Clinical trials: Distal Femoral
Distal Femur Fracture
DIFFIR - Geriatric Distal Femur Fixation Versus Replacement
The current standard of care for most intra-articular distal femur fractures (above the knee joint) in geriatric patients is a surgical fixation using plates and screws to hold the fracture pieces in the correct position, until…
- Trial name
- DIFFIR (NCT04076735)
- Testing
- Distal femoral replacement, Surgical Fixation (ORIF)
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Unity Health Toronto
Distal Femoral Musculoskeletal Tumors, Megaprosthesis
Analysis of Spatiotemporal Gait Parameters in Patients With Megaprosthesis.
The main objective of the study is to evaluate spatiotemporal parameters of gait in tumoral patients with megaprosthesis of the distal femur.
- Trial name
- MP-GP (NCT05202873)
- Testing
- Gait analysis
- Where
- Spain
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Femoral Fractures
Plate Fixation of Distal Femur Fractures: A Protocol for a Study of Two Plate Options
Internal fixation of femur fractures improves alignment and provides stability to the bone and the surrounding soft tissues. This generally allows for early motion of the adjacent joints; thus maximizing overall function of the…
- Trial name
- NCT00644397
- Testing
- 95-degree Angled Blade Plate, 4.5mm Condylar Locking Plate
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- MetroHealth Medical Center
Distal Femur Fracture
Locking Plates for Distal Femur Fractures - a Multicenter Case Review
In order to assess the rate and mode of failure cases observed in patients with distal femur fractures treated with a distal femur plates, anonymized radiographs from those patients will be collected retrospectively.
- Trial name
- VA_LCP (NCT04008940)
- Testing
- Distal femur plates
- Where
- 5 sites in United States, Switzerland
- Volunteers
- 100 people
- Sponsor
- AO Innovation Translation Center
Pain After Total Knee Arthroplasty, Pain Management
Combined Distal Femoral Nerve Block for Pain Control After Knee Replacement
The goal of this clinical trial is to see whether a combined distal femoral nerve block improves pain relief after total knee replacement in adults having planned surgery.
- Trial name
- FEM-COMB (NCT07629388)
- Testing
- Combined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
- Where
- France
- Volunteers
- 240 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Osteotomy of Lower Extremity
PediLoc® Blade Plate in Distal Femoral Osteotomies
Background: The PediLoc® Locking Cannulated Blade Plate System, originally designed for proximal femoral osteotomies, has also been used for multidimensional deformity correction of the distal femur.
- Trial name
- NCT06950047
- Testing
- distal femoral osteotomies using the PediLoc® Locking Cannulated Blade Plate System, distal femoral osteotomies using the 90°LCP-PCP
- Where
- Switzerland
- Volunteers
- 111 people
- Sponsor
- University Children's Hospital, Zurich
ST Elevation Myocardial Infarction
Comparison of Vascular Access in STEMI
Distal radial access (DRA) has recently introduced and previous studies have demonstrated that it is feasible option, showing several advantages including less bleeding and access-site complications over proximal radial access…
- Trial name
- NCT04941638
- Testing
- Distal radial access
- Where
- South Korea
- Volunteers
- 109 people
- Sponsor
- Yonsei University
Humerus Fracture, Femur Fracture
Evaluation of Handling and Possible Complications Related to the Newly Developed Angular Stable Locking System (ASLS)
In many cases, the existing locking bolts and screws in intramedullary nails do not provide sufficient stability. Due to the play between screw and nail, the reduction can be lost and the instability can result in malunions…
- Conditions
- Humerus Fracture, Femur Fracture, Tibia Fracture
- Trial name
- ASLS-Pre (NCT00793637)
- Where
- 4 sites in Austria, Germany
- Volunteers
- 30 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Hip Fractures, Femoral Shaft Fractures
Trial of a Distal Targeting System for Cephalomedullary Nails as Part of Surgical Repair of Hip and Femoral Shaft Fractures
This study will be a prospective, case - control trial looking at the use of a previously FDA approved device made by Stryker, a distal targeting system that eases the distal targeting of screws in cephalomedullary nails in hip…
- Trial name
- NCT03943329
- Testing
- Standard of Care, Distal targeting device technique of distal screw placement
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Distal Femur Fractures
Single vs. Dual Implant Fixation for Distal Femur Fractures in Older or Compromised Adults
The goal of this clinical trial is to assess the feasibility of conducting a larger study comparing single implant fixation (SIF) and dual implant fixation (DIF) for treating distal femur fractures (DFF) in older or compromised…
- Trial name
- NCT06944964
- Testing
- Single Implant Fixation (SIF), Dual Implant Fixation (DIF)
- Where
- 2 sites in Canada
- Volunteers
- 44 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Traumatic; Lesion, Degenerative Lesion of Articular Cartilage of Knee
Randomized Evaluation of BST-CarGel Versus Microfracture Alone On Recovery From Distal Femoral Cartilage Lesions
This multi-centre randomized, controlled trial will assess the impact of BST-CarGel scaffold with microfracture versus microfracture alone on short and long term clinical benefit in patients with cartilage lesions of the femoral…
- Trial name
- RECORD (NCT02981355)
- Testing
- Microfracture treatment, BST-CarGel
- Where
- 15 sites in Australia, Canada and 5 more
- Volunteers
- 5 people
- Sponsor
- Piramal Healthcare Canada Ltd
Infected Distal Femoral Fractures, Knee Stiffness
Preventing Knee Stiffness in Infected Distal Femoral Fractures in Children
The goal of this observational study is to prevent keen stiffness health in in Infected Distal Femoral Fractures in Children. This prospective study aimed to compare the effects of early patellar traction versus no patellar…
- Trial name
- ABCCI (NCT07864441)
- Testing
- Patellar Traction
- Volunteers
- 101 people
- Sponsor
- The Second Hospital of Qinhuangdao
Femoral Neck Fractures, Intertrochanteric Fractures
Opioid-Free Pain Treatment in Trauma Patients
Analgesic drug study that will compare pain outcomes of opioid analgesia and opioid-free analgesia in post-operative orthopedic patients.
- Conditions
- Femoral Neck Fractures, Intertrochanteric Fractures, Femoral Shaft Fracture, Distal Femur Fracture
- Trial name
- NCT06078371
- Testing
- Opioid-free pain treatment
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Kansas Medical Center
Articular Fractures
Single Versus Dual Implant Fixation of Distal Femur Fractures
The goal of this clinical trial is to compare two types of surgical fixation in patients with specific kinds of distal femur fractures.
- Trial name
- PRORP (NCT06286670)
- Testing
- Single Implant Fixation, Dual Implant Fixation
- Where
- 16 sites in United States
- Volunteers
- 144 people
- Sponsor
- Wake Forest University Health Sciences
Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture
Observational Patient Registry of the Dynamic Locking Screws
The purpose of this multi-center patient registry is to obtain first clinical results and to assess short and mid-term clinical outcome data of patients treated with DLS.
- Conditions
- Proximal or Diaphyseal Humerus Fracture, Diaphyseal or Distal Femur Fracture, Diaphyseal, Distal or Proximal Tibia Fracture
- Trial name
- DLS (NCT02656628)
- Testing
- Dynamic Locking Screw 3.7mm and 5.0mm
- Where
- Australia
- Sponsor
- Synthes GmbH
Femur Distal Fracture, Nonunion of Fracture
Distal Femur Fracture Nonunion - Statistical Analysis Plan
Here the investigators describe the statistical analysis plan for the study assessing the prediction of fracture nonunion leading to secondary surgery in patients with distal femur fractures.
- Trial name
- NCT05163795
- Testing
- Lateral locking plate
- Where
- Finland
- Volunteers
- 299 people
- Sponsor
- Töölö Hospital
Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee
pDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement
Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of…
- Conditions
- Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture
- Trial name
- pDIFFIR (NCT05805774)
- Testing
- Distal Femur Replacement, Surgical fixation
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Unity Health Toronto
Distal Femoral, Proximal Tibial
Subchondral Perfusion Mapping Using Indocyanin Green Laser
Laser Angiography using indocyanin green (ICG) is a relatively new technique and has been utilized to assess the viability of soft tissue, most prominently in the general surgery and plastic surgery literature.
- Conditions
- Distal Femoral, Proximal Tibial, Knee Surgery
- Trial name
- ICG (NCT02918383)
- Testing
- Indocyanin Green Dye (ICG)
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Cancer of the Bone, Limb Salvage
Tranexamic Acid Use to Reduce Blood Transfusion in Pediatric Cancer Patients Undergoing Limb Salvage Procedure
This is a randomized double-blind control trial evaluating the use Tranexamic acid (TXA) to decrease blood loss and transfusion requirements in pediatric and young adult cancer patients undergoing a limb salvage procedure that…
- Trial name
- NCT04410042
- Testing
- Tranexamic Acid, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- St. Jude Children's Research Hospital
Distal Femur Fractures
Early Weight Bearing on Supracondylar Distal Femur Fractures in Elderly Patients
The investigators will be looking at geriatric distal femur fractures. The investigators will prospectively enroll these patients and allow patients to either weight bear as tolerated or limit their weight bearing post…
- Trial name
- NCT02475941
- Testing
- Non Weight bearing, Early Weight Bearing
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- St. Louis University