Clinical trials: Distal Pancreatectomy
Pancreatic Fistula
Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy
To date, there has been many methods suggested to reduce pancreatic fistula. But there are no evidence of superiority to the other methods.
- Trial name
- NCT01550406
- Testing
- Tachocomb, Polyglycolic acid (PGA) (Neoveil)
- Where
- 5 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- Seoul National University Hospital
Cancer of Pancreas
Effects of Epidural Block on the Prognosis in Patients With Pancreatic Cancer Undergoing Distal Pancreatectomy
The purpose of this randomized controlled clinical trial is to investigate the effects of epidural block on overall survival，disease-free survival and recovery in patients with pancreatic cancer undergoing distal pancreatectomy.
- Trial name
- NCT03659292
- Testing
- GEA, PCEA, GA
- Where
- 3 sites in China
- Volunteers
- 540 people
- Sponsor
- Fudan University
Pancreatectomy, Pancreatic Fistula
Preoperative Endoscopic Pancreatic Stent for Distal Pancreatectomy
Distal pancreatectomy (DP) with or without splenectomy is commonly indicated for pancreatic body or tail lesions. Postoperative pancreatic fistula (POPF) remains the commonest complication after DP.
- Trial name
- NCT05297136
- Testing
- Pancreatic Stenting, No Stent
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Chinese University of Hong Kong
Chronic Pancreatitis, Distal Pancreatectomy
A Phase IIa Study With Escalating Dose of MS1819-SD
This is a Phase IIa study sponsored by AzurRx SAS and Syneos Health is a local representative sponsor and involves testing of a new medication for the compensation of exocrine pancreatic insufficiency (EPI) caused by chronic…
- Trial name
- NCT03481803
- Testing
- MS1819-SD
- Where
- 6 sites in Australia, France and 1 more
- Volunteers
- 11 people
- Sponsor
- AzurRx SAS
Pancreatic Fistula, Distal Pancreatectomy Complications
An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancreas Following Removal of the Tail of the Pancreas
The purpose of this trial is to determine whether the use of an autologous falciform ligament patch combined with fibrin glue will reduce the rate of pancreatic fistula in patients completing distal pancreatectomy.
- Conditions
- Pancreatic Fistula, Distal Pancreatectomy Complications, Falciform Patch Pancreatic Closure, Fibrin Glue Pancreatic Closure
- Trial name
- NCT00889213
- Testing
- Falciform patch and fibrin glue application, standard pancreatic closure
- Where
- 2 sites in United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Pancreatectomy
Laparoscopic Versus Open Pancreatectomy
The study will randomized patients to either open or laparoscopic pancreatic surgery. The primary purpose of the study is to determine whether laparoscopic distal pancreatectomy is associated with improved outcomes compared to…
- Trial name
- NCT00988793
- Testing
- Laparoscopic distal pancreatectomy, Open distal pancreatectomy
- Where
- United States
- Sponsor
- Indiana University
Distal Pancreatectomy, Spleen Preservation
Comparison of Outcomes Between Warshaw and Kimura Techniques for Spleen-preserving Minimally Invasive Distal Pancreatectomy
Spleen-persevering distal pancreatectomy (SP-DP) has been widely advocated as a routine procedure for benign or low-grade malignant tumors in the pancreatic body and tail, especially with a minimally invasive approach.
- Conditions
- Distal Pancreatectomy, Spleen Preservation, Postpancreatectomy Hemorrhage
- Trial name
- NCT06084975
- Testing
- Splenic vessels preservation
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Zhejiang University
Pancreas Neoplasm, Stump
Routine Staple Line Reinforcement for Minimally Invasive Distal Pancreatectomy
Postoperative fistula is the major complications of distal pancreatectomies which prohibit patients' recovery. Previous studies have reported controversial results regarding the efficacy of pancreatic stump reinforcement methods.
- Conditions
- Pancreas Neoplasm, Stump, Surgery--Complications
- Trial name
- Double-Lock (NCT04663789)
- Testing
- reinforcement of the staple line, staple only
- Where
- China
- Volunteers
- 124 people
- Sponsor
- Peking Union Medical College Hospital
Serum Uric Acid
Whether Control of Serum Uric Acid (SUA) Improves Survival After Pancreatic Cancer
This retrospective study aims to analyze the impact of postoperative changes in serum uric acid (SUA) levels on the prognosis of patients undergoing pancreatic cancer resection.
- Trial name
- NCT07091526
- Testing
- serum uric acid test
- Where
- China
- Volunteers
- 168 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Pancreatectomy, Fluid Therapy
Comparison of Fluid Requirements in Pancreatectomy: Laparotomy vs. Laparoscopy
In this retrospective cohort study, the investigators reviewed and analyzed the electronic medical records of consecutive patients who underwent distal pancreatectomy either via laparotomy or laparoscopy.
- Conditions
- Pancreatectomy, Fluid Therapy, Laparoscopy
- Trial name
- NCT03060408
- Volunteers
- 304 people
- Sponsor
- Seoul National University Bundang Hospital
Pancreatoduodenectomy, Periampullary Carcinoma
Application of "Heidelberg Triangle" Dissection in Pancreatoduodenectomy and Distal Pancreatectomy
Aim of the study : To evaluate the effect and safety of "Heidelberg Triangle" dissection (TRIANGLE operation) combined with Pancreatoduodenectomy or Distal Pancreatectomy on the prognosis of pancreatic cancer and periampullary…
- Conditions
- Pancreatoduodenectomy, Periampullary Carcinoma, Pancreatic Cancer
- Trial name
- NCT05703581
- Testing
- TRIANGLE operation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Fudan University
Pancreatic Fistula
A Prospective Randomized Trial of Efficacy of Stump Closure for Distal Pancreatectomy
Overall morbidity rate remained high after distal pancreatectomy (DP), ranging from 30% to 60%. Whilst postoperative pancreatic fistula (POPF) remains serious and also is one of the most common complications after DP (12% to…
- Trial name
- NCT03201653
- Testing
- Stump closure using NU-KNIT SURGICEL
- Where
- Taiwan
- Volunteers
- 84 people
- Sponsor
- National Taiwan University Hospital
Pancreaticoduodenectomy, Distal Pancreatectomy
The Novel Modified Cattell-Warren Duct-To-Mucosa Pancreaticojejunostomy Technique Significantly Reduces POPF.
Pancreatic surgeries, such as pancreaticoduodenectomy and distal pancreatectomy, are associated with high morbidity and mortality. The most common cause of this morbidity is postoperative pancreatic fistula(POPF).
- Conditions
- Pancreaticoduodenectomy, Distal Pancreatectomy, Postoperative Pancreatic Fistula
- Trial name
- POPF (NCT07038161)
- Testing
- Modified Cattell-Warren duct-to-mucosa pancreaticojejunostomy, Institutional Prehabilitation Protocol
- Where
- Nepal
- Volunteers
- 27 people
- Sponsor
- Nepal Medical College and Teaching Hospital
Distal Pancreatectomy, Postoperative Pancreatic Fistula
Intrapapillary Botulinum Toxin Injection for PREvention of Post-surgical PAncREactic Fistula
Surgery is required for the treatment of many pancreatic conditions, either malignant or benign. Mortality of pancreatic surgery can be up to 3% even in expert centers.
- Trial name
- PREPARE (NCT04220931)
- Testing
- botulinum toxin injection
- Where
- France
- Volunteers
- 460 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pancreatic Fistula, Pancreatectomy
Distal Pancreatectomy Pancreatic Fistula Risk Prediction Model Validation Study
Distal pancreas resection is a relatively rare procedure with a known risk of postoperative pancreatic fistula. Until quite recently, no valid risk prediction models for this have been available.
- Trial name
- DPFValid (NCT05737875)
- Where
- United Kingdom
- Volunteers
- 2,284 people
- Sponsor
- University of Edinburgh
Diabetes Mellitus
Risk Factors for the Development of Diabetes Mellitus After Distal Pancreatectomy
Glucose homeostasis changes after distal pancreatectomy are not well understood. This study aim to identify the incidence of and risk factors for, a change in glucose homeostasis in patients who underwent distal pancreatic…
- Trial name
- NCT03030209
- Testing
- Distal pancreatectomy
- Where
- China
- Volunteers
- 485 people
- Sponsor
- Peking Union Medical College Hospital
Surgery
A Cost Effectiveness Analysis of Robotic Versus Laparoscopic Distal Pancreatectomy
This is a clinical and cost-effectiveness analysis within a retrospective comparative study of RDP and LDP conducted at Sanchinarro University Hospital from 2011 to 2017.
- Trial name
- NCT03989739
- Testing
- Da Vinci
- Volunteers
- 59 people
- Sponsor
- Fundación de investigación HM
Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor
Comparison of Kimura Versus Warshaw Technique for Laparoscopic Spleen-Preserving Distal Pancreatectomy
This study aims to compare the surgical outcomes of laparoscopic spleen-preserving distal pancreatectomy using the Kimura technique versus the Warshaw technique.
- Conditions
- Pancreatic Tumor, Benign, Pancreatic Neuroendocrine Tumor, Solid Pseudopapillary Tumor of the Pancreas
- Trial name
- NCT06167421
- Testing
- Laparoscopic spleen-preserving distal pancreatectomy using the Kimura technique, Laparoscopic spleen-preserving distal pancreatectomy using the Warshaw technique
- Volunteers
- 240 people
- Sponsor
- Fudan University
Pancreatectomy
Attachable Coolingbis® for Distal Pancreatectomy
This pilot study evaluates the safety and technical feasibility of a new radiofrequency-assisted device, the Attachable Coolingbis® (ACB), when used during robotic distal pancreatectomy.
- Trial name
- NCT07687901
- Testing
- Internally-cooled bipolar radiofrequency device
- Volunteers
- 20 people
- Sponsor
- Hospital del Mar
Pancreatic Cancer
Randomized Trial of Restrictive Versus Liberal Perioperative Fluid Management for Patients Undergoing Pancreatic Resection
The purpose of this study is to help us learn what the best amount of fluid is that patients should receive during pancreas surgery.
- Trial name
- NCT01058746
- Testing
- restrictive perioperative fluid management, Liberal perioperative fluid management
- Where
- United States
- Volunteers
- 331 people
- Sponsor
- Memorial Sloan Kettering Cancer Center