Clinical trials: Distension
Hypertrophic Obstructive Cardiomyopathy, Thoracic Aortic Dilatation
A Cardiac Disease Quality of Life Study
A prospective, longitudinal, non-comparator, non-randomized observational cohort study to assess the quality of life in adult patients affected by hypertrophic cardiomyopathy and thoracic aortic dilatations who are not amenable…
- Conditions
- Hypertrophic Obstructive Cardiomyopathy, Thoracic Aortic Dilatation, Heart Disease Caused by Ionising Radiation, Quality of Life
- Trial name
- UPLIFT (NCT04080492)
- Testing
- QOL Survey
- Where
- United States
- Volunteers
- 380 people
- Sponsor
- The Cleveland Clinic
Type 2 Diabetes Mellitus, Endothelial Dysfunction
Huangqi Gegen Decoction for Endothelial Function in Type 2 Diabetes at Very High ASCVD Risk
This clinical trial evaluates whether Huangqi Gegen Decoction can improve blood vessel function in adults with type 2 diabetes mellitus who are at very high risk of atherosclerotic cardiovascular disease and meet the traditional…
- Conditions
- Type 2 Diabetes Mellitus, Endothelial Dysfunction, Cardiovascular Risk
- Trial name
- NCT07775664
- Testing
- Huangqi Gegen Decoction Granules, Conventional Treatment
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Putuo Hospital, Shanghai University of Traditional Chinese Medicine
Keratoconus, Ectasia
Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia
This prospective, randomized study is being conducted to evaluate the safety and effectiveness of corneal cross-linking (CXL) in patients with keratoconus or post-refractive ectasia (post-LASIK or PRK) utilizing two techniques…
- Trial name
- CXL (NCT03080077)
- Testing
- Ricrolin+, Epi-Off
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pancreatitis, Acute, Bleeding
Quick Large Balloon Dilatation for Removal of Large Bile Duct Stones (SHODBADI)
ESGE guidelines suggests 30-60 seconds endoscopic large balloon papillary dilation from the disappearance of the waist of the papilla.
- Conditions
- Pancreatitis, Acute, Bleeding, Cholangitis
- Trial name
- SHODBADI (NCT05061680)
- Testing
- endoscopic short duration papillary large balloon dilation
- Where
- 2 sites in Finland
- Volunteers
- 600 people
- Sponsor
- Helsinki University Central Hospital
Shoulder Pain
Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone
The purpose of this study is to assess the efficacy of mild hydraulic distension with intra-articular corticosteroid injection for the treatment of subacute hemiparetic shoulder pain with a capsular pattern of restricted shoulder…
- Trial name
- NCT05845125
- Testing
- Physiotherapy alone, Glenohumeral injection of 40mg (1cc) of Triamcinolone and 7cc of 0.5% Bupivacaine coupled with physiotherapy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Claire Bourgeois
Metabolic Syndrome
Mesoglycan, Vascular Reactivity and Metabolic Syndrome
The purpose of the study was to characterize the action of mesoglycan on vascular endothelium through the non-invasive assessment of vascular reactivity humeral artery by comparing effects of mesoglycan on Flow Mediated…
- Trial name
- NCT02254850
- Testing
- Flow Mediated Dilation, Mesoglycan
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Federico II University
Acute Coronary Syndromes, Flow Mediated Dilation
A Prospective, Single-center, Observational Study Aiming to Assess the Predictive Role of Flow Mediated Dilatation in Acute Coronary Syndromes, Combined With Echocardiographic and Biochemical Indices
A prospective, single-center, observational study aiming to assess the predictive role of flow mediated dilatation in acute coronary syndromes, combined with echocardiographic and biochemical indices.
- Conditions
- Acute Coronary Syndromes, Flow Mediated Dilation, Endothelial Function (FMD)
- Trial name
- FLARE-ACS (NCT06890013)
- Testing
- Observation group
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Primary Sclerosing Cholangitis (PSC)
Endoscopy and Primary Sclerosing Cholangitis
Primary Sclerosing Cholangitis (PSC) is a chronic, cholestatic, immune-mediated liver disease characterized by segmental inflammation, fibrosis and destruction of the intra and / or extrahepatic biliary tree.
- Trial name
- NCT06686810
- Testing
- Endoscopic Retrogradade CholangioPancreatography (ERCP)
- Where
- Italy
- Volunteers
- 118 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Management of Intraoperative Floppy-iris Syndrome and Small Pupils With Different Mechanical Devices
Methods to Manage Intra-operative Floppy-iris Syndrome and Poor Pupil Dilation in Cataract Surgery
Cataract surgery is one of the most frequently performed surgeries worldwide and complications are rare. However, there are factors that increase the risk of complications, such as poor pupil dilation and intra-operative floppy…
- Trial name
- IFIS (NCT01778959)
- Testing
- Malyugin Ring, Iris hooks, standard OVD
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Keratoconus, Ectasia
Collagen Cross-Linking for Keratoconus/Ectasia With and Without Intacs
This study will determine the efficacy of collagen cross linking for progressive keratoconus and ectasia after lasik. It will try and determine which is a more effective treatment: collagen cross linking alone or collagen cross…
- Trial name
- NCT01081561
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Yaron S. Rabinowitz M.D.
Stenosis, Crohn's Disease
Comparative Prospective Multicenter Randomized Study of Endoscopic Treatment of Stenosis in Crohn´s Disease
This study will be a multicentre randomized controlled trial to assess the efficacy between balloon dilatation and self-expanding metallic stent placement for endoscopic treatment of stenosis in Crohn´s Disease.
- Conditions
- Stenosis, Crohn's Disease, Chronic Inflammation
- Trial name
- PROTDILAT (NCT02395354)
- Testing
- Placing a self-expanding metallic stent, A balloon dilatation
- Where
- Spain
- Volunteers
- 122 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Cystic Fibrosis (CF), Mucoviscidosis
Prevalence of Exercise-induced Ventilatory Limitation and Associated Factors in Patients With Cystic Fibrosis Receiving Elexacaftor-Tezacaftor-Ivacaftor
Cystic fibrosis is a genetic disorder affecting the entire body and associated with respiratory exacerbations, impaired quality of life and reduced life expectancy.
- Trial name
- MUCOLIMEX (NCT07314229)
- Testing
- Measurement of resistance through forced oscillations and continuous measurement of ventilation and inspiratory capacity during TM6
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Lille
Achalasia
Pneumatic Dilatation or Surgical Myotomy for Achalasia
Patients with newly diagnosed achalasia have been submitted to either treatment with pneumatic dilatation or surgical myotomy. Minimal follow up five years.
- Trial name
- NCT02086669
- Testing
- Pneumatic dilatation, Laparoscopic myotomy
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Karolinska University Hospital
Cervical Cancer, Endometrial Cancer
Compliance to Vaginal Dilation Therapy in Patients Who Have Undergone Radiation Therapy For Stage IB, Stage IIA, Stage IIB, Stage IIIA, or Stage IIIB Cervical Cancer or Stage IA, Stage IB, Stage IIA, or Stage IIB Endometrial Cancer
RATIONALE: Understanding how well patients comply with their treatment regimen may help doctors determine best treatment and ongoing care for future patients.
- Conditions
- Cervical Cancer, Endometrial Cancer, Radiation Toxicity, Sexuality and Reproductive Issues
- Trial name
- NCT00735514
- Testing
- compliance monitoring, questionnaire administration, assessment of therapy complications
- Where
- 8 sites in United States
- Volunteers
- 83 people
- Sponsor
- Case Comprehensive Cancer Center
Keratoconus, Unstable, Ectasia Corneal
Safety and Effectiveness of the PXL Platinum 330 System for Corneal Collagen Cross-Linking in Eyes With Corneal Thinning Position
To determine whether the Peschke PXL-330 is safe and effective in the treatment of corneal thinning conditions.
- Conditions
- Keratoconus, Unstable, Ectasia Corneal, Bacterial Keratitis
- Trial name
- NCT04213885
- Testing
- PXL 330 Platinum device/Riboflavin
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Eye Specialists of Indiana
Tricuspid Regurgitation Functional
Early Feasibility Study of the Cardiac Implants Percutaneous Ring Annuloplasty System
An early feasibility study to evaluate the safety and performance of 1) the transcatheter delivery and implantation of the Cardiac Implants (CI) annuloplasty ring and 2) the adjustment of the ring approximately 90 days following…
- Trial name
- NCT04890821
- Testing
- CI Percutaneous Ring Annuloplasty System
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Cardiac Implants LLC
Aortic Stenosis, Ascending Aortic Dilatation
Efficacy of Self-expandable and Balloon-expandable Valves in Patients With Ascending Aortic Dilation
This study evaluated the efficacy of self-expandable valves and balloon-expandable valves in patients with ascending aortic dilation who undergo transcatheter aortic valve replacement.
- Trial name
- NCT06743568
- Testing
- Transcatheter aortic valve replacement
- Where
- 3 sites in China
- Volunteers
- 100 people
- Sponsor
- China National Center for Cardiovascular Diseases
Gastric Disease, Capsule Endoscopy
The Usage of Soda-Water in Gastric Preparation for Magnetically Controlled Capsule Endoscopy
Magnetically controlled capsule endoscopy (MCE) is a noninvasive technique (90.4% sensitivity, 94.7% specificity and 93.4% accuracy) without requiring sedation or air insufflation, which makes it welcomed by most of participants.
- Trial name
- NCT04479423
- Testing
- Soda-water instead of pure water to observe gastric filling
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Cervical Ripening
Hysteroscopy After Pretreatment With Misoprostol and Estradiol Trial
The aim of this study is to investigate whether 1000 micrograms of self-administered vaginal misoprostol 12 hours before operative hysteroscopy results in effective preoperative cervical ripening after two weeks pretreatment with…
- Trial name
- NCT00572819
- Testing
- Misoprostol
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Ullevaal University Hospital
Pain
Pupillary Dilation Reflex (PDR) Evaluation During General Anesthesia
In this study, the pupillary dilation reflex is measured as a nociceptive indicator during elective abdominal surgery under general anesthesia.
- Trial name
- NCT02942316
- Testing
- Pupil dilation reflex measurement
- Where
- Belgium
- Volunteers
- 41 people
- Sponsor
- University Hospital, Antwerp