Clinical trials: Disseminated Sclerosis
Multiple Sclerosis
Performance Evaluation of a 3D PSIR Sequence in MRI at 1.5T
Inclusion visit (D0): verification of inclusion and non-inclusion criteria information and collection of consent standard imaging protocol prescribed as part of the usual treatment: sagittal T1 and T2 slices after injection of…
- Trial name
- ESPOIR1-5 (NCT04707144)
- Testing
- MRI 1.5 tesla
- Where
- 6 sites in France
- Volunteers
- 106 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Multiple Sclerosis
Correlation Between Cognitive Functions and MRI in Multiple Sclerosis
The purpose of this study is to determine whether there is a correlation between cognitive functions and volume of specific brain area measured in MRI of multiple sclerosis patients.
- Trial name
- NCT00423111
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Multiple Sclerosis
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Intravenous Immune Globulin for Multiple Sclerosis
OBJECTIVES: I. Determine whether high-dose intravenous immune globulin (IVIG) is more effective than placebo in restoring neurologic function (muscle strength) in patients with multiple sclerosis. II.
- Trial name
- NCT00004744
- Testing
- immune globulin
- Volunteers
- 76 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Sclerosis
Intensity Depended Impacts on Cognitive Functions in Persons With Multiple Sclerosis - a Pilot Study
Multiple Sclerosis (MS) is a chronic autoimmune disease where lymphocytes inflict damage to the axons and myelin sheaths of the central nervous system.
- Trial name
- NCT02408367
- Testing
- Exercise, Relaxation
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Jens Bansi
Multiple Sclerosis
Neuromodulation in MS Using Translingual Stimulation
The overarching aim of this study is to examine if there is additional benefit to adding trans-lingual electrical stimulation to physiotherapy aimed at improving walking and balance in people with multiple sclerosis (MS).
- Trial name
- NeuroMSTraLS (NCT05275049)
- Testing
- PT plus translingual stimulation device, PT plus translingual stimulation control device
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- University of Saskatchewan
Relapsing Multiple Sclerosis (RMS)
Study to Assess the Efficacy and Safety of Ublituximab in Participants With Relapsing Forms of Multiple Sclerosis (RMS)
This study determines the Annualized Relapse Rate (ARR) in participants with RMS after 96 weeks (approximately 2 years) treatment with intravenous (IV) infusion of ublituximab/oral placebo compared to 14 mg oral teriflunomide/IV…
- Trial name
- ULTIMATE II (NCT03277248)
- Testing
- Ublituximab, Teriflunomide
- Where
- 13 sites in United States
- Volunteers
- 545 people
- Sponsor
- TG Therapeutics, Inc.
Multiple Sclerosis
Detection of Pattern of Some Unusual Signs and Symptoms of Multiple Sclerosis
Each Multiple Sclerosis patient will be submitted to Cognitive Abilities Screening Instrument (CASI), Expanded Disability Status Scale, Epowrth Sleeping Scale(ESS),Fatigue Severity Scale(FSS), Hamilton Depression Rating Scale…
- Trial name
- NCT04100343
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Multiple Sclerosis
Study to Assess OCT: RNFL and GCL in MS Patients
The purpose of this study is to collect preliminary data on retinal nerve fiber layer and ganglion cell layer damage in multiple sclerosis (MS) patients, using optical coherence tomography (OCT).
- Trial name
- NCT03313843
- Where
- 2 sites in United States
- Volunteers
- 73 people
- Sponsor
- Tampa Bay Uveitis Center, LLC
Multiple Sclerosis
National Multicenter, Controlled, Single-blind Study With Two Parallel Groups Evaluating the Safety and Efficacy of Sequential Treatment With Mitoxantrone and Interferon Versus Interferon Alone in Patients With Strong Risk of Progression in the Initial Phase of Multiple Sclerosis
The relative effectiveness of current treatments and their different mechanisms of action yield to consider more and more that the multiple sclerosis (MS) therapeutic approach must use multiple molecules, both combined and…
- Trial name
- MITOX-REBIF (NCT02937285)
- Testing
- Interferon beta 1a, Mitoxantrone
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Rennes University Hospital
Primary Progressive Multiple Sclerosis
This Was an Open-label, Single-arm Extension Study (CFTY720D2306E1) to a Double-blind, Randomized Multicenter, Placebo-controlled, Parallel-group Core Study (CFTY720D2306) in PPMS.
The purpose of this study is to evaluate whether FTY720 is effective in delaying MS disability progression compared to placebo in patients with PPMS.
- Trial name
- INFORMS (NCT00731692)
- Testing
- FTY720
- Where
- 157 sites in United States, Australia and 16 more
- Volunteers
- 970 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis, Respiratory; Disorder, Functional, Impaired
Respiratory Function and Walking Capacity in Multiple Sclerosis
Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory dysfunction due to weakness in the respiratory musculature has been described in MS.
- Conditions
- Multiple Sclerosis, Respiratory; Disorder, Functional, Impaired, Difficulty Walking
- Trial name
- NCT01774201
- Testing
- Breathing exercises
- Volunteers
- 50 people
- Sponsor
- Region Örebro County
Multiple Sclerosis
MS-Related Disability Worsening and Thalamic Volume Loss
PENTAGON is an observational, non-interventional, multicenter, prospective cohort study conducted at approximately 20 neurology centers and affiliated radiology centers across Germany.
- Trial name
- PENTAGON (NCT07753928)
- Testing
- Disease-Modifying Therapies (DMTs)
- Where
- 2 sites in Germany
- Volunteers
- 2,400 people
- Sponsor
- Jung Diagnostics GmbH
Crohn's Disease, Prenatal Exposure
Pregnancy Exposure Registry for Tysabri®
The primary objective of the Registry was to evaluate the outcomes of pregnancy in women with Multiple Sclerosis (MS) or Crohn's Disease (CD) who were exposed to TYSABRI® at any time within 90 days prior to first day of Last…
- Conditions
- Crohn's Disease, Prenatal Exposure, Multiple Sclerosis, Pregnancy
- Trial name
- NCT00472992
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Biogen
Multiple Sclerosis
A Study to Evaluate the Efficacy, Safety and Pharmacokinetics (PK) of a Higher Dose of Ocrelizumab in Adults With Relapsing Multiple Sclerosis (RMS)
This is a randomized, double-blind, controlled, parallel group, multicenter study to evaluate efficacy, safety and PK of a higher dose of ocrelizumab per intravenous (IV) infusion every 24 weeks (Q24W) in participants with RMS…
- Trial name
- MUSETTE (NCT04544436)
- Testing
- Ocrelizumab, Antihistamine, Methylprednisolone
- Where
- 120 sites in United States, Argentina and 19 more
- Volunteers
- 864 people
- Sponsor
- Hoffmann-La Roche
Clinically Isolated Syndrome, Multiple Sclerosis
Tear Analysis by Isoelectric Focusing in Clinically Isolated Syndrome as Multiple Sclerosis Criterion
This is a multicentric and prospective study for the validation of a diagnostic method in multiple sclerosis. Our hypothesis is that there is a characteristic profile of tears that can be recognized in order to help in the…
- Trial name
- POLAR (NCT02043964)
- Testing
- tears and cerebrospinal fluid sampling
- Where
- 15 sites in France
- Volunteers
- 165 people
- Sponsor
- Lille Catholic University
Multiple Sclerosis
An Extension Clinical Study of the Efficacy and Safety of BCD-132 in Patients With Multiple Sclerosis Who Previously Received Therapy in Clinical Studies of JSC BIOCAD
The aim of this clinical study is to assess the long-term efficacy and safety of BCD-132 (divozilimab) in patients with multiple sclerosis who previously participaded in BCD-132-2 and BCD-132-4/MIRANTIBUS studies
- Trial name
- NCT06987851
- Testing
- Divozilimab
- Where
- 15 sites in Russia
- Volunteers
- 44 people
- Sponsor
- Biocad
Hemiplegia, Spasticity
Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing With Shoulder Pain and Functional Problems Caused by Spasticity and Motor Impairment
This trial is part of the spastiCRYO clinical research project. The primary objective of this clinical trial is to test the hypothesis: "Upper limb nerve cryoneurolysis is non inferior to the usual care and has therapeutic add…
- Conditions
- Hemiplegia, Spasticity, Shoulder Spasticity, Shoulder Stiffness
- Trial name
- spastiCRYO-UL (NCT06782464)
- Testing
- Treatment
- Where
- Luxembourg
- Volunteers
- 50 people
- Sponsor
- Centre National de Rééducation Fonctionnelle et de Réadaptation
Multiple Sclerosis, Progressive Multiple Sclerosis
Comparing Tolerability and Absorption of Racemic and R-lipoic Acid in Progressive Multiple Sclerosis
This is a three-week crossover study that will compare how the body absorbs and tolerates two different forms of lipoic acid: R form and racemic form.
- Conditions
- Multiple Sclerosis, Progressive Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
- Trial name
- NCT03493841
- Testing
- Alpha Lipoic Acid
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rebecca Spain
Multiple Sclerosis, Diet, Healthy
Time Restricted Eating Outcomes in Multiple Sclerosis
The purpose of this pilot study is to determine the preliminary efficacy, safety, and acceptability of time restricted feeding (TRF) among a sample of 12 adults with Relapsing-Remitting Multiple Sclerosis (RRMS).
- Trial name
- TREO_MS (NCT04389970)
- Testing
- Time Restricted Feeding
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Alabama at Birmingham
Multiple Sclerosis
Pharmacodynamic Study to Better Understand the Therapeutic Response and Immunomodulatory Effects of Avonex in Multiple Sclerosis (MS) Patients and Healthy Volunteers
This study will look at differences in bioanalytical measures among different groups of MS patients and Healthy Volunteers, when administered interferon beta-1a.
- Trial name
- NCT00913666
- Testing
- Interferon beta-1a (Avonex)
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Biogen