Clinical trials: Diuretics
Bronchopulmonary Dysplasia
Pragmatic Research on Diuretic Management in Early BPD Pilot
Babies who are born prematurely often develop a chronic lung disease called bronchopulmonary dysplasia (BPD). BPD puts babies at higher risk for problems with growth and development.
- Trial name
- PRIMED (NCT05898022)
- Testing
- Furosemide (plus potassium chloride)
- Where
- 4 sites in United States
- Volunteers
- 19 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Hypertension
Pharmacogenomic Evaluation of Antihypertensive Responses
There are many medications available for the treatment of high blood pressure (hypertension), but finding the right one for a specific patient can be challenging.
- Trial name
- NCT00246519
- Testing
- Hydrochlorothiazide, Atenolol
- Where
- 3 sites in United States
- Volunteers
- 1,701 people
- Sponsor
- University of Florida
Congestive Heart Failure
Comparison of Long- and Short-acting Diuretics in Congestive Heart Failure
The purpose of this study is to compare therapeutic effects of furosemide, a short-acting loop diuretic, and azosemide, a long-acting one, in patients with heart failure, and to test our hypothesis that long-acting diuretics are…
- Trial name
- J-MELODIC (NCT00355667)
- Testing
- furosemide, azosemide
- Where
- Japan
- Volunteers
- 320 people
- Sponsor
- Hyogo Medical University
Renal Edema, Nephrogenic Edema
A Study of JMKX003142 Tablet to Treat Renal Edema
To evaluate the efficacy, safety, and of JMKX003142 administered randomly, double-blind, placebo-controlled study in Chinese renal edema patients with inadequate response to conventional diuretic therapy.
- Trial name
- NCT07841093
- Testing
- JMKX003142 Tablets
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Jemincare
Heart Failure, Congestive
PROTECT-2: A Study of the Selective A1 Adenosine Receptor Antagonist KW-3902 for Patients Hospitalized With Acute HF and Volume Overload to Assess Treatment Effect on Congestion and Renal Function
The study is being conducted to examine whether KW-3902IV will result in greater improvement in signs and symptoms of heart failure, with less treatment failure than standard therapy, when it is added to IV loop diuretics in…
- Trial name
- NCT00354458
- Testing
- rolofylline
- Volunteers
- 1,102 people
- Sponsor
- NovaCardia, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Nocturia, Benign Prostatic Hypertrophy (BPH)
Dose Response Study of VA106483 in Males With Nocturia and Benign Prostatic Hypertrophy (BPH)
The purpose of this study is to establish the dose response relationship of VA106483 and nocturnal urine volumes in a population of elderly male subjects with Benign Prostatic Hypertrophy (BPH) who are likely to present with…
- Trial name
- NCT01330927
- Testing
- VA106483
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Vantia Ltd
Primary Hypertension
Nijmegen Antihypertensive Management Improvement Study
High blood pressure is an important risk factor for diseases of heart and blood vessels like myocardial infarction and stroke. Many patients are not treated to target blood pressures, even though good blood pressure lowering…
- Trial name
- NAMIS (NCT00457483)
- Testing
- hydrochlorothiazide, valsartan, 80 mg once-a-day
- Where
- Netherlands
- Volunteers
- 120 people
- Sponsor
- Radboud University Medical Center
Diurnal Enuresis, Hypertension
Diuretic Effect Evaluation of Petroselinum Crispum (Parsley) in Hypertensive Patients
The use of alternative therapy, particularly herbal treatment is becoming prevalent among patients. Many herbs are in-use for various ailments such as diabetes, digestive problems, fever, hepatitis and hypertension etc.
- Trial name
- DEEP (NCT03468361)
- Testing
- Natural Product Petroselinum crispum (Parsley)
- Where
- 2 sites in Saudi Arabia
- Sponsor
- Universiti Sains Malaysia
Hypertension
A Study in Chinese Mild to Moderate Hypertensive Patients Comparing the Efficacy of Co-Diovan With Diovan.
Valsartan, an orally active angiotensin II receptor blocker, is registered in most countries worldwide for the treatment of hypertension. In China the usual recommended starting and maintenance dose is 80 mg o.d.
- Trial name
- NCT00250562
- Testing
- valsartan plus hydrochlorothiazide
- Where
- United States
- Volunteers
- 1,171 people, healthy volunteers welcome
- Sponsor
- Novartis
Urinary Tract Obstruction
A Comparative Study of Normalized Residual Activity and Standard Parameters in 99mTc-DTPA Diuretic Renography:
The present study aims to compare the diagnostic performance of Normalized Residual Activity (NORA) with conventional renographic parameters obtained from 99mTc-diethylenetriamine pentaacetic acid (99mTc-DTPA) diuretic renography…
- Trial name
- NCT07811388
- Testing
- 99m Tc-DTPA, Furosemide
- Volunteers
- 57 people
- Sponsor
- Assiut University
Heart Failure
Investigating the Inotropic Potential of Apelin
The apelin-APJ system is a recently discover hormone system that has several important actions in the cardiovascular system. Apelin causes the heart pump with more force and also causes blood vessels to relax.
- Trial name
- INO-apelin (NCT01179061)
- Testing
- Apelin
- Where
- 3 sites in United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Heart Failure, Heart Failure Acute
Nitroglycerin vs. Furosemide Using Lung Ultrasound Pilot Trial
Nearly 80% of acute heart failure (AHF) patients admitted to the hospital are initially treated in the emergency department (ED). Once admitted, within 30 days post-discharge, 27% of patients are re-hospitalized or die.
- Conditions
- Heart Failure, Heart Failure Acute, Acute Cardiac Failure, Acute Cardiac Pulmonary Edema
- Trial name
- N-FURIOUS (NCT03259165)
- Testing
- Nitrates, Loop Diuretics
- Where
- 3 sites in United States
- Volunteers
- 52 people
- Sponsor
- Indiana University
Cardiac Edema
A Clinical Pharmacological Study of OPC-41061 in the Treatment of Cardiac Edema (Congestive Heart Failure)
To investigate the pharmacokinetics, pharmacodynamics (urine volume and fluid intake), efficacy(body weight, pulmonary congestion and other congestions including cardiothoracic ratio) and safety of 7-day repeated oral…
- Trial name
- NCT00525265
- Testing
- OPC-41061(Tolvaptan)
- Where
- 2 sites in Japan
- Volunteers
- 20 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Heart Failure, Cardiac Failure
Study of Heart Failure Hospitalizations After Aquapheresis Therapy Compared to Intravenous (IV) Diuretic Treatment
The purpose of the research is to determine if patients have fewer Heart Failure (HF) events after receiving Aquapheresis (AQ) therapy compared to intravenous (IV) diuretics up to 90 days of discharge from the hospital.
- Conditions
- Heart Failure, Cardiac Failure, Acute Decompensated Heart Failure (ADHF)
- Trial name
- AVOID-HF (NCT01474200)
- Testing
- Isolated veno-venous ultrafiltration (AQ), IV Loop Diuretics (LD)
- Where
- 38 sites in United States
- Volunteers
- 224 people
- Sponsor
- Nuwellis, Inc.
Acute Decompensated Heart Failure
Cardiorenal Interactions During Treatment of Acute Decompensated Heart Failure: Diuretics Versus Ultrafiltration
The CRUF trial is a prospective randomized monocentric trial comparing different impact of diuretics versus ultrafiltration on renal congestion, plasma refill rate, echocardiographic filling pressures, neurohormonal activation…
- Trial name
- CRUF (NCT01138683)
- Testing
- ultrafiltration, diuretics
- Where
- Belgium
- Volunteers
- 1 people
- Sponsor
- University Hospital, Ghent
Hypertension
Diuretics In the Management of Essential Hypertension (DIME) Study
The purpose of DIME is to evaluate the safety (i.e. new onset of diabetes and other metabolic adverse events), efficacy and cost-effectiveness of antihypertensive treatment with low dose diuretics.
- Trial name
- NCT00131846
- Testing
- Thiazide diuretics, No diuretics
- Where
- Japan
- Volunteers
- 1,130 people
- Sponsor
- Kyoto University
Heart Failure
Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure
Effective diuresis is the primary goal of most acute decompensated heart failure hospitalizations, but diuretic resistance is common and our ability to detect it is limited.
- Trial name
- NCT02546583
- Testing
- Increased Intravenous Bolus Loop Diuretic Dose (Bumetanide or Furosemide), IV Chlorothiazide
- Where
- United States
- Volunteers
- 458 people
- Sponsor
- Yale University
Critical Illness, Oliguria
Performance of Diuretic Stress Test in Predicting Short Term Renal Recovery in Oliguric Critically-ill Patients Recovery in the Short Term
Acute kidney injury (AKI) is a common disorder and associated with high morbidity and mortality. However, distinguishing transient AKI from persistent AKI may help in individualizing treatment and limit short and long term…
- Trial name
- NCT02800135
- Testing
- Furosemide
- Where
- 4 sites in France
- Volunteers
- 93 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Chronic Kidney Insufficiency
Diuretic/Cool Dialysate Trial
The proposed pilot study challenges the current widespread paradigm of discontinuing loop diuretics when initiating chronic HD and/or maintaining the dialysate at a constant temperature of 37 °C for all patients.
- Trial name
- DIDIT (NCT02593526)
- Testing
- Bumetanide, Cool Dialysate
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of New Mexico
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University