Clinical trials: Diuretics
Chronic Kidney Diseases, Renal Failure Chronic
Study to Examine the Effect of the Diuretic Furosemide on the Plasma Levels of Toxins and the Removal of Toxins from the Blood in Patients with Chronic Kidney Disease
The goal of this observational study is to examine the interaction between the diuretic furosemide and certain toxins called protein-bound uremic toxins (PBUTs) in patients with chronic kidney disease (CKD).
- Trial name
- FUROPBUT (NCT06750575)
- Testing
- Invasive measurements
- Where
- Netherlands
- Volunteers
- 34 people
- Sponsor
- UMC Utrecht
COVID-19
Lung Injury (Pulmonary Edema) in COVID-19: Treatment With Furosemide and Negative Fluid Balance (NEGBAL)
In COVID-19, pulmonary edema has been attributed to "cytokine storm". However, it is known that SARS-CoV-2 promotes angiotensin-converting enzyme 2 deficiency, it increases angiotensin II and this triggers volume overload.
- Trial name
- NCT05304702
- Where
- Argentina
- Volunteers
- 120 people
- Sponsor
- Clinica Colon
Preeclampsia
Diuretics for Postpartum High Blood Pressure in Preeclampsia
The purpose of this study is to determine if furosemide administered after the first 24 hours of delivery, in women with severe peeclampsia and eclampsia accelerates high blood pressure control and diminishes hospital stay.
- Trial name
- DIUPRE (NCT02163655)
- Testing
- FUROSEMIDE
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto Materno Infantil Prof. Fernando Figueira
Heart Failure
Preparatory Work for a Trial of Adjuncts to Diuretic Treatment in Patients Hospitalised With Heart Failure: Addressing Uncertainties and Building Consensus
Aims and Objectives 1. Choose which adjunctive therapies, at what dose, and for how long 2. Choose the dose(s) of IV furosemide to be used as the comparator 3. Choose primary and secondary outcomes 4.
- Trial name
- Pre-MAMMOTH-HF (NCT07281040)
- Testing
- Patient and carer panel using nominal group approach and thematic analysis
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Acute Heart Failure
VExUS in Patients With Acute Heart Failure
The importance of assessing venous congestion in heart failure patients is widely acknowledged, but its study is hampered by the lack of a practical evaluation tool.
- Trial name
- NCT06397404
- Testing
- Venous excess ultrasound score (VExUS) protocol
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Pulmonary Edema, Congestive Heart Failure
DECONGEST-AHF: Vasodilatation or Loop Diuretics in Acute Heart Failure
DECONGEST-AHF compares three initial treatments for adults admitted with suspected pulmonary congestion due to acute heart failure: intravenous furosemide, intravenous isosorbide dinitrate, or both medicines together.
- Conditions
- Pulmonary Edema, Congestive Heart Failure, Acute Heart Failure
- Trial name
- DECONGEST-AHF (NCT05276219)
- Testing
- Furosemide Injection, Isosorbide Dinitrate, Furosemide and isosorbide dinitrate
- Where
- 5 sites in Denmark
- Volunteers
- 1,041 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Hypertension
EBMtrialcentral- Comparing Initial Diuretic Therapies Using a Collaborative Network
Clinical equipoise exists with respect to the important question, "What is the best initial diuretic for the treatment of Hypertension"? A pragmatic comparative effectiveness research (CER) study comparing Chlorthalidone to…
- Trial name
- NCT01748123
- Testing
- Chlorthalidone, Hydrochlorothiazide
- Where
- United States
- Sponsor
- Johns Hopkins University
Hypertension
Kanagawa Combination Anti-hypertensive Therapy (K-CAT)
The purpose of this study is to compare the effect and safety of the antihypertensive combination therapies between losartan/amlodipine and fixed dose drug of losartan/hydrochlorothiazide.
- Trial name
- NCT00492128
- Testing
- Losartan/amlodipine or losartan/hydrochlorothiazide
- Where
- Japan
- Volunteers
- 196 people
- Sponsor
- Yokohama City University Medical Center
Kidney Disease, Chronic
Diuretic Testing in Chronic Kidney Disease
The goal of this clinical trial is to predict the progression of chronic kidney disease by diuretic testing in patients with chronic kidney disease.
- Trial name
- U-TUBE 2 (NCT06841692)
- Testing
- Diuretic Testing
- Where
- Netherlands
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Heart Failure
ACetazolamide in Patients With Heart Failure, to Decrease Weight and relIEVE Symptoms.
Acute congestion is common in patients with heart failure (HF) and is associated with impaired renal function, reduced quality of life, hospital readmissions, and mortality.
- Trial name
- ACHIEVE (NCT07737964)
- Testing
- Acetazolamide, Furosemide
- Where
- 25 sites in France
- Volunteers
- 366 people
- Sponsor
- University Hospital, Montpellier
BPH With Urinary Obstruction, BPH
Intra-operative Loop Diuretics to Improve Same-day Discharge Rates After HoLEP
Holmium Laser Enucleation of the Prostate (HoLEP) is a size-independent treatment option for benign prostatic hypertrophy (BPH) as recommended by the American Urological Association (AUA) Guidelines.
- Conditions
- BPH With Urinary Obstruction, BPH, Hematuria, Same Day Discharge
- Trial name
- NCT05620784
- Testing
- Furosemide
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Heart Failure
Effectiveness of a Diuretic Algorithm in Clinical Stability in Heart Failure Patients
One of the challenges in treating patients with heart failure (HF) is achieving clinical stability and reducing the hospital readmission rate.
- Trial name
- NCT02068937
- Testing
- Furosemide and Phone contact, Furosemide
- Where
- Brazil
- Volunteers
- 206 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Hypertension
Enalapril Folic Acid Tablets Combined With CCB or Diuretic to Prevent Stroke in Patients With Type H Hypertension
Hypertension is a common condition that can cause serious events such as stroke, coronary heart disease and heart failure. Homocysteine (Hcy) is a substance in the body that is harmful to blood vessels.
- Trial name
- NCT04952051
- Testing
- Enalapril Folic Acid Tablets Combined With amlodipine, Enalapril Folic Acid Tablets Combined With hydrochlorothiazide
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure
Percutaneously Delivered Automated Continual Fluid Removal System in Patients With Advanced Diuretic-Resistant Heart Failure
The study aims to assess the feasibility, safety, tolerability and functionality of a percutaneously delivered automated continual fluid removal System in up to 8 patients with Heart Failure (HF) and diuretic resistance.
- Trial name
- CLEAR-HF (NCT06689553)
- Testing
- Automated Continual Fluid Removal System
- Where
- 3 sites in Serbia, Spain
- Volunteers
- 2 people
- Sponsor
- Paragate Medical LTD
Hypertension, Diabetes Type 2
Evaluating the Effect of Aliskiren Versus HCTZ on Coronary Flow Reserve in Hypertensive Type II Diabetics
The purpose of this study is to assess the effect of Tekturna (aliskiren), in combination with an ACE and calcium channel blocker in hypertensive patients diagnosed with Type II diabetes.
- Trial name
- NCT00994253
- Testing
- Aliskiren, Hydrochlorothiazide
- Where
- United States
- Sponsor
- Corewell Health East
Heart Failure, Volume Overload
Management of Volume Overload HF Patients by Individual DSR Treatment adJustment-a clinicAl inVestigation of InfusatE2.0
This study is a multi-center, prospective, randomized (2:1), open-label study to evaluate the safety and efficacy of DSR therapy using the Infusate 2.0 peritoneal solution (composed of 30% icodextrin and 10% dextrose) in diuretic…
- Trial name
- MOJAVE (NCT05965934)
- Testing
- Direct Sodium Removal Infusate 2.0
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Sequana Medical N.V.
Acute Heart Failure, Chronic Kidney Diseases
Natriuresis-Guided Diuretic Therapy in Patients With Acute Heart Failure With Reduced Ejection Fraction and Chronic Kidney Disease
To investigate the effectiveness and feasibility of natriuresis-guided diuretic therapy as a personalized approach to managing acute heart failure in patients with underlying chronic kidney disease and its effect on short term…
- Trial name
- NCT06203236
- Testing
- Furosemide 20 MG, diuretic therapy
- Volunteers
- 300 people
- Sponsor
- Assiut University
Heart Failure
Diuretic and Renal Effects of Vaprisol When Administered Along With Furosemide and Nesiritide Continuous Infusion
Heart Failure is a growing and challenging public health concern in the United States. Heart failure commonly manifests as a syndrome of salt and water retention.
- Trial name
- NCT00806910
- Testing
- Conivaptan
- Sponsor
- Albert Einstein Healthcare Network
Chronic Heart Failure, Acute Heart Failure
Canagliflozin in Patients With Acute Decompansted Heart Failure
The study aims to investigate the efficacy and safety of the early initiation of canagliflozin treatment in hospitalized heart failure patients with volume overload (warm-wet) who require the use of I.V loop diuretic during the…
- Conditions
- Chronic Heart Failure, Acute Heart Failure, Diabetes Mellitus
- Trial name
- The CANA -AHF (NCT05364190)
- Testing
- Canagliflozin, Empagliflozin
- Where
- Egypt
- Volunteers
- 142 people
- Sponsor
- October 6 University
Heart Failure
Efficacy of Oral Acetazolamide in Decongestion in Patients With Heart Failure
This is a 1:1 ratio single-center, double-blind, randomized controlled trial, aiming to enroll 130 patients admitted in infusion ward.
- Trial name
- NCT05940220
- Testing
- Acetazolamide
- Where
- Iran
- Volunteers
- 130 people
- Sponsor
- Tehran University of Medical Sciences