Clinical trials: Distension
Keratoconus, Ectasia Corneal
Comparison of Standard vs. Accelerated Corneal Crosslinking
The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.
- Trial name
- NCT03922542
- Testing
- riboflavin 0.1%
- Where
- United States
- Volunteers
- 508 people
- Sponsor
- Price Vision Group
Mydriasis
Evaluation of Pupil Dilation Speed With the MAP Dispenser
1 mist or 2 mists of the study drug will be administered to both eyes according to a pre-specified randomization plan to determine the effect on pupil dilation
- Trial name
- SPEED (NCT04907474)
- Testing
- tropicamide-phenylephrine fixed combination ophthalmic solution
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Benign Prostatic Hyperplasia, Benign Prostatic Hypertrophy
Optilume™ BPH Prostatic Drug Coated Balloon Dilation Catheter
A prospective, non-randomized study. The subjects will be enrolled and treated with the Optilume BPH Prostatic DCB Dilation Catheter System at up to 8 clinical sites. The post-treatment follow-up visit can be up to 5 years.
- Trial name
- EVEREST-I (NCT03423979)
- Testing
- Optilume™ BPH Prostatic DCB Dilation Catheter, Paclitaxel
- Where
- 5 sites in Dominican Republic, Panama
- Volunteers
- 80 people
- Sponsor
- Urotronic Inc.
Refractory Anastomotic Esophageal Strictures
WallFlex Esophageal Fully Covered (FC) Benign Anastomotic Stricture
The purpose of this of this study is to compare the safety and effectiveness of temporary indwell of the WallFlex Esophageal FC Metal Stent to Bougie Dilation for the treatment of refractory anastomotic esophageal strictures
- Trial name
- E7025 (NCT01699542)
- Testing
- WallFlex Esophageal RX Fully Covered Stent, Esophageal Bougie Dilator Per Investigator preference
- Where
- 4 sites in Brazil, Netherlands and 1 more
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Coronary Artery Disease
Safety and Efficacy of Spinous Balloon Dilatation Catheter in CAD Treatment
The purpose of this study is to evaluate the safety and effectiveness of spinous process balloon dilation catheter (Plastic-Blade) in coronary vascular diseases, which is not inferior to the similar product on the market …
- Trial name
- NCT05342961
- Testing
- spinous balloon dilatation catheter (Plastic-Blade), spinous balloon dilatation catheter(lacrosse NSE)
- Volunteers
- 160 people
- Sponsor
- CCRF Inc., Beijing, China
Coronary Artery Disease
Wedge NC - Scoring Balloon Dilatation Catheter
To evaluate the efficacy and safety of Wedge NC Scoring Balloon Dilatation Catheter for dilating coronary stenosis during PCI in comparison with a similar product on the market.
- Trial name
- NCT06214247
- Testing
- Wedge NC Scoring Balloon Dilatation Catheter, Scoreflex Scoring Balloon Dilatation Catheter
- Where
- 11 sites in China
- Volunteers
- 198 people
- Sponsor
- BrosMed Medical Co., Ltd
Keratoconus, Ectasia
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01189864
- Testing
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 16 sites in United States
- Volunteers
- 3,493 people
- Sponsor
- Cxlusa
Healthy
Efficacy of Dietary Supplement in Subjects With Acid Reflux and/or Abdominal Bloating/Distention and GI Symptoms
This study was a prospective randomized clinical study. There was interventional treatment for a total of 8 weeks including a 2-week washout period.
- Trial name
- NCT06808867
- Testing
- Dietary Supplement with Active Ingredient Blend
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Olly, PBC
Physiologic Venous Dilation, Air Travel
Randomized Assessor-Masked Trial of Moderate Graduated Compression Stockings for Popliteal Vein Dilation During Long-Haul Economy-Class Air Travel After Aesthetic Surgery
This randomized assessor-masked trial will evaluate whether knee-high moderate graduated compression stockings reduce popliteal vein dilation during long-haul economy-class air travel to Bogota.
- Trial name
- NCT07810192
- Testing
- Enoxaparine, Knee-High Graduated Compression Stockings, Standardized Bilateral Popliteal Vein Ultrasound
- Where
- Colombia
- Volunteers
- 160 people
- Sponsor
- Research Inc
Postprandial Abdominal Distension, Bloating
A Study to Evaluate Acute and Short-term Efficacy of Digest Gold on Postprandial Abdominal Distension and Subjective Bloating in Healthy Adults
The goal of this clinical trial is to investigate the acute and short-term efficacy of Digest Gold on postprandial abdominal distension and subjective bloating in healthy adults.
- Trial name
- NCT07830992
- Testing
- Digest Gold
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Enzymedica
Vascular Function
Effect of Black Tea on Vascular Function
Epidemiological studies indicate that regular consumption of three cups of black tea per day reduces the risk of stroke or myocardial infarction.
- Trial name
- Heraclitus (NCT01945970)
- Testing
- Black tea extract, Positive control
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
COPD
Efficacy and Safety of Broncho Muco Cleaner Balloon Dilation Therapy
In COPD patients with chronic bronchitis, it is aimed to determine whether the broncho muco cleaner balloon dilation method can provide clinical and functional benefit by causing destruction in hyperplasic goblet cells in the…
- Trial name
- EXERTION (NCT05868941)
- Testing
- Broncho Muco Cleaner
- Where
- Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- Clinodevice
Corneal Ectasia, Keratoconus
Safety and Effectiveness of the PXL-Platinum 330 System
To evaluate the safety and effectiveness of the PXL Platinum 330 system for performing corneal cross-linking (CXL) for the treatment of ectatic disorders.
- Conditions
- Corneal Ectasia, Keratoconus, Pellucid Marginal Corneal Degeneration
- Trial name
- NCT04401865
- Testing
- PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
- Where
- 3 sites in United States
- Volunteers
- 300 people
- Sponsor
- Colorado Eye Consultants/Cornea Consultants of Colorado
Healthy
Efficacy of Brooke Bond Black Tea Extract on Flow Mediated Dilation in Indian Males
This study examines the effect of 1800 mg/day standardized Brooke Bond black tea extract, equivalent to 400 mg flavonoids, on Flow Mediated Dilation in healthy Indian males.
- Trial name
- NCT01561300
- Testing
- Nutrition intervention study with a black tea extract, Nutrition intervention study with a control
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unilever R&D
Abdominal Aortic Aneurysm, AAA
First In Human Study for Small to Medium-sized Abdominal Aortic Aneurysm (AAA)
This is a first in human study to evaluate the safety and clinical utility of an investigational medical device called the Nectero EAST System to treat Abdominal Aortic Aneurysms or AAA.
- Conditions
- Abdominal Aortic Aneurysm, AAA, Dilation Aorta
- Trial name
- AAA (NCT05133492)
- Testing
- Endovascular Aneurysm Stabilization Treatment (EAST)
- Where
- 5 sites in Australia, China and 3 more
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Nectero Medical, Inc.
Atherosclerotic Cardiovascular Diseases, Endothelial Dysfunction
TB-500 (Thymosin Beta 4 17-23 Fragment) for Cardiovascular Biomarkers in Stable ASCVD
This fictional study is an example of a ClinicalTrials.gov-style record. It describes a Phase 1/2 trial evaluating the safety and tolerability of TB-500 (a 17-23 fragment of thymosin beta 4) versus placebo in adults with stable…
- Trial name
- TBRIDGE-CV (NCT07487363)
- Testing
- TB-500
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Hudson Biotech
Coronary Artery Disease, Coronary Disease
Sapphire II PRO US Clinical Study
A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device procedural success of the Sapphire II PRO 1.0 and 1.25 mm PTCA dilatation catheters in subjects with…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT03052530
- Testing
- Sapphire II PRO
- Where
- 4 sites in United States
- Volunteers
- 61 people
- Sponsor
- OrbusNeich
Irritable Bowel Syndrome (IBS)
Study to Evaluate the Effects of ONO-2952 on Pain Perception Produced by Rectal Distention in Female Subjects With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D)
The objective is to evaluate whether ONO-2952 modulates visceral pain perception produced by rectal distention in female patients with IBS-D
- Trial name
- RESTORE (NCT01887002)
- Testing
- ONO-2952
- Where
- 4 sites in United States
- Volunteers
- 39 people
- Sponsor
- Ono Pharma USA Inc
Inflammatory Bowel Diseases, Irritable Bowel Syndrome
Fecal Calprotectin Collection Protocol
The primary objective is to obtain stool samples from subjects diagnosed with , and displaying signs and/or symptoms of IBD and/or IBS will be evaluated in this study.
- Conditions
- Inflammatory Bowel Diseases, Irritable Bowel Syndrome, Ulcerative Colitis, Crohn Disease
- Trial name
- CALFE (NCT03143517)
- Testing
- Stool collection
- Where
- 13 sites in United States
- Volunteers
- 240 people
- Sponsor
- DiaSorin Inc.
Anemia
The Effect of Epoetin Alfa on Cardiac Function and Quality of Life in Patients With Early Renal ((Kidney) Disease
The purpose of this study is to assess whether maintaining hemoglobin (Hb) levels at normal or sub-normal levels with Epoetin Alfa can influence the health status, left ventricular mass and quality of life of early renal…
- Trial name
- NCT00446576
- Testing
- Epoetin Alfa
- Volunteers
- 176 people
- Sponsor
- Janssen-Cilag B.V.