Clinical trials: Disorders, Blood Coagulation
Atrial Fibrillation
nContactSurgical Numeris-AF Tethered Coagulation System for Treatment of Persistent & LSP AF
This is a multi center, non-randomized, prospective, open label, clinical trial evaluating the safety and efficacy of the nContact Surgical Numeris-AF Tethered Coagulation System when used to treat patients with persistent and…
- Trial name
- NCT00950092
- Testing
- Numeris-AF Tethered Coagulation System with VisiTrax
- Where
- 2 sites in United States
- Volunteers
- 5 people
- Sponsor
- nContact Surgical Inc.
Quality of Life, Muscle Weakness
Effects of Progressive Resistance Training Compared With Aerobic Training in Patients With Hemophilia
This study aims to assess the effects of progressive resistance training compared with aerobic training, among those with hemophilia. Participants will be divided into two groups.
- Trial name
- NCT04892628
- Testing
- Progressive resistance training, Aerobic training
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Dow University of Health Sciences
Thromboelastography, Coagulation; Fetus or Newborn
Thromboelastographic Profile in Healthy Newborns and Infants of Diabetic Mothers Using TEG6s
Thromboelastography (TEG) is a laboratory technique used to examine the process of clot formation and degradation by measuring and reporting the kinetic changes, the rate of clot formation, clot strength, and clot stability.
- Conditions
- Thromboelastography, Coagulation; Fetus or Newborn, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT04917965
- Testing
- Laboratory clotting studies
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Arkansas Children's Hospital Research Institute
Hemophilia B, Mucopolysaccharidosis I
Long Term Follow-up (LTFU) of Subjects Who Received SB-318, SB-913, or SB-FIX
Long-term follow-up of subjects who received SB-318, SB-913, or SB-FIX in a previous trial and completed at least 52 weeks post-infusion follow-up in their primary protocol.
- Conditions
- Hemophilia B, Mucopolysaccharidosis I, Mucopolysaccharidosis II
- Trial name
- LTFU (NCT04628871)
- Testing
- SB-318, SB-913, SB-FIX
- Where
- 5 sites in United States
- Volunteers
- 13 people
- Sponsor
- Sangamo Therapeutics
Hemophilia A
Neutrophil-to-lymphocyte and Platelet-to-lymphocyte Ratio in Predicting the Incidence of Nausea and Vomiting
By comparing the incidence of PONV, the dosage of postoperative antiemetic drugs, the postoperative VAS score and the utilization rate of PCIA of hemophilia A patients in the NLR≥2 and NLR<2 groups, investigators could find out…
- Trial name
- NCT05636163
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Qianfoshan Hospital
Haemophilia
Effectiveness of the Myofascial Therapy in the Hemophilic Arthropathy of Ankle
Randomized clinical trial to assess the efficacy of a treatment protocol applied fascial therapy in patients with hemophilic arthropathy ankle, oriented to know and describe the observed differences on the dependent variables…
- Trial name
- NCT02825667
- Testing
- Physiotherapy sessions
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Real Fundación Victoria Eugenia
Retinopathy of Prematurity
European Disease Registry on Retinopathy of Prematurity (ROP)
The EU-ROP registry is a European wide multicenter non-interventional observational registry study intended to run open-ended in as many countries as possible including infants treated for retinopathy of prematurity irrespective…
- Trial name
- EU-ROP (NCT04939571)
- Testing
- Registry of preterm born infants with treatment-requiring ROP
- Where
- 59 sites in Austria, Bulgaria and 10 more
- Volunteers
- 3,000 people
- Sponsor
- University Medicine Greifswald
Menorrhagia
The Assessment of Tranexamic Acid in Women With Menorrhagia Who Have Bleeding Disorders
Many women have heavy periods and this can be associated with low blood, tiredness and inability to carry out normal activities. Approximately 10-30% of these women will have an underlying bleeding disorder.
- Trial name
- NCT00904709
- Testing
- tranexamic acid
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- K. Sue Robinson
Trauma, Acute Hemorrhage
Evaluation of a Transfusion Therapy Using Whole Blood in the Management of Coagulopathy in Patients With Acute Traumatic Hemorrhage
The prognosis of traumatized hemorrhages is correlated with the nature of transfusion therapy: a 50% reduction in mortality for an early and massive supply of plasma, and 20% for an early and massive supply of platelets.
- Conditions
- Trauma, Acute Hemorrhage, Coagulopathy
- Trial name
- T-STORHM (NCT04431999)
- Testing
- Whole blood transfusion, Fractionated blood products transfusion
- Where
- 6 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
Fistula-In-Ano, Anal Fistula
Treatment of Anal Fistula With Lasercoagulation
The purpose of this study is to determine whether treatment with laser coagulation is an effective and safe treatment option for patients with anal fistula
- Trial name
- NCT03017898
- Testing
- Laser Coagulation
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Region Skane
Von Willebrand Disease, Type 2B
Impact of Von Willebrand Factor-platelet Aggregates in Patients With Type 2B Disease
The working hypothesis is that patients with Von Willebrand Disease-type 2B may have neurological symptoms due to the chronic formation of platelets/Von Willebrand Factor aggregates.
- Trial name
- Von2B (NCT05015244)
- Testing
- 3T (Tesla) Magnetic Resonance Imaging (MRI)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Caen
Thrombosis
A Study to Investigate Biomarkers After Single Doses of Anticoagulants in Healthy Young Male and Healthy Elderly Participants (MK-0000-216 AM1)
This is a study to investigate biomarkers after single oral doses of the anticoagulant agents dabigatran etexilate and rivaroxaban in healthy young male subjects and in healthy elderly subjects.
- Trial name
- NCT01379300
- Testing
- dabigatran etexilate, rivaroxaban
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Idiopathic Thrombocytopenic Purpura
Study of Platelets Sialylation by Flow Cytometry for the Differential Diagnosis of ICT
Idiopathic thrombocytopenic purpura (ITP) is the most frequent auto-immune cytopenia. There is no specific biological marker and the diagnosis often results from the exclusion of other differential diagnoses, notably inherited…
- Trial name
- SYMPATHIC (NCT03421392)
- Testing
- non interventional study
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Hemophilia A
A Study of Recombinant AAV2/6 Human Factor 8 Gene Therapy SB-525 (PF-07055480) in Subjects With Severe Hemophilia A
The purpose of the study is to evaluate the safety, tolerability and time-course profile of FVIII activity after dosing with SB-525 (PF-07055480)
- Trial name
- NCT03061201
- Testing
- SB-525 (PF-07055480)
- Where
- 22 sites in United States
- Volunteers
- 13 people
- Sponsor
- Pfizer
Immune Thrombocytopenia
Phase II Trial of Romiplostim With Danazol in Patients With Eltrombopag-resistant Immune Thrombocytopenia
In this study, we tried to demonstrate clinical benefit of additive danazol to romiplostim therapy in patients with eltrombopag-resistant immune thrombocytopenia
- Trial name
- NCT04289207
- Testing
- Romiplostim and danazol
- Volunteers
- 55 people
- Sponsor
- Seoul National University Hospital
Hypofibrinogenemia, Afibrinogenemia
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
The goal of the study is to determine whether the use of Human Fibrinogen Concentrate (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and infants undergoing cardiopulmonary bypass.
- Conditions
- Hypofibrinogenemia, Afibrinogenemia, Bleeding Disorders
- Trial name
- RiaSTAP (NCT02822599)
- Testing
- RiaStAP, Saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
COVID, Embolism and Thrombosis
COVID-19, bLOod Coagulation and Thrombosis
Coronavirus 2 (SARS-CoV2) has been identified as the pathogen responsible for severe acute respiratory syndrome associated with severe inflammatory syndrome and pneumonia (COVID-19).
- Conditions
- COVID, Embolism and Thrombosis, Pneumonia, Viral
- Trial name
- CLOT (NCT04388657)
- Testing
- Echo-Doppler
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Hemophilia A, Severe
An Open-label Study Evaluating the Efficacy, Safety, Pharmacokinetics, and Immunogenicity of SKP-0141 for the Treatment and Prophylaxis in Severe Hemophilia a Patients
This is a prospective, multicenter, open-label study to assess efficacy, safety, pharmacokinetics (PK), and immunogenicity of human plasma-derived Factor VIII (FVIII) in previously treated patients (PTPs) with severe hemophilia…
- Trial name
- NCT06738901
- Testing
- SKP-0141
- Volunteers
- 55 people
- Sponsor
- SK Plasma Co., Ltd.
Thromboembolism, Cardiac Event
Influence of Cardiac Implantable Electronic Devices on the Hemostatic System
The hemostasis system is one of the many biological systems of the human body, designed to preserve the liquid state of blood and prevent its loss during vascular injuries.
- Conditions
- Thromboembolism, Cardiac Event, Hemostatic Disorder
- Trial name
- NCT04499612
- Testing
- Cardiac implantable electronic device implantation., Cardiac implantable electronic device replace., Duplex ultrasound.
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Ryazan State Medical University
Thrombotic Thrombocytopenic Purpura
Rituximab in Adult Acquired Idiopathic Thrombotic Thrombocytopenic Purpura
Multicentric non-randomized phase II opened prospective study (10 centres involved). Primary endpoint: To evaluate the kinetics of B-cell depletion by rituximab and its pharmacokinetics in patients treated with rituximab in…
- Trial name
- PTTritux (NCT00907751)
- Testing
- rituximab
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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