Clinical trials: Disorder of Upper Respiratory System
Cough, Upper Respiratory Tract Infections
Effect of Over-the-counter NSAIDS on Cough Reflex Sensitivity in Patients with Upper Respiratory Tract Infections
The goal of this mechanism of disease study is to investigate the effect of flurbiprofen, a non-steroidal anti-inflammatory drug (NSAID), on the cough hypersensitivity associated with upper respiratory tract infections (URTI).
- Trial name
- NCT05955885
- Testing
- Flurbiprofen Oral Lozenge, Difflam, Flurbiprofen 8.75 MG
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Upper Airway Obstruction
Safety Study of Continuous Positive Airway Pressure Via a Nasal Mask
Upper airway obstruction (UAO) is common complication during induction of general anesthesia. The mechanism of UAO during anesthesia has not been well understood.
- Trial name
- NCT01524614
- Testing
- nasal mask
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Emphysema
Bronchoscopic Thermal Saline Ablation (BTSA) of Emphysematous Lung. A New Emphysema Therapy
Aim: To evaluate feasibility, safety and efficacy of relatively simple approach of bronchoscopic lung volume reduction (LVR) technology, independent of collateral ventilation.
- Trial name
- BTSA (NCT01920321)
- Testing
- Endoscopic lung volume reduction
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Assaf-Harofeh Medical Center
Influenza
Study to Evaluate the Safety and Immunogenicity of a Pandemic Influenza Vaccine in Adults Aged 18 Years and Above
Today, the leading contender for the next pandemic of influenza is H5N1, a strain of avian virus. Prevention and control will depend on the rapid production and worldwide distribution of specific pandemic vaccines.
- Trial name
- NCT00319098
- Testing
- Adjuvanted pandemic influenza candidate vaccine, Fluarix
- Where
- 40 sites in Estonia, France and 5 more
- Volunteers
- 5,075 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Upper Respiratory Infection
Effect of Probiotics on Health-related Quality of Life in College Students With Upper Respiratory Infections
The main purpose of the study is to find out if probiotics (healthy bacteria found in yogurt) can improve the health-related quality of life (HRQL) during upper respiratory infections (like the common cold) in college students…
- Trial name
- NCT01657643
- Testing
- Probiotics
- Where
- United States
- Volunteers
- 231 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Dentistry of New Jersey
Complex Regional Pain Syndromes, CRPS
Effect of Delta-9-Tetrahydrocannabinol on the Prevention of Chronic Pain in Patients With Acute CRPS (ETIC-Study)
The purpose of this study is to determine whether application of low dose Delta9-Tetrahydrocannabinol can prevent the development of chronic pain in patients with acute CRPS.
- Trial name
- NCT00377468
- Testing
- Delta9-Tetrahydrocannabinol
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Hematological Malignancies
Intermittent Use of Aerosolized Ribavirin for Treatment of RSV
Primary Objectives: 1. To determine whether aerosolized ribavirin is effective when given at an intermittent dose over 3 hours every 8 hours for therapy of RSV upper respiratory tract infection (URI) and whether it can prevent…
- Trial name
- NCT00500578
- Testing
- Ribavirin
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
COVID-19
Immunogenicity and Safety of Booster Immunization of COVID-19 Vaccine (Vero Cell), Inactivated (Omicron Variant) in Healthy People Aged 18 Years and Above
This is a randomized, double-blind, active-controlled Phase Ⅲ clinical trial, as well as an immuno-bridging clinical trial by parallel testing previous serum after primary immunization of COVID-19 vaccine (Vero cell), inactivated…
- Trial name
- NCT05381350
- Testing
- COVID-19 Vaccine (Vero cell), Inactivated (Omicron variant), COVID-19 Vaccine (Vero cell), Inactivated (CZ strain)
- Where
- China
- Volunteers
- 1,750 people, healthy volunteers welcome
- Sponsor
- Sinovac Research and Development Co., Ltd.
Upper Extremity Injury, COVID-19
Public Health Risks and Characteristics of Upper Extremity Trauma During COVID-19
The aim of this study was to evaluate for the first time in the Gaza-strip the characteristics and incidence of Upper Extremity Trauma (UET) during the COVID-19 pandemic.
- Trial name
- NCT05422989
- Testing
- X-ray, CT
- Where
- Israel
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Islamic University of Caza, Gaza, Palestine
Primary Ciliary Dyskinesia
Upper Extremity Exercise Capacity, Muscle Oxygenation, Balance in Patients With Primary Ciliary Dyskinesia
The main aim of the study is to evaluate upper extremity exercise capacity and muscle oxygenation in patients with primary ciliary dyskinesia.
- Trial name
- NCT04895150
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Gazi University
Upper Resp Tract Infection, Rhinitis Acute
Evaluation of a Hypertonic Seawater Aerosol Therapy Solution in Adults and Children
The purpose of this study is to evaluate the tolerance, the performance and safety of this device, 22‰ Hypertonic seawater aerosol therapy solution in unidose container, to treat adult and peadiatric patients with of upper…
- Conditions
- Upper Resp Tract Infection, Rhinitis Acute, Rhinopharyngitis, Cold Symptom
- Trial name
- AIR (NCT07267689)
- Testing
- Treatment (22‰ Hypertonic seawater aerosol therapy solution)
- Where
- 4 sites in Poland
- Volunteers
- 110 people
- Sponsor
- Laboratoires Gilbert
Carcinoma, Non-Small-Cell Lung
The Effect of a Combined Drainage Strategy in Uniportal Upper Lung Lobectomy
Traditional drainage for uniportal video assisted thoracoscopic surgery (VATS) is a routine method, usually with one or two chest tubes at intercostal incisions, but postoperative pain due to the chest tube and unsatisfied…
- Trial name
- NCT04461652
- Testing
- prophylactic air-extraction catheter drainage
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Tongji University
Obstructive Sleep Apnea
Use of High-resolution Manometry to Detect Upper Airway Obstruction During Sleep
Obstructive sleep apnea (OSA) is a major public health issue in both children and adults, present in 1-5% of children and 10-30% of adults.
- Trial name
- NCT04139499
- Testing
- Drug-induced sleep endoscopy (DISE), High-resolution manometry (HRM):
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Human Influenza
Safety and Immunogenicity of a Subunit Trivalent Influenza Vaccine, Northern Hemisphere Formulation 2013/2014, in Healthy Adults Aged 18 Years and Above
The present study is designed to confirm the safety and immunogenicity of trivalent, surface antigen, inactivated influenza vaccine in 2 age cohorts: 18 to ≤60 years and ≥61 years.
- Trial name
- NCT01879553
- Testing
- TIV
- Where
- Belgium
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Cervical Spinal Cord Injury
Combined Therapeutic Air Mixture and Electrical Stimulation to Improve Breathing and Hand Function in Spinal Cord Injury
The goal of this clinical trial is to determine whether people with paralysis due to a spinal cord injury can benefit from breathing short intermittent bouts of air with low oxygen (O2) combined with slightly higher levels of…
- Trial name
- AIHH+tSCS (NCT06101199)
- Testing
- Acute Intermittent Hypercapnic Hypoxia, Transcutaneous spinal cord stimulation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Coagulopathy
COVID-19 Associated Coagulopathy in Egypt
Coagulopathy is one of the most significant prognostic factors in patients with COVID-19 and is associated with increased mortality and admission to critical care.
- Trial name
- NCT04507230
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Assiut University
Upper Respiratory Tract Infection
Pharmacokinetics of Adrenaline After Administration of ARS -1 in Subjects With Upper Respiratory Tract Infection
This is a Phase 1, single-dose, two-period study that will consist of a combined screening and baseline period and an open-label treatment period.
- Trial name
- NCT04930900
- Testing
- ARS-1 with URTI, ARS-1 without URTI
- Where
- Australia
- Volunteers
- 15 people
- Sponsor
- ARS Pharmaceuticals, Inc.
Influenza
Tolerability, Safety and Immunogenicity Trial of the FLU-M® Tetra
Comparative assessment of the tolerability, safety, and immunogenicity of the FLU-M® Tetra quadrivalent inactivated split influenza vaccine and the Ultrix® vaccine in volunteers aged 60 years and above.
- Trial name
- NCT05308212
- Testing
- Flu-M Tetra [Inactivated split influenza vaccine] w/p, Flu-M Tetra [Inactivated split influenza vaccine] w/o/p, Ultrix [Inactivated split influenza vaccine]
- Where
- 11 sites in Russia
- Volunteers
- 633 people, healthy volunteers welcome
- Sponsor
- St. Petersburg Research Institute of Vaccines and Sera
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Upper Respiratory Infection, Common Cold
The Natural History of Viral Upper Respiratory Infections in Children Aged 6 to Less Than 14 Years
This study examines the cold processes of children aged 6 to less than 14. Children will be seen by the study staff 6 days in a row during the course of their naturally-acquired colds.
- Trial name
- NCT00405509
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- West Penn Allegheny Health System