Clinical trials: Disorder of Vein
Deep Vein Thrombosis
Coagulation Changes in Trauma Patients
Hypothesis to be tested: placement of a central venous catheter will induce a systemic hypercoagulable state. To determine this, the investigators will measure thromboelastography (TEG), PT(prothrombin time), PTT (partial…
- Trial name
- NCT00795743
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Miami
Traumatic Intracranial Haemorrhage
OPtimal Timing of Thromboprophylaxis in Traumatic IntraCranial Haemorrhage - Pilot Study
Victims of trauma with severe head injury who have bled into their brains are at high risk of developing blood clots in their legs.
- Trial name
- OPTTICH (NCT02260908)
- Testing
- Enoxaparin
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Venous Thromboembolism
Once Weekly Subcutaneous Ports for the Administration of Anticoagulants
The purpose of this study is to ascertain whether subcutaneous ports are an effective and reliable way to administer the low molecular weight heparin (LMWH) enoxaparin to patients for the prevention or treatment of venous…
- Trial name
- NCT00774748
- Testing
- Insuflon
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of North Carolina, Chapel Hill
Venous Hemodynamics
Effects of Positive End-Expiratory Pressure (PEEP) and Prone Positioning in Healthy Volunteers on Venous Hemodynamics Including the Venous Excess Ultrasound (VExUS) Score
The hemodynamic effects of proning and PEEP may vary depending on pre- existing cardiac function, lung mechanics, and volume status, and the available evidence remains conflicting.
- Trial name
- VeNIVPro (NCT07273617)
- Testing
- application of PEEP: starting PEEP = 15 mbar, application of PEEP: starting PEEP = 0 mbar
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Venous Thromboembolism
Dose-confirmatory Bridging Study in Total Hip Replacement
The objective of this dose-confirmatory bridging study is to investigate the safety and efficacy of rivaroxaban 5 to 10 mg once-daily (od) dosing in the prevention of venous thromboembolism (VTE) in Japanese patients undergoing…
- Trial name
- NCT01205932
- Testing
- Rivaroxaban (BAY59-7939), Enoxaparin
- Where
- 41 sites in Japan
- Volunteers
- 402 people
- Sponsor
- Bayer
Atrial Fibrillation
Randomized Trial of Two Different Strategies to Treat Paroxysmal Atrial Fibrillation
The purpose of this study is to investigate the significance of complete versus incomplete electrical isolation of pulmonary veins by radiofrequency-induced linear lesions in patients with paroxysmal atrial fibrillation.
- Trial name
- NCT00293943
- Testing
- Pulmonary vein ablation
- Where
- 3 sites in Germany
- Volunteers
- 232 people
- Sponsor
- Atrial Fibrillation Network
Varicose Veins
Laser Ablation Versus Mechanochemical Ablation Trial
A randomised clinical trial comparing endovenous laser ablation and mechanochemical ablation (ClariVein®) in the management of superficial venous insufficiency.
- Trial name
- LAMA (NCT02627846)
- Testing
- EVLA, ClariVein®, Lidocaine with 1:200,000 epinephrine solution
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Healthcare Associated Infection, Critically Ill
Dynamic Full-Field Optical Coherence Tomography for Structural and Microbiological Characterization of Central Venous Catheter-deposited Biofilm in Critically Ill Patients
29.3% of bacteremias in intensive care units (ICU) are linked to vascular devices, with a significant proportion related to central venous catheters, and an influence on both morbility and mortality.
- Conditions
- Healthcare Associated Infection, Critically Ill, Central Venous Catheter Associated Bloodstream Infection
- Trial name
- OCT-BIO-CVC (NCT06216080)
- Testing
- D-FF-OCT analysis of CVC
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier William Morey - Chalon sur Saône
Lymphedema
Randomized Clinical Trial of Pneumatic Compression Device for the Treatment of Venous Ulcers and Lymphedema
The purpose of this study is to evaluate the effect of pneumatic compression in improving symptoms, quality of life and wound healing in patients with venous ulcers and/or lymphedema.
- Trial name
- NCT02284373
- Testing
- Flexitouch for 1 month in addition to routine wound care, Routine wound care for venous ulcers and lymphedema, Flexitouch pneumonic compression
- Volunteers
- 39 people
- Sponsor
- NYU Langone Health
Hepatocellular Carcinoma
A Study to Evaluate Sintilimab Plus Lenvatinib as Adjuvant Therapy in Hepatocellular Carcinoma With Portal Vein Tumor Thrombosis (PVTT) After Surgical Resection
To compare the impact on recurrence risk of adjuvant Sintilimab (a recombinant fully human anti-PD-1 monoclonal antibody) plus Lenvatinib for patients with hepatocellular carcinoma and portal vein tumor thrombus (PVTT ) after…
- Trial name
- NCT06089382
- Testing
- Sintilimab, Lenvatinib, Transarterial Chemoembolization (TACE)
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Tongji Hospital
Primary Aldosteronism, Secondary Hypertension
PETAL Trial: Impact of Gallium-68 Pentixafor PET-CT on Surgical Outcomes in Primary Aldosteronism
This study is a randomized controlled trial to assess the clinical utility of gallium-68 pentixafor PET/CT in the management of primary aldosteronism (PA).
- Conditions
- Primary Aldosteronism, Secondary Hypertension, Aldosterone-Producing Adenoma, Idiopathic Hyperaldosteronism
- Trial name
- NCT07027254
- Testing
- 68Ga-pentixafor PET/CT
- Where
- 2 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul National University Hospital
Macular Edema, Central Retinal Vein Occlusion
Ranibizumab Intravitreal Injections in Patients With Visual Impairment Due to Macular Edema Secondary to Central Retinal Vein Occlusion
The present study provided additional efficacy and safety data for 0.5-mg ranibizumab using as needed (PRN) dosing over 24 months in patients with visual impairment due to macular edema secondary to Central Retinal Vein Occlusion…
- Trial name
- CRYSTAL (NCT01535261)
- Testing
- Ranibizumab 0.5 mg/0.05 ml
- Where
- 78 sites in Australia, Austria and 16 more
- Volunteers
- 357 people
- Sponsor
- Novartis Pharmaceuticals
Venous Reflux, Chronic Venous Insufficiency
Venclose digiRF System Post Market Study
A Post-Market, Multi-Center, Prospective, Interventional Study for Treatment of Chronic Venous Disease of the Great and Small Saphenous Veins and Incompetent Perforator Veins.
- Trial name
- NCT05504070
- Testing
- Venclose System (digiRF generator w EVSRF catheter), Venclose MAVEN System (digiRF generator w MAVEN catheter)
- Where
- 7 sites in United States
- Volunteers
- 203 people
- Sponsor
- C. R. Bard
Drug Effect, Children, Only
The Efficacy and Safety of Different Phlebotonic Drugs in Children With Venous Malformations
The aim of this study is to evaluate the efficacy and safety of different phlebotonic drugs in children and to assess patient satisfaction after treatment.
- Conditions
- Drug Effect, Children, Only, Vascular Malformations, Surgery
- Trial name
- NCT05113420
- Testing
- Detralex, Troxevasin
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Center for Vascular Pathology, Moscow
Hepatocellular Carcinoma (HCC) With Type III Portal Vein Tumor Thrombus (PVTT)
Safety and Efficacy of GSMs-TACE Combined With Surgical Resection in the Treatment of Hepatocellular Carcinoma (HCC) With Type III Portal Vein Tumor Thrombus (PVTT)
A Single center, Open, Randomized Controlled Trial Evaluating the Safety and Efficacy of GSMs-TACE Combined with Surgical Resection in the Treatment of Hepatocellular Carcinoma (HCC) with Type III Portal Vein Tumor Thrombus…
- Trial name
- NCT04619342
- Testing
- GSMs-TACE, Surgical Resection
- Where
- China
- Volunteers
- 98 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Hypertension, Portal
Virtual Hepatic Venous Pressure Gradient (vHVPG) With CT Angiography (CHESS1601)
This is a prospective, multi-center trial conducted at 1 Guangzhou and 2 Beijing centers designed to determine the diagnostic performance of virtual hepatic venous pressure gradient (vHVPG) (investigational technology) by…
- Trial name
- vHVPG (NCT02842697)
- Testing
- HVPG measurement, CTA, Doppler ultrasound
- Where
- 3 sites in China
- Volunteers
- 102 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Venous Leg Ulcer
Effect of rhGM-CSF on the Healing of Venous Leg Ulcers
The objective of this study is to examine whether local administration of the growth factor rhGM-CSF incorporated into a hydrogel, can accelerate wound healing when applied to venous leg ulcers, and whether this is safe.
- Trial name
- NCT04823962
- Testing
- rhGM-CSF + hydrogel, Standard care
- Where
- Denmark
- Volunteers
- 6 people
- Sponsor
- Reponex Pharmaceuticals A/S
Venous Thromboembolism, Total Hip Arthroplasty (THA)
The Effect of a VTE Prevention Care Bundle in Total Hip Arthroplasty Patients
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), remains a critical and potentially life-threatening complication following total hip arthroplasty (THA).
- Conditions
- Venous Thromboembolism, Total Hip Arthroplasty (THA), Deep Vein Thrombosis
- Trial name
- VTE-CARE-THA (NCT07702903)
- Testing
- VTE Prevention Care Bundle, Standard Routine Care
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Murat Erten
Atrial Fibrillation
INtra-procedural ultraSound Imaging During Pulmonary Veins Isolation
One of the biggest limitations of the currently used percutaneous techniques for Pulmonary Vein Isolation (PVI) in the setting of atrial fibrillation ablation is the lack of real-time information about the left atrial (LA) wall…
- Trial name
- INSIDEPVs (NCT03372798)
- Testing
- ICE/IVUS imaging during atrial fibrillation ablation
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Oxford University Hospitals NHS Trust
Traumatic Brain Injury, Venous Thromboembolism
Evaluation of the SCALED (SCaling AcceptabLE cDs)
This project will adapt a currently deployed Clinical Decision Support (CDS) system to deliver a VTE prevention guideline for adult patients with traumatic brain injury (TBI).
- Trial name
- NCT05628207
- Testing
- Observational, Observational-control
- Where
- United States
- Volunteers
- 15,000 people
- Sponsor
- University of Minnesota
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