Clinical trials: Disturbed Sleep
Insomnia (moderate)
Impact of GABA Probiotic Lactiplantibacillus Plantarum Lp815 on Sleep Outcomes in Participants with Self-Reported Sleep Disturbance
The rationale for this study is to observe differences in sleep outcomes between a consumer-grade probiotic capsule called GABA Probiotic and a placebo control group.
- Trial name
- NCT06789718
- Testing
- GABA Probiotic Lactiplantibacillus plantarum Lp815 (5 Billion cfu/dose), Optional Sub-Study: Neurotransmitter Urine Test
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Verb Biotics LLC
Sleep Disturbance, Amnestic Mild Cognitive Impairment
Sleep Interventions and Neurocognitive Outcomes
This protocol focuses on the effect of sleep interventions on improving sleep and building cognitive/brain resilience in older adults with amnestic mild cognitive impairment and sleep disturbance.
- Trial name
- SINA (NCT05987007)
- Testing
- Acoustic slow-wave activity enhancement, Cognitive behavioral therapy for insomnia
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- New York State Psychiatric Institute
Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug
Changes in Circadian Rhythm After Anaesthesia in Children
In this study the investigators will examine the effect of general anesthesia and surgery on sleep duration and sleep quality in children, using questionnaires and a sleep diary.
- Conditions
- Circadian Rhythm Sleep Disorder, Circadian Rhythm Disorder Caused by Drug, Circadian Rhythm Sleep Disorder, Jet Lag Type, Jet Lag
- Trial name
- CLOCKSkids (NCT05618405)
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Knee Osteoarthritis, Knee Pain Chronic
Effects of Internet / Web-based Exercises on the Population With Knee Arthritis
1. To test whether internet-based exercises reduce the pain in knee OA 2. To check whether internet-based exercises improve the physical activity in the patients with knee OA. 3.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Sleep Disturbance
- Trial name
- Knee OA (NCT03545048)
- Testing
- Internet based exercises
- Where
- United Kingdom
- Volunteers
- 105 people
- Sponsor
- University of Nottingham
Sleep Disturbance, Dementia
Sleep Enhancement for Older Adults Living With Memory Loss And Their Care Partners
The purpose of this study is to determine if a 6-week videoconference intervention to teach skills to improve sleep is practical, acceptable, and helpful to persons living with memory loss, cognitive impairment, and/or dementia…
- Trial name
- SLEEPMATE (NCT06250725)
- Testing
- Cognitive Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Emory University
Sleep Disturbance
An Integration of Tai Chi and Repetitive Transcranial Magnetic Stimulation for Sleep Disturbance in Older Adults
The investigators designed an RCT aimed at 1) exploring the effectiveness of combining TC with rTMS for synergistically improving sleep disturbances in community-dwelling older adults, 2) investigating the mediating roles of…
- Trial name
- NCT05808517
- Testing
- Tai Chi, repetitive transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 38 people
- Sponsor
- The Hong Kong Polytechnic University
Sleep Disturbance
Bonafide Sleep Supplement for Menopausal Women With Sleep Complaints
This open-label study was designed to evaluate whether a daily dietary sleep supplement could improve sleep quality and related daytime well-being in menopausal women aged 40 to 65 with sleep complaints.
- Trial name
- NCT07839312
- Testing
- S-Adenosyl Methionine (SAMe), Propyl Gallate, Gamma-Aminobutyric Acid (GABA), L-Theanine, and Magnesium Glycinate
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Bonafide Health
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Tooth Eruption Disorder
Effects of a Gum Gel Intended to Treat Signs and Symptoms of Teething
Teething discomfort is a widespread disorder affecting a very high percentage of infants. The use of hyaluronic acid gels has been shown in the last 20 years to be an effective tool, generally devoid of side effects, in reducing…
- Trial name
- NCT04879836
- Testing
- Teething Gel, Teething Ring
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- University of Urbino "Carlo Bo"
COVID-19
Sleep Quality and Quality of Life in Coronavirus 19 Disease ( COVID 19) Patients
To study the impact of COVID 19 infection on sleep habit as regards quality of sleep, emergence of insomnia. To assess quality of life in patients after COVID 19 infection.
- Trial name
- NCT05148858
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sleep Disturbance
Prevention of Insomnia Using a Stepped Care Model in Adults
Insomnia is one of the most common sleep disorders and affects approximately 10 - 40% of the population across different age groups in Hong Kong.
- Trial name
- NCT06156293
- Testing
- Cognitive behavioral prevention program for insomnia (CBP-I)
- Where
- China
- Volunteers
- 1,016 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Anxiety State, Sleep Disturbance
Anxiety/Depression, Sleep and Alcohol in Elderly Anxiety/Depression, Sleep Disturbances and Alcohol Use Disorder in Elderly With Cognitive Complaints
The goal of MEM-ASA is to investigate the prevalence of anxiety/depression, sleep disturbances and alcohol use disorder in elderly with cognitive complaints.
- Conditions
- Anxiety State, Sleep Disturbance, Alcohol Abuse, Aging
- Trial name
- MEM-ASA (NCT04368416)
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- University Hospital, Caen
Sleep Disturbance, Sleep Disorders
Effect of Progressive Muscle Relaxation and Diaphragmatic Breathing on Sleep Disturbances in Chemotherapy Patients
This randomized controlled trial aims to investigate the effect of combined Progressive Muscle Relaxation (PMR) and Diaphragmatic Breathing (DB) techniques on sleep disturbances among patients receiving chemotherapy.
- Conditions
- Sleep Disturbance, Sleep Disorders, Cancer
- Trial name
- PMR & DB (NCT07639710)
- Testing
- Progressive Muscle Relaxation and Diaphragmatic Breathing
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Breast Cancer, Depression
The Effect of Melatonin on Depression, Anxiety, Cognitive Function and Sleep Disturbances in Breast Cancer Patients
The purpose of this study is to investigate the effect of 6 mg melatonin daily for 1 week preoperatively to 12 weeks postoperatively on depressive symptoms, anxiety, cognitive function and sleep disturbances in breast cancer…
- Trial name
- MELODY (NCT01355523)
- Testing
- Melatonin (N-acetyl-5-methoxytryptamine)
- Where
- Denmark
- Volunteers
- 54 people
- Sponsor
- Melissa Voigt Hansen
Sleep Health, Binge Eating
Sleep Optimization to Aid in Recovery Digital Program
The purpose of this pilot study is to evaluate the usability and feasibility of SOAR (Sleep Optimization to Aid Recovery), a brief and self-guided digital program designed to share evidence-based sleep hygiene information with…
- Conditions
- Sleep Health, Binge Eating, Disordered Eating, Sleep Disturbances
- Trial name
- SOARPilot (NCT07518368)
- Testing
- SOAR
- Volunteers
- 154 people
- Sponsor
- University of Nevada, Las Vegas
Sleep Disturbance
The SLEEP-CARE Study
Sleep disorder is common in ICU patients, such as reduced sleep time, fragmentation, and abnormal sleep rhythm. In 2023, American Thoracic Society released a research statement on sleep and circadian disruption(SCD) in ICU, which…
- Trial name
- NCT06336408
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Shanghai Zhongshan Hospital
Fibromyalgia Syndrome
Sleep Disturbance and Sleep Quality in Women With Fibromyalgia Syndrome
The purpose of this week long study is to describe sleep and problems with sleep in women diagnosed with Fibromyalgia syndrome.
- Trial name
- NCT00482859
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Kentucky
Breast Cancer, Quality of Life
Pilates and Dance to Breast Cancer Patients Undergoing Treatment
Breast cancer is one of the most common types of cancer in Brazil, and its treatment, namely surgery, chemotherapy, radiotherapy or hormone therapy, has consequences and side effects that significantly affect the quality of life…
- Conditions
- Breast Cancer, Quality of Life, Lymphedema, Fatigue
- Trial name
- NCT03194997
- Testing
- Dance, Pilates
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- Laboratório de Pesquisa em Lazer e Atividade Física
Traumatic Brain Injury
An Exploration of Sleep Disturbance and Outcomes in TBI (SLEEP-TBI)
This study aims to look at how sleep disturbance affects people who have had a traumatic brain injury. Sleep disturbance can include waking frequently in the night, difficulty falling asleep, excessive sleepiness or changes to…
- Trial name
- SLEEP-TBI (NCT07120373)
- Where
- United Kingdom
- Volunteers
- 180 people
- Sponsor
- University of Nottingham
Postoperative Sleep Disturbance
Dynamic Prediction of Sleep Protection Demand on the First Postoperative Night and Its Influence on Ward Process After Thoracoscopic Lobectomy or Segmentectomy
This study combines retrospective data analysis with a single-center prospective non-interventional cohort study to understand postoperative sleep disturbance on the first night after video-assisted thoracoscopic (VATS) lobectomy…
- Trial name
- NCT07716085
- Testing
- Video-assisted thoracoscopic (VATS) lobectomy or segmentectomy
- Volunteers
- 400 people
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine