Clinical trials: Distension; Bowel
Colorectal Neoplasms
Gluteal Squeeze for Left Colon Distension
Good distension of the colon during colonoscopy is essential to detect polyps. Gas sometimes escapes the colon through the anus resulting in compromised distension.
- Trial name
- NCT04827485
- Testing
- Gluteal squeeze, No squeeze
- Where
- 2 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Indiana University
Chronic Ischemic-Hypoxic Enteropathy
Gut Oxygen Therapy for Ischemic-Hypoxic Bowel Disease
This single-center, double-blind, randomized, intra-individual crossover controlled study aims to investigate the efficacy and safety of intestinal oxygen therapy via a deep intestinal catheter as a targeted route for intestinal…
- Trial name
- NCT07621367
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Hospital of Nanjing Medical University
Nausea and Vomitting, Distension; Bowel
Reiki After Bariatric Surgery
The aim of this clinical trial was to determine whether Reiki administered to patients after bariatric surgery reduced abdominal distension, nausea and vomiting, and pain severity, and improved their comfort levels.
- Conditions
- Nausea and Vomitting, Distension; Bowel, Pain, Comfort
- Trial name
- NCT07887035
- Testing
- reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- TC Erciyes University
Crohn Disease
Endoscopic Balloon Dilatation Combined With PRP Injection in Colonic Stenosis in Crohn's Disease
The aim was to investigate whether endoscopic balloon dilatation combined with PRP injection can help prevent or prolong restenosis in patients with Crohn's disease with colonic stenosis, and to explore the concentration of PRP.
- Trial name
- NCT06165289
- Testing
- PRP Injection
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Ulcerative Colitis, Irritable Bowel Syndrome
Cerebral Resonance Magnetic Imaging During Rectal Distention
Irritable bowel syndrome is responsible for chronic abdominal pain, diarrhea and/or constipation. It is a very frequent problem. However, the exact cause of irritable bowel syndrome remains unknown.
- Trial name
- NCT00213330
- Testing
- rectal distension
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Crohn Disease
Endoscopic Balloon Dilation Versus Endoscopic Stricturotomy for Short Crohn's Strictures
Crohn's disease (CD) related strictures can be treated endoscopically by endoscopic balloon dilation (EBD) or endoscopic stricturotomy (EST). EBD is is the established endoscopic treatment for short strictures in Crohn's disease.
- Trial name
- BEST-CD (NCT05521867)
- Testing
- Endoscopic balloon dilation, Endoscopic stricturotomy with or without stricturoplasty
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Asian Institute of Gastroenterology, India
Irritable Bowel Syndrome, Dyspepsia
Treatment of Functional Abdominal Distension
Background. Abdominal distention is produced by an abnormal somatic postural tone. We developed an original biofeedback technique based on electromyography-guided control of abdominothoracic muscular activity.
- Trial name
- NCT04043208
- Testing
- Biofeedback
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Crohn Disease
Prospective Multicenter Randomized Comparative Study of the Treatment of de Novo Stenosis in Chron's Disease.
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome (1-3).
- Trial name
- ENDOCIR (NCT04330846)
- Testing
- Surgical resection
- Where
- 16 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Crohn Disease (CD)
Hybrid Endoscopic Stricturotomy Plus Balloon Dilation Versus Stricturotomy Alone for Short Crohn's Disease Strictures
Crohn's disease is a chronic condition that can lead to inflammation and narrowing (strictures) of the intestine, causing symptoms like pain, bloating, and difficulty with bowel movements.
- Trial name
- HEIST (NCT06958159)
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Irritable Bowel Syndrome
The Effects of Added Enzyme α-Galactosidase at a Carbohydrate-rich Meal in Irritable Bowel Syndrome (IBS)
IBS (irritable bowel syndrome) is a functional gastrointestinal disorder which is characterized by recurrent pain and/or discomfort, altered stool form, and abdominal distension.
- Trial name
- NCT01483287
- Testing
- Alpha-Galactosidase
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Women With IBS-C
A Single-centre, Randomised, Double-blind, Controlled, Parallel-group Study to Evaluate the Effect of a Fermented Dairy Product on Abdominal Distension, Digestive Symptoms and Rectal Sensitivity in Patients With Irritable Bowel Syndrome With Constipation (IBS-C)
The purpose of this study is to evaluate the effect of a commercially available fermented dairy product containing probiotics (4 weeks, twice a day) on abdominal distension in IBS patients with constipation (IBS-C).
- Trial name
- NCT01097993
- Testing
- 1-fermented dairy product, 2- milk-based non-fermented dairy product (control product)
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Danone Global Research & Innovation Center
Irritable Bowel Syndrome
Pain Relief In Irritable Bowel Syndrome
The purpose of this study is to determine whether Proklama is effective in significative reduction of pain, other symptoms IBS's related, and improves quality of life concerning IBS disease.
- Trial name
- PRITON (NCT02573844)
- Testing
- Proklama
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Geophyt S.r.l.s.
Pain, Cancer
Study on Analgesia of GIC-1001 & GIC-1002 on Visceral Pain, Rectal Sensory Threshold Using the Barostat Method
This study evaluates colonic analgesia by comparing two novel formulations, GIC-1001 and GIC-1002 with placebo using a barostat distender.
- Conditions
- Pain, Cancer, Colonic Disease
- Trial name
- NCT02276768
- Testing
- GIC-1001 375 mg TID, GIC-1001 500 mg TID, GIC-1002 345 mg TID (equimolar to GIC-1001 375 mg TID)
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- gicare Pharma Inc.
Small Intestine Bacterial Overgrowth
Study of Clinical Features and Efficacy of Small Intestinal Bacterial Overgrowth in Patients With Abdominal Distension
Most studies of bloating have focused on functional factors, while data on organic abdominal distention are rare, and studies that combine small intestine bacterial overgrowth and/or oral cecum transit time abnormalities are more…
- Trial name
- NCT06518850
- Testing
- Rifaximin
- Volunteers
- 30 people
- Sponsor
- Peking Union Medical College Hospital
Crohn Disease, Stenosis
Long-term Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
Stenosis is one of the most frequent complications in patients with Crohn's disease (CD), causing greater morbidity and increasing the probability of repeated surgery and short bowel syndrome.
- Trial name
- Long-ProtDilat (NCT06036680)
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital Mutua de Terrassa
Anorectal Disorder
The Guarding Reflex Anal, Study of the Modulation Function of Rectal Distension
The term Guarding Reflex refers to a progressive, involuntary increase in the external urethral sphincter activity during bladder filling.This is a mechanism of continence, preventing from unwanted urine leakage in situation of…
- Trial name
- NCT04409054
- Testing
- Cough and Valsalva effort
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Gérard Amarenco
Pain, Colorectal Adenomas
Comparison of Methods to Distend the Colon During Insertion: CO2, Air Insufflation, Water-aided Colonoscopy
Insufflation of the colon, usually with room air, is necessary to distend the lumen for exploration. Carbon dioxide (CO2) insufflation instead of room air insufflation (AI) has been shown to decrease symptoms of abdominal pain or…
- Conditions
- Pain, Colorectal Adenomas, Colorectal Cancer
- Trial name
- NCT01954862
- Testing
- Air Insufflation method., CO2 insufflation, Water Immersion/CO2
- Where
- 3 sites in United States, Czechia and 1 more
- Volunteers
- 624 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Crohn Disease (CD)
WAter Preparation in Crohn's Disease's Imagery
The goal of this clinical trial is to compare distension quality and patient experience of water and polyethylene glycol preparation as oral contrast media in Magnetic Resonance Enterography (MRE) in patients with Crohn's…
- Trial name
- WAM (NCT06690632)
- Testing
- water preparation, polyethylene glycol preparation
- Where
- France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Toulouse