Clinical trials: Disturbed Sleep
Stress Disorders, Post-traumatic
Analyzing Female Trauma Exposed Responses to a Medication
This purpose of this study is to look at the safety of the experimental drug GSK561679 as well as its effects on PTSD symptoms, thinking and memory, startle reaction, stress hormones, and mental health symptoms in comparison to…
- Trial name
- AFTER (NCT01814332)
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- VA Office of Research and Development
Rheumatoid Arthritis, Sleep Disturbances
Effect of Moderate to High Intensity Aerobic Interval Training on Polysomnographic Measured Sleep in Patients With Rheumatoid Arthritis
Poor sleep quality and sleep disturbances are common in patients with rheumatoid arthritis and are associated with an increased risk of co-morbidity and all-cause mortality.Few studies have examined the possibilities of improving…
- Trial name
- JR (NCT01966835)
- Testing
- High intensity aerobic interval training
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Sarcopenic Obesity
Sleep Disturbances and Biomarkers of Sarcopenic OBesity
The general objective of this study is to identify biomarkers of sleep quality, sarcopenia, insulin resistance, oxidative stress and inflammation associated with prefrailty in middle-aged and elderly obese subjects through the…
- Trial name
- SleSOB (NCT03175601)
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istituto di Fisiologia Clinica CNR
Sleep, Postpartum Depression
The Dream Team: Testing Implementation of a Sleep Intervention for Perinatal Women Delivered by Direct Care Workers
Insufficient and disrupted sleep are rarely addressed in expectant and new mothers, despite evidence that disturbed sleep is a modifiable risk factor for negative health outcomes for mothers and their children.
- Conditions
- Sleep, Postpartum Depression, Pregnancy Related, Insomnia
- Trial name
- NCT06737055
- Testing
- Education about behavioral strategies to improve sleep
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
Sleep Disorders
Sleep Disturbances in Hospitalized Children
Background Sleep disturbances are prevalent in hospitalized adult patients manifested as reduced sleep time and sleep efficiency as well as increased awakenings. Insomnia is the most frequent sleep disturbance.
- Trial name
- NCT00749814
- Testing
- Melatonin
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Smith-Magenis Syndrome, Circadian
Evaluating the Effects of Tasimelteon vs Placebo on Sleep Disturbances in SMS
The aim of this study is to investigate tasimelteon vs. placebo on sleep disturbances of individuals with Smith-Magenis Syndrome.
- Trial name
- NCT02231008
- Testing
- tasimelteon
- Where
- 4 sites in United States
- Volunteers
- 49 people
- Sponsor
- Vanda Pharmaceuticals
Depression
Promoting Sleep and Healthy Aging Research Study (PRO-SHARE)
The objective of this study is to evaluate the ability of a behavioral intervention, cognitive behavioral therapy for sleep quality (CBT-SQ) to reduce sleep complaints, depression recurrence, and cellular and genomic markers of…
- Trial name
- PRO-SHARE (NCT01641263)
- Testing
- Sleep Education Therapy, Cognitve Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Sleep Disturbance, Aging
Sleep Quality in Assisted-Living Residents
Assisted living residents who have sleep disturbances are at great risk of developing cognitive impairments. The identification of factors that increase sleep problems in this population is the first step towards improving sleep…
- Trial name
- NCT04400617
- Testing
- Cross-sectional assessments to examine the relationship among sleep quality, functional/physical capacity, and cognitive performance.
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of Calgary
Psychotic Disorders, Psychosis
CBT to Reduce Insomnia and Improve Social Recovery in Early Psychosis
Sleep disturbances and cognitive dysfunction are consistently reported as extremely troublesome aspects of psychotic illnesses. While sleep disturbances are not included in definitions of psychosis they are associated with poor…
- Conditions
- Psychotic Disorders, Psychosis, Sleep
- Trial name
- CRISP (NCT04180709)
- Testing
- Sleepio
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Cambridge
Sleep, Sleep Disturbance
Sounds Locked to ElectroEncephalogram Phase For the Acceleration of Sleep Onset Time
This study seeks to test whether auditory stimulation delivered at specific phases of the alpha oscillation (as measured by electroencephalogram) can accelerate sleep onset.
- Trial name
- SLEEPFAST (NCT05743114)
- Testing
- Elemind Neuromodulation (ENMod)
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Elemind Technologies, Inc.
Multiple Sclerosis
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
Sleep disturbance, especially insomnia (i.e., difficulty initiating and maintaining sleep), affects over half of people with MS.
- Trial name
- NCT04147052
- Testing
- iSLEEPms
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Hemoperfusion
HP Improves Sleep and Overall Survival Rate in Maintenance Hemodialysis Patients
Sleep disturbance has been long-standing torments in most of patients with maintenance hemodialysis (HD). In this study, we attempted to explore whether long-term hemoperfusion (HP) could improve sleep disorder and increase…
- Trial name
- NCT03487146
- Testing
- hemoperfusion(HP)
- Volunteers
- 156 people
- Sponsor
- Shanghai Pudong Hospital
Esketamine, Sleep Disturbance
Esketamine on Postoperative Sleep Disturbance of Patients Undergoing Spinal Surgery
The goal of this clinical trial is to learn about the effect of intraoperative esketamine infusion on postoperative sleep disturbance(PSD) of patients undergoing spinal surgery.
- Conditions
- Esketamine, Sleep Disturbance, Spinal Surgery
- Trial name
- NCT06451627
- Testing
- Esketamine, saline
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Beijing Tiantan Hospital
Elderly Depression, Sleep Disturbance
Wearable-Based Study of Depression and Sleep in Older Adults
This 4-year study aims to develop a safe and effective management model for late-life depression using wearable technologies. The research will recruit older adults (aged 60 and above) with major depressive disorder, confirmed by…
- Trial name
- NCT07232472
- Testing
- Photobiomodulation
- Where
- United Kingdom
- Volunteers
- 162 people
- Sponsor
- China Medical University Hospital
Chronic Fatigue Syndrome
Coenzyme Q10 Plus NADH Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis
The main aim of the study is to examine the effect of oral CoQ10 plus NADH (Reconnect®) supplementation twice daily for 8-weeks on the changes in fatigue perception, sleep disturbances, autonomic dysfunction and HRQoL assessed by…
- Trial name
- CONNeCT (NCT03186027)
- Testing
- Coenzyme Q10 plus NADH, phosphoserine plus vitamin C
- Where
- Spain
- Volunteers
- 282 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Reflux Esophagitis
Vonoprazan Study of Investigating the Effect on Sleep Disturbance Associated With Reflux Esophagitis- Exploratory Evaluation
The purpose of this study is to exploratorily evaluate the effect of vonoprazan 20 mg on sleep disturbance of patients with reflux esophagitis, who have heartburn and/or regurgitation and ≥ 6.0 in the Pittsburgh Sleep Quality…
- Trial name
- VISTAEXE (NCT03116841)
- Testing
- Vonoprazan
- Where
- 6 sites in Japan
- Volunteers
- 3 people
- Sponsor
- Takeda
Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm
A Prospective Study: the Impact of Sleep Disturbances on Immunotherapy in Patients With Lung Cancer
In recent years, immunotherapy has made significant progress in the treatment of lung cancer, especially immune checkpoint inhibitors (such as PD-1/PD-L1 antibodies) against non-small cell lung cancer (NSCLC).
- Conditions
- Lung Cancer (NSCLC), Sleep Disorders, Circadian Rhythm, PD-1
- Trial name
- NCT06953765
- Testing
- PSQI, PQSI
- Volunteers
- 350 people
- Sponsor
- Shanghai Zhongshan Hospital
Type 2 Diabetes Mellitus, Insomnia
Suvorexant on Sleep Disturbance in Patients With Chronic Insomnia and Suboptimally Controlled Type 2 Diabetes
The investigators aim to determine the effect of suvorexant on subjective total sleep time (TST) in suboptimally controlled Type 2 diabetics with chronic insomnia in a randomized placebo-controlled trial for 3 months.
- Conditions
- Type 2 Diabetes Mellitus, Insomnia, Sleep Disorder, Inflammation
- Trial name
- NCT03818581
- Testing
- Suvorexant
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- Massachusetts General Hospital
Circadian Dysrhythmia, Sleep Disturbance
PICU-related Sleep and Circadian Dysregulation Pilot Study
A single center pilot trial investigating the feasibility of using actigraphy and salivary melatonin levels to measure the sleep and circadian rhythm of critically ill children aged 3 to 6 years old.
- Conditions
- Circadian Dysrhythmia, Sleep Disturbance, Critical Illness, Children, Only
- Trial name
- NCT06505447
- Testing
- Daytime light exposure, Daytime restricted feeding
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- State University of New York at Buffalo
Hepatic Encephalopathy, Liver Cirrhosis
The Effect of Induced Hyperammonaemia on Sleep and Melanopsin-mediated Pupillary Light Response in Patients With Liver Cirrhosis
Sleep disturbances are common among patients with liver cirrhosis, but the reasons are not well understood. In this project the investigators evaluated whether an increase in blood ammonia in patients with cirrhosis had an impact…
- Conditions
- Hepatic Encephalopathy, Liver Cirrhosis, Sleep Disturbance
- Trial name
- NCT04771104
- Testing
- Amino Acid Challenge (AAC)
- Where
- Denmark
- Volunteers
- 9 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet