Clinical trials: Distension
Marfan Syndrome
Clinical Signs and Activity Limitations Associated With Dural Ectasia in Patients With Marfan Disease
Primary outcome is to compare the frequency and clinical features of spinal symptoms between Marfan patients with dural ectasia (cases) and those without (controls). 1. / Frequency of orthostatic headaches 2.
- Trial name
- MARFANLOMB (NCT05123339)
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block
Conduction System Pacing Versus Biventricular Pacing for Cardiac ResYNChronization
Cardiac resynchronization therapy (CRT) with biventricular pacing (BiV) is the cornerstone treatment for heart failure patients with ventricular dyssynchrony.
- Conditions
- Dilated Cardiomyopathy with Conduction Defect, Left Bundle-Branch Block, Heart Failure, Resynchronization Therapy
- Trial name
- CSP-SYNC (NCT05155865)
- Testing
- Resynchronization with conduction system pacing, Cardiac resynchronization therapy with biventricular stimulation
- Where
- Slovenia
- Volunteers
- 62 people
- Sponsor
- University Medical Centre Ljubljana
Biliary Strictures
Comparison of Diagnostic Accuracy Before or After Stricture Dilation in Biliary Stricture
Biliary strictures present a diagnostic and therapeutic challenge to clinicians due to unsatisfied accuracy of sampling modality.
- Trial name
- NCT02465229
- Testing
- Multimodal tissue-sampling methods before and after stricture dilation
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Diabetes (DM), Retinopathy, Diabetic
Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients
Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams.
- Conditions
- Diabetes (DM), Retinopathy, Diabetic, Pupil Dilation
- Trial name
- NCT07495670
- Testing
- 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Burapha University
Atrial Fibrillation, Thrombosis
Association of Genetic Polymorphisms With Atrial Fibrosis and Thrombogenic Substrate in Patients With Non-valvular Atrial Fibrillation
Atrial fibrillation (AF) is the most frequently encountered cardiac arrhythmia. Emerging data suggests that common genetic variants are associated with the development of AF.
- Conditions
- Atrial Fibrillation, Thrombosis, Stroke, Genetic Predisposition
- Trial name
- ANATOLI-AF (NCT03560219)
- Testing
- Biomarkers, Cardiac Magnetic Resonance Imaging, Echocardiography, Flow Mediated Dilatation, Genetic Analysis
- Volunteers
- 225 people
- Sponsor
- Memorial Ankara Hospital
Termination of Pregnancy
Ulipristal Acetate for Cervical Preparation
This is a prospective cohort study exploring a broadened use of ulipristal acetate as a cervical preparation agent for second trimester surgical abortion.
- Trial name
- U-Prep (NCT03802149)
- Testing
- Ulipristal Acetate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Stanford University
Dilation, Pupil Reaction Absent
Efficacy of the MydCombi on Pupillary Dilation in Pediatric and Adult Patients
To raise the standard of care, improve the overall patient experience and streamline practice flow, Eyenovia has developed an innovative mydriatic to be delivered as a microdose by a specialized dispenser.
- Trial name
- NCT06366217
- Testing
- MydCombi Device, MydCombi Drug
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
PCOS
Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin…
- Trial name
- NCT06155708
- Testing
- Ketone, Water
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
Metabolic Syndrome
The PostprAndial eNdothelial Function After Combination of Ezetimibe and simvAstatin Study
The purpose of this study is to investigate whether low-dose simvastatin in combination with ezetimibe in comparison to high-dose simvastatin alone, has a beneficial effect on the function of the endothelium after an oral fat…
- Trial name
- PANACEA (NCT00817843)
- Testing
- Simvastatin, Simvastatin/Ezetimibe
- Where
- 5 sites in Netherlands, Spain
- Volunteers
- 100 people
- Sponsor
- dr.Frank L.J. Visseren
Cryptogenic Stroke, Atrial Fibrillation
Atrial Imaging and Cardiac Rhythm In Embolic Stroke
The ARIES study is an observational study in which patients with a recent acute ischemic stroke of cryptogenic aetiology are consecutively enrolled in order to perform a extensive cardiologic work-up.
- Conditions
- Cryptogenic Stroke, Atrial Fibrillation, Atrial Dilatation, Stroke, Ischemic
- Trial name
- ARIES (NCT05486221)
- Testing
- Extensive cardiologic work-up
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Keratoconus, Cornea Ectasia
Dietary Riboflavin (Vitamin B-2) and Cornea Cross-Linking
Corneal ectasia is characterized by irregularity and thinning of the cornea, causing the cornea to bulge forward and cause distorted vision and impaired visual acuity.
- Trial name
- NCT03095235
- Testing
- Dietary riboflavin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Vascular Dilation, Arterial Stiffness
Effects of Inorganic Nitrate and Intensity of Exercise on Cardiovascular Health in Post-Menopausal Females
Post-menopausal females experience elevated cardiovascular disease risk (CVD), compared to premenopausal females and age-matched males.
- Trial name
- NCT05221905
- Testing
- BEET IT - Concentrate Beet root juice, BEET IT - Concentrate Beet root juice (nitrate depleted)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Heart Failure
The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients
This is a phase IV, prospective, randomized, double-blind, double-dummy, parallel-group study. The study assessed the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on the…
- Trial name
- TurkuPET (NCT03300427)
- Testing
- sacubitril/valsatran, valsartan
- Where
- Finland
- Volunteers
- 55 people
- Sponsor
- Novartis Pharmaceuticals
Abortion, Dilation and Evacuation
Tranexamic Acid for Second Trimester Dilation and Evacuation and Bleeding Outcomes
Although procedural abortion in the second trimester is extremely safe, hemorrhage is one of the leading causes of morbidity and mortality.
- Conditions
- Abortion, Dilation and Evacuation, Hemorrhage, Prophylactic Tranexamic Acid Use
- Trial name
- NCT06820177
- Testing
- Tranexamic Acid
- Where
- 3 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Smoking
Endothelial Function and Autonomic Regulation After Short-term Smoking Cessation: Varenicline Versus Placebo
The purpose of this study is to evaluate endothelial function and autonomic regulation (for example, heart rate and blood pressure) in smokers before and after short-term smoking cessation.
- Trial name
- NCT00673595
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tracheostomy Techniques
Ultrasound-guided Percutaneous Dilatation Tracheostomy: Does it Have a Role in Obese Patients?
To evaluate the usefulness of ultrasound-guided percutaneous dilatation tracheostomy PCT in obese patients.
- Trial name
- NCT03059654
- Testing
- tracheostomy
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Keratoconus; Post-Refractive Ectasia
Retrospective Study of Corneal Tissue Addition Keratoplasty for Keratoconus and Post-Refractive Ectasia
This retrospective, multi-center observational study evaluates clinical outcomes in patients with keratoconus or post-refractive ectasia who previously underwent Corneal Tissue Addition Keratoplasty (CTAK) as part of routine…
- Trial name
- NCT07905079
- Testing
- Corneal Tissue Addition Keratoplasty (CTAK)
- Where
- 5 sites in United States
- Volunteers
- 61 people
- Sponsor
- Corneagen LLC
Adhesive Capsulitis, Adhesive Capsulitis of Shoulder
Using Kinect Motion Capture to Measure Shoulder Motion in Patients Undergoing Capsular Distension for Adhesive Capsulitis
This study will compare shoulder range of motion assessment using the Kinect motion tracking system vs goniometer in patients with adhesive capsulitis (frozen shoulder) undergoing ultrasound-guided capsular distention procedures…
- Conditions
- Adhesive Capsulitis, Adhesive Capsulitis of Shoulder, Frozen Shoulder, Shoulder Frozen
- Trial name
- NCT04413162
- Testing
- Kinect motion tracking system
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Marfan Syndrome
Nebivolol Versus Losartan Versus Nebivolol+Losartan Against Aortic Root Dilation in Genotyped Marfan Patients
The major clinical problems in patients with Marfan Syndrome (MFS) are aortic root dilation (ARD), dissection and rupture. Although the available treatments (beta-blockers, BBs) improve the evolution of the disease, they do not…
- Trial name
- MaNeLo (NCT00683124)
- Testing
- Losartan and nebivolol, Losartan, Nebivolol
- Where
- Italy
- Volunteers
- 291 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Bicuspid Aortic Valve
Evaluating the Effectiveness of Atorvastatin on the Progression of Aortic Dilatation and Valvular Degeneration in Patients With Bicuspid Aortic Valve
Bicuspid Aortic Valve (BAV) is the most common congenital heart disease affecting 1-2% of the population. The aortic dilation and aortic valve degeneration are common complications in patients with BAV.
- Trial name
- BICATOR (NCT02679261)
- Testing
- Atorvastatin
- Where
- 10 sites in Spain
- Volunteers
- 220 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute