Clinical trials: Distension
Rokitansky Syndrome, Surgical or Vaginal Dilatation of Vaginal Aplasia
Assessment of Quality of Global and Sexual Life and Impact of Surgical and Non Surgical Vaginal Aplasia in Patients With a Rokitansky Syndrome
The principal objective is to assess the general health status and the sexual health status of women with Rokitansky syndrome having received a surgical or non surgical treatment.
- Trial name
- MRKH (NCT01911884)
- Testing
- evaluate quality of life of surgical and non surgical vaginal aplasia
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cervical Dilatations
Clinical Study on "Pain Control of Cervical Dilation by Lidocaine Solution Injected Into a Disposable Cervical Dilator"
This study is a multicenter, randomized (each group was assigned 1:1), double-blind controlled trial. This study aims to investigate if lidocaine injection into the single-use micro-non-invasive injection cervical dilator (short…
- Trial name
- NCT05955768
- Testing
- Disposable cervical dilator stick combined with lidocaine hydrochloride injection, Disposable cervical dilator stick combined with normal saline injection
- Where
- China
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Refractive Surgery
Accelerated Versus Standard CXL in the Treatment of Ectasia Post Refractive Surgery and Penetrating Keratoplasty.
WHAT WAS KNOWN *Standard CXL is the common procedure for treating progressive corneal ectasia. Modifications of the standard protocol were introduces to reduce its complications especially long exposure to ultraviolet rays.
- Trial name
- NCT03791684
- Testing
- Cross linking
- Volunteers
- 111 people
- Sponsor
- Menoufia University
Primary Sclerosing Cholangitis
Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the biliary tract of unknown origin. Around 50% of patients develop during their disease course narrowing of the main bile duct with corresponding increase…
- Trial name
- NCT01398917
- Testing
- plastic endoprosthesis, balloon dilatation
- Where
- 4 sites in Belgium, Netherlands and 2 more
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Blood Pressure, Hypertension
Intervention With Riboflavin to Improve Vascular Health and ENdothelial Functioning in Genetically at- Risk Adults
High blood pressure is the leading risk factor for heart disease and stroke. Approximately 12% of the population have a particular genetic factor (known as the TT genotype) which increases the risk of high blood pressure.
- Trial name
- InteRVENE (NCT05488106)
- Testing
- Riboflavin 1.6mg/d, Riboflavin 5mg/d, Riboflavin 20mg/d
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Overactive Bladder, Constipation
Dysfunctional Voiding and Lower Urinary Tract Symptoms With Baclofen
Dysfunctional voiding is often associated with constipation. The association of constipation with urologic pathologic processes has previously been described since the 1950's, but it was only over the past decade that clinicians…
- Conditions
- Overactive Bladder, Constipation, Lower Urinary Tract Symptoms
- Trial name
- NCT01003249
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Wake Forest University Health Sciences
Lower Esophageal Ring, Dysphagia
Trial of Electrosurgical Incision Versus Bougie Dilation of Symptomatic Lower Esophageal (Schatzki's) Rings
The primary objective of this study is to compare the efficacy of bougie dilation to electrosurgical incision of symptomatic schatzki's rings at one year follow-up in the presence of rabeprazole treatment.
- Trial name
- NCT00204750
- Testing
- Bougie Dilation, Needle-knife incision
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Achalasia Cardia
POEM Versus Pneumatic Dilatation in Achalasia Cardia
The aim of this study is to compare efficacy of POEM and pneumatic dilatation in treatment of achalasia cardia.
- Trial name
- NCT02025790
- Testing
- Per Oral Endoscopic Myotomy (POEM), Pneumatic Dilatation
- Where
- India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India
Diabetes Mellitus, Hypertension
The Effect of Broccoli Sprouts as a Nutritional Supplement in the Prevention of Cardiovascular Disease
The purpose of this study is to investigate whether a daily intake of dried broccoli sprouts will improve the endothelial function of the participants as measured by Flow mediated dilation (FMD) The dried sprouts are chosen…
- Conditions
- Diabetes Mellitus, Hypertension, Hypercholesterolemia, Cardiovascular Disease
- Trial name
- NCT00252018
- Testing
- Daily intake of broccoli sprouts
- Where
- Denmark
- Volunteers
- 160 people
- Sponsor
- Bispebjerg Hospital
Crohn Disease (CD)
Hybrid Endoscopic Stricturotomy Plus Balloon Dilation Versus Stricturotomy Alone for Short Crohn's Disease Strictures
Crohn's disease is a chronic condition that can lead to inflammation and narrowing (strictures) of the intestine, causing symptoms like pain, bloating, and difficulty with bowel movements.
- Trial name
- HEIST (NCT06958159)
- Testing
- Endoscopic Stricturotomy, Endoscopic Balloon Dilation
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Obesity
Effect of Acute Dietary Supplementation With Grape Seed Extract on Aortic Stiffness, Arterial Pressure, and Blood Vessel Dilation in Collegiate Obese Individuals at Rest
This study investigated if elevated BP and aortic stiffness characterized in obese individuals are attenuated following acute grape seed extract supplementation.
- Trial name
- NCT04389060
- Testing
- Grape seed extract
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Erectile Dysfunction, Arterial Hypertension
Correlation Study of Vascular Parameters in Hypertensive Men With Erectile Dysfunction
The purpose of the study is to assess the correlation of FMD of brachial artery and carotid intima media thickness with ED severity and clinical response to vardenafil in hypertensive men.
- Conditions
- Erectile Dysfunction, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- NCT01084187
- Testing
- Vardenafil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Pedro Ernesto
HIV/AIDS
People Living With HIV/AIDS, Nitrate, Endotelial Function, Arterial Stiffness and Skeletal Muscle Oxygenation
Administration of antiretroviral therapy has brought benefits for infective human immunodeficiency virus-1 (HIV-1)-patients, reducing the number of AIDS-related morbidity and mortality.
- Trial name
- NCT03485248
- Testing
- Beetroot Juice
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Choledochal Cyst
Efficacy and Safety of Surgical Treatment for Type IVa CBD
This study is a multicenter, bidirectional cohort study aimed at continuously enrolling patients with biliary dilatation from 25 medical centers in China.
- Trial name
- NCT07036848
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Aortic Diseases, Aortic Aneurysm
LANDMARC Study: a Study With Focus on Aorta Ascendens
Rationale: Aortic diameter is currently used as a gold standard in international guidelines for prediction of aorta pathology (aortic aneurysm and aortic dissection).
- Conditions
- Aortic Diseases, Aortic Aneurysm, Aortic Dissection, Aortic Aneurysm, Thoracic
- Trial name
- NCT05655767
- Testing
- 4D-flow MR & CT-scan
- Where
- Netherlands
- Volunteers
- 65 people
- Sponsor
- Maastricht University Medical Center
Keratoconus, Ectasia
Cross-linking of Corneal Collagen (CXL) With Ultraviolet-A in Asymmetric Corneas
The purpose of this study is to evaluate the efficacy of ultraviolet-A (UVA)-induced cross-linking of corneal collagen (CXL) as a method to increase the biomechanical and biochemical stability of the cornea by inducing additional…
- Conditions
- Keratoconus, Ectasia, Degeneration
- Trial name
- NCT01189864
- Testing
- Ciprofloxicin or Vigamox or other., Nonsteroidal (Acular, Acuvail, Voltaren Xibrom, etc), Steroid (FML, Pred Forte, Flarex, etc.)
- Where
- 16 sites in United States
- Volunteers
- 3,493 people
- Sponsor
- Cxlusa
Atrial Fibrillation, Left Atrial Dilatation
His-pacing and AV-node Ablation vs. Pulmonary Vein Isolation for Atrial Fibrillation
Objective To investigate if conduction system pacing ((CSP) i.e. atrioventricular node ablation + His bundle pacing or Left Bundle Branch pacing) is as good as (or better than) atrial fibrillation ablation with pulmonary vein…
- Trial name
- His-PAAF (NCT04512586)
- Testing
- Conduction System pacing and AV node ablation, Atrial fibrillation ablation by pulmonary vein isolation
- Where
- 4 sites in Sweden
- Volunteers
- 45 people
- Sponsor
- Region Skane
Healthy
Trial to Assess the Effects of Different Trans-fatty Acids on Endothelial Function in Humans
The aim of the study is to compare a diet rich in trans fatty acids (TFA) from ruminant sources with a diet rich in TFA from hydrogenated vegetable oils (PHVO) in regard to their effects on cardiovascular risk markers…
- Trial name
- NCT00933322
- Testing
- diet enriched with industrial trans fatty acids, diet enriched with ruminant trans fatty acids, diet without any trans fatty acids
- Where
- Switzerland
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Middle-aged Adults, Major Depressive Disorder
Daily Stress and Vascular Function in Midlife as a Risk Factor for Cognitive Decline
The goal of this pilot clinical trial is to begin to understand how day-to-day stress affects cardiovascular health and brain function in middle-aged adults.
- Trial name
- NCT06466655
- Testing
- MitoTempol, Lactated Ringer's (control)
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Flow-mediated Dilation Evaluation of the Brachial Artery
Vascular Effect of Estradiol Valerate Versus Placebo Evaluated by Flow-mediated Dilatation of Brachial Artery
The aim of this study is to evaluate the vascular effects of estradiol valerate on climacteric women measured by flow-mediated evaluation of the brachial artery using high resolution ultrasound and compare to placebo.
- Trial name
- VEDILA (NCT02161614)
- Testing
- Estradiol valerate
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais