Clinical trials: Distension
Bicuspid Aortic Valve (BAV), Aortic Aneurysm
Research on Aneurysm Growth Prediction in Vascular Dilation Caused by Bicuspid Aortic Valve Based on VDM and CFD
Bicuspid aortic valve (BAV) is the most common congenital valvular malformation, characterized by heterogeneous phenotypic subtypes that predispose patients to secondary aortic pathologies, including valvular dysfunction and…
- Conditions
- Bicuspid Aortic Valve (BAV), Aortic Aneurysm, TAVR
- Trial name
- NCT07782918
- Testing
- Transcatheter Aortic Valve Replacement
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
COVID-19, Chronic Heart Failure
Intermittent Hypoxic-hyperoxic Training in Patients With Cardiovascular Pathology After COVID-19 Infection.
Aim of this prospective, interventional, single-center, randomized study is to evaluate the efficacy and safety of intermittent hypoxic-hyperoxic training (IHHT) as a rehabilitation method in patients with cardiovascular…
- Conditions
- COVID-19, Chronic Heart Failure, Hypertension, Arrhythmia
- Trial name
- NCT05379608
- Testing
- Intermittent hypoxic-hyperoxic training, Intermittent hypoxic-hyperoxic training/control
- Where
- Russia
- Volunteers
- 43 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Healthy
Acute Effect of a Proprietary Botanical Blend Rich in Polyphenols on Flow-mediated Dilation in Healthy Subjects
It is well established that endothelial dysfunction is an early predictor of cardiovascular events in at-risk patients. Finding safe and effective product able to improve endothelial function is of public health interest.
- Trial name
- NCT04697589
- Testing
- Memophenol 300 mg, Memophenol 600 mg
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Type 2 Diabetes
The Effect of Vitamin D Supplementation on Glucose Metabolism in Non-Diabetic African American Adults
Type 2 diabetes is more common among African Americans than Caucasians. African Americans are also at a higher risk for lower levels of vitamin D compared to other ethnic groups.
- Trial name
- AVIS (NCT01141192)
- Testing
- vitamin D3, cholecalciferol, Inactive comparator
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Augusta University
Keratoconus, Artificial Intelligence, Support Vector Machine
Efficiency of an Algorithm Derived From Corneal Tomography Parameters to Distinguish Highly Susceptible Corneas to Ectasia From Healthy
The objective of this study was to identify and build an algorithm through an imaging process using a support vector machine (SVM) with the tomography variables of cases with, KC, highly susceptible corneas to ectasia (HSCE), and…
- Trial name
- NCT04313387
- Testing
- Corneal tomography multivariate index derived from a support vector machine (CTMVI).
- Volunteers
- 588 people
- Sponsor
- Gildasio Castello de Almeida Junior
Frontal Sinusitis
Treatment of Chronic Frontal Sinusitis by a Simple Technique Using Dilation Balloons
The sinuplasty balloon offers a more physiological first of the sinuses which minimizes risks associated to traditional surgery.
- Trial name
- SIBA (NCT02509663)
- Testing
- Functional Endoscopic Sinus Surgery, Functional Endoscopic Sinus Surgery using rigide instrumentation, Sinuplasty balloon
- Where
- 8 sites in France
- Volunteers
- 9 people
- Sponsor
- University Hospital, Strasbourg, France
Biliary Anastomotic Stenosis
Plastic Stenting Versus Retrievable Metallic Stenting for Biliary Anastomotic Stricture After Liver Transplantation
Liver transplantation is the best treatment option for patients with end-stage liver disease and early unresectable hepatocellular carcinoma.
- Trial name
- LT (NCT04144504)
- Testing
- Retrievable metallic stenting, Plastic stenting
- Where
- Hong Kong
- Volunteers
- 64 people
- Sponsor
- The University of Hong Kong
Eustachian Tube Dysfunction
XprESS Eustachian Tube Dilation Study
Study to assess the safety and efficacy of the XprESS device for transnasal Eustachian tube dilation.
- Trial name
- NCT02391584
- Testing
- XprESS, Control
- Where
- 5 sites in United States
- Volunteers
- 60 people
- Sponsor
- Entellus Medical, Inc.
Heart Failure
Safety Study of the Ventricular Partitioning Device (VPD) Implant System in Heart Failure Patients
The CardioKinetix Ventricular Partitioning Device (VPD) is intended to isolate the malfunctioning portion of the left ventricle in patients with symptoms of heart failure due to ischemic heart disease.
- Trial name
- PARACHUTE (NCT00573560)
- Testing
- VPD Implant System
- Where
- 7 sites in United States, Serbia
- Volunteers
- 20 people
- Sponsor
- CardioKinetix, Inc
Dysphagia With Normal Endoscopy
The Role Of Empiric Dilation In Patients With Dysphagia With Normal Endoscopy
The goal of our study is to determine if stretching the esophagus with a rubber dilator helps patients with swallowing difficulties who have a normal appearing esophagus on upper endoscopy.
- Trial name
- NCT01444066
- Testing
- Dilation of the esophagus
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Achalasia
Botox or Botox With Esophageal Dilation in Patients With Achalasia
Achalasia is a rare esophageal motility disorder. Treatment of achalasia is aimed toward palliation of symptoms. These include botox injections to the lower esophageal sphincter (LES), pneumatic dilation, surgical myotomy, and…
- Trial name
- NCT03654066
- Testing
- Botulinum toxin type A, Endoscope balloon dilator, Patient reported outcomes
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Vanderbilt University Medical Center
Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic
Effect of Urethral Balloon Dilatation on Urinary Retention After Spinal Cord Injury
Trial Objectives: This clinical trial aims to explore whether ultrasound - guided urethral balloon dilation can effectively improve the micturition function of patients with urinary retention after spinal cord injury, and to…
- Conditions
- Spinal Cord Injuries (SCI), Urinary Bladder, Neurogenic, Urinary Retention
- Trial name
- NCT06978205
- Testing
- Urethral Balloon Dilation, intermittent catheterization, Acupuncture treatment
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Qilu Hospital of Shandong University
Abnormal Uterine Bleeding
Comparison of Manual Vacuum Aspiration and Dilatation and Curettage for Endometrial Sampling Adequacy in Women With Abnormal Uterine Bleeding
This randomized controlled trial was conducted in the Department of Obstetrics and Gynecology, Sheikh Zayed Hospital, Rahim Yar Khan, to compare two commonly used methods for obtaining endometrial tissue in women aged 30 to 60…
- Trial name
- NCT07349108
- Testing
- Manual Vacuum Aspiration, Dilatation and Curettage
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Sheikh Zayed Medical College
Histiocytosis, Langerhans-Cell
Cardiovascular Risk Factors and LCH in Adults
Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and hypopituitarism, conditions associated with increased risk of cardiovascular diseases.
- Trial name
- NCT00483925
- Where
- Greece
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Healthy
Acute Strawberry Intake on Endothelial Function
The primary objectives of the study are (1) to evaluate the effects of acute dietary strawberry intake on measures of vascular function in healthy adults following a meal challenge, (2) to evaluate the effects of acute dietary…
- Trial name
- SFMD (NCT03596008)
- Testing
- Active drink
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Corneal Ectasia of Both Eyes
Collagen Cross-linking Clinical and Oct Study
1. Assessment of corneal changes in AS-OCT after collagen cross-linking (corneal thickness and demarcation line). 2. Assessment of the effect of collagen cross-linking on best-corrected visual acuity
- Trial name
- NCT05717517
- Testing
- anterior segment oct
- Volunteers
- 100 people
- Sponsor
- Assiut University
Depression, Anxiety Depression
Comparison of Beck Depression Score in Multipar and Nulliparous Women Who Have Gone Under Dilatation and Curettage
It is aimed to compare the beck depression and anxiety values of the nulliparous and multipar pregnant women who undergo optional abortion below 12 weeks and to evaluate the effect of the parity on depression and anxiety.
- Conditions
- Depression, Anxiety Depression, Pregnancy Early
- Trial name
- NCT04321564
- Where
- Turkey (Türkiye)
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Coronary Artery Ectasia
Endothelial Function in Patients With Ectatic Compared to Normal Coronary Arteries
The aim of this study is to show the frequency of endothelial dysfunction in patients suffering from ectatic coronary arteries as compared to those who have normal coronary arteries.
- Trial name
- NCT00548457
- Where
- Israel
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Chronic Sinusitis
Balloon Sinus Dilation In Office or OR
Endoscopic sinus surgery will be performed either in the physician's office or in the operating room (OR). Patients treated in the physician's office will have endoscopic sinus surgery performed with balloon sinuplasty devices.
- Trial name
- ORIOS (NCT00939393)
- Testing
- FESS instruments with or without balloon treatment, Balloon Sinuplasty
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Integra LifeSciences Corporation
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company