Clinical trials: Distension
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Acute Coronary Syndrome, Coronary Artery Ectasia
Antithrombotic Therapy in Acute Coronary Syndromes and Coronary Artery Ectasia
The optimal anti-thrombotic therapy to prevent recurrent ischemic events in patients with acute coronary syndrome and coronary artery ectasia (CAE) remains unclear.
- Trial name
- OVER-TIME (NCT05233124)
- Testing
- Rivaroxaban 15 MG, Acetylsalicylic acid 100mg, Clopidogrel 75 Mg Oral Tablet
- Where
- 2 sites in Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Physiologic Venous Dilation, Air Travel
Prospective Comparative Cohort Study of Premium Versus Economy Cabin Travel and Popliteal Vein Diameter After Long-Haul Flight After an Aesthetic Surgery
This prospective cohort study will compare popliteal vein diameter changes in international travelers who independently fly to Bogota in premium business/first class or economy class.
- Trial name
- NCT07810179
- Testing
- Premium Cabin Air Travel Exposure, Economy Cabin Air Travel Exposure, Standardized Bilateral Popliteal Vein Ultrasound
- Where
- Colombia
- Volunteers
- 200 people
- Sponsor
- Research Inc
Evaluation of Association Between Opiate Use and Biliary Dilation
Opiate Use and Biliary Dilation
We hope to better define the association between opiate use and biliary dilation, which was evident in our previous retrospective study.
- Trial name
- NCT03870347
- Testing
- Endoscopic ultrasound
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Stanford University
Congestive Heart Failure
Multicenter, Randomized, Double-Blind, Placebo Controlled, Efficacy Study on the Effects of Tolvaptan on Left Ventricular Dilatation in Congestive Heart Failure Patients
The purpose of this study is to study the effects of tolvaptan on the size and function of the left heart chamber (ventricle) in patients with congestive heart failure (CHF)
- Trial name
- NCT00043758
- Testing
- Tolvaptan
- Where
- 40 sites in United States, Canada
- Volunteers
- 170 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Pregnancy, No Pregnancy Complications
Effect of Maryam Plant and Surah on Birth Pain, Anxiety and Satisfaction
This randomized controlled trial was conducted to determine the effects of spiritual support provided by Virgin Mary's hand plant and Surah Maryam on labor anxiety, labor pain, and satisfaction.
- Conditions
- Pregnancy, No Pregnancy Complications, Cervical Dilatation of 4-6 cm (Early Active Phase), Muslim
- Trial name
- NCT07175337
- Testing
- Surah Maryam group, Virgin Mary's Hand Plant Group
- Where
- Turkey (Türkiye)
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Aging, Endothelial Dysfunction
COMP-4 Supplementation and Brachial Artery FMD
In a young and healthy person, the production of nitric oxide (NO) by the endothelium, the inner lining of the blood vessel, is responsible for a) the ability of the blood vessel to dilate so it can increase its blood flow and b)…
- Conditions
- Aging, Endothelial Dysfunction, Senescence
- Trial name
- NCT05595915
- Testing
- COMP-4
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Coronary Artery Disease
WEDGES: Coronary Lesion Preparation With Enhanced Dilatation for Good Expansion of Stent: Assessment of a New Scoring Balloon by Quantitative Stent Enhanced Visualization
Stent under-expansion during percutaneous coronary intervention (PCI) is one of the suboptimal results associated with a higher risk of restenosis and thrombosis.
- Trial name
- WEDGES (NCT05019443)
- Testing
- Wedge Scoring Balloon, Conventional Balloon
- Where
- 5 sites in Belgium
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Stephane Carlier
Crohn Disease
Endoscopic Balloon Dilation Versus Endoscopic Stricturotomy for Short Crohn's Strictures
Crohn's disease (CD) related strictures can be treated endoscopically by endoscopic balloon dilation (EBD) or endoscopic stricturotomy (EST). EBD is is the established endoscopic treatment for short strictures in Crohn's disease.
- Trial name
- BEST-CD (NCT05521867)
- Testing
- Endoscopic balloon dilation, Endoscopic stricturotomy with or without stricturoplasty
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Asian Institute of Gastroenterology, India
Surgery, Cardiac Death
Endothelial Dysfunction and Non-cardiac Surgery
Endothelial dysfunction is a cardiovascular disease hallmark. After non-cardiac surgery, cardiovascular events correlate with surgical outcomes. Understanding the role of endothelial function in these events is crucial.
- Conditions
- Surgery, Cardiac Death, Stroke, Myocardial Injury
- Trial name
- NCT05778981
- Testing
- FMD - Troponin measurement
- Where
- Chile
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Chile
Constipation
Anal Dilatation for Infants and Children With Constipation
This study is to evaluate the effect of anal dilation in infants and children with constipation.
- Trial name
- NCT02255747
- Testing
- Lactulose
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tongji Hospital
Healthy Volunteers
The Haem and Nitrite Study - The Effects of Haemoglobin NO-blockade on Nitrite-induced Forearm Vessel Dilatation
The study is a pharmacodynamic random order cross-over trial investigating the physiological effects of intra-arterial infusion of nitrite following a haemolysed autologous blood transfusion.
- Trial name
- NCT03077763
- Testing
- Sodium Nitrite
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
BPH (Benign Prostatic Hyperplasia)
A Single-center, Single-arm Study to Evaluate the Safety and Efficacy of Ultra-minimally Invasive Prostate Dilation in Treating Patients With Significant Obstructive Symptoms Caused by Benign Prostatic Hyperplasia
This single-center, single-arm, prospective clinical study aims to preliminarily evaluate the safety and effectiveness of ultra-minimally invasive prostatic dilation using a prostate dilation catheter under real-time transrectal…
- Trial name
- UMPD-BPH (NCT07583706)
- Testing
- Prostate Dilation Catheter
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Qing Yuan
Suspected Eosinophilic Esophagitis
Study of the Efficiency of Esophageal Dilation on Patient With Eosinophilic Esophagitis
This study is for patients who have had a food impaction and/or difficulty swallowing, who are scheduled to have endoscopy, biopsy and possibly dilatation (stretching) of the esophagus.
- Trial name
- EOE (NCT00880906)
- Testing
- Esophageal dilation, Steroid and Proton Pump Inhibitor Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Vanderbilt University
Esophageal Stenosis, Esophageal Dilation
An Innovative Endoscopic Cap for Dilating Benign Esophageal Strictures in Children
The goal of this study is to find out if using the BougieCap device is a safe and effective way to stretch narrow areas in the esophagus (food pipe) in children.
- Trial name
- BOUGIE-PED (NCT06675825)
- Testing
- BougieCap, Savary-Bougie (A) or balloon dilation (B)
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 40 people
- Sponsor
- University Children's Hospital, Zurich
Irritable Bowel Syndrome (IBS)
Feasibility and Reproducibility of Barostat Assessments of Colorectal Sensation During Colorectal Distention and Its Pharmacological Modulation Using Octreotide
This study is designed to provide information on feasibility and reproducibility of barostat assessments of colorectal sensory functions and compliance and their pharmacological modulation
- Trial name
- NCT00584298
- Testing
- SMS995
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 50 people
- Sponsor
- Novartis
Healthy, Ageing
Can Cocoa Flavanols Protect Endothelial Function During Prolonged Sitting in Healthy Older Adults?
Sitting time is high in older adults and has been shown to temporarily impair endothelial function and blood pressure. Flavanols, plant-derived compounds, acutely enhance endothelial function and reduce Blood pressure in older…
- Trial name
- NCT07265869
- Testing
- High-flavanol cocoa powder, Low-flavanol cocoa powder
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Pulmonary Disease, Chronic Obstructive
Timing of Dilation Tracheostomy in Mechanically Ventilated Chronic Obstructive Pulmonary Disease (COPD) Patients
The purpose of this study is: to evaluate the optimal time-point for percutaneous dilation tracheostomy in COPD patients in terms of duration on mechanical ventilation, length of stay on ICU and mortality; to evaluate the rate of…
- Trial name
- NCT01021202
- Testing
- Percutaneous dilation tracheostomy
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertriglyceridemia
Vascular and Lipid Effects of Omega-3 Fatty Acids in People With Moderately Elevated Triglycerides
The purpose of this study is to evaluate the cardiovascular and lipid effects of two doses of an omega-3 fatty acid concentrate in a group of people who normally are not treated for high lipids.
- Trial name
- OMEGA (NCT00504309)
- Testing
- 4/day of 4g P-OM3 capsules, 4/day of 1g P-OM3 capsules
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Penn State University
Gastric Distention
High Flow Nasal Oxygenation and Gastric Insufflation in Anesthetized Patients
Transnasal humidified rapid-insufflation ventilatory exchange(THRIVE), or also termed high flow nasal oxygenation (HFNO) is a method of supplying heated, humidified high concentrations of oxygen via nasal cavity.
- Trial name
- NCT04629911
- Testing
- THRIVE
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Ajou University School of Medicine