Clinical trials: Disorder of Upper Respiratory System
Otitis Media, Tonsillitis
Acceptance of Clarithromycin in a Straw Compared to Syrup in Children With Upper Respiratory Tract Infections
This study was performed in children with upper respiratory tract infections (acute ear infection, infection of the tonsils or throat, or bacterial inflammation of the bronchi) who needed treatment with an antibiotic…
- Conditions
- Otitis Media, Tonsillitis, Pharyngitis, Bronchitis
- Trial name
- DoSe iT (NCT04016051)
- Testing
- Clarithromycin DST (125 mg), Clarithromycin DST (187.5 mg), Clarithromycin DST (250 mg)
- Where
- 20 sites in Germany, Poland
- Volunteers
- 265 people
- Sponsor
- Grünenthal GmbH
Human, Influenza
Safety and Immunogenicity of One Dose of Seasonal Trivalent Influenza Virus Vaccine (TIVf, Purified Surface Antigen, Inactivated, Egg Derived) in Adults Aged 18 Years and Above
This protocol was designed to evaluate the safety, clinical tolerability and immunogenicity of the Trivalent Influenza Virus Vaccine (TIVf, purified surface antigen, inactivated, egg derived), Northern Hemisphere formulation…
- Trial name
- NCT01640327
- Testing
- Trivalent influenza virus vaccine (TIVf)
- Where
- Germany
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Sore-throat, Upper Respiratory Infection
Clinical Trial of a Mouth and Throat Rinse for the Treatment of Acute Sore Throat
The aim of this study is to confirm the efficacy, safety and tolerability of the Mouth and Throat Rinse in adult participants with acute sore throat (upper respiratory tract infection e.g., pharyngitis/laryngitis) compared to…
- Trial name
- NCT06244615
- Testing
- Verum (WO 6607)
- Where
- Ukraine
- Volunteers
- 154 people
- Sponsor
- Dr. August Wolff GmbH & Co. KG Arzneimittel
Respiratory Syncytial Virus
Presatovir in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus Infection of the Upper Respiratory Tract
The primary objective of this study is to evaluate the effect of presatovir on respiratory syncytial virus (RSV) viral load in autologous or allogeneic hematopoietic cell transplant (HCT) recipients with an acute RSV upper…
- Trial name
- NCT02254408
- Testing
- Presatovir
- Where
- 68 sites in United States, Australia and 13 more
- Volunteers
- 189 people
- Sponsor
- Gilead Sciences
COVID-19
Efficacy,Immunogenicity and Safety of COVID-19 Vaccine , Inactivated Booster Dose in Adults Aged 18 Years and Above
This is a multi-center, case-driven, randomized, double-blinded, and placebo-controlled Phase Ⅲb clinical trial of COVID-19 Vaccine manufactured by Sinovac Research \& Development Co., Ltd.The purpose of this study is to evaluate…
- Trial name
- NCT05156632
- Testing
- Medium-dosage COVID-19 Vaccine,Inactivated, High-dosage COVID-19 Vaccine,Inactivated
- Volunteers
- healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Healthy Subjects
HEALSea Nasal Spray for Prevention of Infections in Children
Healsea® Children is a class IIa medical device. This is an isotonic seawater-based nasal spray supplemented with a natural Symbiofilm™ extract (0.02%) isolated from marine bacteria.
- Trial name
- HEALSPIC (NCT06582589)
- Testing
- Healsea Children
- Where
- 8 sites in Bulgaria
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Lallemand Pharma AG
Primary Snoring, Sleep Apnea
Study Will Test the Theory That Training With the Facial-Flex Exercise Device Will Improve Snoring in Patients
The study will test the hypothesis that training with the Facial-Flex exercise device for six weeks will improve snoring in patients with primary snoring or very mild sleep apnea.
- Trial name
- NCT01554904
- Testing
- Facial-Flex
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Facial Concepts, Inc.
Common Cold
Evaluation of ColdZyme® Mouth Spray on Prevention and Alleviation of Rhinovirus Induced Common Cold
This study evaluates the performance of ColdZyme® mouth spray on prevention and alleviation of induced rhinovirus upper respiratory tract infection in healthy volunteers.
- Trial name
- COLDPREV (NCT02522949)
- Testing
- ColdZyme® mouth spray
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Enzymatica AB
Rhinitis, Sinusitis
Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections/Conditions
The goal of this interventional clinical trial is to test the safety and efficacy of two medical devices in subjects aged from 3 months old for the treatment of colds, rhinitis, sinusitis, and other upper respiratory…
- Conditions
- Rhinitis, Sinusitis, Upper Respiratory Infections, Colds
- Trial name
- NCT06498843
- Testing
- administration of an isotonic seawater solution (9g/L) in the nose, administration of a hypertonic seawater solution (21g/L) in the nose
- Where
- Poland
- Volunteers
- 89 people
- Sponsor
- YSLab
Influenza
Study to Evaluate Immunogenicity & Safety of an Investigational Influenza Vaccine in Adults
The objective of this study is to evaluate the immunogenicity and safety of GSK Biologicals' investigational vaccine GSK2340272A.
- Trial name
- NCT00975884
- Testing
- GSK investigational vaccine GSK2340272A
- Where
- 5 sites in France
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza, Acute Upper Respiratory Infection
Treatment of Influenza and ARVI in Children by Kagocel ®
This study examined the etiology of acute respiratory viral infections (ARVI) during the 2015-2016 season, evaluated the statistics of the incidence of influenza and ARVI in this period (epidemiology: severity of the disease and…
- Trial name
- NCT04651491
- Testing
- Kagocel
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Nearmedic Plus LLC
Influenza
Study to Evaluate the Immunogenicity and Safety of a Second Vaccination With the Adjuvanted Influenza Vaccine Candidate
The purpose of this study is to evaluate the immunogenicity and the safety of a second vaccination with candidate vaccine compared to Fluarix™ administered intramuscularly in elderly aged 60 years and above
- Trial name
- NCT00385840
- Testing
- Influenza Vaccine GSK1247446A, FluarixTM
- Where
- 4 sites in Norway
- Volunteers
- 678 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Upper Respiratory Tract Infections, Mental Stress
A Clinical Study to Determine if Beta Glucan Reduces the Incidence, Duration or Severity of URTIs Among Skiers
This study is designed to determine if a dieatary supplement containing beta-glucan can reduce the incidence, severity and duration of upper respiratory tract infections among a group of highly trained athletes
- Trial name
- NCT05917015
- Testing
- Treatment
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- USANA Health Sciences
COVID-19
Safety and Immunogenicity of Adjuvanted SARS-CoV-2 (SCB-2019) Vaccine in Adults With Chronic Immune-Mediated Diseases
The purpose of the study is to evaluate the safety and immunogenicity of the investigational CpG 1018/Alum-adjuvanted recombinant SARS-CoV-2 trimeric spike (S)-protein subunit vaccine (SCB-2019) in adult participants with stable…
- Trial name
- COVID-19 (NCT05012787)
- Testing
- CpG 1018/Alum-adjuvanted SCB-2019 vaccine, Havrix
- Where
- 4 sites in Ukraine
- Volunteers
- 1 people
- Sponsor
- Clover Biopharmaceuticals AUS Pty
Influenza
Phase Ⅱ Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above
To evaluate the immunogenicity of administering one dose of influenza virus split vaccine (0.7mL/dose) to individuals aged 60 and above.
- Trial name
- NCT07327398
- Testing
- Influenza virus split vaccine (0.7mL/vial), Influenza virus split vaccine
- Where
- 2 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Diarrhea, Upper Respiratory Infections
Children Immune Functions
The purpose of the planned study is to investigate the effect of heat-treated lactobacilli on diarrhea outcome in healthy children 1-4 years old in a randomized, double-blind, placebo-controlled study.
- Trial name
- NCT01717534
- Where
- 2 sites in Mexico
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer
Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression
This clinical trial is evaluating a drug called BT5528 alone and in combination with nivolumab in participants with advanced solid tumors historically known for expression of EphA2.
- Conditions
- Advanced Solid Tumor Historically Known for High EphA2 Expression, Urothelial Cancer, Ovarian Cancer, Non-small Cell Lung Cancer
- Trial name
- NCT04180371
- Testing
- BT5528, Nivolumab
- Where
- 28 sites in United States, Belgium and 3 more
- Volunteers
- 288 people
- Sponsor
- BicycleTx Limited
Tracheitis, Tracheobronchitis
Evaluation of Effectiveness of the Treatment After Repeated Administration of Klacid®SR
This post-marketing observational study (PMOS) will be conducted in a prospective, single-arm, single-country, multicenter format.
- Conditions
- Tracheitis, Tracheobronchitis, Bronchitis, Chronic Bronchitis
- Trial name
- NCT01130883
- Where
- 135 sites in Czechia
- Volunteers
- 3,130 people
- Sponsor
- Abbott
Influenza
A Clinical Trial of Influenza Virus Split Vaccine for Individuals Aged 60 Years and Above
This is a randomized, blinded, controlled phase I clinical trial with a total of 120 participants aged ≥ 60 years. Experimental group: Influenza virus split vaccine (0.7mL/vial), control group 1: Influenza virus split vaccine…
- Trial name
- NCT07302256
- Testing
- Influenza virus split vaccine (0.7mL/vial), Influenza virus split vaccine, Phosphate buffer solution (PBS)
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shanghai Institute Of Biological Products
Diarrhea, Upper Respiratory Infections
Children Immune Functions(2)
To investigate the effect of milk-based formulas on infections and immune functions in healthy children.
- Trial name
- NCT01731392
- Testing
- Milk with Bifidobacteria, Milk with non replicating lactobacilli
- Where
- Indonesia
- Volunteers
- 604 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)