Clinical trials: Disorder of Upper Respiratory System
Airway Obstruction
Acoustic Reflection Method and Work of Breathing
Upper airway obstruction (UAO) is very common in children. Presently, the importance of the UAO is evaluated by the physician during an endoscopic evaluation under general anaesthesia.
- Trial name
- MAVAS (NCT00950443)
- Testing
- Acoustic reflection method, Acoustic method and breathing/endoscopic evaluation
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Upper Respiratory Infections
Evaluation of Accuracy and Ease of Use of the FilmArray™ Respiratory Panel (RP EZ) in a CLIA-Waived Clinical Setting
The purpose of this study is to assess the accuracy and ease-of-use of a simplified FilmArray Respiratory Panel test (FilmArray RP EZ) when performed according to the manufacturer's instructions by personnel in laboratories…
- Trial name
- NCT02232711
- Where
- 4 sites in United States
- Volunteers
- 1,082 people
- Sponsor
- BioFire Diagnostics, LLC
Upper Respiratory Infection
Effect of Intake of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement
This study was conducted to investigate the effects of daily supplementation of Allium Cepa L. Peel Heated Water Extract on Immunity Enhancement
- Trial name
- NCT05666752
- Testing
- Allium Cepa L. Peel Heated Water Extract
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Sleep Apnea, Obstructive, Metabolism
Treatment of Sleep Apnea to Improve Metabolic Health
Diabetes and prediabetes prevail among obstructive sleep apnea (OSA) patients. OSA and short sleep both detrimentally affect glycemic control regardless of obesity.
- Conditions
- Sleep Apnea, Obstructive, Metabolism, CPAP, Patients Above 18 Years
- Trial name
- GLYCOSACT (NCT06848647)
- Where
- Sweden
- Volunteers
- 600 people
- Sponsor
- Uppsala University
Rhinitis, Sinusitis
Efficacy of Two Nasal Products Based on Diluted Seawater in the Treatment of Upper Respiratory Infections/Conditions
The goal of this interventional clinical trial is to test the safety and efficacy of two medical devices in subjects aged from 3 months old for the treatment of colds, rhinitis, sinusitis, and other upper respiratory…
- Conditions
- Rhinitis, Sinusitis, Upper Respiratory Infections, Colds
- Trial name
- NCT06498843
- Testing
- administration of an isotonic seawater solution (9g/L) in the nose, administration of a hypertonic seawater solution (21g/L) in the nose
- Where
- Poland
- Volunteers
- 89 people
- Sponsor
- YSLab
Influenza
Immunogenicity and Reactogenicity of GlaxoSmithKline (GSK) Biologicals' Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 Season Southern Hemisphere) in Adults 18 Years of Age and Above
The purpose of this study is to evaluate the safety and immunogenicity of GSK Biologicals' Quadrivalent Split Virion Influenza Vaccine Fluarix Tetra (2015 Southern hemisphere) in adults (18 to 60 years of age) and in the elderly…
- Trial name
- NCT02369341
- Testing
- Fluarix Tetra
- Where
- 2 sites in Brazil
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Respiratory Syncytial Virus Infections
A Study on the Immune Response and Safety Elicited by a Vaccine Against Respiratory Syncytial Virus (RSV) When Given Alone and Together With a Vaccine Against Influenza in Adults Aged 60 Years and Above
The purpose of this study is to assess the immunogenicity, safety and reactogenicity of the RSVPreF3 OA investigational vaccine when co-administered with the seasonal quadrivalent influenza vaccine (FLU-QIV) in adults aged 60…
- Trial name
- NCT04841577
- Testing
- RSVPreF3 OA investigational vaccine, FLU-QIV
- Where
- 14 sites in New Zealand, Panama and 1 more
- Volunteers
- 976 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Epistaxis
Medico-economic Evaluation of Management Strategies for Severe Epistaxis
Current recommendations consider surgical ligation and supra-selective embolization as equivalent in terms of efficacy and there is no clear consensus to choose between one and the other technique.
- Trial name
- EPICOST (NCT05281952)
- Testing
- endoscopic ligation, Supra-selective embolization
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Toulouse
Common Cold
Efficacy and Safety of Resveratrol and Carbossimetyl Beta Glucan in Treatment of Upper Airways Disease in Infancy
outpatient infants (0-6 months of life), affected by symptoms of upper airways disease will be randomly assigned to two type of intervention: A: treatment group, receiving resveratrol and carbossimetyl beta glucan; B: control…
- Trial name
- VIRNEO (NCT03683108)
- Testing
- Resveratrol and Carbossimetyl Beta Glucan, Saline Solution
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Policlinico Hospital
Chronic Obstructive Pulmonary Disease
Characteristics That Identify Exacerbation Risk Following Colds in COPD Patients
Respiratory virus infections are a common cause of COPD exacerbations and antiviral therapies have potential as treatments for exacerbations.
- Trial name
- NCT01376830
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- Imperial College London
Pediatric Obesity, Sleep Apnea, Obstructive
Exercise and Venous Compression on Upper Airway Resistance in Obese Teenagers With OSA
The purpose of this study is to assess the effects of physical exercise, associated or not with venous compression of the leg, on obstructive sleep apnea (OSA) severity and upper airway resistance in obese teenagers.
- Trial name
- OBESOMAC (NCT02588469)
- Testing
- Interventional group, Control group
- Where
- France
- Volunteers
- 32 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Upper Extremity Fractures, Postoperative Anxiety
The Effect of the Cold Arm Sling Elevation Pillow on Postoperative Anxiety and Comfort in Children
The purpose of this clinical trial is to learn whether the use of a "cold and arm sling elevation pillow" affects anxiety and comfort levels in children aged 7-12 years undergoing surgery for upper extremity fractures.
- Conditions
- Upper Extremity Fractures, Postoperative Anxiety, Patient Comfort
- Trial name
- NCT07475975
- Testing
- Cold and arm sling elevation pillow, Standard postoperative care
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University - Cerrahpasa
Mechanical Ventilation Complication, Upper Airway Obstruction
Nasal Mask Ventilation During the Induction of General Anesthesia
Recently, the investigators demonstrated that nasal route ventilation is superior to the nasal-oral combined ventilation in the absence of jaw thrust and chin up maneuvers.
- Trial name
- NCT01651286
- Testing
- nasal mask, full face mask
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Massachusetts General Hospital
Chronic Obstructive Pulmonary Disease (COPD)
Efficacy and Safety of Indacaterol in Adults (40 Years and Above) With Chronic Obstructive Pulmonary Disease (COPD)
This study evaluated the efficacy and safety of two doses of indacaterol in adults aged 40 or over with chronic obstructive pulmonary disease (COPD) in China and in two other countries.
- Trial name
- NCT00792805
- Testing
- Indacaterol 150 µg, Indacaterol 300 μg
- Where
- 15 sites in Australia, China and 1 more
- Volunteers
- 563 people
- Sponsor
- Novartis Pharmaceuticals
Fever, Respiratory Tract Infection
The Efficacy and Safety of Dexibuprofen Syrup
The purpose of this study is to compare the safety and efficacy of dexibuprofen syrup and ibuprofen syrup in patients with fever due to common cold.
- Trial name
- NCT00812422
- Testing
- Dexibuprofen, Ibuprofen
- Where
- 4 sites in South Korea
- Volunteers
- 260 people
- Sponsor
- Inje University
Hyperactivity, Chronic Rhinosinusitis (Diagnosis)
Prevalence of Nasal Hyperreactivity in Chronic Upper Airway Inflammation
Rhinitis, or inflammation of the nasal mucosa, can present with nasal obstruction, nasal discharge, itch or sneezing. If the sinusal mucosa is involved as well, it is called rhinosinusitis and facial pain or loss of smell is…
- Conditions
- Hyperactivity, Chronic Rhinosinusitis (Diagnosis), Chronic Rhinitis, Upper Respiratory Disease
- Trial name
- NCT03893227
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 756 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Unilateral Vocal Cord Paralysis
Establish Quantitative Measurements of Laryngeal Sensorimotor Functions and Evaluating the Grade of Phonation and Swallowing Impairment
Laryngeal motor and sensory nerve dysfunction may cause phonation and swallowing disturbance, which often happens after the treatment for laryngopharyngeal and esophageal cancer and may induce fatal complications such as…
- Trial name
- NCT02243722
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- Chang Gung Memorial Hospital
Emphysema, Chronic Obstructive Pulmonary Disease
Bronchoscopic Thermal Vapor Ablation (BTVA) for Lung Volume Reduction
To assess the safety and efficacy of BTVA for the treatment of patients with heterogeneous upper lobe emphysema.
- Trial name
- BTVA (NCT01041586)
- Testing
- BTVA System
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Uptake Medical Corp
Anemia, Cardiomyopathies
Anesthesia for Upper Endoscopy and Colonoscopy in Cardiac Patients With Acute Anemia
The aim of this study was to try to reduce the required dose of etomidate used in anesthesia for upper endoscopy and colonoscopy in critically ill cardiac patients who complain of severe anemia in cardiac intensive care units by…
- Conditions
- Anemia, Cardiomyopathies, Pulmonary Hypertension
- Trial name
- NCT04857450
- Testing
- Etomidate, Ketamine Hydrochloride
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Saud University
Upper Respiratory Tract Infection, Gut Microbiota
The Effect of Synbiotics on the Upper Respiratory Tract Infection
Gut microbiome manipulation to alter the gut-lung axis may potentially protect humans against respiratory infections. However, clinical trials of synbiotics, one of the microbiota-targeted intervention, in this regard is few.
- Conditions
- Upper Respiratory Tract Infection, Gut Microbiota, Immune Function
- Trial name
- NCT04960878
- Testing
- Synbiotic
- Where
- China
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology