Clinical trials: Disorder of Consciousness
Eveningness, Insomnia
Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students
Depression is a leading cause of global disease burden, poor quality of life, disability and suicide, and commonly occurs in adolescence and early adulthood.
- Conditions
- Eveningness, Insomnia, Circadian Rhythm, Depressed Mood
- Trial name
- NCT07677930
- Testing
- digital cognitive behavioral therapy for insomnia and digital circadian intervention, digital cognitive behavioral therapy for insomnia, digital health education
- Volunteers
- 195 people
- Sponsor
- Chinese University of Hong Kong
Disorder of Consciousness, Acquired Brain Injury
Describing the Effect of Familiar Song on Arousal and Awareness for Children With Disorders of Consciousness (DoC)
The goal of this clinical trial is to compare the effect of live music therapy and recorded music on recovery of consciousness in children aged 1 to 18 years who have a disorder of consciousness (DoC) after a severe brain injury.
- Trial name
- SongDoC (NCT07209657)
- Testing
- Live Music Therapy, Recorded Music
- Where
- Australia
- Volunteers
- 10 people
- Sponsor
- Murdoch Childrens Research Institute
Disorder of Consciousness
Electroacupuncture at Jing-Well Points for Chronic Disorders of Consciousness: A Randomized Controlled Study With Multimodal Assessment
Disorder of consciousness (DOC) is a common complication of severe central nervous system injury. It is defined as prolonged DOC when lasting more than 28 days.
- Trial name
- NCT07551076
- Testing
- Electrostimulation at the Twelve Hand Jing-Well Points
- Volunteers
- 66 people
- Sponsor
- The Third People's Hospital of Huizhou
Traumatic Brain Injury (TBI) Patients, Intracerebral Hemorrhage (ICH)
Sleep to Predict Recovery In Unconscious Patients With Acute Brain Injury
Severe brain injuries can leave people in states where they are unconscious or only partly aware, such as a coma. These conditions are common after injuries like head trauma or bleeding in the brain.
- Trial name
- SPRINT (NCT07794605)
- Where
- 2 sites in United States
- Volunteers
- 230 people
- Sponsor
- Columbia University
Chronic Pain
Mixed Reality-Based Rehabilitation Software for Chronic Secondary Musculoskeletal Pain
This study evaluated the efficacy and safety of a mixed reality-based chronic pain rehabilitation software (PK-MPT) for adults with chronic secondary musculoskeletal pain.
- Trial name
- NCT06936059
- Testing
- Mixed Reality based analgesic therapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Disorders of Consciousness, Spontaneous Intracerebral Hemorrhage
Transcutaneous Auricular Vagus Nerve Stimulation for Recovery of Consciousness After Surgery for Spontaneous Intracerebral Hemorrhage
Disorders of consciousness are common after surgery for severe spontaneous intracerebral hemorrhage and are associated with high mortality, disability, and long-term dependence.
- Trial name
- TAVNS-SICH (NCT07761507)
- Testing
- Active Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Beijing Tiantan Hospital
Chronic and Severe Post-coma Disorders of Consciousness (Permanent Vegetative State, Minimally Conscious State)
Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness
Chronic post-coma consciousness impairment is a severe handicap. Preliminary studies suggest that deep brain stimulation of the thalamic-tegmental reticular system could improve consciousness disorders, and facilitate the…
- Trial name
- Post-coma DBS (NCT01718249)
- Testing
- Implantable neurostimulation system
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Clermont-Ferrand
Disorders of Consciousness Due to Severe Brain Injury
Transcutaneous Electrical Acupoint Stimulation at Jing-Well Points for Disorders of Consciousness
Effective treatment options for disorders of consciousness (DoC) remain limited, and available interventions show heterogeneous efficacy.
- Trial name
- Wells-DoC II (NCT07535593)
- Testing
- Transcutaneous electrical stimulation
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Xijing Hospital
Consciousness Disorders
Transcranial Alternating Current Stimulation in Patients With Disorders of Consciousness
In recent years, many literatures have reported that tACS, as a non-invasive electrical brain stimulation technique, has been applied in depression, schizophrenia, dementia and other fields.
- Trial name
- NCT06211439
- Testing
- real transcranial alternating current stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- First Affiliated Hospital of Zhejiang University
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Consciousness Disorders, Persistent Vegetative State
Multimodal Assessment and Prognosis in Disorders of Consciousness After Severe Brain Injury (CyDoC-MAP)
After a severe brain injury some patients survive but cannot communicate, and deciding early which of them are likely to recover consciousness remains one of the hardest problems in neurocritical care.
- Conditions
- Consciousness Disorders, Persistent Vegetative State, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- CyDoC-MAP (NCT07736820)
- Where
- Cyprus
- Volunteers
- 40 people
- Sponsor
- Nicosia General Hospital
Disorders of Consciousness
The Temporally Interfering in Patients With Disorders of Consciousness
This project will help the patient recover consciousness by giving TI (temporally interfering) treatment
- Trial name
- NCT06822192
- Testing
- real TI
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Zhejiang Provincial People's Hospital
Traumatic Brain Injury, Severe Traumatic Brain Injury
Vagus Nerve Stimulation in Patients in Comatose State
Some patients with severe traumatic brain injury cannot respond at the bedside, yet about 1 in 4 may be aware but unable to show it - a hidden state called cognitive motor dissociation.
- Conditions
- Traumatic Brain Injury, Severe Traumatic Brain Injury, Disorders of Consciousness Due to Severe Brain Injury, Coma, Traumatic
- Trial name
- NCT07719595
- Testing
- Dual-Site Transcutaneous Auricular Nerve Stimulation (taVNS + taTNS)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Sima Mofakham
Anxiety, Depression
Evaluating Knowledge Insight Tools (KIT) for Reducing Anxiety and Low Mood in UK Secondary School Students
Background and Study Aims: Secondary school students are reporting unprecedented levels of anxiety and mood difficulties. To ensure that the needs of all young people are met, there is a need to evaluate more accessible forms of…
- Conditions
- Anxiety, Depression, Internalizing Problems, Low Mood
- Trial name
- NCT06188962
- Testing
- CBT-informed school-based counselling
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University College, London
Psychological Distress, Depressed Mood
Ecological Momentary Intervention (E-Breathing) to Reduce Psychological Distress in Adolescents
A two-arm randomized controlled trial (RCT) will be conducted to test a mobile-based intervention, E-breathing, for early detection and intervention to address psychological distress in at-risk adolescents in Hong Kong.
- Conditions
- Psychological Distress, Depressed Mood, Anxiety, Stress
- Trial name
- NCT07717112
- Testing
- Slow-paced breathing via ecological momentary intervention, Ecological momentary assessments
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Depression
Cognitive Control Training for Depression
Depression is frequently characterized by patterns of inflexible, maladaptive, and ruminative thinking styles; these patterns themselves are thought to result from a combination of decreased attentional control, decreased…
- Trial name
- NCT01454141
- Testing
- Cognitive Control Training, Peripheral Vision Task
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Consciousness Disorders, Severe Acquired Brain Injury
Cross-cultural Adaptation and Multicenter Validation of the Italian Versions of the Brief Evaluation of Receptive Aphasia (BERA) and SWallowing Assessment in Disorders of Consciousness (SWADOC)
Patients with severe acquired brain injury may evolve from coma into prolonged disorders of consciousness. In these patients, residual language comprehension and swallowing abilities are difficult to evaluate because standard…
- Trial name
- NCT07711119
- Testing
- Italian SWallowing Assessment in Disorders of Consciousness (SWADOC), Italian Brief Evaluation of Receptive Aphasia (BERA)
- Where
- 4 sites in Italy
- Volunteers
- 79 people
- Sponsor
- Alfonso Magliacano
Disorders of Consciousness Due to Severe Brain Injury
Hand Jing-Well Points Stimulation to Treat Disorders of Consciousness
The purpose of this academic lead study is to explore the ideal stimulation strategies at Hand twelve jing-well points in patients with disorders of consciousness.
- Trial name
- Wells-DoC (NCT06927713)
- Testing
- Bloodletting Acupuncture, Transcutaneous electrical stimulation
- Where
- 4 sites in China
- Volunteers
- 59 people
- Sponsor
- Xijing Hospital
Disorders of Consciousness
Spontaneous Eye Blinking in Disorders of Consciousness
Differential diagnosis between Unresponsive Wakefulness Syndrome (UWS) and Minimally Conscious State (MCS) is complicated due to severe cognitive and/or sensorimotor deficits in these patients.
- Trial name
- Blink-DoC (NCT06323031)
- Where
- 8 sites in Belgium, Germany and 2 more
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Disorder of Consciousness
tACS Alters EEG Microstates in DoC
Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), remain difficult to diagnose at the bedside.
- Trial name
- NCT07699055
- Testing
- Transcranial Alternating Current Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Istanbul Medipol University Hospital