Clinical trials: Disorder of Upper Respiratory System
Cystic Fibrosis
Safety and Efficacy of Inhaled BMD003 (CFTR mRNA) in Chinese Cystic Fibrosis Patients Aged ≥12 Years
This is a prospective, single-center, open-label clinical study designed to evaluate the safety, tolerability, and preliminary efficacy of inhaled BMD003 (CFTR mRNA) in Chinese patients aged 12 years and above with cystic…
- Trial name
- NCT07485543
- Testing
- BMD003 (CFTR mRNA)
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Peking Union Medical College Hospital
Hoarseness, Post Operative Complicaiton
Intraperitoneal Dexamethasone Spraying on Vagal Nerve-Rich Areas for Prevention of Hoarseness After Upper Abdominal Surgery
The goal of this clinical trial is to evaluate whether intraoperative spraying of dexamethasone onto the abdominal vagal nerve-rich areas can prevent postoperative hoarseness in patients undergoing elective upper abdominal…
- Trial name
- NCT07722091
- Testing
- Dexamethasone, Saline (0.9% NaCl)
- Where
- 4 sites in China
- Volunteers
- 584 people
- Sponsor
- Fujian Medical University Union Hospital
Biopsy Confirmed Head and Neck Cancer and Tumors of the Chest
Oral Glutamine and Thoracic/Upper Aerodigestive Tumors Radiation Toxicity
PROTOCOL FOR PREVENTIVE ADMINISTRATION OF GLUTAMINE TO AVOID RADIATE SIDE EFFECTS IN PATIENTS UNDER RADIOTHERAPY IN THE CHEST AND HEAD \& NECK PURPOSE OF THE STUDY The purpose of the protocol is to study the acute and distant…
- Trial name
- NCT05054517
- Testing
- Glutamine
- Volunteers
- 72 people
- Sponsor
- National and Kapodistrian University of Athens
Obstructive Sleep Apnea
Assessment of the Impact of a Stepped Mouthpiece on the Upper Airways Measured Through Acoustic Pharyngometry
Mandibular advancements during tidal breathing, achieved through a stepped mouthpiece design, affect the size of the upper airways in subjects with and without Obstructive Sleep Apnea.
- Trial name
- NCT01069068
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Doctor's Directive Strategies Inc.
Anesthesia, Endotracheal
The Effects of Beclomethasone Upper the Endotracheal Cuff on the Occurrence of Sore Throat at Extubation
The aim of the study is to test the effectiveness of a solutions of beclomethasone repeatedly instilled through the supraglottic line of the endotracheal tube on post-extubation airway disturbances related to tracheal intubation.
- Trial name
- BEnTS (NCT02687100)
- Testing
- Beclomethasone
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Gastroenteritis, Upper Respiratory Tract Infections
Fermented Milk on the Appearance of Common Winter Infectious Diseases
Respiratory and gastrointestinal infections are common in children under the age of 4 years, especially after the start of schooling.
- Trial name
- NCT02367612
- Testing
- Fermented milk
- Where
- 3 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Federico II University
Upper Respiratory Tract Infection, Prevention
Clinical Trial to Evaluate the Efficacy of Lacticaseibacillus Rhamnosus CRL1505 in the Prevention of Upper Respiratory Tract Infections in Children
Randomized, double-blind, placebo-controlled, parallel-group, clinical trial to assess the efficacy of the intake of a probiotic product composed of Lacticaseibacillus rhamnosus CRL1505 strain in reducing or preventing upper…
- Trial name
- NCT07154992
- Testing
- Probiotic - Lacticaseibacillus rhamnosus CRL1505
- Where
- Spain
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- Bioithas SL
Acute Upper Respiratory Tract Infection, Acute Bronchitis
Clinical Trials to Assess the Efficacy and Safety of HLIM
The purpose of this study is to assess the efficacy and safety of HLIM
- Trial name
- NCT03827590
- Testing
- Test, Active Comparator Control 1, Active Comparator Control 2
- Where
- South Korea
- Volunteers
- 487 people
- Sponsor
- SamA Pharmaceutical Co., Ltd
Laryngopharyngeal Reflux
Assessing the Impacts of a UESAD on Laryngeal Symptoms and Salivary Pepsin
It is postulated that the incompetence of the upper esophageal sphincter (UES) to restrict passage of esophageal refluxate is fundamental to the development of LPR.
- Trial name
- NCT02552966
- Testing
- UESAD
- Volunteers
- 20 people
- Sponsor
- Northwestern University
Common Cold
Nasal Swab Study to Explore the Nasal Microbia
The objective of this study is to evaluate the microbial consortia and the host inflammatory factors present in the nasal passages of patients during upper respiratory symptomology and when healthy using culture and molecular…
- Trial name
- NCT02535442
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kimberly-Clark Corporation
Burn Injury, Pulmonary Rehabilitation
Effect of Pulmonary Rehabilitation on Respiratory Parameters in Upper Extremity Burns
This study will evaluate the effects of a pulmonary rehabilitation program on breathing function, respiratory muscle activity, respiratory muscle thickness, and functional capacity in adults with upper extremity burns.
- Trial name
- NCT07577960
- Testing
- Pulmonary Rehabilitation Program, Conventional Exercise Program
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Fenerbahce University
Advanced Upper Lobe Predominant Emphysema
Phase 3 Study of the Biologic Lung Volume Reduction (BLVR) System in Advanced Upper Lobe Predominant (ULP) Emphysema
The purpose of the study is to evaluate the efficacy and safety of the 20 mL BLVR System in treating patients with advanced upper lobe predominant emphysema.
- Trial name
- NCT00716053
- Testing
- BLVR
- Volunteers
- 225 people
- Sponsor
- Aeris Therapeutics
COVID-19, Corona Virus Infection
Nasal Photodisinfection COVID-19 Proof of Concept Study
The study proposes to test photodisinfection (PDF) on SARS-CoV-2 in the nose. The study will use Health Canada approved Steriwave™ Nasal Decolonization (ND) in he nostril of patients infected with SARS-CoV-2.
- Conditions
- COVID-19, Corona Virus Infection, SARS-CoV 2
- Trial name
- NCT04615936
- Testing
- Methylene-Blue Photodisinfection
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Sunnybrook Health Sciences Centre
Neoplasms
GSK3359609 Plus Tremelimumab for the Treatment of Advanced Solid Tumors
The purpose of this study is to evaluate if the combination of GSK3359609 and tremelimumab is safe and tolerable (Part 1) and provides significant survival benefit to subjects with relapsed/refractory (R/R) Head and Neck Squamous…
- Trial name
- NCT03693612
- Testing
- feladilimab, Tremelimumab, Docetaxel
- Where
- 8 sites in United States, Australia and 1 more
- Volunteers
- 26 people
- Sponsor
- GlaxoSmithKline
Hyperactivity, Chronic Rhinosinusitis (Diagnosis)
Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Chronic Rhinosinusitis (Diagnosis), Chronic Rhinitis, Upper Respiratory Disease
- Trial name
- NCT03893227
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Upper Resp Tract Infection
TEM-PCR™ Prospective Clinical Utility Study
This is a randomized, open-label, multi-center, prospective study to assess the clinical utility of the TEM-PCR Upper Respiratory Infection (URI) Panel in adult subjects age 65 and older presenting to the primary care clinic with…
- Trial name
- NCT04248361
- Testing
- TEM-PCR URI Panel, SOC/Empiric Diagnosis
- Where
- 4 sites in United States
- Volunteers
- 314 people
- Sponsor
- Diatherix Laboratories, LLC
Upper Respiratory Infection
Appropriate Care of URI (ACURI): Early Head Start
The purpose of this study is to comparatively assess the effectiveness of a tailored educational intervention to improve health literacy levels regarding upper respiratory infections (URIs) and to decrease pediatric emergency…
- Trial name
- NCT01916031
- Testing
- Education
- Sponsor
- Columbia University
Pharynx Cancer, Larynx Cancer
Randomized Trial to Assess the Impact of a Screening Program on Upper Aerodigestive Tract Cancer Mortality in a High Risk Population
Randomized multicenter trial to assess the impact of a screening program for heavy alcohol drinkers and smokers treated in alcohol addiction clinics on upper aerodigestive tract cancer mortality.
- Conditions
- Pharynx Cancer, Larynx Cancer, Oral Cavity Cancer, Oesophageal Cancer
- Trial name
- NCT00359645
- Testing
- Screening by head and neck clinical examination with a fiberoptic nasolaryngoscopy and an oesopharyngeal brush biopsy annually during 3 years
- Where
- 35 sites in France
- Volunteers
- 1,993 people, healthy volunteers welcome
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cancer, Breast Cancer
Genomic Investigation of Unusual Responders
Studies have shown that tumors from the same patient may respond very differently to the same therapeutic agents. This study aims to investigate the genetic basis of tumors that respond abnormally well or poorly to therapeutic…
- Conditions
- Cancer, Breast Cancer, Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- GENIUS (NCT03740503)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Acute Rhinitis, Acute Pharyngitis
Efficacy and Safety of Jinhua Qinggan Granules (JHQG) for the Use of Acute Upper Respiratory Infection
The goal of this clinical trial is to learn if drug Jinhua Qinggan Granules (JHQG) works to treat acute upper respiratory tract infection in adults. It will also learn about the safety of drug JHQG.
- Conditions
- Acute Rhinitis, Acute Pharyngitis, Acute Tonsillitis, Acute Sinusitis
- Trial name
- (JHQG-AURI) (NCT07720583)
- Testing
- Jinhua Qinggan Granules
- Where
- Pakistan
- Volunteers
- 546 people
- Sponsor
- University of Karachi