Prolonged Loss of Consciousness
Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury
Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to evaluate the therapeutic effect of…
- Trial name
- NCT04306601
- Testing
- Low-Intensity Focused Ultrasound
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Seoul National University Hospital
Disorders of Consciousness
Clinical Evaluation of Chronic Consciousness Disorders Using Resting-state EEG and ERP
Currently, there are significant challenges in the clinical assessment of patients with consciousness disorders, such as distinguishing between vegetative state (VS) and minimally conscious state (MCS), and predicting patient…
- Trial name
- NCT05949528
- Testing
- no intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Brain Injury, Consciousness Disorders
Early Stepping Verticalization in ICU for ABI Patients
Verticalization was reported to improve the level of arousal and awareness in patients with severe acquired brain injury (ABI) and to be safe in ICU.
- Trial name
- NCT02828371
- Testing
- stepping verticalization, conventional mobilization
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Delirium, Confusion
Intelligent Intensive Care Unit
Delirium, as a common complication of hospitalization, poses significant health problems in hospitalized patients. Though about a third of delirium cases can benefit from intervention, detecting and predicting delirium is still…
- Trial name
- ICU_Delirium (NCT02465307)
- Testing
- Confusion Assessment Method, Accelerometer, Commercially available camera
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Florida
Minimally Conscious State, Vegetative State
Further Psychometric Data for the Reliability and the Diagnostic Validity of CRS-R
This study aims to provide, in a large sample, further psychometric data as regards the internal consistency, the test-retest reliability and the diagnostic validity of the Coma Recovery Scale-Revised (CRS-R).
- Trial name
- NCT03126929
- Testing
- Coma Recovery Scale-Revised and Glasgow Coma Scale
- Volunteers
- 169 people
- Sponsor
- Hangzhou Normal University
Nursing Caries, Consciousness, Level Altered
Mindfulness Training in Nurses and Its Effect on Work Stress
The aim of the study, which was planned in the experimental design type, was to determine the effect of the mindfulness-based stress reduction training on nurses' job stress.
- Trial name
- NCT06029205
- Testing
- Conscious Awareness-Based Educatıon, Stress coping training
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Disorder of Consciousness
Transcranial Magnetic Stimulation in Patients With Disorders of Consciousness
Transcranial magnetic stimulation involves the use of alternating magnetic fields to stimulate neurons in the brain.To date, several studies have focused on the use of TMS in patients with impaired consciousness.However,its…
- Trial name
- NCT03385278
- Testing
- rTMS
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Post-Resuscitation Syndrome, Critical Illness
Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest
This retrospective observational cohort study aims to identify early predictors of short- and mid-term mortality in adult patients who achieved return of spontaneous circulation (ROSC) after cardiac arrest.
- Conditions
- Post-Resuscitation Syndrome, Critical Illness, Cardiac Arrest, Hypoxic-Ischemic Encephalopathy
- Trial name
- PROM-ROSC (NCT07020091)
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people
- Sponsor
- Ahmet Düzgün
Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS
POLish Registry of CArdioneuroablation and CArdioneuromodulation
The multicentre observational study POL-CA involves a wide spectrum of patients with a history of syncopy. The study recruits patients with diagnosed vasovagal syndrome, cardioinhibitory carotid sinus syndrome, symptomatic sinus…
- Conditions
- Vasovagal Syndrome VVS, Cardioinhibitory Carotid Sinus Syndrome CSS, Symptomatic Sinus Bradycardia SB or Atrioventricular Block AV, Postural Orthostatic Tachycardia Syndrome POTS
- Trial name
- POL-CA (NCT07196397)
- Testing
- cardioneuroablation, SN sparing hybrid ablation, Cardiac sympathetic denervation
- Where
- Poland
- Volunteers
- 1,000 people
- Sponsor
- SABAMED Medical Center Ltd.
Syncope, Vasovagal
The Effectiveness of Metoprolol in the Prevention of Syncope Recurrence in Children and Adolescents
The purpose of this study to evaluate the effectiveness of metoprolol versus conventional treatment in the prevention of syncope recurrence in children and adolescents.
- Trial name
- NCT00475462
- Testing
- metoprolol, conventional treatment
- Volunteers
- 28 people
- Sponsor
- Peking University First Hospital
Disorder of Consciousness
Study of Brain Function Evaluation System for Acute and Prolonged Disorders of Consciousness
The research focuses on establishing a system for detecting loss of consciousness, developing clinical prognostic and awakening-related brain function testing criteria.
- Trial name
- NCT06097013
- Testing
- Routine clinical rehabilitation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Xuanwu Hospital, Beijing
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Assessment of Safety and Feasibility of FUS Next Generation Dome Helmet (NGDH) to Perform Neuromodulation in Patients With Disorders of Consciousness
The main questions this study aims to answer are: Can low-intensity FUS neuromodulation be safely and feasibly administered to the bilateral central thalamus in patients with disorders of consciousness (DoC)? Does FUS…
- Trial name
- NCT07694258
- Testing
- Next Generation Dome Helmet (NGDH)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Sunnybrook Health Sciences Centre
Bradycardia, Syncope
Comparison of the Efficacy and Safety of Cardioneuroablation to Permanent Pacing in Patients With an Implanted Pacemaker for Symptomatic Bradycardia.
Background Sinus node dysfunction (SND) and atrioventricular block (AVB) are significant diagnostic and therapeutic problems. The primary method of their treatment is cardiac pacemaker implantation (PM).
- Trial name
- GENTLE-PACE (NCT05896592)
- Testing
- Invasive electrophysiological study, Extracardiac vagal stimulation, Cardioneuroablation
- Where
- 2 sites in Poland
- Volunteers
- 99 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent
Deep Sedation in Catheter Ablation of Atrial Fibrillation
The current practice of anesthesia for atrial fibrillation catheter ablation （CA） procedure is inconsistent, including general anesthesia, deep sedation, and conscious sedation.Due to the nature of deep sedation, it has been…
- Conditions
- Atrial Fibrillation, Atrial Fibrillation, Paroxysmal or Persistent, Deep Sedations, Conscious Sedation
- Trial name
- PRIORI-AF (NCT06836999)
- Testing
- deep sedation, Conscious sedation
- Where
- 16 sites in China
- Volunteers
- 1,334 people
- Sponsor
- The First Affiliated Hospital of Dalian Medical University
Atrial Fibrillation (Paroxysmal)
Safety and Efficacy of Conscious Sedation Versus General Anesthesia in Pulsed-Field Ablation for Paroxysmal Atrial Fibrillation
The goal of this clinical trial is to compare the safety and efficacy of conscious sedation and general anesthesia in patients with paroxysmal atrial fibrillation undergoing their first pulsed-field ablation (PFA) procedure.
- Trial name
- SEDATE-PFA (NCT07541339)
- Testing
- conscious sedation, General Anesthesia (control group)
- Where
- China
- Volunteers
- 224 people
- Sponsor
- Beijing Anzhen Hospital
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
Walking With Overground Robotic Exoskeleton Device to Increase Behavioral Responsiveness in Patients With Disorders of Consciousness (WALK DOC)
The goal of this observational study is to learn whether walking with an overground robotic exoskeleton (ORE) can improve responsiveness and brain activity in adults with disorders of consciousness (DoC) during inpatient…
- Trial name
- WALK DOC (NCT07709559)
- Testing
- Overground Robotic Exoskeleton (ORE)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Spaulding Rehabilitation Hospital