Clinical trials: Disorder of Vein
Venous Leg Ulcer
Efficacy of TR 987, Beta-1,3-1,6-D-glucan, in the Treatment of Chronic Venous Insufficiency Ulcers
The safety and efficacy of beta glucan products, and specifically TR 987, in the treatment of chronic venous insufficiency ulcers has been established. This study is designed to determine the most efficient method of treatment.
- Trial name
- NCT03154619
- Testing
- 0.1% TR 987
- Where
- 9 sites in United States
- Volunteers
- 80 people
- Sponsor
- SerenaGroup, Inc.
Atrial Fibrillation, Venous Thromboembolism
Prothrombin Times Outside the Therapeutic Range in Otherwise Stable Patients
Warfarin is very effective for the prevention of blood clots (thrombosis). A test of coagulation, the prothrombin time (PT) is used to monitor the effect.
- Conditions
- Atrial Fibrillation, Venous Thromboembolism, Ischemic Stroke, Myocardial Infarction
- Trial name
- FORESPEAK-0 (NCT00814177)
- Testing
- warfarin
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Hamilton Health Sciences Corporation
Gynecologic Neoplasms, Venous Thromboembolism
Thromboprophylaxis After Surgery for Gynecologic Malignancy in China
Venous thromboembolism (VTE) is an important cause of post-operative morbidity and mortality in women undergoing surgery for gynecologic malignancies.
- Conditions
- Gynecologic Neoplasms, Venous Thromboembolism, Low Molecular Weight Heparin, Argatroban
- Trial name
- NCT02935530
- Testing
- s-LMWH, LMWH, Argatroban
- Where
- China
- Volunteers
- 315 people
- Sponsor
- Huazhong University of Science and Technology
Colorectal Surgery, VTE (Venous Thromboembolism)
A Multicenter, Open-Label, Non-Inferiority Randomized Controlled Trial of Postoperative VTE Prevention in Chinese Patients After Colorectal Cancer Surgery
research objective 1. Optimize VTE prevention management after CRC surgery. 2. Improve the prevention and treatment level of VTE in current perioperative patients. 3. Reduce the social burden of VTE related diseases.
- Trial name
- NCT06583330
- Testing
- Low Molecular Weight Heparin (dalteparin)
- Volunteers
- 1,448 people
- Sponsor
- Beijing Friendship Hospital
Venous Thromboembolism
ODEN Trial: Option vs. Denali IVC Filters
This research study is a prospective randomized trial evaluating the relative safety of two inferior vena cava (IVC) filters used to prevent the migration of potentially dangerous deadly blood clots from the legs to the lung in…
- Trial name
- ODEN (NCT02201277)
- Testing
- Filter Placed
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Francisco
Deep Venous Thrombosis, Upper Extremity Deep Venous Thrombosis
Apixaban for Routine Management of Upper Extremity Deep Venous Thrombosis
This study will assess the safety and effectiveness of a drug called apixaban for the treatment of upper extremity deep vein thrombosis (UEDVT) and clinically important bleeding.
- Conditions
- Deep Venous Thrombosis, Upper Extremity Deep Venous Thrombosis, Thrombus, Venous Thromboembolism
- Trial name
- ARM-DVT (NCT02945280)
- Testing
- apixaban
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Intermountain Health Care, Inc.
Other Diseases of Veins and Lymphatics
ACCUvein Measure Before ULtrasound as A facilitataTION Tool for Venous Marking
Ultrasound marking of saphenous veins before varicose vein surgery or for saphenectomy for vascular or coronary artery bypass grafting is a long, tedious, low-grading examination, generating overconsumption of many consumables…
- Trial name
- ACCUMULATION (NCT03538080)
- Testing
- ACCUVEIN plus ultrasound, Ultrasound only
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Venous Disease
Efficacy on Pain Following a Procedure for Injecting Sclerotherapeutic Foam Into the Great Saphenous Vein
The trial objectives are to compare efficacy relative to pain, along the route of the vein following echoguided endovenous injection of sclerotherapeutic foam into the Great Saphenous vein, of class III microfibre compression…
- Trial name
- NCT01368159
- Testing
- Compression Stockings
- Volunteers
- 120 people
- Sponsor
- Le Club Mousse
Atrial Fibrillation Paroxysmal, Recurrence
Early Recurrences of Atrial Arrhythmias and Their Impact on Late Recurrence After Pulmonary Vein Isolation With Pulsed Field Ablation of Paroxysmal Atrial Fibrillation
This is a prospective, single-arm study conducted in University Hospital of Split, Department of Cardiology. Patients treated with PFA for symptomatic paroxysmal atrial fibrillation will be asked to participate in the study.
- Trial name
- NCT05328882
- Testing
- Monitoring of paroxysmal atrial fibrillation recurrence after pulsed field catheter ablation
- Where
- Croatia
- Volunteers
- 40 people
- Sponsor
- University of Split, School of Medicine
Post Thrombotic Syndrome, Deep Vein Thrombosis
Physical Activity in Children at Risk of Post-thrombotic Sequelae (PACT)
'The PACT trial' is randomized pilot trial to demonstrate the feasibility and potential effectiveness of a personal "fitness tracker" to improve adherence to an activity regimen following an initial acute DVT in children.
- Trial name
- PACT (NCT03075761)
- Testing
- Fitbit, 30-minute education session
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- University of Texas Southwestern Medical Center
Orthostatic Hypotension, Dysautonomic, Orthostatic Intolerance
The STAND-UP Study
Orthostatic hypotension (OH) and orthostatic intolerance (OI) are common conditions where blood pressure drops when standing up, causing dizziness, fainting, or fatigue.
- Trial name
- NCT07195903
- Testing
- Angioplasty or stenting
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- St. Francis Hospital, New York
Vascular Access Complication, Central Line Complication
Novel Strategy to Encourage Early Removal of Central Venous Catheters
The goal of this study is to determine if early placement of a midline catheter in patients with a central venous catheter (CVC) will decrease the number of days the CVC is in place.
- Conditions
- Vascular Access Complication, Central Line Complication, Central Line-Associated Infection, Superficial Vein Thrombosis
- Trial name
- NCT04136561
- Testing
- Midline catheter
- Where
- United States
- Sponsor
- Corewell Health East
Atrial Fibrillation (Paroxysmal), Atrial Fibrillation (AF)
Systematic Workflow for Pentaspline Pulsed-field Ablation Optimization
While radiofrequency and cryoballoon ablation have shown high rates of pulmonary vein reconnection in patients undergoing repeat electrophysiological evaluation for AF recurrence, early evaluations demonstrated a remarkably high…
- Conditions
- Atrial Fibrillation (Paroxysmal), Atrial Fibrillation (AF), Ablation of Atrial Fibrillation
- Trial name
- SWEET P-PFA (NCT06706518)
- Testing
- Single-shot ablation technologies
- Where
- Spain
- Volunteers
- 118 people
- Sponsor
- Daniel Rodríguez Muñoz
Atrial Fibrillation
Evaluation of Optimal Ablation Index for Pulmonary Vein Isolation in Patients With AF Prospective Registry
In this study, the investigators identify the optimal AI value for achieving good acute outcomes in PVI. Through the Phase 1 study, the investigators will prospectively analyze data including ablation parameters, AI and acute…
- Trial name
- NCT03389074
- Testing
- Radiofrequency catheter ablation
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Venous Retinal Branch Occlusion, Central Retinal Vein Occlusion
Impact of Lucentis on Psychological Morbidity in Patients With Retinal Vein Occlusion
This is a prospective, single-center, non-randomized clinical study on the impact of intravitreally administered ranibizumab (Lucentis) treatment on vision-related functioning and emotional well-being in subjects with central or…
- Conditions
- Venous Retinal Branch Occlusion, Central Retinal Vein Occlusion, Retinal Vein Occlusion, Depression
- Trial name
- NCT01011374
- Testing
- ranibizumab (Lucentis)
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Retina Associates of Cleveland, Inc
Cirrhosis, Variceal Bleeding
EBL Versus EBL and Propranolol for the Prevention of Variceal Rebleeding in Pts With Previous Variceal Treatment
This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients who were previously performed endoscopic variceal treatment.
- Trial name
- NCT00966082
- Testing
- endoscopic band ligation, endoscopic band ligation+Propranolol
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Korea University
Liver Cancer, Metastatic Cancer
Hepatic Arterial Infusion With Melphalan in Treating Patients With Unresectable Liver Cancer
RATIONALE: Heating melphalan to several degrees above body temperature and infusing it to the affected area directly around the tumor may kill more tumor cells.
- Trial name
- NCT00030082
- Testing
- isolated perfusion, melphalan
- Where
- United States
- Sponsor
- National Cancer Institute (NCI)
Recurrent Venous Thrombosis
Risk of Recurrent Venous Thromboembolism After Provoked Venous Thromboembolism
Venous thromboembolism (VTE) is a common disease with an incidence of 1-2/1000 persons per year. VTE is a chronic disease with a considerable risk of recurrence. Patients with unprovoked VTE, i.e.
- Trial name
- AURECpro (NCT04124159)
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation
Evaluation of a Preventive Therapeutic Strategy for Postpartum Venous Thromboembolism in Women With Genetic Risk Factor
Background : pregnancy and postpartum period are times of increased risk for deep vein thrombosis (DVT). The incidence of venous thromboembolic disease (VTE) during pregnancy is estimated at 1-2 per 1,000, and this risk increases…
- Conditions
- Factor V Leiden Heterozygous Mutation, Factor II Heterozygous Mutation, Pregnancy, Postpartum
- Trial name
- POSTPART AS5-2 (NCT07342127)
- Testing
- Retrospective collection of health data, Phone call to every participant
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Hospices Civils de Lyon
Venous Thromboembolism, Lung Neoplasm
Prophylaxis of Venous Thromboembolism in Advanced Lung Cancer (PROVE)
Prospective randomized open multicenter trial with blinded adjudication of endpoints to assess the efficacy of six-month low-dose LMWH (Low Molecular Weight Heparin) for the prevention of symptomatic or incidental VTE in patients…
- Trial name
- PROVE (NCT03090880)
- Testing
- Tinzaparin Sodium
- Where
- 27 sites in France
- Volunteers
- 59 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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