Clinical trials: Disorders of the Autonomic Nervous System
ME/CFS, Long COVID
LIFT: Life Improvement Trial
The LIFT will be conducted at Brigham and Women's Hospital (BWH) of Harvard Medical School, focusing on the effect of Pyridostigmine (Mestinon) and Low-Dose Naltrexone (LDN) in subjects aged 18-70 meeting the Canadian consensus…
- Conditions
- ME/CFS, Long COVID, PASC
- Trial name
- LIFT (NCT06366724)
- Testing
- Pyridostigmine, Low-Dose Naltrexone
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Brigham and Women's Hospital
Migraine, Chronic Tension-Type Headache
Nurse Intervention Trial
This randomized open-label prospective study focus on headache patients initiating preventive treatment, where the treating physician identifies a need for follow-up visits in specialized healthcare.
- Conditions
- Migraine, Chronic Tension-Type Headache, Cluster Headache, Hemicrania Continua
- Trial name
- NCT06200480
- Testing
- Telephone by nurse
- Where
- Norway
- Volunteers
- 147 people
- Sponsor
- Norwegian University of Science and Technology
Syncope, Vasovagal
The Effectiveness of Metoprolol in the Prevention of Syncope Recurrence in Children and Adolescents
The purpose of this study to evaluate the effectiveness of metoprolol versus conventional treatment in the prevention of syncope recurrence in children and adolescents.
- Trial name
- NCT00475462
- Testing
- metoprolol, conventional treatment
- Volunteers
- 28 people
- Sponsor
- Peking University First Hospital
Uncontrolled Hypertension, High Blood Pressure
SCRATCH-HTN Study: Evaluating Autonomic Neuromodulation Using Trans-cutaneous Vagal Stimulation in Hypertensive Patients
This is a pilot, sham-controlled, double blind, single-site device clinical trial designed to evaluate the safety, acceptability and efficacy of non-invasive autonomic neuromodulation in a cohort of 63 adult patients with…
- Trial name
- SCRATCH-HTN (NCT05179343)
- Testing
- Active AffeX-CT device
- Where
- United Kingdom
- Volunteers
- 63 people
- Sponsor
- Queen Mary University of London
Multiple System Atrophy
Study of ATH434 in Participants with Multiple System Atrophy
This study will assess the safety and efficacy of ATH434 in participants with Multiple System Atrophy
- Trial name
- NCT05109091
- Testing
- ATH434 dose level 1, ATH434 dose level 2
- Where
- 23 sites in United States, Australia and 4 more
- Volunteers
- 77 people
- Sponsor
- Alterity Therapeutics
Ovarian Cancer, Breast Cancer
Study of CYH33 in Combination With Olaparib an Oral PARP Inhibitor in Patients With Advanced Solid Tumors.
The purpose of this study is to assess the safety, tolerability and preliminary efficacy of CYH33 in combination with olaprib in patients with DDR gene mutations and/or PIK3CA mutations, in patients who have progressed on prior…
- Conditions
- Ovarian Cancer, Breast Cancer, Solid Tumor, Prostate Cancer
- Trial name
- NCT04586335
- Testing
- CYH33
- Where
- 7 sites in United States, Australia and 1 more
- Volunteers
- 24 people
- Sponsor
- Haihe Biopharma Co., Ltd.
Spinal Cord Injury, Orthostatic Hypotension
Prevention of Orthostatic Hypotension With Electric Stimulation in Persons With Acute SCI
Background: The presence of orthostatic hypotension (OH) as a consequence of blood volume redistribution during verticalisation in persons with spinal cord injury (SCI) is a common condition.
- Trial name
- NCT01891110
- Testing
- ES of the abdominal muscles, ES of the limb muscles, ES of limbs & abdomen
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Parkinson's Disease, Multiple System Atrophy
Analysis of the Enteric Nervous System Using Colonic Biopsies
The aim of this project is to develop an original biomarker for Parkinson's disease (PD) and other parkinsonian syndromes (multiple system atrophy and progressive supranuclear palsy) based upon the detection of pathological…
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- ColoBioParker (NCT01353183)
- Testing
- colonoscopy or rectosigmoidoscopy
- Where
- France
- Volunteers
- 34 people
- Sponsor
- Nantes University Hospital
Autonomic Disturbances in Parkinson's Disease
Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
Disabling symptoms of blood pressure dysregulation, impaired swallowing and digestion are common amongst Parkinson's patients. So far the exact pathophysiology for this is not fully understood.
- Trial name
- NCT01993680
- Testing
- Pyridostigmine bromide, fludrocortisone
- Where
- Switzerland
- Volunteers
- 18 people
- Sponsor
- Christian Baumann
Causalgia
Efficacy of Parecoxib on Patients With CRPS
The complex regional pain syndrom is a weighty disease that often results in a lifelong disability. Mostly this disease appears unilateral after comparatively mundane fractures or operations.
- Trial name
- NCT01523379
- Testing
- Parecoxib
- Sponsor
- Ruhr University of Bochum
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Chronic Pain, Complex Regional Pain Syndromes
The Success of Lumbar Sympathetic Ganglion Block Using Lower Extremity Perfusion Index
The patient, who is experiencing chronic pain in the lower extremities persisting for more than three months, is scheduled to undergo lumbar sympathetic ganglion block.
- Conditions
- Chronic Pain, Complex Regional Pain Syndromes, Peripheral Neuropathy, Post Herpetic Neuralgia
- Trial name
- NCT06241820
- Testing
- Lumbar Sympathetic Ganglion Block
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Jeongsoo Kim
Periodontal Disease, Gingivitis and Periodontal Diseases
Hippo Signaling Pathway Proteins in Gingival Crevicular Fluid of Individuals With Periodontal Disease
Periodontal disease is a chronic inflammatory condition of the tooth-supporting tissues in which the host inflammatory response drives the destruction of alveolar bone and periodontal attachment.
- Conditions
- Periodontal Disease, Gingivitis and Periodontal Diseases, Biomarker Discovery and Validation, Pathways
- Trial name
- BYHN-GCF-HIPPO (NCT07759466)
- Testing
- ELISA Biomarker Analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Inonu University
Familial Dysautonomia
The Safety and Tolerability of Kinetin, in Patients With Familial Dysautonomia
This is a study of kinetin, a nutritional supplement that corrects the mRNA splicing defect in patients with familial dysautonomia (FD, also known as Riley Day syndrome or hereditary sensory and autonomic neuropathy type III).
- Trial name
- NCT02274051
- Testing
- Kinetin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- NYU Langone Health
Autonomic Dysfunction
Low-intensity Focused Ultrasound and Autonomic Response
Studying the effects of Low Intensity Focused Ultrasound (LIFU) to the dorsal posterior insula (dPI) and dorsal anterior cingulate cortex (dACC) on autonomic control using a test to probe the autonomic system.
- Trial name
- NCT05834829
- Testing
- Low-intensity focused ultrasound neuromodulation
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Orthostatic Hypotension, Alzheimer Disease
Efficacy, Safety and Response Predictors of Adjuvant Astragalus for Cognition in Orthostatic Hypotension
Background: This pragmatic clinical trial aims to determine the efficacy and safety of add-on Astragalus for cognition and non- cognition in patients with of mild to moderate Alzheimer's disease complicated with orthostatic…
- Trial name
- NCT05647473
- Testing
- Routine treatment, add-on low dose Astragalus, add-on high dose Astragalus
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Fujian Medical University Union Hospital
Autonomic Failure, Dysautonomia
Concentration and Attentional Deficits in POTS and Other Autonomic Neuropathies
People with POTS, autoimmune autonomic neuropathy (AAN), pure autonomic failure (PAF), SFN and Ehlers Danlos Syndrome (EDS) do not only suffer from orthostatic symptoms such as dizziness, headache, neck pain, blurred vision or…
- Conditions
- Autonomic Failure, Dysautonomia, Cognitive Impairment, Ehlers-Danlos Syndrome
- Trial name
- POTSKog (NCT03681080)
- Testing
- leg crossing
- Where
- Germany
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Complex Regional Pain Syndromes, Healthy
Study of Proteins Associated With Complex Regional Pain Syndrome
This study will try to learn more about complex regional pain syndrome, or CRPS (previously known as reflex sympathetic dystrophy, spreading neuralgia, and sympathalgia), by examining the release of small proteins in the blood of…
- Trial name
- NCT00033969
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- National Institute of Nursing Research (NINR)
Sleep Apnea Syndromes, Multiple System Atrophy
Assessment of Ambulatory Polygraphy in the Detection of Sleep Apnea in Multiple System Atrophy (SAMSA)
The purpose of this study is to determine whether ambulatory polygraphy during a short hospitalization in a neurology unit has the same performance than inpatient polysomnography, the actual gold standard, in the diagnosis of…
- Trial name
- NCT00743561
- Testing
- Polysomnography, ambulatory polygraphy
- Where
- 2 sites in France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Bordeaux
Other Disorders of the Autonomic Nervous System, Vertebra; Degeneration
Autonomic Effects of T4 Mobilization in Asymptomatic Subjects
The purpose of this study is to determine whether passive accessory intervertebral mobilization applied to the fourth thoracic vertebra produces autonomic effects.
- Trial name
- NCT02164123
- Testing
- Spinal mobilization, Spinal Mobilization II
- Where
- Brazil
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre