Clinical trials: Disorder of Consciousness
Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission
Kinetics and Prognostic Value of NeuroFilament Light in Post-cardiac Arrest: A Prospective Multicenter Study
The purpose of this study is to assess the prognostic value of absolute value and kinetic of neurofilament light chain (NFL) collected at different time points (at admission, 12h, 24h, 48h, 72h, 96h, and day 7 after ICU…
- Conditions
- Cardiac Arrest (CA), Intensive Care Unit (ICU) Admission, Return of Spontaneous Circulation, Comatose
- Trial name
- CINEFIL (NCT07760636)
- Testing
- Value of neurofilament light chain (NFL) at different time points
- Where
- France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eveningness, Insomnia
Digital Insomnia and Circadian Therapy for Reducing Depression Symptoms in College Students
Depression is a leading cause of global disease burden, poor quality of life, disability and suicide, and commonly occurs in adolescence and early adulthood.
- Conditions
- Eveningness, Insomnia, Circadian Rhythm, Depressed Mood
- Trial name
- NCT07677930
- Testing
- digital cognitive behavioral therapy for insomnia and digital circadian intervention, digital cognitive behavioral therapy for insomnia, digital health education
- Volunteers
- 195 people
- Sponsor
- Chinese University of Hong Kong
Brain Death, Organ Donor
The Effect of Nebulized Albuterol on Donor Oxygenation
The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation…
- Conditions
- Brain Death, Organ Donor, Pulmonary Edema
- Trial name
- NCT00310401
- Testing
- Albuterol, Saline
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- Vanderbilt University Medical Center
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Syncope
Risk of Syncopal Relapses in Patients Treated With Permanent Pacing for Bradyarrhythmic Syncope
Prospective, multicenter, observational registry designed to collect data on syncopal relapses in patients undergoing pacemaker implantation for bradyarrhythmic syncope.
- Trial name
- SYNCOPACED (NCT04229589)
- Testing
- Clinic follow-up
- Where
- 7 sites in Italy
- Volunteers
- 1,364 people
- Sponsor
- Azienda Ospedaliera Cardinale G. Panico
Disorder of Consciousness
Clinical Validity of the Minimally Conscious State "Plus" and "Minus"
The goal of this observational retrospective study is to investigate and compare the clinical evolution of a sample of patients with the diagnosis of MCS+ versus MCS- according to the CRS-R.
- Trial name
- NCT05954650
- Testing
- Rehabilitation
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospitales Nisa
Anxiety
the Activating Consciousness Technique (Hypnosis) in General Practice
Anxiety is an emotion considered unpleasant but resulting from a normal phenomenon. It corresponds to an adaptive response to events, to stress and helps to ensure our survival.
- Trial name
- MG HYPNOSIS (NCT04649762)
- Testing
- activating consciousness technique (hypnosis)
- Where
- 6 sites in France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Acquired Brain Injury
Action Observation Theraphy in Severe Acquired Brain Injury.
Action Observation Therapy (AOT) is a rehabilitation technique, used for several years, aimed at the recovery of motor function in patients with neurological and orthopedic conditions.
- Trial name
- NCT05747222
- Testing
- Action Observation Tharapy, Conventional Therapy
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Alzheimer Disease
Transcranial Pulse Stimulation. a Potential Treatment for Early Dementia
Alzheimer's Disease (AD) is characterized by the absence of treatments to slow, stop, or reverse its course, with patients finally losing cognitive functions, skills and independence.
- Trial name
- NCT06730438
- Testing
- Transcranial Pulse Stimulation
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Francesca Pistoia
Coma, Electrographic Status Epilepticus
Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2)
The goal of this comparative effectiveness trial is to study electrographic status epilepticus (ESE) treatment in comatose patients after cardiac arrest.
- Trial name
- TELSTAR-2 (NCT06549426)
- Testing
- anti-seizure medication + sedative agent(s)
- Where
- 21 sites in Belgium, Netherlands
- Volunteers
- 150 people
- Sponsor
- University of Twente
Fibromyalgia Syndrome, Fibromyalgia Impact Questionnaire
Effects of Conscious Connected Breathing Exercises on Fibromyalgia
Our aim in this study is to investigate the effects of conscious connected breathing exercises on sexual function, sleep, and mood in fibromyalgia patients.
- Conditions
- Fibromyalgia Syndrome, Fibromyalgia Impact Questionnaire, Breathing Pattern Disorder, Female Sexual Dysfunction (FSD)
- Trial name
- NCT07030374
- Testing
- conscious connected breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Adana City Training and Research Hospital
Bipolar I Disorder
A Study of Aripiprazole in Patients With Bipolar I Disorder With a Major Depressive Episode
The purpose of this study is to evaluate several doses of aripiprazole in patients with bipolar depression.
- Trial name
- NCT00094432
- Testing
- Aripiprazole
- Where
- 40 sites in United States
- Volunteers
- 650 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Stroke, Acute Ischemic Stroke
Effectiveness and Safety of Angongniuhuang Pill on Restoring Consciousness for Patients Who Have Suffered From a Stroke
This study will determine if Angongniuhuang Pill (Composed of Niuhuang, Yujin, Xijiao, Huangqin, Huanglian, Xionghuang, Zhizi, Zhusha, Bingpian, Shexiang, and Zhenzhu) will have a better effect in restoring consciousness for…
- Trial name
- NCT00817609
- Testing
- Angongniuhuang Pill
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Fudan University
Disorders of Consciousness Due to Severe Brain Injury
the Prediction Value of Combined Electroencephalographic and Electromyographic Response in Disorders of Consciousness
The goal of this observation study is to learn about the prediction value of combined electroencephalographic and electromyographic response in disorders of consciousness. The main ways of stimulation is thermal and itch.
- Trial name
- NCT06922864
- Testing
- thermal stimulation, itch
- Volunteers
- 36 people
- Sponsor
- KY20242235jiangwen
Unconscious State
The Effect of Auditory Stimulation and the "Love Glove" Technique
The aim of this study was to determine the effect of the "love glove" intervention, combined with the voices of family members and nurses, on vital signs in unconscious patients in the intensive care unit.
- Trial name
- NCT07602998
- Testing
- Voice of a patient's relative, Voice of nurse, Love glove
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Manisa Celal Bayar University
Vasovagal Syncope
Effect of Closed Loop Pacemaker Treatment on Recurrent Vasovagal Syncope
The main purpose is to prevent syncope in patients with recurrent syncopal episodes caused by malignant vasovagal faints and bradycardia.
- Trial name
- NCT00292825
- Testing
- Pacemaker treatment, pacemaker programmed as active = CLS, Pacemaker, programmed as passive = VVI 30 beats per minute (bpm)
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Aarhus University Hospital Skejby
Consciousness Disorder, Brain Injuries
Neurovascular Reactions to AAT in Patients With DOC
There is practical evidence but no scientific investigations that persons with severe disorders of consciousness can profit from animal-assisted therapy regarding their level of awareness.
- Trial name
- AAT NIRS (NCT03341325)
- Testing
- animal-assisted activity, control activity
- Where
- Switzerland
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Swiss Tropical & Public Health Institute
Brain Death, Liver Disease
Pre-recovery Bedside Liver Biopsy in Brain Death Organ Donors
This study's objective is to obtain preliminary data to test the hypotheses that percutaneous liver biopsy in brain death donors is safe and provides reliable histological information.
- Trial name
- PPB (NCT01810640)
- Testing
- Percutaneous Liver Biopsy
- Where
- 2 sites in United States
- Volunteers
- 6 people
- Sponsor
- Rutgers, The State University of New Jersey
Coma
Role of Intravenous Lipid Emulsion in Improving Coma of Acute Antipsychotics Poisoning
Intravenous Lipid Emulsion in Improving Coma Of Antipsychotic drugs Acute Poisoning: A Randomized Controlled Trial in Poison Control Center of Ain Shams University Hospitals
- Trial name
- NCT04807634
- Testing
- Intravenous Lipid Emulsion (Intralipid 20%)
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Delirium, Confusion
Improving Safety of Diagnosis and Therapy in the Inpatient Setting
To improve the safety of diagnosis and therapy for a set of conditions and undifferentiated symptoms for hospitalized patients, the investigators will employ a set of methods and tools from the disciplines of systems engineering…
- Conditions
- Delirium, Confusion, Mental Status Change, Back Pain
- Trial name
- PSLL2-0 (NCT04393909)
- Testing
- Diagnostic Uncertainty Educational Curriculum, Diagnostic Timeout, Patient Diagnostic (Dx) Questionnaire
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- Brigham and Women's Hospital