Clinical trials: Disorders of Gallbladder
Biliary Tract Cancer
Gemcitabine and Cisplatin With or Without CPI-613 as First Line Therapy for Patients With Advanced Unresectable Biliary Tract Cancer (BilT-04)
The purpose of this research study is to determine the safety and efficacy of CPI-613 (devimistat) in the treatment of advanced biliary tract cancer when used in combination with standard of care chemotherapy (gemcitabine plus…
- Trial name
- NCT04203160
- Testing
- CPI 613, Gemcitabine, Cisplatin
- Where
- 10 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Michigan Rogel Cancer Center
Acute Cholecystitis
Validation of a New Simplified Scoring System for Acute Calculous Cholecystitis
Acute calculous cholecystitis (ACC) is the second most frequent surgical condition in emergency departments. The recommended treatment is surgical treatment (ST) and the accepted mortality is <1%, but in severe and/or fragile…
- Trial name
- ACME (NCT06213740)
- Where
- Spain
- Volunteers
- 387 people
- Sponsor
- Hospital del Mar
Adenocarcinoma of the Gallbladder, Adenocarcinoma With Squamous Metaplasia of the Gallbladder
Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced Gallbladder or Bile Duct Cancer That Cannot Be Removed By Surgery
This phase II trial studies how well selumetinib and Akt inhibitor MK-2206 work in treating patients with refractory or advanced gallbladder or bile duct cancer that cannot be removed by surgery.
- Conditions
- Adenocarcinoma of the Gallbladder, Adenocarcinoma With Squamous Metaplasia of the Gallbladder, Adult Primary Cholangiocellular Carcinoma, Advanced Adult Primary Liver Cancer
- Trial name
- NCT01859182
- Testing
- selumetinib, Akt inhibitor MK2206, laboratory biomarker analysis
- Sponsor
- National Cancer Institute (NCI)
Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma
Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab
This phase Ib trial studies side effects and best dose of dasatinib in preventing oxaliplatin-induced peripheral neuropathy in patients with gastrointestinal cancers who are receiving FOLFOX regimen with or without bevacizumab.
- Conditions
- Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma, Stage IV Colorectal Cancer AJCC v8, Stage IVA Colorectal Cancer AJCC v8
- Trial name
- NCT04164069
- Testing
- Bevacizumab, Dasatinib, Fluorouracil
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Anne Noonan
Inflammatory Bowel Diseases, Crohn Disease
Seattle Spatial Transcriptomic Research in Inflammatory Bowel Disease Evaluation (STRIDE)
This is a prospective observational study collecting long-term clinical data and samples for research in pediatric inflammatory bowel disease (IBD) patients with gut inflammation and a control cohort of pediatric patients with…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Indeterminate Colitis
- Trial name
- STRIDE (NCT06315179)
- Testing
- Esophagogastroduodenoscopy (EGD) with biopsy, Colonoscopy w/ biopsy
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Seattle Children's Hospital
Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis
Modified Laparoscopic Transcystic Biliary Drainage in the Management of Cholecystocholedocholithiasis
The modified laparoscopic transcystic biliary drainage which we developed in the treatment of cholecystocholedocholithiasis has some advantages over conventional techniques.
- Conditions
- Common Bile Duct Calculi, Acute; Cholecystitis, Choledocholithiasis, Acute Cholecystitis With Obstruction, Acute Cholangitis
- Trial name
- NCT06011941
- Testing
- Modified laparoscopic transcystic biliary drainage
- Where
- China
- Volunteers
- 310 people
- Sponsor
- Peking University Third Hospital
Acute Cholecystitis, Acute; Cholecystitis, Choledocholithiasis
Indocyanine Green to Visualize Critical View of Safety During Laparoscopic Cholecystectomy for Acute Cholecystitis
The purpose of this prospective randomized trial is to study the role of Indocyanine green (ICG) to visualize the Critical View of Safety during emergency Laparoscopic Cholecystectomy for patients with Acute Cholecystitis.
- Conditions
- Acute Cholecystitis, Acute; Cholecystitis, Choledocholithiasis, Acute Cholecystitis With Obstruction
- Trial name
- NCT04624841
- Testing
- Indocyanine Green
- Where
- Qatar
- Volunteers
- 80 people
- Sponsor
- Hamad Medical Corporation
Gallstone
The Discovery of the Double Sphincter in Gallbladder
We found a new Double sphincter which located in the neck of gallbladder，we supposed it may be related to control pressure of bile duct.Its formation is related to genetic factors.
- Trial name
- NCT01998451
- Testing
- Tauroursodeoxycholic acid
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University
Acute Cholecystitis, Chronic Cholecystitis
Evaluation of Closed-loop TIVA Propofol, Sufentanil and Ketamine Guided by BIS Monitor
The purpose of this study is to compare a closed-loop intravenous anesthetic using Bispectral Index as a feedback loop and a controller based on reinforcement learning to titrate dose and intravenous anesthetic that is manually…
- Trial name
- NCT01942356
- Testing
- TIVA - Hypotension, TIVA - Hypertension, TIVA - Bradycardia
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Uterine Cervical Neoplasms, Endometrial Neoplasms
MK-7684A With or Without Other Anticancer Therapies in Participants With Selected Solid Tumors (MK-7684A-005) (KEYVIBE-005)
The purpose of this study is to determine the safety, tolerability, and preliminary efficacy of pembrolizumab/vibostolimab co-formulation (MK-7684A) with or without other anticancer therapies in participants with selected…
- Conditions
- Uterine Cervical Neoplasms, Endometrial Neoplasms, Squamous Cell Carcinoma of Head and Neck, Gallbladder Neoplasms
- Trial name
- NCT05007106
- Testing
- Pembrolizumab/Vibostolimab Co-Formulation, Pembrolizumab, Lenvatinib
- Where
- 73 sites in United States, Canada and 13 more
- Volunteers
- 611 people
- Sponsor
- Merck Sharp & Dohme LLC
Cholecystitis, Gall Stone Pancreatitis
Randomized Control Trial of Intraperitoneal Bupivacaine During Cholecystectomy
Laparoscopic cholecystectomy (removal of the gall bladder via 'keyhole surgery') is a common procedure. This can be performed as an emergency operation when a patient has a complication of gall stones such as acute inflammation…
- Trial name
- NCT01528722
- Testing
- Bupivacaine, Normal saline
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Physical Activity, Breast Neoplasm
The Impact of Physical Activity on the Outcome of Surgery
Over the last decades different life style factors have been established as risk factors for various diseases. The obesity pandemic displays a good example of a disease where great effort is undertaken to characterize risk…
- Conditions
- Physical Activity, Breast Neoplasm, Colorectal Neoplasm, Gall Stones
- Trial name
- NCT01707121
- Where
- 2 sites in Sweden
- Volunteers
- 450 people
- Sponsor
- Sahlgrenska University Hospital
Cholecystitis, Acute
Emergency Versus Elective Cholecystectomy in Acute Cholecystitis in the Era of Laparoscopy.
The aim of study is compare outcome of patients undergoing early laparoscopic cholecystectomy within 72 hours from the begging of symptoms to those of patients managed conservatively and operated late after 6-8weeks after the…
- Trial name
- NCT05502744
- Testing
- Laparoscopic cholecystectomy
- Volunteers
- 50 people
- Sponsor
- Assiut University
Biliary Tract Cancer, Cholangiocarcinoma
A Study of CTX-009 in Combination With Paclitaxel in Adult Patients With Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers (COMPANION-002)
This is a multi-center, open-label, randomized, phase 2/3 trial of the bispecific antibody CTX-009 plus paclitaxel versus paclitaxel in patients with previously treated, unresectable advanced or metastatic biliary tract cancers.
- Conditions
- Biliary Tract Cancer, Cholangiocarcinoma, Gall Bladder Cancer, Ampullary Cancer
- Trial name
- NCT05506943
- Testing
- CTX-009, Paclitaxel
- Where
- 34 sites in United States
- Volunteers
- 168 people
- Sponsor
- Compass Therapeutics
Extrahepatic Bile Duct Cancer, Gallbladder Cancer
Capecitabine or Observation After Surgery in Treating Patients With Biliary Tract Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Extrahepatic Bile Duct Cancer, Gallbladder Cancer, Liver Cancer
- Trial name
- NCT00363584
- Testing
- capecitabine, clinical observation, adjuvant therapy
- Where
- 46 sites in United Kingdom
- Volunteers
- 360 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Acute Cholecystitis
GB34 Acupuncture in Acute Cholecystitis
The purpose of this pilot study is to investigate the effects of GB34 acupuncture, performed as adjuvant to standard medical treatment, on clinical response and laboratory parameters of patients with a diagnosis of acute…
- Trial name
- NCT04960189
- Testing
- Acupuncture
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Nigde Omer Halisdemir University
Esophageal Cancer, Gastric Cancer
T Cell Mediated Adaptive Therapy for Her2-positive Neoplasms of Digestive System
This phase I trial is to investigate the safety and the possible side effects of bi-specific antibody armed T-cell therapy when given together with low-dose IL-2 in treating patients with Her2-positive neoplasms of digestive…
- Conditions
- Esophageal Cancer, Gastric Cancer, Pancreatic Cancer, Liver Cancer
- Trial name
- NCT02662348
- Testing
- Recombinant Human Interleukin-2, HER2Bi-Armed T Cells
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Yi Miao
Gallstones
A Clinical Trial of Electro-acupuncture for Treating Gallstone Diseases
Background: Electro-acupuncture (EA) is commonly used as an alternative treatment for gallstone disease. This study aimed to investigate the effectiveness of EA.
- Trial name
- NCT03891147
- Testing
- Electro-acupuncture
- Where
- China
- Volunteers
- 132 people
- Sponsor
- Chinese University of Hong Kong
Acute Cholecystitis
One-year Outcomes by Index Treatment in Elderly Patients With Acute Cholecystitis
Background: The GOLDENEYE study is an international, multicenter, prospective observational investigation designed to compare the outcomes of various management strategies for acute cholecystitis in patients aged 70 years and…
- Trial name
- GOLDENEYE (NCT07006298)
- Where
- Spain
- Volunteers
- 376 people
- Sponsor
- Instituto de Investigación Sanitaria y Biomédica de Alicante
Music Therapy, Cholecystitis/Cholelithiasis
Effect of Preoperative Music on Sterile Inflammation Induced by Laparoscopic Surgery
Surgery induced sterile inflammation leaves behind a biomolecular footprint measurable by various pro-inflammatory markers e.g. IL-6, CD(Cluster of differentiation)19B, HsCRP(High-sensitivity CRP) etc.
- Conditions
- Music Therapy, Cholecystitis/Cholelithiasis, Inflammatory Response, Surgical Injury
- Trial name
- NCT03429478
- Testing
- Preoperative application of a bluetooth enabled Headphones.
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Sir Ganga Ram Hospital