Clinical trials: Disorder of Upper Respiratory System
Respiratory Failure
Effects of High-flow Oxygen Therapy and Non-invasive Ventilation on Lung Volumes and on Upper Airway
Respiratory failure is the most frequent organ failure and cause for admission in the Intensive Care Unit (ICU) . It is a severe complication with an ICU mortality ranged from 31% to 33%.
- Trial name
- HONIVAH (NCT05643911)
- Testing
- HFNC, NIV
- Where
- France
- Volunteers
- 56 people
- Sponsor
- University Hospital, Montpellier
Obstructive Sleep Apnea, Muscle Disorder
Effects of Newly-created Individualized Upper Airway Muscle Functional Training on Patients With OSA
Objectives: To observe the effect of newly-created individualized upper airway muscle functional training on the condition and intraday symptoms of OSA patients; to study the effect of this training method on the excitability of…
- Trial name
- NCT05346705
- Testing
- New individualized upper airway muscle functional training
- Where
- China
- Volunteers
- 300 people
- Sponsor
- First Hospital of China Medical University
Upper Respiratory Tract Infections
Phenotype of Headache and Facial Pain in Upper Respiratory Tract Infections
The goal of this longitudinal study is to assess headache and facial pain features in patients with upper respiratory tract infections (URTI). The main question it aims to answer are: 1.
- Trial name
- NCT06127186
- Testing
- Swab test for viral antigens
- Where
- Poland
- Volunteers
- 223 people
- Sponsor
- Marcin Straburzynski
Controlled Asthma
Modelling of the Upper Airway in Children With Controlled Asthma
Asthma in children is recognized as a disease area with a high medical need. As the investigators move into this field it is necessary to improve the investigators knowledge of upper airway anatomical structure in paediatric…
- Trial name
- NCT01594151
- Testing
- Cone Beam Computed Tomography
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- FLUIDDA nv
Obstructive Sleep Apnea, Malocclusion
Premolar Extractions for Obstructive Sleep Apnea in Children With Overjet
This research aims to provide pediatric patients with polysomnography (a sleep study) before and after orthodontic treatment to determine if the extraction of upper premolars for treating excessive overjet results in an increase…
- Trial name
- NCT04946201
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mohamed Bazina
Upper Respiratory Tract Infection
Combined Vitamins and Minerals Decrease Incidence of Upper Respiratory Tract Infections in Older Persons
Nutrient deficiency and immune dysfunction in older persons result in high prevalence of acute respiratory infection,which can lead to impaired nutritional status.
- Trial name
- NCT01484756
- Testing
- daily multi micronutrient supplement
- Where
- Indonesia
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Trisakti University
Hypopharyngeal Neoplasms, Laryngeal Neoplasms
Assessing the da Vinci® Robotic Surgical System for Surgery of the Upper Aerodigestive Tract
To assess the use of the da Vinci® Robotic Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) in transoral surgeries in patients with benign and malignant lesions of the oral cavity and laryngopharynx.
- Conditions
- Hypopharyngeal Neoplasms, Laryngeal Neoplasms, Head and Neck Cancers
- Trial name
- NCT00721539
- Testing
- da Vinci Surgical Robot Platform, Transoral Robotic Surgery
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Pneumonia, Pneumococcal
Safety Study of 15-Valent Pneumococcal Conjugate Vaccine in Healthy Volunteers Aged Above 2 Months
The purpose of this study is to evaluate safety of 15-Valent Pneumococcal Conjugate Vaccine in healthy volunteers aged above 3 Months.
- Trial name
- NCT04108845
- Testing
- 15-Valent Pneumococcal Conjugate Vaccine
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Beijing Zhifei Lvzhu Biopharmaceutical Co., Ltd
Obstructive Sleep Apnea
Head to Head Comparison of Upper Airway Stimulation and Continuous Positive Airway Pressure; a Pilot Study.
To date, there has been no head to head comparison of Upper Airway Stimulation (UAS) and Continuous Positive Airway Pressure (CPAP) utilizing a full night polysomnographic evaluation.
- Trial name
- NCT04191512
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Thomas Jefferson University
Upper Respiratory Tract Infection
A Clinical Study to Determine the Safety and Efficacy of an Oral Supplementation of Bio-Immune®for Managing Upper Respiratory Tract Infection and Its Symptoms.
This is a prospective, interventional, randomised, double-blind, placebo-controlled, proof-of-science, in-use safety and efficacy study of an oral supplementation of Bio-Immune® for managing upper respiratory tract infection and…
- Trial name
- NCT06689995
- Testing
- Bio-immune Capsule
- Where
- India
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- NovoBliss Research Pvt Ltd
COPD
Long-term Oxygen Therapy in Patients With Chronic Obstructive Pulmonary Disease Who Live at High Altitude
A clinical, prospective, randomized controlled trial to determine the effect of prescribing oxygen in a group of COPD (chronic pulmonary disease) patients with PaO2 (arterial oxygen tension) ≥50 and ≤55 mmHg who do not have…
- Trial name
- COPD-LTOT (NCT03020212)
- Testing
- Oxygen
- Where
- Colombia
- Volunteers
- 220 people
- Sponsor
- Fundación Neumologica Colombiana
CYSTIC FIBROSIS
Effect of Lactobacillus Reuteri in Cystic Fibrosis
The purpose of this study is to evaluate in patients with cystic fibrosis the effect of Lactobacillus Reuteri (LR) on the rate of respiratory exacerbations and of the infections of both upper respiratory and gastrointestinal…
- Trial name
- NCT01737983
- Testing
- Lactobacillus reuteri
- Where
- Italy
- Volunteers
- 61 people
- Sponsor
- Azienda Policlinico Umberto I
COVID-19, SARS-CoV-2
A Phase III Clinical Study of a SARS-CoV-2 Messenger Ribonucleic Acid (mRNA) Vaccine Candidate Against COVID-19 in Population Aged 18 Years and Above
Approximately 28,000 subjects will be enrolled in this trial. Eligible subjects will be stratified by age (<60 years of age and ≥60 years of age, the proportion of elderly people ≥60 years old is planned to be ≥25%) and randomly…
- Trial name
- NCT04847102
- Testing
- SARS-CoV-2 mRNA Vaccine
- Where
- 12 sites in Indonesia, Mexico
- Volunteers
- 28,000 people, healthy volunteers welcome
- Sponsor
- Walvax Biotechnology Co., Ltd.
Influenza
A Study to Evaluate the Safety and Immunogenicity of GSK Biologicals' Seasonal Influenza Vaccine in Adults
This study is designed to test the immunogenicity and reactogenicity of the Fluarix™/Influsplit SSW® influenza vaccine containing the influenza strains recommended for the 2010-2011 season.
- Trial name
- NCT01144299
- Testing
- Fluarix™/Influsplit SSW®
- Where
- 6 sites in Germany
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Influenza
Immunogenicity, Safety and Tolerability of a Trivalent Subunit Inactivated Vaccine in Healthy Subjects 50 Years and Above
Demonstrate non-inferiority of the post-vaccination (Day 22) Hemagglutination inhibition (HI) Geometric Mean Titers (GMTs) of trivalent, inactivated, subunit influenza vaccine (TIV) over the corresponding GMTs of the comparator…
- Trial name
- NCT01867021
- Testing
- Fluvirin(TIVf), Agriflu (TIV)
- Where
- 25 sites in Czechia, Philippines and 2 more
- Volunteers
- 2,902 people, healthy volunteers welcome
- Sponsor
- Novartis
Primary Snore, Obstructive Sleep Apnea (Mild and Moderate).
Effects of Oropharyngeal Exercises on Patients With Primary Snore, Mild and Moderate Obstructive
Randomized study of patients with primary snore, mild and moderate obstructive sleep apnea. Protocol include 40 patients randomized to oropharyngeal exercise or use of nasal dilator, breathing exercise and nasal lavage.
- Trial name
- EOE (NCT01636856)
- Testing
- Oropharyngeal exercises, Respiratory exercises, nasal dilator, nasal lavage
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obstructive Sleep Apnea
The Effect of Eszopiclone on the Arousal Threshold in Sleep Apnea Syndrome
The purpose of this study is to find out whether taking eszopiclone (Lunesta) changes the breathing effort required to briefly wake people with obstructive sleep apnea from sleep (respiratory arousal threshold).
- Trial name
- NCT01102270
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Brigham and Women's Hospital
Upper Respiratory Tract Infection
Montelukast as Prophylaxis for Upper Respiratory Tract Infections in Children: a Randomised, Double-blind, Placebo-controlled Study
Viral upper respiratory tract infection (URI) is one of the most common diseases among toddlers and pre-school children.Complete and effective prevention measures for URI are currently unavailable.
- Trial name
- NCT00551382
- Testing
- Muntelukast
- Where
- 3 sites in Israel
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Influenza, Human, Infections
Study to Evaluate Immunogenicity, Safety and Tolerability of Adjuvanted and Non-Adjuvanted H2N3 Influenza Vaccines in Adults
This Phase 1, randomized, observer-blind, dose-ranging clinical study is evaluating 6 different formulations of MF59-adjuvanted and non-adjuvanted H2N3 influenza vaccine.
- Conditions
- Influenza, Human, Infections, Respiratory Tract Infections, Virus Diseases
- Trial name
- NCT05875961
- Testing
- Low dose A/H2N3c + standard dose MF59, Intermediate dose A/H2N3c + standard dose MF59, High dose A/H2N3c + standard dose MF59
- Where
- 7 sites in United States, Philippines
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Seqirus
Chronic Rhinosinusitis (Diagnosis), Asthma
Unified Airway Model
Chronic rhinosinusitis (CRS) impacts approximately 5% of Canadians. CRS patients suffer from a combination of symptoms that include facial pain, nasal obstruction, hyposmia and mucopurulence discharge.
- Trial name
- NCT03937427
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- University of British Columbia