Clinical trials: Distress, open to volunteers
SMARD1, CMT2S
Gene Therapy for IGHMBP2-Related Diseases
Open-label, single intrathecal injection study of a AAV9 vector carrying the IGHMBP2 gene for IGHMBP2-related diseases.
- Trial name
- NCT05152823
- Testing
- Gene Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Megan Waldrop
Viral Lung Infection and Acute Respiratory Failure
Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
- Trial name
- TILIA (NCT05624450)
- Testing
- Tozorakimab
- Where
- 473 sites in United States, Argentina and 37 more
- Volunteers
- 3,527 people
- Sponsor
- AstraZeneca
Ophthalmic Artery, Labor and Delivery
The Ophthalmic Artery Doppler Evaluation Prior to Labor Induction and Adverse Intrapartum Fetal Outcomes
The ophthalmic artery Doppler has been recently proposed as a potential "soft marker" for placental insufficiency in retrospective and observational studies, with similar clinical significance with respect to Uterine Artery (UA)…
- Conditions
- Ophthalmic Artery, Labor and Delivery, Induction of Labor, Intrapartum Fetal Distress
- Trial name
- OPHELIA (NCT07846137)
- Testing
- Ophthalmic Artery Doppler
- Where
- Italy
- Volunteers
- 1,477 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Acute Respiratory Distress Syndrome (ARDS)
Early Switch in Moderate ARDS
The optimal timing for transition from controlled to assisted mechanical ventilation in patients with acute respiratory distress syndrome (ARDS) remains uncertain.
- Trial name
- SWITCH-ARDS (NCT07907276)
- Testing
- Protocolized Transition From Controlled to Assisted Mechanical Ventilation
- Volunteers
- 30 people
- Sponsor
- University of Thessaly
Caregiver Distress, Emotional Distress
The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Injury
The purpose of this research study is to determine whether COMA-F is more efficacious at reducing emotional distress in caregivers of patients with severe acute brain injuries, compared to health education control.
- Conditions
- Caregiver Distress, Emotional Distress, Caregivers, Resilience
- Trial name
- COMA-F (NCT07331324)
- Testing
- Coma Family Program 1, Coma Family Program 2
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Diabetes Mellitus, Psychological Distress
Prevalence of Diabetes-related Distress Among Patients Living With Type 2 Diabetes in a University Hospital Center and Identification of Its Associated Factors.
Diabetes-related distress is a psychological construct associated with poorer glycaemic control in people living with diabetes. In France, few data are available on this topic and none focus specifically on adults with type 2…
- Trial name
- DIAMIND (NCT07392437)
- Testing
- Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 290 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Respiratory Distress Syndrome, ARDS
Fostamatinib for Treating Acute Respiratory Distress Syndrome (ARDS) in Hospitalized Adults
This study is designed to evaluate the safety and efficacy of fostamatinib in hospitalized adult participants with acute respiratory distress syndrome (ARDS).
- Trial name
- FOSTA-ARDS (NCT06564207)
- Testing
- Fostamatinib
- Volunteers
- 40 people
- Sponsor
- Inova Health Care Services
Preterm, Respiratory Distress Syndrome in Premature Infant
The Hemodynamic Impact of High-frequency Oscillatory Ventilation and Periodic Sighs in Preterm Infants
To evaluate the effectiveness of early lung recruitment using high-frequency oscillatory ventilation (HFOV) alone versus HFOV with superimposed sigh breaths in moderate-to-late preterm infants requiring invasive respiratory…
- Conditions
- Preterm, Respiratory Distress Syndrome in Premature Infant, Recruitment, Mechanical Ventilation
- Trial name
- NCT07896824
- Testing
- Superimposed sigh breaths, High frequency ventilation
- Volunteers
- 100 people
- Sponsor
- Alexandria University
ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure
Development and Prospective Validation of the AutoEIT Foundation Model for ARDS
Acute Respiratory Distress Syndrome (ARDS) is a highly heterogeneous condition, making precision mechanical ventilation challenging.
- Conditions
- ARDS (Acute Respiratory Distress Syndrome), Respiratory Failure, Mechanical Ventilation, Ventilator-induced Lung Injury (VILI)
- Trial name
- NCT07898319
- Testing
- AutoEIT Model Training, AutoEIT Blinded Validation
- Where
- China
- Volunteers
- 1,200 people
- Sponsor
- Ruijin Hospital
Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia
Ventilator Pressure and Optimization of Compliance and Hemodynamics
In preterm infants < 34 weeks' gestation at birth receiving respiratory support with invasive positive pressure ventilation, the positive end-expiratory pressure (PEEP) of best compliance will increase the cardiac output and…
- Conditions
- Bronchopulmonary Dysplasia, Pulmonary Hypertension Due to Lung Diseases and Hypoxia, Extreme Prematurity, Ventilator Lung; Newborn
- Trial name
- VPOCH (NCT06512935)
- Testing
- Increase in the PEEP followed by decrease in the PEEP, Decrease in the PEEP followed by increase in the PEEP
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Neonatal Respiratory Distress Related Conditions, Meconium
Amnioinfusion's Protective Effects on Respiratory and Longitudinal Pediatric Outcomes After Intrapartum Meconium Exposure
Meconium in the amniotic fluid occurs in about one out of seven pregnancies and increases the chance that a newborn may have breathing problems after birth.
- Conditions
- Neonatal Respiratory Distress Related Conditions, Meconium, Perinatal Morbidity, Neonatal Acidosis
- Trial name
- PEARL (NCT07274527)
- Testing
- Intrauterine pressure catheter, Standard obstetric care at discretion of delivery provider
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- Medical College of Wisconsin
Disorders of Gut-brain Interaction, Distress, Psychological
Efficacy, and Cost-effectiveness of an Online ACT Intervention for Disorders of Gut-Brain Interaction (iACTforDGBI)
Test of efficacy and cost-effectiveness of the iACTforDGBI intervention vs an active control group (DGBI School)
- Trial name
- iACTforDGBI (NCT07814196)
- Testing
- iACTforDGBI intervention, DGBI School
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Örebro University, Sweden
ARDS, Human
Pulmonary Immune Cell-microbiome Interactions in ARDS
The overall aim is to compare the composition and spatial heterogeneity of the following in critically ill intensive care unit (ICU) patients: i) immune cell populations and their activation patterns, ii) the surrounding…
- Trial name
- ILLUMINA-1 (NCT05795257)
- Testing
- Bronchoalveolar lavage
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Hvidovre University Hospital
Emotional Distress, Anhedonia
Promoting Positive Emotions in Adolescents Using Positive Events Training: An Indicated Approach
Research shows that high positive emotionality is an essential ingredient in building resilience in youngsters, especially those with a vulnerability to develop depressive symptomatology.
- Trial name
- iPET (NCT07288541)
- Testing
- Positive Events Training (PET)
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- KU Leuven
Diabetes (DM), Diabetes Mellitus
Changes in Person-reported Outcomes and Behavior Using the Accu-Chek SmartGuide CGM and Predict App
The goal of this controlled pre-post-trial is to test the Accu-Chek SmartGuide continuous glucose monitoring (CGM) system and whether its predictive features provide additional benefits for adults with type 1 diabetes or insulin…
- Conditions
- Diabetes (DM), Diabetes Mellitus, Diabetes Mellitus Type 2, Diabetes Mellitus Type 1
- Trial name
- NCT07814508
- Testing
- SmartGuide CGM with Predictive Features
- Where
- Germany
- Volunteers
- 89 people
- Sponsor
- FIDAM RDC
Depression - Major Depressive Disorder, Psychological Distress
Testing a Non-Deceptive Placebo Intervention for Subclinical Depressive Symptoms
Subclinical depression - depressive symptoms that fall below the threshold for major depressive disorder - is common in young adults and predicts later depressive episodes, yet it often goes untreated.
- Conditions
- Depression - Major Depressive Disorder, Psychological Distress, Depression / Major Depressive Disorder
- Trial name
- NDP_CCG (NCT07889908)
- Where
- United States
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Miami University
Type 2 Diabetes Mellitus (T2DM), Diabetes Distress
Achieving Routine Intervention and Screening for Emotional Health
The purpose of this project is to evaluate the effectiveness of diabetes distress screening and intervention on patients with type 2 diabetes mellitus (T2DM).
- Trial name
- ARISE (NCT06887049)
- Testing
- ARISE Learning Community Diabetes Distress Screening and Intervention, ARISE Enhanced Care brief training
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- University of Chicago
Psychological Distress, Psychological Well-being
Two Sessions of Coach-Delivered Core Transformation for Distress and Well-Being
The goal of this study is to learn if Core Transformation, a guided coaching process, lowers psychological distress in adults. It will also look at well-being, daily functioning, and whether any changes last over time.
- Trial name
- NCT07879196
- Testing
- Core Transformation Process
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Andreas NLP (Legal Entity - Real People Press)
Psychological Distress, Stress Psychological
A Community-based, Peer-led Counseling Service: A Hybrid Type 3 Effectiveness-implementation Study
The goal of this observational study is to learn how a community-based peer counselling service works in everyday practice and whether it helps people who are going through a psychologically difficult time.
- Conditions
- Psychological Distress, Stress Psychological, Mental Health, Recovery
- Trial name
- NCT07879443
- Volunteers
- 65 people
- Sponsor
- St.Gallen University of Applied Sciences
Psychological Distress, Adverse Childhood Experience
EMI for Reducing Psychological Distress in Young Adults With Multiple ACEs: A RCT Study
This study is a two-arm randomized controlled trial designed to evaluate the effectiveness of an ecological momentary intervention (EMI) in reducing psychological distress among young adults with multiple adverse childhood…
- Trial name
- NCT07885579
- Testing
- EMI
- Volunteers
- 100 people
- Sponsor
- Peking University