Clinical trials: Disorders of the Autonomic Nervous System
Blood Donors
Addressing Fear and Risk of Vasovagal Reactions Among High School Donors
In this study, high school donors will be asked about their blood donation-related fears prior to their donation. Half of the donors reporting fear will be assigned to a brief coping skills intervention.
- Trial name
- NCT03835299
- Testing
- Fear Intervention
- Where
- United States
- Volunteers
- 4,035 people
- Sponsor
- Ohio University
Chronic Pain, Low Back Pain
High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Study designed to compare the conventional stimulation programming versus the high frequency stimulation programming of the spinal cord stimulator for subjects who already have a spinal cord stimulator.
- Conditions
- Chronic Pain, Low Back Pain, Radiculopathy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- HFSCS (NCT02265848)
- Testing
- High frequency stimulation, Low frequency stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical Research, Winston-Salem, NC
POTS - Postural Orthostatic Tachycardia Syndrome
The Effect of Physical Activity on Postural Orthostatic Tachycardia Syndrome
Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown origin characterized by orthostatic intolerance and increased heart rate (HR) of ≥ 30 beats/minute during orthostasis in the absence of orthostatic…
- Trial name
- POTS (NCT05554107)
- Testing
- Training program
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Lund University
Alzheimer's Disease, Dementia
Diagnosis and Natural History Study of Patients With Neurological Conditions
The purpose of this study is to improve understanding of neurological conditions. Patients participating in this study will continue receiving medical care, routine laboratory tests, and diagnostics tests (X-rays, CT-scans, and…
- Conditions
- Alzheimer's Disease, Dementia, Movement Disorder, Multiple System Atrophy
- Trial name
- NCT00001549
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Obesity, Pre-hypertension
Whole Body Vibration Combined With L-citrulline Supplementation on Cardiovascular Function and Body Composition
Arterial dysfunction contributes to the development of cardiovascular disease (CVD), which is currently afflicting millions of individuals.
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT02143817
- Testing
- L-citrulline supplementation, Whole Body Vibration Training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance
Effects of Transcutaneous Vagus Nerve Stimulation in Older Adults
The autonomic nervous system consists of two branches, the sympathetic and the parasympathetic, which must work in balance. Its functioning can be measured indirectly by heart rate variability, which is the time between…
- Conditions
- Older Adults Without Any Specific Clinical Condition, Autonomic Nervous System Imbalance, Transcutaneous Vagus Nerve Stimulation
- Trial name
- tVNS_older (NCT07292623)
- Testing
- Active location tVNS
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade da Coruña
Peptic Ulcer
Efficacy and Safety Study of HZT-501 in Reducing the Risk of Ibuprofen-associated Ulcers
The purpose of this study is to evaluate whether HZT-501 is effective in reducing the rate of development of ibuprofen-associated ulcers in patients who require long-term daily use of ibuprofen.
- Trial name
- NCT00450658
- Testing
- HZT-501, Ibuprofen
- Volunteers
- 627 people
- Sponsor
- Amgen
CRPS (Complex Regional Pain Syndromes), Radiculopathy
Intermittent Dosing of Dorsal Root Ganglion Stimulation as an Alternate Paradigm to Continuous Low-Frequency Therapy
This study seeks to evaluate the use of intermittent dosing as an alternative paradigm for patients with DRG stimulation in place for at least 1 year and minimum 50% pain relief in the targeted area.
- Conditions
- CRPS (Complex Regional Pain Syndromes), Radiculopathy, Peripheral Neuropathy
- Trial name
- NCT04909138
- Testing
- DRG stimulation 20 Hz 30/90, DRG stimulation 5 Hz 30/90
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Hypertension (HTN)
Spinal Cord Stimulation for Blood Pressure Control in Hypertension
High blood pressure, also called hypertension, raises the risk of heart disease, stroke, and kidney disease. Medications work well for many people, but some people still have blood pressure that stays too high, or they have side…
- Trial name
- HTN-SCS (NCT07842315)
- Testing
- Lower Thoracic Spinal Cord Stimulation
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Altitude Training Adaptation, Autonomic Nervous System
Effect of Hot Spring Therapy on Autonomic Nervous System and Exercise Performance During Altitude Training
This randomized controlled trial aims to investigate the effects of balneotherapy (hot spring bathing) on cardiac autonomic nervous system function and exercise performance in healthy athletes undergoing high-altitude training.
- Conditions
- Altitude Training Adaptation, Autonomic Nervous System, Hydrotherapy, Exercise Performance
- Trial name
- NCT07608887
- Testing
- Control Group：Natural Recovery, Hot water immersion group, hot spring immersion group
- Where
- China
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Macao Polytechnic University
Parkinson's Disease, Multiple System Atrophy
Exploit the Neural Source and the Feasibility of Transcranial Direct Current Stimulation for Freezing of Gait in Parkinson's Disease and Multiple System Atrophy
In this project, the investigators will deliver a 5-day session of transcranial direct current stimulation (tDCS) to the leg motor cortex of the FOG patients to examine whether the intervention will benefit the patients in a…
- Trial name
- NCT03721887
- Testing
- Transcranial direct current stimulation
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Complex Regional Pain Syndrome, Chronic Pain
Spinal Cord Stimulation Versus Nerve Blocks and Physical Therapy
The primary objective of this study is to compare the efficacy of SCS using the Precision implantable neurostimulation device and conventional medical treatment (nerve blocks + physical therapy) in subjects with…
- Conditions
- Complex Regional Pain Syndrome, Chronic Pain, Pain
- Trial name
- NCT00414804
- Testing
- Precision SCS, Nerve Blocks and PT
- Sponsor
- Boston Scientific Corporation
Proctitis, Proctosigmoiditis
The Safety and Tolerability of Budesonide Foam in Participants With Active Ulcerative Proctitis or Proctosigmoiditis
The purpose of this study is to evaluate safety and tolerability of cyclically-dosed rectal budesonide foam in participants with active ulcerative proctitis (UP) or ulcerative proctosigmoiditis (UPS).
- Trial name
- NCT01349673
- Testing
- Budesonide Foam
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Bausch Health Americas, Inc.
Complex Regional Pain Syndrome (CRPS)
Efficacy and Safety of Intravenous Neridronic Acid in Complex Regional Pain Syndrome (CRPS)
The aim of this trial was to investigate the efficacy and safety of intravenous neridronic acid in subjects with Complex Regional Pain Syndrome (CRPS).
- Trial name
- NCT03560986
- Testing
- Neridronic acid 100 mg
- Where
- 71 sites in United States, Canada and 5 more
- Volunteers
- 267 people
- Sponsor
- Grünenthal GmbH
Cardiovascular Diseases, Post-Exercise Hypotension
The Influence of Cardiorespiratory Fitness on Firefighter Cardiovascular Health Under Exercise Conditions
Sudden cardiac death (SCD) is the number one cause of on-duty firefighter death. It is most likely to occur in adults who are not physically fit that engage in sudden vigorous exercise.
- Trial name
- FIT & FIRED UP (NCT04514354)
- Testing
- GEST
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Connecticut
Autonomic Nervous System Imbalance, Heart Rate Variability (HRV)
Evaluating the Feasibility, Acceptability, and Preliminary Outcomes of Heart Rate Variability Biofeedback for Individuals With Opioid Use Disorder.
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary outcomes of a heart rate variability biofeedback (HRVB) intervention among adults with opioid use disorder (OUD) receiving residential…
- Conditions
- Autonomic Nervous System Imbalance, Heart Rate Variability (HRV), Opioid Use Disorder, Breathing Techniques
- Trial name
- NCT07361731
- Testing
- Heart rate variability biofeedback
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Arizona State University
Healthy Adult
Evaluation of the Pharmacokinetics, Biodistribution and Radiation Dosimetry of [18F]MODAG-009 Positron Emission Tomography (PET) Radiotracers in Adult Healthy Volunteers
This is an open-label, single-center, phase 1 study to further characterize [18F]MODAG-009 in Healthy Volunteers (HV). Approximately 6 participants will be enrolled in this study.
- Trial name
- NCT07617688
- Testing
- [¹⁸F]MODAG-009 PET Imaging
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Multiple System Atrophy - Parkinsonian Subtype (MSA-P), Multiple System Atrophy - Cerebellar Subtype (MSA-C)
PET Imaging Study of Neurochemical and Autonomic Disorders in Multiple System Atrophy (MSA)
Multiple system atrophy (MSA) is a disorder of the nervous system of unclear cause. In MSA there is degeneration (progressive loss) of nerve cells in several brain and spinal cord regions.
- Trial name
- NCT02035761
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Reflex Syncope
Implantable Loop Recorder and Cardioneuroblation
The study aims to determine which method of vagal ganglia ablation is most effective in preventing recurrences of reflex asystole syncope.
- Trial name
- ILR-CNA (NCT07162740)
- Testing
- Right atrial ablation, Bi-atrial ablation
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Istituto Auxologico Italiano