Clinical trials: Disorder of Upper Gastrointestinal Tract
Upper Respiratory Tract Infections, Rhinopharyngitis
Effect of the Consumption of a Fermented Milk on Common Infections in Adults Submitted to Multi-stressor Situation
This multicentric, randomized, double-blind and controlled study aims to examine the effect of a fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel® = tested product) on the incidence of…
- Conditions
- Upper Respiratory Tract Infections, Rhinopharyngitis, Sore Throat, Sinusitis
- Trial name
- NCT01315418
- Testing
- 1-Fermented dairy product containing the probiotic Lactobacillus casei DN-114 001 (Actimel®), 2-Non fermented dairy product (control)
- Where
- France
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Patients With Upper Gastro-intestinal Symptoms
Prevalence of Gastroesophageal Reflux Disease (GERD) in Patients With Upper Gastrointestinal Tract Symptoms in Egypt
The purpose of this study is to calculate the prevalence of gastroesophageal reflux disease (GERD) by mean of GERD-Q questionnaire in patients with upper gastrointestinal tract symptoms in Egypt.
- Trial name
- GERD Q NIS (NCT01635959)
- Where
- 21 sites in Egypt
- Volunteers
- 3,170 people
- Sponsor
- AstraZeneca
Cough
Therapeutic Confirmatory Clinical Trial to Evaluate the Safety and Efficacy of AG1321001 in Chronic Cougher
This study is for therapeutic confirmation of AG1321001 to evaluate the safety and efficacy as an anti-tussive agent in cough patients.
- Trial name
- NCT00380315
- Testing
- AG1321001(drug)
- Where
- South Korea
- Volunteers
- 396 people
- Sponsor
- Ahn-Gook Pharmaceuticals Co.,Ltd
Osteoporosis
Upper GI Handling of Branded vs. Generic Alendronate
To compare upper GI handling of fosamax and generic, because the main AE profile of alendronate is before systemic absorption in the esophagus; differences could be relevant to the side effect profile.
- Trial name
- NCT00400530
- Testing
- MK0217, alendronate sodium / Duration of Treatment: 1 Month, Comparator: Alendronate-Teva / Duration of Treatment: 1 Month
- Volunteers
- 25 people
- Sponsor
- Merck Sharp & Dohme LLC
Upper Gastrointestinal Bleeding (UGIB)
Evaluation of ClearPlasma in Patients With Upper Gastrointestinal Bleeding.
Upper gastrointestinal hemorrhage (UGIH) is one of the most common gastrointestinal emergencies, and is associated with significant morbidity and mortality. Plas-Free aims to evaluate ClearPlasma safety in patients with UGIH.
- Trial name
- CLearPlasma (NCT06761430)
- Testing
- ClearPlasma
- Where
- Italy
- Volunteers
- 7 people
- Sponsor
- PlasFree Ltd.
Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2.
- Conditions
- Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT04180371
- Testing
- BT5528, Nivolumab
- Where
- 28 sites in United States, Belgium and 3 more
- Volunteers
- 288 people
- Sponsor
- BicycleTx Limited
Gastrointestinal Cancer
Immunonutrition and Quality of Life of Cancer Patients Undergoing Oncological Treatment
The purpose of this study is to compare the health-related quality of life following dietary supplementation with an immunonutrition formulation vs an isocaloric/isoprotein control diet supplement in patients suffering from upper…
- Trial name
- Neoimmune (NCT01423799)
- Testing
- Nutritional supplements containing arginine, n-3 and nucleotides, Isocaloric control
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Société des Produits Nestlé (SPN)
Acute Coronary Syndrome, Myocardial Infarction
Clopidogrel and the Optimization of Gastrointestinal Events (COGENT-1)
The purpose of the COGENT-1 clinical trial is to determine whether CGT-2168 (clopidogrel and omeprazole) compared to clopidogrel is safe and effective in reducing the incidence of gastrointestinal bleeding and symptomatic ulcer…
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- COGENT-1 (NCT00557921)
- Testing
- CGT-2168 (clopidogrel 75 mg/omeprazole 20 mg) and aspirin, Plavix (clopidogrel 75 mg) and aspirin
- Where
- 491 sites in United States, Australia and 14 more
- Volunteers
- 5,000 people
- Sponsor
- Cogentus Pharmaceuticals
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -Healthy Volunteers Study
The objective of the investigation is to evaluate the feasibility of detecting blood in healthy volunteers after ingestion of autologous blood mixed with water.
- Trial name
- NCT05631652
- Testing
- PillSense System
- Where
- Czechia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- EnteraSense Limited
Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma
Phase III Open-labeled Study of NPO-11 in Patients Undergoing Therapeutic Upper Gastrointestinal Endoscopy
Patients who require therapeutic upper gastrointestinal endoscopy, such as polypectomy, endoscopic hemostasis, percutaneous endoscopic gastrostomy (PEG), endoscopic mucosal resection (EMR) and endoscopic submucosal dissection…
- Conditions
- Gastric Cancer, Colon Nos Polypectomy Tubular Adenoma, Gastric Adenoma
- Trial name
- NCT01411189
- Testing
- Menthol
- Where
- Japan
- Volunteers
- 33 people
- Sponsor
- Nihon Pharmaceutical Co., Ltd
Advanced Upper Gastrointestinal Tract Adenocarcinoma
A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
This randomized Phase 3 open-label study will compare the efficacy of the T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) monoclonal antibody domvanalimab, the anti programmed cell…
- Trial name
- STAR-221 (NCT05568095)
- Testing
- Domvanalimab, Zimberelimab, Capecitabine
- Where
- 168 sites in United States, Argentina and 27 more
- Volunteers
- 1,040 people
- Sponsor
- Arcus Biosciences, Inc.
GERD
Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs
This study was a multicentre, double-blind, randomised, placebo-controlled parallel group study consisting of 4 visits over a period of 6 months.
- Trial name
- NCT00241514
- Testing
- Esomeprazole
- Where
- 113 sites in United States, Belgium and 4 more
- Volunteers
- 334 people
- Sponsor
- AstraZeneca
Upper GI Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding With a Novel Bleeding Sensor Capsule [DING]
The clinical trial entitled "Detection of upper gastrointestinal (GI) bleeding with a novel bleeding sensor capsule - a pilot study" was carried out in a monocentric clinical trial with 30 patients.
- Trial name
- DING (NCT03176407)
- Testing
- HemoPill acute
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Ovesco Endoscopy AG
Upper Gastrointestinal Bleeding
Detection of Upper Gastrointestinal (GI) Bleeding Using a Novel Bleeding Sensor Capsule -A Pilot Study
This is a multi-center, prospective, non-randomized, open-label, exploratory clinical investigation performed to evaluate safety and effectiveness of the PillSense System when used for detection of blood in the stomach of…
- Trial name
- NCT05631639
- Testing
- PillSense System
- Where
- 3 sites in Czechia
- Volunteers
- 30 people
- Sponsor
- EnteraSense Limited
Diabetes, Diabetes Mellitus, Type 2
Investigation of the Effect of Upper Gastrointestinal Disease on the Pharmacokinetics of Oral Semaglutide in Subjects With Type 2 Diabetes.
This trial is conducted in Europe. The aim of this trial is, to investigate the effect of upper gastrointestinal disease on the pharmacokinetics (the exposure of the trial drug in the body) of oral semaglutide in subjects with…
- Trial name
- NCT02877355
- Testing
- semaglutide
- Where
- 2 sites in Germany
- Volunteers
- 55 people
- Sponsor
- Novo Nordisk A/S
Upper Gastrointestinal Symptoms
Comparative Study of MCCE With/Without Tether vs Conventional Upper Endoscopy in Patients With Upper Abdominal Symptoms
A prospective single blinded, tandem study, comparing a magnetically controlled capsule with or without a tether (MCC or MCC-T) with conventional upper endoscopy for the diagnosis of patients with upper abdominal symptoms.
- Trial name
- NCT04605302
- Testing
- MCC/MCC-T, Standard gastroscopy
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- AnX Robotica Corp.
Gallbladder Disease, Biliary Colic
Fluorescence Imaging on the da Vinci Surgical System for Intra-operative Near Infrared Imaging of the Biliary Tree (up to 2-weeks Post-operatively)
The investigators hypothesize that the da Vinci Fluorescence Imaging Vision System provides real-time endoscopic near infrared fluorescence imaging of the biliary anatomy as defined as identifying biliary vessels; either cystic…
- Conditions
- Gallbladder Disease, Biliary Colic, Gallstones
- Trial name
- NCT01410734
- Testing
- Indocyanine green (ICG)
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 72 people
- Sponsor
- Intuitive Surgical
Peptic Ulcer
Study to Assess the Efficacy and Safety of Somatostatin in the Treatment of Acute Severe Upper Gastrointestinal Bleeding
To assess the efficacy and safety of the early administration of somatostatin in infusion during 72 hours plus 2 boluses, compared to placebo in the control of acute severe UGIB with suspicion of PUB.
- Trial name
- NCT00152399
- Testing
- Somatostatin UCB (drug)
- Where
- 22 sites in Belgium, France and 4 more
- Volunteers
- 370 people
- Sponsor
- UCB Pharma
Upper Gastrointestinal Hemorrhage
A Pilot and Feasibility Study to Evaluate Capsule Endoscopy
This study is aimed at assessing the capability of the PillCam Platform using the PillCam ESO 2 Capsule in: Determining whether there is 1) active bleeding in the Upper gastrointestinal (UGI) tract, 2) identifying the anatomic…
- Trial name
- MA-79 (NCT00974701)
- Testing
- PillCam ESO2
- Where
- 2 sites in Hong Kong, Israel
- Volunteers
- 50 people
- Sponsor
- Medtronic - MITG
UGI Bleed, Upper Gastrointestinal Bleeding
PillSense System for Detecting UGI Bleed
This is a prospective, non-randomized, open-label clinical investigation to evaluate feasibility, effectiveness and safety of the PillSense System, the transit of the PillSense Capsule through the GI tract, patient tolerability…
- Conditions
- UGI Bleed, Upper Gastrointestinal Bleeding, Upper Gastrointestinal Bleed
- Trial name
- NCT05385224
- Testing
- PillSense
- Where
- United States
- Volunteers
- 131 people
- Sponsor
- EnteraSense Limited