Clinical trials: Disseminated Fungal Infection
Refractory IPA
Safety and Efficacy of PC945 (Opelconazole) in Combination With Other Antifungal Therapy for the Treatment of Refractory Invasive Pulmonary Aspergillosis (OPERA-T Study)
To assess the safety and efficacy of nebulized PC945 in combination with systemic antifungal therapy for the treatment of refractory IPA
- Trial name
- NCT05238116
- Testing
- PC945
- Where
- 83 sites in United States, Argentina and 18 more
- Volunteers
- 85 people
- Sponsor
- Pulmocide Ltd
Candidiasis
Study to Compare the Efficacy and Safety of Micafungin Versus Conventional Amphotericin B for the Treatment of Neonatal Candidiasis
The study will evaluate how effective and how safe the drug micafungin is when compared to the drug amphotericin B deoxycholate in treating neonates and young infants with certain fungal infections.
- Trial name
- MAGIC-2 (NCT00815516)
- Testing
- micafungin, amphotericin B deoxycholate
- Where
- 17 sites in United States, Brazil and 10 more
- Volunteers
- 30 people
- Sponsor
- Astellas Pharma Global Development, Inc.
Mycoses, Fungemia
Anidulafungin Versus Fluconazole for the Prevention of Fungal Infections in Liver Transplant Recipients
The purpose of this study is to compare the efficacy of anidulafungin versus fluconazole for the prevention of fungal diseases in liver transplant recipients
- Conditions
- Mycoses, Fungemia, Central Nervous System Fungal Infections, Lung Diseases, Fungal
- Trial name
- NCT00841971
- Testing
- Anidulafungin, Fluconazole
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Kidney Cancer, Leukemia
Voriconazole in Preventing Fungal Infections in Children With Neutropenia After Chemotherapy
RATIONALE: Voriconazole may be effective in preventing systemic fungal infections following chemotherapy. PURPOSE: Phase II trial to study the effectiveness of voriconazole in preventing systemic fungal infections in children who…
- Conditions
- Kidney Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00066599
- Testing
- voriconazole
- Where
- 7 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Coccidioidomycosis
Pathogenesis and Genetics of Disseminated or Refractory Coccidioidomycosis
Background: Coccidioidomycosis is caused by a fungus that grows in the southwest United States and parts of Mexico and South America. This disease is caused by breathing dust containing the fungus.
- Trial name
- NCT02190266
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Invasive Fungal Infections
Open, Non Comparative Study Of Voriconazole In Slovak Patients With Very High Risk Of Developing An Invasive Fungal Infection
Assessment of safety and efficacy of voriconazole in real-life setting in the treatment of high risk patients with invasive fungal infections. The study is conducted in Slovakia only.
- Trial name
- Ve-RIFI (NCT01137292)
- Testing
- voriconazole (VFEND®)
- Volunteers
- 177 people
- Sponsor
- Pfizer
Pulmonary Nodule, Invasive Fungal Infections
Granulomatous Pneumocystis Pneumonia
The intra-alveolar form of Pneumocystis jiroveci pneumonia (PjP) is a common pathology in immunocompromised patients, particularly those infected with HIV. The diagnosis is based on the detection of Pj in a LBA.
- Conditions
- Pulmonary Nodule, Invasive Fungal Infections, Pneumocystis Jirovecii
- Trial name
- NC (NCT03731156)
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Invasive Fungal Infections
Using of Biomarkers and Blood Culture in Early Detection of Systemic Infections
This work aims to: 1. Validate the performance of CRP, and PCT in early differentiating IFI from bacterial bloodstream infections. 2. Compare the results of CRP and PCT with the results of β-D- glucan. 3.
- Trial name
- NCT05737537
- Testing
- procalcitonin ,CRP and 1, 3- β -D- glucan in early diagnosis of invasive infections
- Volunteers
- 90 people
- Sponsor
- Assiut University
Pulmonary Candidiasis, Invasive Candidiasis
Candida Spp. in the Lower Respiratory Tract: Harmless Residents or Pathogen?
In critically ill patients Candida spp. are frequently isolated from respiratory tract secretions such as endotracheal aspirates and bronchoalveolar lavages (BAL) and are most often considered as colonizers of the respiratory…
- Trial name
- NCT00786903
- Where
- Austria
- Volunteers
- 202 people
- Sponsor
- Robert Krause, MD
Invasive Candidiasis
Variability of Fluconazole Concentration in Critically Ill Patients
Fluconazole is the first-line agent in the treatment of invasive candidiasis. Studies showed inappropriate drug exposure causes high mortality in critically ill patients.
- Trial name
- NCT02491151
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- University Medical Center Groningen
Systemic Mycosis
Optimized Diagnostics for Improved Therapy Stratification in Invasive Fungal Infections
Invasive fungal infections (IFI) in immunocompromised patients pose a major challenge for diagnostics designed to permit timely onset of appropriate treatment.
- Trial name
- FUNGITECT (NCT02492594)
- Testing
- Peripheral blood sampling
- Where
- 7 sites in Austria, Netherlands and 1 more
- Volunteers
- 244 people
- Sponsor
- St. Anna Kinderkrebsforschung
Candidiasis
Micafungin Versus AmBisome in Invasive Candidiasis and Candidemia
The purpose of this study is to determine the efficacy and safety of micafungin (FK463) versus liposomal amphotericin B (AmBisome) in treating neutropenic and non-neutropenic patients with confirmed invasive candidiasis or…
- Trial name
- NCT00106288
- Testing
- Micafungin, Liposomal Amphotericin B
- Where
- 37 sites in United States, Canada
- Volunteers
- 637 people
- Sponsor
- Astellas Pharma Inc
Breast Cancer, Chronic Myeloproliferative Disorders
Campath-1H + FK506 and Methylprednisolone for GVHD
RATIONALE: Alemtuzumab, tacrolimus, and methylprednisolone may be an effective treatment for graft-versus-host disease caused by a donor stem cell transplant.
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00109993
- Testing
- alemtuzumab, methylprednisolone, tacrolimus
- Where
- 6 sites in United States
- Volunteers
- 34 people
- Sponsor
- Case Comprehensive Cancer Center
Invasive Fungal Infections
Retrospective Study of Invasive Fungal Infections With Filamentous Fungi in Heart Transplant Patients
Invasive filamentous fungal infections (aspergillosis, scedosporiosis, mucormycosis, fusarium wilt) are common and serious in immunocompromised subjects and particularly organ transplant patients.
- Trial name
- IMI-CART (NCT06498310)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Invasive Candidiasis, Candidemia
Risk Of Severe Hepatic Injury In Patients With Invasive Candidiasis Treated With Echinocandins
The purpose of this study is to estimate the relative risk of severe hepatic injury in hospitalized patients with invasive candidiasis and candidemia who received anidulafungin, compared to patients who received caspofungin…
- Trial name
- NCT01213823
- Testing
- Does not apply
- Volunteers
- 536 people, healthy volunteers welcome
- Sponsor
- Pfizer
Immunodepressed Patients (Hemato-oncology)
Metagenomic Sequencing for the Identification of Pathogens in Febrile Neutropenic Patients
The development of targeted therapies and intensive protocols in oncohaematology has improved the survival of patients with haematological malignancies.
- Trial name
- ADNEMIA (NCT06075888)
- Testing
- Metagenomic diagnosis (mNGS, DISQVER)
- Where
- 5 sites in France
- Volunteers
- 184 people
- Sponsor
- Poitiers University Hospital
Invasive Fungal Infections
Absorption, Metabolism and Excretion of 14C-olorofim in Man
Single-centre, open-label, non-randomised, single dose study in 2 cohorts of healthy subjects. It is planned to enrol 6 healthy male subjects in Cohort A (standard mass balance and metabolite profiling cohort) and up to 6…
- Trial name
- hAME (NCT04039880)
- Testing
- Olorofim
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Breast Cancer, Chronic Myeloproliferative Disorders
Beclomethasone in Treating Patients With Graft-Versus-Host Disease of the Esophagus, Stomach, Small Intestine, or Colon
RATIONALE: Beclomethasone may be an effective treatment for graft-versus-host disease. PURPOSE: Phase I/II trial to study the effectiveness of beclomethasone in treating patients who have graft-versus-host disease of the…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Graft Versus Host Disease
- Trial name
- NCT00010283
- Testing
- beclomethasone dipropionate
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Mycoses
Voriconazole to Treat Fungal Infections
Voriconazole is a new drug developed to treat fungal infections. As of March 1999, the drug had been studied in more than 1,900 healthy volunteers or patients with fungal infections.
- Trial name
- NCT00001940
- Testing
- Voriconazole
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Cancer Institute (NCI)
Fungal Infection
The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock
To explore the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis/septic shock;To compare the PK/PD of deoxycholic amphotericin B in invasive fungal infection patients with sepsis and septic…
- Trial name
- NCT05642624
- Testing
- Deoxycholic acid amphotericin B
- Where
- 2 sites in China
- Volunteers
- 20 people
- Sponsor
- Southeast University, China