Clinical trials: Diuresis
Nocturia, Menopause
Hormonal Influences on Diuresis
The aim of this study was to observe the effect of hormonal treatment (oral or transdermal substitution therapy) on diuresis (salt and water diuresis) and lower urinary tract symptoms (LUTS) in postmenopausal women
- Conditions
- Nocturia, Menopause, LUTS, Diuresis
- Trial name
- HODI (NCT04891926)
- Testing
- ICIQ FLUTS Questionaires, Frequency Volume Chart, Renal Function Profile
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Lower Urinary Tract Symptoms, End Stage Renal Disease
Diuresis, Functional Bladder Capacity and LUTS in CKD and ESRD Patients.
The aim of the study is to evaluate the prevalence of LUTS in patients with moderate to severe (Stage IIIb), severe (Stage IV) CKD and ESRD : Stage V CKD) without renal transplantation (both pre-dialysis and dialysis patients).
- Trial name
- NCT04622215
- Testing
- ICIQ questionnaire
- Where
- 3 sites in Belgium
- Volunteers
- 128 people
- Sponsor
- Universitair Ziekenhuis Brussel
Cirrhosis, Liver, Ascites Hepatic
Refractory Ascites in Patients With Liver Cirrhosis, and the Potential Treatment With 48 Hours Infusion of Ularitide.
This clinical trial intends to investigate the safety, tolerability and efficacy of ularitide on the renal response in patients with liver cirrhosis and refractory ascites for a maximum exposure duration of 48 hours, through a…
- Trial name
- ULA04 (NCT04311489)
- Testing
- Ularitide
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- University of Aarhus
Cardiac Surgery Associated - Acute Kidney Injury, AKI - Acute Kidney Injury
Safety & Efficacy of RenalGuard® Therapy in the Prevention of Cardiac Surgery Associated Acute Kidney Injury
The goal of this clinical trial is to assess the effect of RenalGuard Therapy in reducing the rates of Acute Kidney Injury (AKI) within 72 hours after cardiac surgery in patients at risk of developing Cardiac Surgery Associated…
- Trial name
- SAFEGUARD (NCT07123935)
- Testing
- RenalGuard® Therapy, Standard of Care (SOC)
- Where
- 2 sites in Malaysia
- Volunteers
- 300 people
- Sponsor
- CardioRenal Systems, Inc.
Acute Decompensated Heart Failure
Effects of Empagliflozin on Diuresis and Renal Function in Patients With Acute Decompensated Heart Failure
Heart failure is the most common hospital admission diagnosis and shows increasing incidence and prevalence in Germany, the United States and worldwide. Improvements in the primary treatment conditions for e.g.
- Trial name
- EMPAG-HF (NCT04049045)
- Testing
- Empagliflozin 25 mg
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Christian Schulze
Diuresis Under Eletrical Stimulation
The Effect of Lower Urinary Tract Electrical Stimulation on Renal Urine Production (diuresis)
In previous studies, in which the perception threshold and / or sensory evoked potentials at different points of the lower urinary tract were examined and measured by means of electrical stimulation, a clear increase in the…
- Trial name
- EFFLUENT (NCT03256656)
- Testing
- electrical stimulation (non painful) of the lower urinary tract to determine the current perception threshold and record sensory evoked potentials
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Preeclampsia
Hypertonic Saline Use in Preeclampsia
To compare hypertonic saline to Lactated Ringer's solution and assess whether one speeds up the process of getting rid of extra body water faster in women with preeclampsia.
- Trial name
- NCT00181077
- Testing
- 2% buffered hypertonic saline administration
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Johns Hopkins University
Uremia
L-Cysteine in Peritoneal Dialysis
Over the last decades, peritoneal dialysis has grown worldwide to become one of the most common modalities of renal replacement therapy, particularly in developing or newly industrialized countries, such as India, China, Korea…
- Trial name
- CINDY (NCT02050139)
- Testing
- L-cysteine
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Heart Failure; With Decompensation
Remote Dielectric Sensing (ReDS) Assisted Diuresis in Acute Decompensated Heart Failure
This study evaluates the use of a wearable vest capable of non-invasively measuring lung fluid content in hospitalized patients with heart failure
- Trial name
- RADAR-HF (NCT03586336)
- Testing
- ReDS-Guided, Usual Care
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Francisco
Cardiac Surgery Subjects
PuO2 in RenalGuard Pilot Study
The PuO2 in RenalGuard (PURE) study is planned as a single center, randomized controlled pilot study comparing renal oxygenation during cardiac surgery with cardiopulmonary bypass (CPB) with or without balanced forced diuresis…
- Trial name
- PURE (NCT06886191)
- Testing
- RenalGuard Therapy
- Volunteers
- 30 people
- Sponsor
- Sahlgrenska University Hospital
Healthy
Effect of Immersion, Performed Under the Conditions of Obstetrical Dilatation Bath, on Diuresis and Hemodynamic Variables in Young Women
Like in the full immersion, studied in the context of diving, immersion in water causes a cascade of events with hemodynamic and hormonal consequences.
- Trial name
- IMMERSION (NCT02409953)
- Testing
- Lying in a bath during 2 hours, Lying in a bed during 2 hours
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Heart Failure, Congestive
Dose Escalation Study of KW-3902 on Diuresis in Subjects With Congestive Heart Failure (CHF).
The purpose of this study is to evaluate the safety of KW-3902IV compared to placebo and to determine the diuretic effect of KW-3902IV compared to placebo in patients hospitalized with volume overload due to CHF who are…
- Trial name
- NCT00159627
- Testing
- KW-3902IV
- Where
- 10 sites in United States
- Volunteers
- 52 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Colorectal Disorders
Early Diuresis Following Colorectal Surgery
The purpose of this study is to find out if giving a medicine called furosemide, which is a diuretic or water pill, after colon surgery will safely shorten the patient's length of hospital stay.
- Trial name
- NCT02351934
- Testing
- Furosemide, Celecoxib, Gabapentin
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Mayo Clinic
Cirrhosis
Bumetanide vs. Furosemide in Cirrhosis
Patients with cirrhosis are frequently hospitalized due to an acute decompensation of their liver disease including bleeding, jaundice, encephalopathy, and volume overload.
- Trial name
- BUFF (NCT06941415)
- Testing
- Bumetanide, Furosemide
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Stacy Johnson
Heart Failure
Influence of Neurohormonal Blockade on Natriuresis in Heart Failure Patients
Heart failure is a condition that can affect a person's health and daily life. In this study, we aim to investigate how diuretic medications work and how they affect patients with heart failure.
- Trial name
- uGDMT (NCT07781826)
- Testing
- Neurohormonal blockade intensification
- Where
- Poland
- Volunteers
- 80 people
- Sponsor
- Wroclaw Medical University
Heart Failure
Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous Infusion
Heart Failure is a growing and challenging public health concern in the United States. Heart failure commonly manifests as a syndrome of salt and water retention.
- Trial name
- NCT00806910
- Testing
- Conivaptan
- Sponsor
- Albert Einstein Healthcare Network
Congestive Heart Failure, Renal Impairment
Effects of MK7418 on Diuresis and Renal Function in Congestive Heart Failure Patients
A study to determine the most appropriate dose of MK7418 in heart failure patients presenting with symptoms of volume overload requiring increased diuretic doses.
- Trial name
- NCT00652782
- Testing
- rolofyline
- Volunteers
- 160 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Heart Failure Acute, Diabetes Type 2
SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution in Acute HF
The purpose of the current investigation is to demonstrate the efficacy of high-dose furosemide plus small-volume hypertonic saline solution and a Sodium-Glucose cotransporter-2 (SGLT-2) inhibitor among patients admitted for…
- Conditions
- Heart Failure Acute, Diabetes Type 2, Heart Failure With Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction
- Trial name
- DAPA-TONIC (NCT06442280)
- Testing
- Dapagliflozin tablet, Hypertonic Saline Solution, 1 Ml, Furosemide Injection
- Volunteers
- 544 people
- Sponsor
- University of Palermo
Heart Failure
Monitoring Outpatient Blood VolumE in Heart Failure
In patients discharged following heart failure treatment, the consistency of blood volume status and components over time is unknown.
- Trial name
- MOVE-HF (NCT04660396)
- Testing
- BVA-100
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Daxor Corporation
Acute Decompensated Heart Failure
Furosemide-induced Diuresis With Matched Dehydration Compared to Standard Diuretic Therapy in Patients With Acute Heart Failure and Overt Fluid Overload
Acute decompensated heart failure (ADHF) is a complex clinical syndrome caused by cardiac abnormalities compromising the ability of the heart to provide a blood supply adequate to the metabolic needs of peripheral tissues.
- Trial name
- MYTHOS-HF (NCT05807152)
- Testing
- RenalGuard device
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Centro Cardiologico Monzino