Clinical trials: Distension
Aortic Valve Stenosis
Balloon Expandable Transcatheter Aortic Valve Implantation Without Predilation of the Aortic Valve
There is limited experience for the balloon expandable THV (transcatheter heart valve) on the need for predilation (ballon aortic valvuloplasty, BAV).
- Trial name
- EASE-IT (NCT02127580)
- Testing
- BAV, without BAV
- Where
- 7 sites in Germany
- Volunteers
- 200 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms
The Italian Coronary Artery Aneurysm and Ectasia In Patients With Acute Coronary Syndrome
The ITACA study is a prospective, observational no profit registry enrolling patients with Acute Coronary Syndrome and angiographic evidence of coronary aneurysms and/or ectasia.
- Conditions
- Acute Coronary Syndrome, Angiographic Evidence if Coronary Aneurysms, Ectasia
- Trial name
- ITACA (NCT05051917)
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Federico II University
Chronic Renal Failure
Evaluation of Endothelial Dysfunction Using the "Flow Mediated Dilation" Test in a Population of Chronic Renal Failure Patients at Different Stages, and Evaluation of the Role of Antiphospholipid Antibodies
The vascular endothelium is an organ in its own right, playing, among other things, a primordial role in the control of vascular tone.
- Trial name
- NCT06347029
- Testing
- Urine sampling, Blood sampling, Flow mediated dilatation test
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Abnormal Uterine Bleeding, Anxiety
Anxiety Scores With Media Based Patient Education Before Dilatation and Curettage
Subjects with abnormal uterine bleeding and scheduled for dilatation and curettage (D\&C) will be randomized to a multimedia-based education (MME group) or verbal information (Control group ) before (D\&C).
- Trial name
- NCT03930303
- Testing
- Multimedia- based patient education
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Obstruction of Esophagus, Respiratory Complication
Hemodynamic and Respiratory Effects of Esophageal Dilation in Children
The aim of this study compares hemodynamic and respiratory changes and complications in children who undergoing endoscopy for esophageal balloon dilatation and endoscopy for only control.
- Conditions
- Obstruction of Esophagus, Respiratory Complication, Hemodynamic Instability
- Trial name
- NCT02512770
- Testing
- endoscopic dilatation
- Volunteers
- 60 people
- Sponsor
- Istanbul University
End-Stage Renal Disease Requiring Haemodialysis
Effect of Amplifi Vein Dilation System Treatment on Radiocephalic AVF Maturation-3
This multi-phase clinical study evaluated the safety and performance of the Amplifi Vein Dilation System (Amplifi System) in subjects requiring arteriovenous fistula (AVF) creation.
- Trial name
- Amplifi FIH (NCT07058610)
- Testing
- Amplifi Vein Dilation System
- Where
- Paraguay
- Volunteers
- 19 people
- Sponsor
- Amplifi Vascular, Inc.
Irritable Bowel Syndrome
The Effects of Added Enzyme α-Galactosidase at a Carbohydrate-rich Meal in Irritable Bowel Syndrome (IBS)
IBS (irritable bowel syndrome) is a functional gastrointestinal disorder which is characterized by recurrent pain and/or discomfort, altered stool form, and abdominal distension.
- Trial name
- NCT01483287
- Testing
- Alpha-Galactosidase
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Sahlgrenska University Hospital
Retinopathy of Prematurity
A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong.
- Trial name
- NCT06288321
- Testing
- Microdrop Mydrin-P, Standard Mydrin-P
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Coronary Artery Ectasia
A New Classification and Interventional Therapy for Coronary Artery Ectasia
This study is aim to present a new classification for coronary artery ectasia and find the best interventional therapy for different types of patients were treated and studied.
- Trial name
- NCIPCAE (NCT04265989)
- Testing
- Single BMS, Single or Double BMS, BMS+DES
- Where
- China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Postoperative Pain
Monitoring Pupillary Reflex Dilatation for Optimized Postoperative Opioid Delivery Before Extubation.
The study will be designed to investigate the effect of pupillometry guided compared to non-PPI-guided postoperative pain therapy, conducted immediately at the end of surgery before extubation, on total postoperative opioid…
- Trial name
- NCT04594382
- Testing
- Pupillometry-Opioid treatment, Pupillometry -standardized opioid treatment
- Where
- Austria
- Volunteers
- 140 people
- Sponsor
- Medical University of Vienna
Keratoconus, Post-Refractive Ectasia
Corneal Crosslinking in Patients With Keratoconus and Post-Refractive Ectasia
The purpose of this study is to evaluate the effectiveness of using riboflavin and UV light to treat progressive keratoconus or post-refractive corneal ectasia.
- Trial name
- NCT01143389
- Testing
- Riboflavin, UVX light
- Where
- United States
- Volunteers
- 510 people
- Sponsor
- Price Vision Group
Pain Management, Emergency Unit
The Effectiveness of Local Dry Cold, Hot and Vibration Applications in Peripheral Intravenous Catheterization
Aim: The aim of the present study was to examine the effect on venous dilation, procedure duration and pain severity of local hot, cold and vibration applications performed on the intervention area before peripheral intravenous…
- Conditions
- Pain Management, Emergency Unit, Diarrhea, Nausea
- Trial name
- NCT06378424
- Testing
- Cold Application, Heat Application, Vibration Application
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Uludag University
Histiocytosis, Langerhans-Cell
Cardiovascular Risk Factors and LCH in Adults
Langerhans-cell histiocytosis (LCH) is a rare disease with features of chronic inflammation and hypopituitarism, conditions associated with increased risk of cardiovascular diseases.
- Trial name
- NCT00483925
- Where
- Greece
- Volunteers
- healthy volunteers welcome
- Sponsor
- Laikο General Hospital, Athens
Abortion, Second Trimester, Abortion, Medical
Foley Balloon for Cervical Preparation Before Dilation and Evacuation
To evaluate the Foley Balloon technique for cervical preparation before second trimester surgical abortion between 16 and 21 weeks estimated gestational age in combination with misoprostol to prepare the cervix before dilation…
- Trial name
- NCT06850974
- Testing
- Foley Balloon Catheter, Misoprostol, Laminaria
- Where
- Mozambique
- Volunteers
- 102 people
- Sponsor
- Stony Brook University
Cervical Dilatation, Bishop Score
the Effects of Epidural Fentanyl on Vaginal Delivery
The study hypothesis was that epidural fentanyl may accelerate the dilation of the cervix and possibly result in a shorter duration of vaginal delivery.
- Conditions
- Cervical Dilatation, Bishop Score, Duration of Delivery
- Trial name
- EFVD (NCT02135224)
- Testing
- Fentanyl, Normal saline
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- University of Athens
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Hypertension in Pregnancy
The Effect of Hydroxytyrosol Administration on Superoxide Dismutase, Pulsatility Index and Resistance Index of Uterine Artery Doppler and Flow-Mediated Dilatation of Brachial Artery In Mothers With Hypertension In Pregnancy
The purpose of this clinical trial is to evaluate the effect of hydroxytyrosol 10 mg/day administered for 4 weeks in pregnant individuals with hypertension.
- Trial name
- HYDROXY-2 (NCT07298759)
- Testing
- Hydroxytyrosol
- Where
- Indonesia
- Volunteers
- 52 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Pain, Colorectal Adenomas
Comparison of Methods to Distend the Colon During Insertion: CO2, Air Insufflation, Water-aided Colonoscopy
Insufflation of the colon, usually with room air, is necessary to distend the lumen for exploration. Carbon dioxide (CO2) insufflation instead of room air insufflation (AI) has been shown to decrease symptoms of abdominal pain or…
- Conditions
- Pain, Colorectal Adenomas, Colorectal Cancer
- Trial name
- NCT01954862
- Testing
- Air Insufflation method., CO2 insufflation, Water Immersion/CO2
- Where
- 3 sites in United States, Czechia and 1 more
- Volunteers
- 624 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Cardiomyopathies, Microcirculation
IMR Assessment in Patients With New Diagnosis of Left Ventricle Dilatation
To establish if, in patients with new diagnosis of left ventricular dilatation without documentation at the coronary artery angiography of significant coronary artery lesions, there is a damage of the coronary microcirculation at…
- Conditions
- Cardiomyopathies, Microcirculation, Microvessels
- Trial name
- IMPAIRED (NCT02705170)
- Testing
- index of microvascular resistance
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital of Ferrara
Breast Cancer
Walking Meditation Exercise in Breast Cancer Patients
This study is to evaluate the effects of Walking Meditation on vascular function in breast cancer patients receiving Anthracyclines chemotherapy
- Trial name
- NCT02676531
- Testing
- Exercise
- Where
- Thailand
- Volunteers
- 30 people
- Sponsor
- Chulalongkorn University