Clinical trials: Disseminated Fungal Infection
Candidemia
Echinocandins Versus Azoles for Candidemia Treatment
Candidemia is the most frequent invasive fungal disease in intensive care units (ICUs). It remains a major health concern, considering its attributable mortality up to 40% in critically ill patients.
- Trial name
- AntiCandiTreat (NCT03799172)
- Testing
- Echinocandin treatment, Triazole treatment
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Hospices Civils de Lyon
Invasive Fungal Infection, Solid Organ Transplantation
Liposomal Amphotericin B for Invasive Fungal Disease in Solid Organ Transplant Recipients
This real-world observational study aims to evaluate the effectiveness, safety, and therapeutic drug monitoring (TDM) of liposomal amphotericin B (L-AmB) in solid organ transplant recipients with invasive fungal disease (IFD).
- Conditions
- Invasive Fungal Infection, Solid Organ Transplantation, Opportunistic Infections
- Trial name
- LAMB-SOT (NCT07656493)
- Testing
- Liposomal Amphotericin B, Alternative Systemic Antifungal Therapy
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Sichuan Provincial People's Hospital
Invasive Fungal Infections
A Russian Prospective Observational Study of Invasive Fungal Infections in Patients With Acute Leukemia and Hematopoietic Stem Cell Transplantation
Estimate the rate of occurrence of Invasive Fungal Infections (IFIs) in patients with acute leukemia for the first 6 months of chemotherapy (that usually correspond to four courses of chemotherapy), and hematopoietic stem cells…
- Trial name
- NCT01519648
- Where
- Russia
- Volunteers
- 808 people
- Sponsor
- National Hematological Society, Russia
Disseminated Histoplasma Capsulatum Infection, AIDS and Infections
Efficacy and Safety of High-dose Liposomal Amphotericin B for Disseminated Histoplasmosis in AIDS
Phase III trial evaluating the safety and efficacy of a single high dose (10 mg/kg) of liposomal amphotericin B for disseminated histoplasmosis in AIDS patients, in comparison to standard therapy (3 mg/kg of liposomal…
- Conditions
- Disseminated Histoplasma Capsulatum Infection, AIDS and Infections, Immunosuppression, Fungal Infection
- Trial name
- NCT05814432
- Testing
- Single high dose of liposomal amphotericin B, L-AmB standard dose
- Where
- 5 sites in Brazil
- Volunteers
- 279 people
- Sponsor
- Federal University of Health Science of Porto Alegre
Infection, Invasive Fungal
Historical Control Study of Refractory IFI or Patients Intolerant to Standard Antifungal Therapy in Patients With Invasive Fungal Infections (Study P02387)
This retrospective study is designed to provide a consistent method of screening and collecting data on patients who will serve as controls for a comparison of the efficacy of the available antifungal therapies used as salvage…
- Trial name
- NCT00230243
- Volunteers
- 330 people
- Sponsor
- Merck Sharp & Dohme LLC
Invasive Fungal Infections
Effectiveness and Efficiency of a Voriconazole Preemptive Genotyping Strategy
This is a phase IV pragmatic, multicentre, randomised, simple-blind, parallel arm, centre-stratified clinical trial. The main objective is to compare efficiency of voriconazole preemptive genotyping strategy, compared with…
- Trial name
- VORIGENPHARM (NCT04238884)
- Testing
- Voriconazole preemptive genotyping strategy, Voriconazole clinical practice
- Where
- Spain
- Volunteers
- 146 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Invasive Fungal Infections
Population Pharmacokinetics and Dose Optimization of Caspofungin in Adolescents
Caspofungin (CAS) is used to prevent and treat invasive fungal infections patients older than 3 months. However, the optimal dosing strategy of CAS is lacking in adolescents from 12 to 17 years old, especially those undergoing…
- Trial name
- NCT05881109
- Testing
- Caspogunfin
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shandong University
Invasive Fungal Infections
A Bioequivalence Study of APX001 High-load and Low-load Tablets
A study to learn about the bioequivalence (the biochemical similarity of two medicines that share the same active ingredient and desired outcome for patients) of the study medicine called APX001 in healthy participants.
- Trial name
- NCT05491733
- Testing
- APX001, APX001A
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Basilea Pharmaceutica
Invasive Pulmonary Aspergillosis, Invasive Fungal Disease
LFD of Aspergillus Antigen in Paediatrics
Many children and young people are at risk of invasive fungal disease (IFD), such as those who have had a haematopoietic stem cell transplants, those with an immune deficiency or those who are prescribed immunosuppressive drugs…
- Trial name
- LFD-AsPaeds (NCT05569824)
- Testing
- Lateral-flow Device
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- St George's University Hospitals NHS Foundation Trust
Invasive Candidiasis
Pharmacokinetics of Micafungin in Patients of Intensive Care Units
Invasive fungal infections (IFIs) are a frequent cause of morbidity and mortality in high-risk patients, such as immunocompromised patients.
- Trial name
- MI-K (NCT02164890)
- Testing
- micafungin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Obesity Morbid
Anidulafungin Pharmacokinetics Given as a Single Intravenous Dose to Obese Patients (ADOPT)
Because anidulafungin is generally well tolerated and appears to have limited interaction with other drugs, it is a potential important agent in the treatment of invasive fungal infections.
- Trial name
- ADOPT (NCT02021123)
- Testing
- Anidulafungin 100mg single dose iv
- Where
- 2 sites in Netherlands
- Volunteers
- 8 people
- Sponsor
- Radboud University Medical Center
Sepsis, Bacteremia
Safety and Efficacy of MBI 226 for the Prevention of Central Venous Catheter-Related Bloodstream Infections
Central venous catheters (CVCs) are used in patient care for such purposes as the administration of medication, fluids, blood products and for functions such as hemodialysis and plasmapheresis.
- Conditions
- Sepsis, Bacteremia, Fungemia
- Trial name
- NCT00027248
- Testing
- MBI 226
- Where
- United States
- Volunteers
- 1,400 people
- Sponsor
- BioWest Therapeutics Inc
Candidemia, Invasive Candidiasis
Non-Conventional Microbiological Methods in the Diagnosis of Candidemia
This study evaluates the diagnostic value of non-conventional microbiological methods for early detection of candidemia and invasive candidiasis in adult hospitalized patients with suspected invasive fungal infection.
- Trial name
- NCT07422155
- Testing
- Candida Diagnostic Testing Panel
- Where
- Slovenia
- Volunteers
- 2 people
- Sponsor
- Institute of Oncology Ljubljana
Invasive Fungal Infections
Endemic Mycoses Treatment With SUBA-itraconazole vs Itraconazole
This is a prospective, multi-center, randomized, open-label parallel arm study involving patients with proven or probable invasive endemic fungal infection to ascertain the pharmacokinetics, safety, efficacy, tolerability and…
- Trial name
- MSG15 (NCT03572049)
- Testing
- SUBA itraconazole, Conventional itraconazole
- Where
- 12 sites in United States, Panama
- Volunteers
- 88 people
- Sponsor
- University of Alabama at Birmingham
Invasive Pulmonary Aspergillosis, Influenza, Human
Prevalence of Influenza RelAted Invasive Aspergillosis
This is a multicenter study with the aim to determine the prevalence of influenza-related invasive pulmonary aspergillosis in Swedish intensive care units and to assess the clinical impact of and risk factors for…
- Trial name
- PIRAIA (NCT04172610)
- Where
- 12 sites in Sweden
- Volunteers
- 55 people
- Sponsor
- Karolinska University Hospital
Invasive Fungal Disease
Efficacy and Safety of Amphotericin B and Azoles in the Treatment of Invasive Fungal Disease
Efficacy and safety of amphotericin B and azoles in the treatment of invasive fungal disease
- Trial name
- NCT06819410
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Sichuan Provincial People's Hospital
Acute Myeloid Leukemia, Adult Acute Monoblastic Leukemia
Caspofungin Versus Fluconazole in Preventing Invasive Fungal Infections (IFI) in Patients Undergoing Chemotherapy for Acute Myeloid Leukemia
This randomized phase III trial compares the effectiveness of caspofungin to fluconazole in preventing invasive fungal infections in patients receiving chemotherapy for acute myeloid leukemia (AML).
- Conditions
- Acute Myeloid Leukemia, Adult Acute Monoblastic Leukemia, Adult Acute Monocytic Leukemia, Adult Acute Myeloid Leukemia in Remission
- Trial name
- NCT01307579
- Testing
- Caspofungin Acetate, Fluconazole, Laboratory Biomarker Analysis
- Where
- 179 sites in United States, Canada and 1 more
- Volunteers
- 517 people
- Sponsor
- Children's Oncology Group
Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis
Voriconazole Inhalation Powder for the Treatment of Pulmonary Aspergillosis
Voriconazole Inhalation Powder is available on an expanded access basis to patients with pulmonary aspergillosis for up to 12 weeks.
- Conditions
- Invasive Pulmonary Aspergillosis, Allergic Bronchopulmonary Aspergillosis, Chronic Pulmonary Aspergillosis, Aspergillus Tracheobronchitis
- Trial name
- NCT05897294
- Testing
- Voriconazole Inhalation Powder
- Sponsor
- TFF Pharmaceuticals, Inc.
Hematological Malignancy, Hematopoetic Stem Cell Transplantation
Middle East Study of Infections in Patients With Hematological Malignancies
The goal of this prospective observational study is to is to prospectively study the epidemiology of bloodstream infection (BSI) in patients with hematological malignancies (HM) and hematopoietic stem cell transplant (HSCT)…
- Conditions
- Hematological Malignancy, Hematopoetic Stem Cell Transplantation, Bloodstream Infection
- Trial name
- MESI-HM (NCT07900542)
- Testing
- No Intervention: Observational Cohort
- Where
- 9 sites in Jordan, Oman and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Hamad Medical Corporation
Candidiasis
Comparison of Two Treatments to Prevent Invasive Fungal Infections in Patients Who Have Received Liver Transplants
The purpose of this study is to compare the safety and effectiveness of 2 treatments to prevent invasive fungal infections (IFI), which are infections caused by yeasts and molds that are common in patients with weak immune…
- Trial name
- NCT00001107
- Testing
- Fluconazole, AmBisome
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)