Clinical trials: Disorder of Upper Respiratory System
Influenza
An Efficacy, Immunogenicity and Safety Study Investigating an Adjuvanted SARS-CoV-2 Influenza Vaccine to Protect Against COVID-19 in Adults Over Aged 18 Years-old and Older
The primary efficacy objective is to demonstrate the efficacy of aCoV2 versus a placebo to prevent the first occurrence of virologically-confirmed symptomatic COVID 19 according to the European Centre for Disease Prevention and…
- Trial name
- NCT04806529
- Testing
- Adjuvanted SARS-CoV-2 Subunit vaccine (aCoV2), Comparator
- Volunteers
- healthy volunteers welcome
- Sponsor
- Seqirus
Malignancy, Metastasis
Same-session MR-only Simulation and Treatment With MRI-guided Adaptive Palliative RadioTherapy
This proposed study is unique in that patients will not undergo computed tomography (CT) simulation at any point during their treatment course and will instead have same-session magnetic resonance (MR)-only simulation and…
- Conditions
- Malignancy, Metastasis, Hemoptysis, Gastrointestinal Bleeding
- Trial name
- MAP-RT (NCT03824366)
- Testing
- Volumetric MR imaging, Radiation therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
SARS-CoV-2 Acute Respiratory Disease
Study of Ameliorating Effect of COVID-19 mRNA Vaccine in Individuals Immunized With Inactivated Vaccine
this is a voluntary, investigator-initiated, inactivated COVID-19 vaccine controlled clinical trial to evaluate the immunogenicity and safety of COVID-19 mRNA vaccine in adults aged 18 years and above which have immunized with…
- Trial name
- COVID-19 (NCT04944381)
- Testing
- SARS-Cov-2 mRNA vaccine immunization, Inactivated SARS-Cov-2 vaccine immunization
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Qihan Li
Lung Neoplasm
Reader Study of DeltaView™ Chest Radiograph Software
A new software product takes two chest radiographs, aligns them, and then subtracts one image from the other. The resulting image represents an image showing any differences between them.
- Trial name
- NCT01261507
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Georgetown University
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Reflux Esophagitis
A Prospective Cohort Study on Endoscopic Features of Upper Gastrointestinal Tract at High Altitude (Zaduo County)
To prospectively enroll participants undergoing gastroscopy at Zaduo County People's Hospital and perform paired analyses with matched cases from Jilin Province.
- Trial name
- NCT07755384
- Testing
- Sedated gastroscopy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Influenza
Safety and Immunogenicity of Different Formulations of an Adjuvanted, Trivalent Subunit Influenza Vaccine in Elderly Subjects 65 Years of Age and Above
In this study, the safety and immunogenicity of the current formulation of aTIV will be compared to aTIV-modified formulations in which the dosage of the MF59 adjuvant will be doubled or tripled and/or the dosage of the 3…
- Trial name
- NCT02126761
- Testing
- Adjuvanted, trivalent subunit influenza vaccine, Adjuvant level modified adjuvanted, trivalent subunit influenza vaccine, Antigen level modified adjuvanted, trivalent subunit influenza vaccine
- Where
- Germany
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Seqirus
Influenza
Immunogenicity and Reactogenicity of Fluarix™ (Influsplit SSW®) 2007/2008 in People 18 Years Old or Above
This study is designed to test the immunogenicity and reactogenicity of the Fluarix™/Influsplit SSW® containing the influenza strains recommended for the 2007-2008 season.
- Trial name
- NCT00476307
- Testing
- Fluarix™/Influsplit SSW® 2007/2008
- Where
- 3 sites in Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Duchenne Muscular Dystrophy
Safety and Efficacy of P-188 NF in DMD Patients
This is an open-label study to evaluate the safety, tolerability and efficacy of daily, subcutaneous dosing with P-188 NF (Carmeseal-MD™) in non-ambulatory boys with Duchenne Muscular Dystrophy (DMD).
- Trial name
- NCT03558958
- Testing
- P-188 NF
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Phrixus Pharmaceuticals, Inc.
COPD, COPD Exacerbation
Weight Training With VR in Out-Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Using weight training with virtual reality can help after discharge patients of acute exacerbation of chronic obstructive pulmonary disease, which maintained their quality of life, and improved their exercise capacity, pulmonary…
- Conditions
- COPD, COPD Exacerbation, Pulmonary Rehabilitation, Weight Training
- Trial name
- NCT04880486
- Testing
- Education, Supervision upper limb weight training exercise with VR
- Where
- Taiwan
- Volunteers
- 22 people
- Sponsor
- National Cheng-Kung University Hospital
Laryngopharyngeal Reflux
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin
It is postulated that the incompetence of the upper esophageal sphincter (UES) to restrict passage of esophageal refluxate is fundamental to the development of LPR.
- Trial name
- NCT02552966
- Testing
- UESAD
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Upper Extremity Fractures, Postoperative Anxiety
The Effect of the Cold Arm Sling Elevation Pillow on Postoperative Anxiety and Comfort in Children
The purpose of this clinical trial is to learn whether the use of a "cold and arm sling elevation pillow" affects anxiety and comfort levels in children aged 7-12 years undergoing surgery for upper extremity fractures.
- Conditions
- Upper Extremity Fractures, Postoperative Anxiety, Patient Comfort
- Trial name
- NCT07475975
- Testing
- Cold and arm sling elevation pillow, Standard postoperative care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Diabetes Mellitus, Upper Respiratory Infection
Effects of URI on Diabetic Subjects Utilizing Technosphere Insulin After a Meal Challenge
Effect of upper respiratory infection (URI) on diabetic subjects with a meal challenge
- Trial name
- NCT00642681
- Testing
- Technosphere Insulin
- Where
- 24 sites in United States, Canada and 1 more
- Volunteers
- 20 people
- Sponsor
- Mannkind Corporation
Pulmonary Sarcoidosis
The Effect of Inspiratory Muscle Training and Breathing Exercises Combined With Upper Extremity and Trunk in Patients With Sarcoidosis
This is an educational work. Thirty patients with pulmonary sarcoidosis will be included in the study and randomly selected into two training groups.One group will receive home inspiratory muscle training (IMT) for 15 minutes…
- Trial name
- physio (NCT04173689)
- Testing
- Threshold IMT, breathing exercises combined with upper extremity and trunk
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Istanbul University - Cerrahpasa
Influenza, Human
A Study to Evaluate the Immunogenicity and Safety of bioCSL Quadrivalent Influenza Vaccine (QIV) in Adults Aged 18 Years and Above.
This is a study to assess the immune (antibody) response and safety of a bioCSL split virion, inactivated quadrivalent influenza vaccine, in comparison with a US licensed 2014/2015 trivalent influenza vaccine (bioCSL TIV-1), and…
- Trial name
- NCT02214225
- Testing
- Quadrivalent Influenza Vaccine (QIV), Trivalent Influenza Vaccine (TIV-1), Trivalent Influenza Vaccine (TIV-2)
- Where
- 33 sites in United States
- Volunteers
- 3,484 people, healthy volunteers welcome
- Sponsor
- Seqirus
Asthma
A Study in Asthma Patients to Evaluate Efficacy, Safety and Tolerability of 14 Days Once Daily Inhaled Interferon Beta-1a After the Onset of Symptoms of an Upper Respiratory Tract Infection
A study to investigate if inhaled Interferon beta-1a is safe and tolerated, and can prevent or reduce the severity of asthma attacks when administered to asthma patients at the onset of symptoms of common cold or influenza
- Trial name
- INEXAS (NCT02491684)
- Testing
- Interferon beta-1a Nebuliser solution 48 μg/mL
- Where
- 35 sites in Argentina, Australia and 5 more
- Volunteers
- 121 people
- Sponsor
- AstraZeneca
Sleep Apnea, Obstructive, Metabolism
Treatment of Sleep Apnea to Improve Metabolic Health
Diabetes and prediabetes prevail among obstructive sleep apnea (OSA) patients. OSA and short sleep both detrimentally affect glycemic control regardless of obesity.
- Conditions
- Sleep Apnea, Obstructive, Metabolism, CPAP, Patients Above 18 Years
- Trial name
- GLYCOSACT (NCT06848647)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Upper Respiratory Infection
Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement
This study was conducted to investigate the effects of daily supplementation of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement
- Trial name
- NCT05666752
- Testing
- Allium Cepa L. Peel Heated Water Extract
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Sleep Apnea
A Combined Surgical and Medical Approach in Mild Sleep Apnea
The aim of the study is to investigate wether the adjuvant (postoperative) administration of acetazolamide can improve the surgical results after uvulopalatopharyngoplasty in patients with mild sleep apnea.
- Trial name
- NCT00497120
- Testing
- acetazolamide, uvulopalatopharygoplasty
- Where
- Belgium
- Sponsor
- University Hospital, Antwerp
Limb-girdle Muscular Dystrophy
A Study of the Natural History of Participants With LGMD2E/R4, LGMD2D/R3, LGMD2C/R5, and LGMD2A/R1 ≥ 4 Years of Age, Who Are Managed in Routine Clinical Practice
This study will follow participants who are screened and confirmed with a genetic diagnosis of Limb-girdle muscular dystrophy type 2E (LGMD2E/R4), Limb-girdle muscular dystrophy type 2D (LGMD2D/R3), Limb-girdle muscular dystrophy…
- Trial name
- NCT04475926
- Where
- 26 sites in United States, Belgium and 8 more
- Volunteers
- 205 people
- Sponsor
- Sarepta Therapeutics, Inc.