Clinical trials: Distension
Abortion, Second Trimester
24-hour Mifepristone and Buccal Versus Mifepristone and Vaginal Misoprostol for Cervical Preparation for D&E
This study aims to compare mifepristone and buccal misoprostol to mifepristone and vaginal misoprostol for cervical preparation for second trimester dilation and evacuation (D\&E).
- Trial name
- NCT03134183
- Testing
- Vaginal Misoprostol, Buccal Misoprostol
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cervical Dilation
Balloon Catheter for Cervical Ripening
Once admitted, women who will have a transcervical balloon catheter inserted for induction will be approached for participation in this study.
- Trial name
- 25148 (NCT02606643)
- Testing
- Slight traction, Foley Catheter to no traction
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- St. Louis University
Abortion, Spontaneous, Abortion in First Trimester
Effect of Paracervical Block Volume on Pain Control for Dilation and Curettage.o
The investigators are conducting a study on pain control for dilation and curettage (D\&C). Participants are eligible to enroll if they are a planning to have a D\&C in a participating clinic.
- Conditions
- Abortion, Spontaneous, Abortion in First Trimester, Pain Uterus, Abortion Early
- Trial name
- NCT03636451
- Testing
- 40cc buffered 0.5% lidocaine with 2 units of vasopressin paracervical block, 20cc 1% lidocaine with 2 units of vasopressin paracervical block
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Metabolic Syndrome, Obesity
Effect of Low Carbohydrate Versus Low Fat Diet in the Treatment of Dyslipidemia in Obese Children With Metabolic Syndrome
Two-arm, parallel design with children between the ages of 10 - 18 with obesity and metabolic syndrome randomized (15 per group) to reduced-carbohydrate diet or a reduced-fat diet for 8 weeks.
- Conditions
- Metabolic Syndrome, Obesity, Dyslipidemias
- Trial name
- NCT03937960
- Testing
- Carbohydrate restricted group, Standard low fat diet
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Mydriasis
Safety and Efficacy of Fixed Combination Phenylephrine-Tropicamide for Pupil Dilation
Subjects will receive ½ of the approved dose of MydCombi to determine the dilation curve with the reduced dose.
- Trial name
- NCT06217796
- Testing
- MydCombi
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Eyenovia Inc.
Ectasia
Safety Study of the VEGA UV-A System to Treat Ectasia
The purpose of this research study is to test the safety, tolerability, and effectiveness of corneal collagen cross-linking (CXL) when used to treat ectasia.
- Trial name
- NCT01398839
- Testing
- VEGA UV-A Illumination System, Riboflavin
- Where
- 12 sites in United States
- Volunteers
- 103 people
- Sponsor
- Topcon Medical Systems, Inc.
Marfan Syndrome
Comparison of Two Medications Aimed at Slowing Aortic Root Enlargement in Individuals With Marfan Syndrome
Marfan syndrome is a hereditary connective tissue disorder. Many individuals with this condition die because of the associated heart and blood vessel abnormalities.
- Trial name
- NCT00429364
- Testing
- Losartan Potassium, Atenolol
- Where
- 26 sites in United States, Belgium and 1 more
- Volunteers
- 608 people
- Sponsor
- Carelon Research
Mydriasis
Evaluation of Pupil Dilation Speed With the MAP Dispenser
1 mist or 2 mists of the study drug will be administered to both eyes according to a pre-specified randomization plan to determine the effect on pupil dilation
- Trial name
- SPEED (NCT04907474)
- Testing
- tropicamide-phenylephrine fixed combination ophthalmic solution
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Eyenovia Inc.
Pancreatic Duct Stone, Pancreatic Duct Stricture
Pancreatic Endotherapy for Refractory Chronic Pancreatitis
The purpose of this study is to evaluate whether endoscopic ultrasound (EUS) only versus EUS + endoscopic retrograde cholangiopancreatography (ERCP) with pancreatic endotherapy reduces pain in the treatment of chronic…
- Conditions
- Pancreatic Duct Stone, Pancreatic Duct Stricture, Pancreatic Duct Dilatation
- Trial name
- PERCePT (NCT04232670)
- Testing
- EUS + Pancreatic Endotherapy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Oregon Health and Science University
Abortion
Intrafetal Digoxin as an Adjuvant for Dilation and Evacuation at 20 to 24 Weeks' Gestation
This is a research study to measure the effect of digoxin injection on Dilation and Evacuation (D\&E) procedure duration. Digoxin is the most commonly used feticidal agent among family planning subspecialists, and is commonly…
- Trial name
- NCT03136068
- Testing
- Digoxin
- Where
- 3 sites in United States
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Induced Abortion, Abortion Techniques
Mifepristone Versus Misoprostol for Cervical Preparation Prior to Surgical Abortion Between 11 to 15 Weeks
Surgical abortion in the late first trimester and early second trimester is usually performed with the aid of a cervical preparing agent, which helps to open up the uterine cervix for the procedure.
- Conditions
- Induced Abortion, Abortion Techniques, Mifepristone, Misoprostol
- Trial name
- MIMI11-15 (NCT01636063)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Boston University
Keratoconus and Ectasia
Safety and Effectiveness Study of the VEGA UV-A System for Cross-linking in Eyes With Keratoconus and Ectasia
The purpose of this research study is to evaluate the long tern safety and effectiveness of cross-linking in eyes with keratoconus and ectasia.
- Trial name
- NCT01398852
- Testing
- Riboflavin, VEGA UV-A Illumination System
- Where
- 13 sites in United States
- Volunteers
- 500 people
- Sponsor
- Topcon Medical Systems, Inc.
Chronic Sinusitis
In-office Placement of the Propel Mini Sinus Implant in the Frontal Sinus Ostia
A randomized controlled trial
- Trial name
- FRONTIER (NCT02880514)
- Testing
- PROPEL Mini Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 9 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Abortion, Dilation and Evacuation
Effects of Oxytocin on Bleeding Outcomes During Dilation and Evacuation
Currently, there is very little research to identify ways to decrease blood loss during D\&E (dilation and evacuation) procedures.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Blood Loss
- Trial name
- NCT02083809
- Testing
- intravenous oxytocin, Intravenous Fluids and Electrolytes
- Where
- 2 sites in United States
- Volunteers
- 166 people
- Sponsor
- University of Hawaii
Chronic Rhinosinusitis (Diagnosis)
A Clinical Evaluation of PROPEL® Contour Sinus Implant
The objective of this study is to evaluate the efficacy of PROPEL Contour placement following an in-office frontal sinus balloon dilation (SBD) in patients with chronic rhinosinusitis (CRS)
- Trial name
- EXPAND (NCT04858802)
- Testing
- PROPEL Contour Sinus Implant, Balloon Sinus Dilation Alone
- Where
- 14 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Intersect ENT
Mydriasis, Dilation
Safety and Efficacy of Ophthalmic Phentolamine Mesylate to Reverse Pharmacologically Induced Mydriasis
The objectives of this study are: To evaluate the efficacy of Nyxol (phentolamine mesylate ophthalmic solution 1%) to expedite the reversal of pharmacologic mydriasis To evaluate the safety of Nyxol To evaluate the effect of…
- Trial name
- NCT04024891
- Testing
- Phentolamine Mesylate Ophthalmic Solution 1%
- Where
- 4 sites in United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Opus Genetics, Inc
Refractory Anastomotic Esophageal Strictures
WallFlex Esophageal Fully Covered (FC) Benign Anastomotic Stricture
The purpose of this of this study is to compare the safety and effectiveness of temporary indwell of the WallFlex Esophageal FC Metal Stent to Bougie Dilation for the treatment of refractory anastomotic esophageal strictures
- Trial name
- E7025 (NCT01699542)
- Testing
- WallFlex Esophageal RX Fully Covered Stent, Esophageal Bougie Dilator Per Investigator preference
- Where
- 4 sites in Brazil, Netherlands and 1 more
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Coronary Stenosis, Coronary Artery Stenosis
Compare the Effectiveness and Safety of Two Different Kinds of Cutting Balloon in Coronary Artery Disease
The objective of this study is to evaluate safety and effectiveness of the SINOMED CBC coronary dilatation catheter during PCI in subjects with stenotic coronary arteries.
- Conditions
- Coronary Stenosis, Coronary Artery Stenosis, In-stent Restenosis
- Trial name
- NCT05509296
- Testing
- SINOMED CBC, NSE Coronary Dilatation Catheter
- Where
- 8 sites in China
- Volunteers
- 136 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Pulmonary Disease, Chronic Obstructive
Nitric Oxide Bioavailability in Chronic Obstructive Pulmonary Disease (COPD)
More patients with chronic obstructive pulmonary disease (COPD) die from cardiovascular disease than direct pulmonary complications.
- Trial name
- NCT01398943
- Testing
- Tetrahydrobiopterin (BH4), Antioxidant Cocktail
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Augusta University
Ectasia
Corneal Collagen Cross-Linking for Ectasia (CXL)
Prospective, randomized multicenter study to determine the safety and effectiveness of performing corneal collagen cross-linking (CXL) using riboflavin and UVA light in eyes with ectasia after refractive surgery.
- Trial name
- CXL (NCT00674661)
- Testing
- riboflavin ophthalmic solution, UVA Irradiation
- Where
- 10 sites in United States
- Volunteers
- 130 people
- Sponsor
- Glaukos Corporation