Clinical trials: Disorder of the Lower Urinary Tract
Anxiety, Overactive Bladder
Do Patient Anxiety Levels Decrease Urodynamic Test Reproducibility?
This study will look at how pre-test anxiety levels affect the reproducibility of symptoms during routine urodynamic testing in women.
- Conditions
- Anxiety, Overactive Bladder, Urinary Incontinence, Stress, Urinary Incontinence, Urge
- Trial name
- NCT02540798
- Where
- United Kingdom
- Volunteers
- 27 people
- Sponsor
- Sandwell & West Birmingham Hospitals NHS Trust
Urinary Incontinence
Transcutaneous Mechanical Nerve Stimulation (TMNS) by Vibration in the Treatment of Incontinence
During transcutaneous mechanical nerve stimulation in spinal cord injured men an increase in pressure was observed in the external urethral sphincter along with an increase in bladder capacity.
- Trial name
- TMNS (NCT00695058)
- Testing
- Transcutaneous mechanical nerve stimulation by A medical vibrator (FERTI CARE personel, Multicept A/S, Albertslund, Danmark)
- Where
- 3 sites in United States, Denmark
- Volunteers
- healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital at Herlev
Prostate Carcinoma, Benign Prostatic Hyperplasia
Phase II Study to Evaluate the Safety and Efficacy of Prostatic Artery Embolization
This is a Phase II prospective clinical trial in which patients with prostate carcinoma and obstructive lower urinary tract symptoms electing for radiation therapy will undergo Prostatic Artery Embolization (PAE) prior to…
- Trial name
- NCT04879940
- Testing
- Merit Medical Embospheres, Radiation Therapy
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Urinary Incontinence (UI)
Urinary Incontinence After Endoscopic Prostatectomy
This is a prospective cohort study aiming to identify the preoperative and intraoperative predictors of urinary incontinence after endoscopic transurethral bipolar prostatectomy
- Trial name
- NCT06939140
- Testing
- Bipolar prostatectomy
- Where
- Egypt
- Volunteers
- 133 people
- Sponsor
- Assiut University
Stress Urinary Incontinence, Postmenopausal Disorder
ToT and Estrogen in Postmenopausal Females
To compare the subjective and objective outcomes of TVT-O procedure alone versus the same procedure followed by the use of premarin vaginal cream for 3 months in postmenopausal female with genuine stress incontinence.
- Trial name
- NCT03295487
- Testing
- TVT-O
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Kasr El Aini Hospital
Parkinson's Disease, Nocturia
Melatonin for Nocturia in Parkinson's Disease
This is an an open label clinical trial of sustained-release Melatonin 2mg once daily for 12 weeks in patients with Parkinsons's Disease reporting nocturia, defined as getting up regularly at night > twice to pass urine.
- Trial name
- NCT02359448
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Overactive Bladder, Urge Urinary Incontinence
Pelvic Floor Muscle Training With Leva System for Urge Incontinence
This is a pilot non-comparative study to assess the effectiveness of pelvic floor muscle training guided by the leva® system for improving change in subject-reported incontinence-related quality of life and urgency urinary…
- Conditions
- Overactive Bladder, Urge Urinary Incontinence, Mixed Urinary Incontinence
- Trial name
- NCT03923348
- Testing
- Leva device
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Christ Hospital
Urinary Incontinence
Intermittent Catheterisation on the Bladder Mucosa of Healthy Volunteers With a Prototype Micro Hole Zone Catheter
This investigation is a randomized, single-blinded, parallel, single-center investigation. In total, up to 50 subjects (40 completers) were included and each subject had two test visits overseen by the Principal Investigator…
- Trial name
- CP341 (NCT05224544)
- Testing
- Investigational prototype device, Comparator device
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Coloplast A/S
Benign Prostatic Hyperplasia (BPH) Requiring Surgical Resection, Benign Prostatic Hyperplasia With Outflow Obstruction
Bipolar Resection vs Enucleation of Prostate
The aim of this study is to evaluate efficacy and safety of transurethral resection of the prostate and bipolar enucleation of the prostate.
- Conditions
- Benign Prostatic Hyperplasia (BPH) Requiring Surgical Resection, Benign Prostatic Hyperplasia With Outflow Obstruction, Benign Prostatic Hyperplasia With Symptomatic Lower Urinary Tract Symptoms, Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
- Trial name
- TURP vs BiTUEP (NCT06983444)
- Testing
- TURP, TUEP
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- South Valley University
BPH (Benign Prostatic Hyperplasia), Incontinence, Urinary
Evaluation of the Impact of Preoperative Pelvic Floor Exercise on Incontinence After Laser Enucleation of the Prostate: a Feasibility Study.
The purpose of this study is to assess the acceptability and feasibility of including a pelvic floor muscle exercise program into the care provided to patients undergoing prostate enucleation, studying both patients and…
- Conditions
- BPH (Benign Prostatic Hyperplasia), Incontinence, Urinary, HoLEP, Pelvic Floor Muscle Exercise
- Trial name
- PPP (NCT07456345)
- Testing
- Pelvic Floor Muscle Exercise before and after surgery
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Female Urogenital Diseases, Urinary Incontinence
Clinical Trial of "Magic Gyno" Laser Device
The aim of this prospective study is investigation of efficiency and safety of medical device "Magic Gyno" in accordance with the stated purpose.
- Conditions
- Female Urogenital Diseases, Urinary Incontinence, Prolapse Genital, Menopausal Syndrome
- Trial name
- NCT05463081
- Testing
- Laser treatment, Blood test, Clinical urine test
- Where
- Russia
- Volunteers
- 70 people
- Sponsor
- MeLSyTech, Ltd
Stress Urinary Incontinence
The Efficacy and Safety of Fotona Smooth® Device for the Treatment of Stress Urinary Incontinence
There are many existing treatments of female stress urinary incontinence such as the use of adult absorbent pads and diapers, behavioral training, including bladder training, pelvic muscle exercises, biofeedback, urethral plugs…
- Trial name
- NCT03098992
- Testing
- Fotona Dynamis Er:YAG Laser System
- Where
- 9 sites in Germany, Greece and 4 more
- Volunteers
- 135 people
- Sponsor
- Cork University Hospital
Benign Prostatic Hypertrophy
The Safety and Efficacy of Ozarelix to Treat Men With Lower Urinary Tract Symptoms Due to Enlargement of the Prostate
This study is to compare the efficacy and safety of ozarelix 15 mg given intramuscular (IM) 2 weeks apart on the improvement of symptoms and the duration of improvement for up to 6 months in men with Benign Prostatic Hypertrophy…
- Trial name
- NCT00427219
- Testing
- Ozarelix
- Where
- 13 sites in United States
- Volunteers
- 74 people
- Sponsor
- Spectrum Pharmaceuticals, Inc
Benign Prostatic Hyperplasia
MCS in Treating Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia
Phase III, Randomized, double-blind, parallel placebo-controlled study. Two arms: MCS (30mg/day) vs. placebo. Subproject MCS-2: alpha-blocker naïve subjects Subproject MCS-3: subjects responding poorly to alpha-blocker
- Trial name
- NCT00501371
- Testing
- MCS
- Where
- 5 sites in Taiwan
- Volunteers
- 85 people
- Sponsor
- Health Ever Bio-Tech Co., Ltd.
Holep Surgery, Pelvic Floor Exercises
The Effect of Pelvic Muscle Exercises on Urinary Incontinence in Patients Undergoing HoLEP Surgery.
Patients meeting the eligibility criteria and scheduled for HoLEP surgery will provide written informed consent prior to enrollment. Participants will be randomly assigned to either the intervention or control group.
- Conditions
- Holep Surgery, Pelvic Floor Exercises, Urinary Incontinence
- Trial name
- NCT07719036
- Testing
- pelvic exercise group
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Atlas University
Bladder Dysfunction, Neurogenic Bladder Dysfunction
Feasibility Study of Transcutaneous Tibial Nerve Stimulation for Urinary Symptoms in People With Multiple Sclerosis
Neurogenic lower urinary tract dysfunction is common among people with Multiple sclerosis with a pooled prevalence of 68.41% using self-report measures and 63.95% using urodynamic studies.
- Conditions
- Bladder Dysfunction, Neurogenic Bladder Dysfunction, Urinary Incontinence, Urinary Bladder, Overactive
- Trial name
- NCT04528784
- Testing
- Transcutaneous tibial nerve stimulation
- Where
- Ireland
- Volunteers
- 23 people
- Sponsor
- University of Limerick
Urinary Stress Incontinence
One Year Outcome Using the Ajust System for Treatment of Urinary Stress Incontinence
During the last decade numerous new procedures have been presented regarding surgical treatment of urinary stress incontinence (1,2).
- Trial name
- NCT01754558
- Testing
- Ajust system, TVT/TVT-O
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Zealand University Hospital
Surgical Treatment of Urge Incontinence
Treatment of Urge Urinary Incontinence in Women After Failure of Cesa or Vasa
Urge urinary incontinence can be a disorder caused by destroyed pelvic structures. We repaired the uteri-sacral ligaments (USL) by cesa or vasa.
- Trial name
- URGE-II (NCT01737918)
- Testing
- TOT, solifenacin
- Where
- 2 sites in Germany
- Volunteers
- 120 people
- Sponsor
- Klinikum der Universität Köln
Overactive Bladder
Study to Evaluate the Efficacy, Safety and Tolerability of Vibegron in Men With Overactive Bladder (OAB) Symptoms on Pharmacological Therapy for Benign Prostatic Hyperplasia (BPH)
This study will assess the efficacy of vibegron compared with placebo in men with overactive bladder (OAB) symptoms on pharmacological therapy for benign prostatic hyperplasia (BPH) as defined by micturition and urgency episodes.
- Trial name
- NCT03902080
- Testing
- Vibegron
- Where
- 140 sites in United States, Belgium and 6 more
- Volunteers
- 1,105 people
- Sponsor
- Urovant Sciences GmbH
Urinary Incontinence
Gynecological Pelvic Floor Muscle Training
A randomized controlled trial pilot study to test the efficacy of a pelvic muscular training intervention led by a physiotherapist on urinary incontinence, quality of life and sexual health in women who report urinary urgency and…
- Trial name
- NCT01811602
- Testing
- Training, Usual Care
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia