Clinical trials: Disorder of Consciousness
Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With No Loss of Consciousness
The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury
The objective of this trial is to evaluate the effectiveness of cognitive rehabilitation in OIF/OEF service members with a history of mild traumatic brain injury and persistent (3-24 months post injury) cognitive complaints.
- Trial name
- SCORE (NCT01339806)
- Testing
- Cognitive Rehab, Brainworks, Informational Handout/Provider Visits
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Brooke Army Medical Center
Disorder of Consciousness
Olfactory Stimulation in Severe Brain Injury
The management of patients with disorders of consciousness (DoC) represents a topic of great importance and topicality in the medical-scientific field because of the complexity and extent of associated disabilities and the…
- Trial name
- NCT05747170
- Testing
- Olfactory sstimulation
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Asthma, Syncope
Vagal Nerve Stimulation Assessed by the Diving Reflex: An Investigation Into Mechanisms of Asthma Death
The investigators' hypothesis is that dysregulation of autonomic function, as revealed during a simulated dive reflex, may result in an attenuation of the heart rate response to a greater degree in asthmatics who collapse during…
- Trial name
- NCT02083029
- Testing
- Simulated dive reflex
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Disorders of Consciousness
The Core Body Temperature Rhythms: Distinguishing MCS From UWS
In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .
- Trial name
- NCT02930213
- Volunteers
- 7 people
- Sponsor
- Jing Wang
Anorexia Nervosa
The Embodied Cognition: Exploratory Study of Automatic and Controlled Processes in Anorexia Nervosa.
Anorexia nervosa (AN) is a common psychiatric illness, with severe prognosis (5% mortality) that has changed little over in half a century. One of the forms is the restrictive anorexia nervosa (ANR).
- Trial name
- NCT02538796
- Testing
- TEA + Grober Test + Task 1 + Grober Test, TEA + Grober Test + Task 2 + Grober Test, TEA + Grober Test + Implicit Task 3 + Grober Test
- Where
- France
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Massachusetts General Hospital
Cataract
Conscious Sedation Efficacy of the MKO Melt (Midazolam, Ketamine, Ondansetron)
The investigators hypothesized that the combination of Valium, Tramadol and Zofran is superior to the substantially more expensive MKO melt in patient satisfaction after cataract surgery.
- Trial name
- NCT03653520
- Testing
- Diazepam, Tramadol, Ondansetron
- Where
- United States
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- Avanti Anesthesia
Vegetative State, Stroke
Navigated Brain Stimulation in Diagnosis of Minimally Conscious State
It has already been demonstrated that mental imagining of the complex motor act, such as limb lifting, can evoke the activation of the involved motor centres even if it doesn't result in movement due to paresis.
- Conditions
- Vegetative State, Stroke, Brain Injury
- Trial name
- C-fMRI-NBS (NCT01467908)
- Testing
- Navigated transcranial magnetic brain stimulation
- Where
- Russia
- Volunteers
- 6 people
- Sponsor
- Clinical Institute of the Brain, Russia
Syncope
Pacemaker Effect With Closed Loop Sensor in Neuromodulated Syncope Refractory to Medical Therapy
Vasovagal syncope is an entity frequently in the emergency services, its treatment includes pharmacological and non-pharmacological measures, and in some severe cases, requires the implantation of cardiac stimulation devices…
- Trial name
- NCT03876652
- Testing
- Pacemaker with Closed Loop Stimulation (CLS)
- Where
- 2 sites in Colombia
- Volunteers
- 48 people
- Sponsor
- CES University
Consciousness Disorders
Etiologies, Definitive Diagnosis and Patient Outcomes in Altered Level of Consciousness in the Emergency Department
When someone starts acting differently in terms of how alert or awake they are, it can be a tough situation for emergency (ER) department doctors.e exact and definitive etiologies of ALOC that can be intracranial or extracranial.
- Trial name
- NCT06744114
- Testing
- Consciousness in the Emergency Department
- Where
- Pakistan
- Volunteers
- 1 people
- Sponsor
- Superior University
Brain Death
Determining ICU Staffs Conceptions, Opinions, Views, Experiences and Reflection of Brain Death and Organ Donation
The study aims to gather information regarding the individual perceptions, opinions, beliefs, and conceptual understanding of healthcare professionals working in the intensive care units at the University Hospital Basel, the…
- Trial name
- DISCOVER (NCT06640088)
- Where
- Switzerland
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Brain Injury, Coma
Brain Death and Organ Donation in Tunisian Intensive Care Units
The goal of this observational study was to identify factors associated with the progression to brain death in critically ill patients with severe brain injuries in Tunisian intensive care units (ICUs).
- Conditions
- Brain Injury, Coma, Organ Transplants
- Trial name
- BDOD-TN (NCT06948669)
- Where
- Tunisia
- Volunteers
- 104 people
- Sponsor
- Faculty of Medicine, Sousse
Stress Disorders, Post-Traumatic
Post Traumatic Stress Among Relatives of Brain-dead, Withdrawal of Life Support, and Sudden Death Patients
This study concerns the nearest relatives of patients who have passed away within 3 days of admission to an ICU due to: (1) brain death with multiple organ donation +/- tissues or (2) death via limitation and / or cessation of…
- Trial name
- NCT01412502
- Testing
- IES-R and HDAS scores
- Where
- 6 sites in France
- Volunteers
- 119 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Syncope, Pacemaker
Syncope-Asystole Latency Time in Tilt Table Test: The SALT-TILT Study
Syncope is a common presenting condition. Pacemaker implantation can significantly reduce syncope recurrences in reflex syncope.
- Conditions
- Syncope, Pacemaker, Asystole, Neurally Mediated Syncope
- Trial name
- SALT-TILT (NCT06356207)
- Testing
- Tilt Table Test
- Where
- Italy
- Volunteers
- 64 people
- Sponsor
- Azienda Ospedaliera di Bolzano
Deep Brain Stimulation Surgery, Electrophysiology
Analysis of Deep Brain Nuclei LFP and Cortical EEG Signals During the Recovery From General Anesthesia
The correlations of deep brain nuclei firing and cerebral cortex activity during recovery from general anesthesia is unclear. In this study, the local field potential (LFP) from the deep brain nuclei and the scalp…
- Conditions
- Deep Brain Stimulation Surgery, Electrophysiology, General Anesthesia, Consciousness, Loss of
- Trial name
- NCT06400901
- Testing
- No interventions
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Ruijin Hospital
Heart Arrest, Out-Of-Hospital, Computed Tomography
Head Computed Tomography for Predicting Neurological Outcome After Cardiac Arrest
The European Resuscitation Council (ERC) and the European Society of Intensive Care Medicine (ESICM) joint guidelines for post-resuscitation care recommend a multimodal approach to prognostication of neurological outcome.
- Conditions
- Heart Arrest, Out-Of-Hospital, Computed Tomography, Unconsciousness, Neurologic Deficits
- Trial name
- NCT03913065
- Testing
- CT
- Where
- Sweden
- Volunteers
- 400 people
- Sponsor
- Lund University
Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique
Effects of Pranayama Breathing Technique on Stress Level, Sleep Quality, and Quality of Life Among Older Adults
Aging is associated with progressive tissue deterioration resulting from a continuous decline in the ability to renew homeostatic cell regeneration and replace cells lost during tissue damage.
- Conditions
- Individuals Aged 60 and Over, Individuals Who Are Physically and Mentally Suitable to Practice Pranayama Breathing Technique, Individuals Without a Malignant Respiratory System Disease (Such as Bronchial and Lung Cancer), Individuals Without a Pathological Condition Affecting Their Level of Consciousness and Concentration
- Trial name
- NCT07451756
- Testing
- Pranayama group
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Namik Kemal University
Ischemic Stroke, Hemorrhagic Shock
Predictors Of Stroke Outcome In Chidren
Stroke can be defined as an abrupt loss of brain function that is caused by decreased cerebral blood flow. Stroke can occur at all stages of life, but presentation is variable depending on age, involved artery, and underlying…
- Trial name
- NCT04331457
- Testing
- Brain magnetic resonance imaging (MRI) , computed tomography (CT)
- Volunteers
- 30 people
- Sponsor
- Assiut University
Brain Injuries, Acute, Brain Injuries, Traumatic
Antiseizure Medication in Seizure Networks at Early Acute Brain Injury
The goal of this clinical trial is to explore the effect of FDA-approved antiseizure drugs in the brain connectivity patterns of severe and moderate acute brain injury patients with suppression of consciousness.
- Conditions
- Brain Injuries, Acute, Brain Injuries, Traumatic, Brain Ischemia, Brain Hypoxia
- Trial name
- NCT06081283
- Testing
- Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of North Carolina, Chapel Hill