Clinical trials: Disorders of Biliary Tract
Pancreatic Cancer, Biliary Cancer
Preoperative Nutritional Support in Malnutritional Cancer Patients
Malnutrition patients are known to have more postoperative complications and mortality. And most of hepatobiliary-pancreatic cancer surgeries accompany high postoperative morbidity and mortality rate.
- Conditions
- Pancreatic Cancer, Biliary Cancer, Malnutrition
- Trial name
- NCT02626195
- Testing
- nutritional support program
- Where
- South Korea
- Volunteers
- 50 people
- Sponsor
- National Cancer Center, Korea
Endometrial Cancer, Cervical Cancer
Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors
The objective of this study is to evaluate the safety, tolerability, and efficacy of BL-M07D1 in patients with HER2 expressing advanced tumors.
- Conditions
- Endometrial Cancer, Cervical Cancer, Ovarian Cancer, Urothelial Carcinoma
- Trial name
- NCT06293898
- Testing
- BL-M07D1
- Where
- 26 sites in United States
- Volunteers
- 280 people
- Sponsor
- SystImmune Inc.
Locally Advanced Ampulla of Vater Carcinoma, Locally Advanced Biliary Tract Carcinoma
Alternating Chemo-immunotherapy and FGFR Inhibitor for FGFR-positive Biliary or Cholangiocarcinoma
This phase II trial tests how well giving gemcitabine, cisplatin and durvalumab alternating with pemigatinib for the treatment of biliary tract cancer with FGFR2 alterations that cannot be removed by surgery (unresectable), that…
- Conditions
- Locally Advanced Ampulla of Vater Carcinoma, Locally Advanced Biliary Tract Carcinoma, Locally Advanced Extrahepatic Cholangiocarcinoma, Locally Advanced Gallbladder Carcinoma
- Trial name
- NCT07780838
- Testing
- Biospecimen Collection, Cisplatin, Computed Tomography
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Liver Cirrhosis, Gall Stone
Genetic Variants Associated With the Risk of Gall Stones and Cirrhosis.
Gall stone disease is more common in patients with cirrhosis. This association has been well established in different studies. Among the various factors which predispose a patient with gall stone disease to have associated liver…
- Trial name
- NCT06679738
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Cholecystitis
Fluorescent Cholangiography in Acute Cholecystitis
Currently, there is limited scientific evidence regarding the effectiveness of fluorescent cholangiography in emergency cholecystectomy for acute cholecystitis.
- Trial name
- NCT06573021
- Testing
- Near-infrared fluorescent cholangiography
- Where
- Italy
- Volunteers
- 81 people
- Sponsor
- University Hospital of Ferrara
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage Versus Endoscopic Ultrasound-guided Biliary Drainage
Prospective multi-site study of ultrasound-guided percutaneous biliary drainage and endoscopic ultrasound-guided biliary drainage with implantation of a self-expanding metal stent in patients with malignant, distal bile duct…
- Trial name
- PUMa (NCT03546049)
- Testing
- US-guided percutaneous biliary drainage, EUS-guided biliary drainage
- Where
- Germany
- Volunteers
- 216 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Anesthesia, Pediatrics
Norepinephrine for Prevention of Intraoperative Hypotension in Infants Undergoing Kasai Portoenterostomy
This study aims to assess the efficacy and safety of prophylactic intraoperative norepinephrine infusion versus the standard technique on decreasing the incidence of intraoperative hypotension in infants undergoing Kasai…
- Conditions
- Anesthesia, Pediatrics, Biliary Atresia
- Trial name
- NCT05521152
- Testing
- Norepinephrine Bitartrate
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Kasr El Aini Hospital
Acute Cholecystitis With Chronic Cholecystitis
Correlation Between Power Doppler and Intraoperative Findings of Chronic and Acute Cholecystitis
In theory, increased vascularity of GB wall could be associated with intraoperative findings, such as, GB wall inflammation and accompanying adhesions.
- Trial name
- NCT02156947
- Testing
- Laparoscopic cholecystectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Samsun Education and Research Hospital
Biliary Tract Neoplasms
Cediranib Versus Placebo Plus Cisplatin/Gemcitabine Chemotherapy for Patients With Advanced Biliary Tract Cancers
As a result of our previous NCRN study (ABC-02) cisplatin and gemcitabine (CisGem) is likely to become the international standard of care for patients with advanced biliary tract cancer (submitted: ASCO 2009).
- Trial name
- ABC-03 (NCT00939848)
- Testing
- gemcitabine, cisplatin, cediranib
- Where
- 2 sites in United Kingdom
- Volunteers
- 124 people
- Sponsor
- University College, London
Pancreatic Cancer, Hepatocellular Cancer
Durvalumab and Tremelimumab in Combination With Propranolol and Chemotherapy for Treatment of Advanced Hepatopancreabiliary Tumors (BLOCKED)
A single-arm, interventional study combining Immunotherapy and propranolol with/without chemotherapy and propranolol 1. Pancreatic Cancer Durvalumab will be administered once every 4 weeks, in combination with gemcitabine +…
- Conditions
- Pancreatic Cancer, Hepatocellular Cancer, Biliary Tract Cancer, Cholangiocarcinoma
- Trial name
- NCT05451043
- Testing
- Durvalumab, Gemcitabine, Nab paclitaxel
- Where
- Canada
- Volunteers
- 62 people
- Sponsor
- AHS Cancer Control Alberta
Gallstone; Colic
Impact of Video Editing Training for Novice Trainees in Laparoscopic Cholecystectomy
Surgical practice training often suffers from poor educational efficiency due to the technical difficulties of the cases, the lack of resources and the cases in the operating room.
- Trial name
- NCT04661319
- Testing
- video editing training
- Where
- South Korea
- Volunteers
- 90 people
- Sponsor
- Seoul St. Mary's Hospital
Pancreatic Cancer, Sepsis
Colonization of Bile Ducts and Postoperative Infectious Complications of Pancreaticoduodenectomies
The aim of the present prospective study was, first, to verify the correlation between biliary colonization and postoperative infectious complications, and secondarily to asses morbidity and mortality for patients who underwent…
- Conditions
- Pancreatic Cancer, Sepsis, Bile Duct Cancer, Duodenal Cancer
- Trial name
- NCT03525067
- Testing
- Bile sampling for bacterial examination
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Central Hospital, Nancy, France
Primary Biliary Cirrhosis
Seladelpar (MBX-8025) in Subjects With Primary Biliary Cholangitis (PBC)
An 8-week, dose ranging, open label, randomized, Phase 2 study with a 44-week extension, to evaluate the safety and efficacy of MBX-8025 in subjects with Primary Biliary Cholangitis (PBC) and an inadequate response to or…
- Trial name
- NCT02955602
- Testing
- MBX-8025 2 mg Capsule, MBX-8025 5 mg Capsule, MBX-8025 10 mg Capsule
- Where
- 38 sites in United States, Canada and 2 more
- Volunteers
- 119 people
- Sponsor
- Gilead Sciences
Biliary Tract Cancer (BTC)
D07001 Softgel-Capsules and Capecitabine Combination Therapy in Patients With Advanced Biliary Tract Cancer
The object of this trial is to evaluate the efficacy of D07001-softgel capsules + capecitabine compared with placebo + capecitabine by overall survival (OS).
- Trial name
- NCT06622057
- Testing
- D07001-Softgel Capsules, Capecitabine
- Where
- 4 sites in United States, Taiwan
- Volunteers
- 240 people
- Sponsor
- InnoPharmax Inc.
Hepatocellular Carcinoma, Biliary Tract Neoplasms
Primary Hepatobiliary Cancer Cohort of Central China
This registry is designed as a longitudinal cohort study of patients diagnosed with primary hepatobiliary cancer in Tongji Hospital, Wuhan.
- Trial name
- CCGLC-002 (NCT05520801)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Tongji Hospital
Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis With Oral Vancomycin by the Study of Its Antimicrobial and Immunomodulating Effects
Determine the benefit of oral vancomycin therapy for Primary Sclerosing Cholangitis.
- Trial name
- PSC (NCT01802073)
- Testing
- Oral Vancomycin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Stanford University
Neoplasms, Non-Neoplastic
AI Guidance for Biopsy in Suspected Cholangiocarcinoma
Digital single-operator cholangioscopy (DSOC) has emerged as a medical advance with an important role in the evaluation of indeterminate biliary lesions.
- Conditions
- Neoplasms, Non-Neoplastic, Bile Duct Neoplasms, Bile Duct Lesions
- Trial name
- NCT05374122
- Testing
- DSOC with AI biopsy guidance, DSOC biopsy without AI guidance
- Where
- Ecuador
- Volunteers
- 48 people
- Sponsor
- Instituto Ecuatoriano de Enfermedades Digestivas
Bile Reflux Gastritis, Gastric Cancer
Study on the Effect of Bile Reflux on Gastric Cancer and Its Precancerous Lesions: a Cross-sectional Study.
To explore the effects of bile reflux on gastric cancer and its precancerous lesions, so as to better prevent the occurrence and development of gastric cancer.
- Conditions
- Bile Reflux Gastritis, Gastric Cancer, Helicobacter Pylori Infection, Intestinal Metaplasia
- Trial name
- NCT03976739
- Where
- China
- Volunteers
- 1,162 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Biliary Tract Diseases
SpyGlass Direct Visualization System Clinical Registry in China
To document indications for cholangioscopy and clinical utility of the SpyGlass Direct Visualization System in China when used per standard of practice. Prospective, Post market, Multi-center, Non-randomized Study
- Trial name
- SpyChina (NCT02287194)
- Testing
- SpyGlass
- Where
- China
- Volunteers
- 197 people
- Sponsor
- Boston Scientific Corporation